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1. 发明专利

JP2001264293A CAPILLARY ARRAY ELECTROPHORESIS DEVICE 失效
公开(公告)号：JP2001264293A
公开(公告)日：2001-09-26
申请号：JP2000084682
申请日：2000-03-22
申请人： HITACHI LTD
发明人： UKAI SEIICHI , MORIOKA TOMONARI , SHIMIZU YASUSHI , KITA TOSHIAKI , TSUKADA SEIJI
IPC分类号： G01N27/447
摘要： PROBLEM TO BE SOLVED: To provide a window base board for a capillary array cutting off background light so as to facilitate incidence of an excited laser beam and to improve an S/N ratio of an electrophoresis device by using the window base board for the capillary array. SOLUTION: In a holding base board constituting a window unit for the capillary array, light shielding areas each spaced at a pitch equal to an arrangement interval of a capillary 1 are arranged in a through window 6 for passing emitted light, and a window 12 for incidence of an excited laser beam is arranged on the base board side face. In this way, background light is reduced because reflected light on the surface of the capillary 1 is cut off by means of the light shielding areas 7 in the holding base board, and the S/N ratio can be improved. In addition, incidence of a laser beam is facilitated and the degree of freedom of an optical system arrangement is increased, so that assembly can be carried out easily.

2. 发明专利

JP2004144479A Multi-capillary array electrophoresis system 有权
公开(公告)号：JP2004144479A
公开(公告)日：2004-05-20
申请号：JP2002281624
申请日：2002-09-26
申请人： Applera Corp , Hitachi Ltd , アプレラコーポレイション , 株式会社日立製作所
发明人： INABA RYOJI , KASAI SHOZO , SHOJI TOMOHIRO , SHIBAZAKI TAKEHIKO , KOJIMA MASAYA , UKAI SEIICHI , SHIMIZU YASUSHI , MORIOKA TOMONARI , NORDMAN ERIC S
IPC分类号： G01N21/64 , G01N27/447
摘要： PROBLEM TO BE SOLVED: To enhance analytical precision in an electrophorestic system wherein irradiation light is emitted to pass successively through a plurality of capillaries to a detecting part of a multi-capillary array comprising the plurality of capillaries. SOLUTION: A liquid or solid having a refractive index higher than that of air and not higher than that of water is interposed in a space between the capillaries to reduce a scattering level of detected light caused by the capillaries. Refraction and reflection are regulated when the irradiation light passes through the capillaries, so as to reduce optical loss caused by the transmission of the light through the plurality of capillaries, and light intensity emitted to a sample is thereby prevented from being reduced. COPYRIGHT: (C)2004,JPO

3. 发明专利

JPH11247763A LIQUID FEEDING DEVICE AND AUTOMATIC ANALYZER 失效
公开(公告)号：JPH11247763A
公开(公告)日：1999-09-14
申请号：JP5176098
申请日：1998-03-04
申请人： HITACHI LTD
发明人： KOIDE AKIRA , MIYAKE AKIRA , TERAYAMA TAKAO , MIMAKI HIROSHI , MORIOKA TOMONARI
IPC分类号： G01N35/10 , F04B43/04 , F04B43/06 , F04B53/10
摘要： PROBLEM TO BE SOLVED: To smoothen the flow of bubbles and to inhibit the fluctuation of pressure by dividing a face at a side opposite to a diaphragm, of a liquid feed chamber into almost two, forming an inlet on a peripheral portion of one side thereof, and an outlet on a peripheral portion of the other side, and mounting the inlet and outlet valves integrally with the liquid feeding chamber in such manner that they are unevenly distributed on a peripheral portion of the liquid feeding chamber. SOLUTION: To replace the gas in the liquid feeding chamber 131 of a liquid feeding device with the liquid, a liquid introducing device is connected with an inlet 144 of the liquid feeding device, and the liquid is pressurized and fed into the inlet 144, so that the pressurized liquid reaches an inlet valve 132 through the liquid passages 143, 134, 122. The liquid is flowed into the liquid feeding chamber 131 when the inlet valve 132 is opened by the pressure of the liquid, the gas existing in the inlet portion is pushed and flowed to a flat plate passage, and the inlet portion is filled with the liquid. The gas in the liquid feeding device is sucked by a vacuum device connected with a discharge nozzle 111, on this occasion, the gas is sucked through an outlet valve 121 which is opened when the back pressure of the outlet valve 121 becomes lower than the internal pressure of the liquid feeding chamber 131.

4. 发明专利

JP2006023319A Capillary array 有权
标题翻译：毛细管阵列
公开(公告)号：JP2006023319A
公开(公告)日：2006-01-26
申请号：JP2005289503
申请日：2005-10-03
申请人： Hitachi Ltd , 株式会社日立製作所
发明人： SHIMIZU YASUSHI , KITA TOSHIAKI , TSUKADA SEIJI , SUZUKI AKIHIRO , MORIOKA TOMONARI , KOJIMA MASAYA , INABA RYOJI , TOKINAGA DAIZO , YAMAMOTO SHUHEI , OKISHIMA YOSHIYUKI , FUKUNAGA MASAO , FURUKAWA TAKAYASU , SHOJI TOMOHIRO
IPC分类号： G01N27/447 , G01N21/64
摘要： PROBLEM TO BE SOLVED: To provide a capillary array capable of being easily assembled into an electrophoresis device. SOLUTION: The capillary array is provided with a photo-detecting part; a sample supply part; a buffer solution supply part; and a voltage impressing part. Since the capillary array is provided with every function required for electrophoresis, it is possible to immediately use the capillary array by assembling it into the electrophoresis device. By this invention, it is possible to provide the capillary array easily handled, capable of sufficiently securing mechanical protection, and being easily mounted on and removed from the electrophoresis device. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供能够容易地组装成电泳装置的毛细管阵列。
解决方案：毛细管阵列设有光电检测部分; 样品供应部分; 缓冲液供应部件; 和电压施加部。由于毛细管阵列具有电泳所需的每个功能，所以可以通过将毛细管阵列组装到电泳装置中立即使用毛细管阵列。通过本发明，可以提供易于处理的能够充分确保机械保护并容易地安装在电泳装置上和从电泳装置移除的毛细管阵列。版权所有（C）2006，JPO＆NCIPI

5. 发明专利

JP2000154783A MICROPUMP AND MANUFACTURE THEREOF 失效
公开(公告)号：JP2000154783A
公开(公告)日：2000-06-06
申请号：JP32475998
申请日：1998-11-16
申请人： HITACHI LTD
发明人： SASAKI YASUHIKO , YOSHIMURA YASUHIRO , KOIDE AKIRA , MIYAKE AKIRA , WATABE SHIGEO , TERAYAMA TAKAO , MIMAKI HIROSHI , ISHIDA YASUHIKO , MORIOKA TOMONARI
IPC分类号： B81C3/00 , F04B43/04
摘要： PROBLEM TO BE SOLVED: To miniaturize a micropump and to prevent a chemical reaction of each member and a working fluid by opposing and overlapping surfaces to be jointed in vacuum or inactive atmosphere and pressurizing and joining the surfaces to be joined after a member forming the micropump is made as a silicon substrate, metallic films are formed on the whole of surfaces to be joined sides and the silicon substrate and the metallic films are cleaned. SOLUTION: In each substrate forming a micropump, monocrystal silicon is made as a base material. After etching working is performed for a chamber and valve substrates 20, 30 at first and thermal oxidation films are formed on the whole surface of each substrate, metallic films are formed on the whole of surfaces to be joined of both substrates and surfaces to be joined are formed. Subsequently, after Ar plasma is irradiated in vacuum, continuously opposed surfaces are opposed in vacuum and joining and positioning are performed, the surfaces are overlapped and the surfaces are joined by heating and pressurizing. Next, metallic films are formed on the whole of each surface to be joined of this joining body and a nozzle substrate 40, surfaces to be joined are formed, surfaces to be joined are joined in the same procedure, metallic films are formed on the whole of each surface to be joined side of this joining body and a diaphragm substrate 10 and surfaces to be joined are joined in the same procedure.

6. 发明专利

JP2010096778A Electrophoresis device 有权
标题翻译：电泳装置
公开(公告)号：JP2010096778A
公开(公告)日：2010-04-30
申请号：JP2010022776
申请日：2010-02-04
申请人： Applied Biosystems Llc , Hitachi Ltd , アプライドバイオシステムズ, エルエルシー , 株式会社日立製作所
发明人： INABA RYOJI , KASAI SHOZO , SHOJI TOMOHIRO , SHIBAZAKI TAKEHIKO , KOJIMA MASAYA , UKAI SEIICHI , SHIMIZU YASUSHI , MORIOKA TOMONARI , NORDMAN ERIC S
IPC分类号： G01N27/447
摘要： PROBLEM TO BE SOLVED: To improve analytical precision of an electrophoresis device wherein irradiation light is irradiated to pass successively through a plurality of capillaries with respect to a detecting part of a multi-capillary array including the plurality of capillaries. SOLUTION: The electrophoresis device is characterized in that a liquid or solid having a refractive index higher than that of air and not higher than that of water is interposed in a space between the capillaries to reduce the amount of detected light scattered by the capillaries. Thereby, by adjusting refraction and/or reflection when the irradiation light passes through the capillaries, optical loss due to transmission through the plurality of capillaries is reduced, and the reduction of intensity of light irradiated to a sample is prevented. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：为了提高照射光的照射光相对于包括多个毛细管的多毛细管阵列的检测部分依次通过多个毛细管的电泳装置的分析精度。解决方案：电泳装置的特征在于，折射率高于空气的液体或固体不高于水的液体或固体插入在毛细管之间的空间中，以减少被毛细管散射的检测光的量毛细血管。因此，通过在照射光通过毛细管时调节折射和/或反射，由于通过多个毛细管的透射而导致的光损失减少，并且防止了照射到样品的光强度的降低。版权所有（C）2010，JPO＆INPIT

7. 发明专利

JP2007171214A Electrophoretic device 有权
标题翻译：电泳装置
公开(公告)号：JP2007171214A
公开(公告)日：2007-07-05
申请号：JP2007040402
申请日：2007-02-21
申请人： Applera Corp , Hitachi Ltd , アプレラコーポレイション , 株式会社日立製作所
发明人： INABA RYOJI , KASAI SHOZO , SHOJI TOMOHIRO , SHIBAZAKI TAKEHIKO , KOJIMA MASAYA , UKAI SEIICHI , SHIMIZU YASUSHI , MORIOKA TOMONARI , NORDMAN ERIC S
IPC分类号： G01N27/447 , G01N21/15 , G01N21/64
摘要： PROBLEM TO BE SOLVED: To improve the analysis accuracy of an electrophoresis device, where irradiation light is applied to the detection section of a multi-capillary array comprising a plurality of capillaries continuously through the plurality of capillaries. SOLUTION: The electrophoretic device makes liquid or a solid whose refractive index is larger than that of air and is not larger than that of water interposed in the space between capillaries 16, thus reducing the amount of detection light scattered by the capillaries 16. As a result, by adjusting the refraction and reflection when the irradiation light passes the capillaries, light loss due to the passage of the plurality of capillaries is reduced, thus reducing the intensity of light applied to the sample. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：为了提高电泳装置的分析精度，其中照射光通过多个毛细管连续地施加到包括多个毛细管的多毛细管阵列的检测部分。电泳装置制造折射率大于空气的液体或固体，并且不大于插入毛细管16之间的水的液体或固体，因此减少毛细管16散射的检测光的量结果，通过调整照射光通过毛细管时的折射和反射，由于多个毛细管的通过而导致的光损失减少，因此降低了施加到样品上的光的强度。版权所有（C）2007，JPO＆INPIT

8. 发明专利

JP2002365262A CAPILLARY ARRAY DEVICE 审中-公开
公开(公告)号：JP2002365262A
公开(公告)日：2002-12-18
申请号：JP2002079914
申请日：2002-03-22
申请人： HITACHI LTD
发明人： FURUKAWA TAKAYASU , SHIMODA NORIYUKI , KASAI SHOZO , UKAI SEIICHI , OKISHIMA YOSHIYUKI , MORIOKA TOMONARI , SHIMIZU YASUSHI , TANAKA HIROYUKI
IPC分类号： G01N27/447 , C12M1/00
摘要： PROBLEM TO BE SOLVED: To facilitate the connection of a connection plate for applying high voltage to the electrode of a capillary array device with an electrode. SOLUTION: The connection plate 23 and a hollow electrode 20 are connected by a solderless spring joining method or by a method utilizing the bulk modulus force of the connection plate 23. By this constitution, both of them can be fixed by inserting the hollow electrode 20 in the connection plate 23 to facilitate the production of a capillary array. Further, since both of them are joined under pressure by spring force or bulk modulus force, a contact resistance value can be reduced.

9. 发明专利

JP2002296235A CAPILLARY ARRAY AND CAPILLARY ARRAY OPTICAL DETECTION DEVICE 失效
公开(公告)号：JP2002296235A
公开(公告)日：2002-10-09
申请号：JP2001103206
申请日：2001-04-02
申请人： HITACHI LTD
发明人： INANAMI YOSHIHITO , KITA TOSHIAKI , OZAWA YOSHIO , MORIOKA TOMONARI , SUZUKI AKIHIRO , SHIMIZU YASUSHI , KOJIMA MASAYA
IPC分类号： G01N21/64 , G01N27/447
摘要： PROBLEM TO BE SOLVED: To provide a multi-focus style capillary array and a capillary array optical detection device capable of reducing crosstalk. SOLUTION: In a board 20 with plural capillaries arranged, a through hole 72 is formed at least at a part of a region positioned behind the capillaries when the capillaries are viewed from an optical detector.

10. 发明专利

JP2002039992A CAPILLARY ARRAY 失效
公开(公告)号：JP2002039992A
公开(公告)日：2002-02-06
申请号：JP2001047518
申请日：2001-02-23
申请人： HITACHI LTD
发明人： KASAI SHOZO , TSUKADA SEIJI , KITA TOSHIAKI , MORIOKA TOMONARI
IPC分类号： G01N27/447 , C12M1/00 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To provide a structure in which gel produced when capillary heads are mounted to a buffer solution container and air bubbles in a buffer solution do not adhere to the ends of the capillary heads nor the air bubbles occur. SOLUTION: In the structure of the capillary head parts, a capillary receiver, capillaries, and the liquid contact surface of an adhesive are flush with each other, and the coarseness of the same plane of the liquid contact surface is provided with a mirror surface equal to 3S or smaller. The total area ratio of the capillaries within the inner-diameter area of the capillary receiver in the same plane in contact with a liquid is set at 60-73%.

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