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1. 发明专利

JP2004000167A Process for preparing fermentation product containing significant amount of nisin by using barley shochu distillation residual liquid as medium 有权
公开(公告)号：JP2004000167A
公开(公告)日：2004-01-08
申请号：JP2003078903
申请日：2003-03-20
申请人： Fumiaki Ishizaki , Omugi Hakko Kenkyusho:Kk , Sanwa Shiyurui Kk , 三和酒類株式会社 , 株式会社大麦発酵研究所 , 石崎文彬
发明人： OMORI TOSHIRO , FURUTA YOSHIFUMI , UMEMOTO YASUSHI , DOBASHI ERIKO , KODERA MIHOKO , NAKAMURA TERUHIRO , ISHIZAKI FUMIAKI
IPC分类号： A23L1/00 , A23J3/20 , C12P21/02 , C12R1/01
摘要： PROBLEM TO BE SOLVED: To provide a process for preparing a fermentation product having an excellent taste which may be used as a food product. SOLUTION: A medium used here is obtained by adding sugar to a liquid which comprises a liquid component (A) obtained through solid-liquid separation of a barley Shochu (distilled liquor) distillation residual liquid and whose Brix concentration is adjusted to 0.5-6.0. Nisin-producing lactic bacteria are added to the medium and incubated while controlling the sugar concentration of the culture broth to ≥0.1 g/l and its pH to 4.0-7.0. COPYRIGHT: (C)2004,JPO

2. 发明专利

JP2004000168A Process for preparing fermentation product containing significant amount of nisin by using barley- and rice shochu distillation residual liquids as medium 有权
公开(公告)号：JP2004000168A
公开(公告)日：2004-01-08
申请号：JP2003078907
申请日：2003-03-20
申请人： Fumiaki Ishizaki , Omugi Hakko Kenkyusho:Kk , Sanwa Shiyurui Kk , 三和酒類株式会社 , 株式会社大麦発酵研究所 , 石崎文彬
发明人： OMORI TOSHIRO , FURUTA YOSHIFUMI , UMEMOTO YASUSHI , DOBASHI ERIKO , KODERA MIHOKO , NAKAMURA TERUHIRO , ISHIZAKI FUMIAKI
IPC分类号： A23L1/00 , A23J3/20 , C12P21/02 , C12R1/01
摘要： PROBLEM TO BE SOLVED: To provide a process for preparing a fermentation product having an excellent taste which is highly suitable for food applications. SOLUTION: A medium used here is obtained by adding sugar to a liquid which comprises liquid components (A) and (B) obtained through solid-liquid separation of a barley Shochu (distilled liquor) distillation residual liquid and a rice Shochu distillation residual liquid, respectively, and whose Brix concentration is adjusted to 0.5-6.0. Nisin-producing lactic bacteria are added to the medium and incubated while controlling the sugar concentration of the culture broth to ≥0.1 g/l and its pH to 4.0-7.0. COPYRIGHT: (C)2004,JPO

3. 发明专利

JP2005065647A Method for producing useful substance by utilizing bacterium that can produce useful product that produces bacteriocin 有权
标题翻译：通过利用细菌生产有用的物质的方法，可以生产有用的产品，生产细菌
公开(公告)号：JP2005065647A
公开(公告)日：2005-03-17
申请号：JP2003303560
申请日：2003-08-27
申请人： Omugi Hakko Kenkyusho:Kk , Sanwa Shiyurui Kk , Shinseiki Hakko Kenkyusho:Kk , 三和酒類株式会社 , 有限会社新世紀発酵研究所 , 株式会社大麦発酵研究所
发明人： ISHIZAKI FUMIAKI , KONO AKIHIKO , OMORI TOSHIRO , FURUTA YOSHIFUMI , NAKAMURA TERUHIRO , UMEMOTO YASUSHI
IPC分类号： C12P7/56 , C12P1/04 , C12R1/01
摘要： PROBLEM TO BE SOLVED: To provide a method for producing a useful substance by utilizing a bacterium that produce the useful substance producing bacteriocin in no need of heat sterilization, inhibits metal corrosion to prevent individual parts of the plant installation from deterioration, suppress the decomposition of culture medium compositions and the production hindrance of the useful substance and can carry out the production of the useful substance without production of by-product hazardous to human body. SOLUTION: In the method for producing a useful substance by utilizing a bacterium that produces the useful substance, the useful substance-producing bacterium forms the useful substance and produces the bacteriocin that has anti-bacterial and/or bacteriocidal effect. Thus, the culture medium is prepared by this bacteriocin formed here and simultaneously the culture apparatus can be subjected to pasteurization treatment. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供一种通过利用不需要加热灭菌来生产产生细菌素的有用物质的细菌来生产有用物质的方法，抑制金属腐蚀以防止植物装置的各个部件劣化，抑制培养基组合物的分解和有用物质的生产阻碍，并且可以在不产生对人体有害的副产物的情况下进行有用物质的生产。解决方案：在通过利用产生有用物质的细菌生产有用物质的方法中，有用的物质产生细菌形成有用物质并产生具有抗细菌和/或杀菌作用的细菌素。因此，通过这里形成的这种细菌素制备培养基，同时可以对培养装置进行巴氏灭菌处理。版权所有（C）2005，JPO＆NCIPI

4. 发明专利

JP2004217928A Production method for composition having activating action of natural killer cell and production method for activated natural killer cell-containing composition 审中-公开
标题翻译：具有自然杀伤细胞活化作用的组合物的生产方法和用于活化的天然杀伤细胞含有组合物的生产方法
公开(公告)号：JP2004217928A
公开(公告)日：2004-08-05
申请号：JP2003433294
申请日：2003-12-26
申请人： National Institute Of Advanced Industrial & Technology , Omugi Hakko Kenkyusho:Kk , Sanwa Shiyurui Kk , 三和酒類株式会社 , 株式会社大麦発酵研究所 , 独立行政法人産業技術総合研究所
发明人： OMORI TOSHIRO , UMEMOTO YASUSHI , FURUTA YOSHIFUMI , SOTOZONO HIDEKI , KODERA MIHOKO , OBA HIDEKI
IPC分类号： A61K31/715 , A61K35/14 , A61K36/06 , A61K36/899 , A61P35/00 , A61P35/02 , A61P43/00 , C08B37/14 , C12N5/07 , C12N5/071 , C12N5/0783 , A61K35/70 , A61K35/72 , A61K35/78 , C12N5/06
摘要： PROBLEM TO BE SOLVED: To provide a production method for a composition having an activating action of a dispensed NK cell from a barley shochu distillation residual liquid, and to provide a production method for an activated NK cell-containing composition. SOLUTION: The producing method of a composition having an activating action of a NK cell comprises at least the steps of: obtaining a liquid component by solid-liquid separating the barley shochu distillation residual liquid by-produced in a producing method of the shochu using barley as a raw material, and applying a thickening treatment to the liquid component by ultrafiltrating using an ultrafiltration membrane, and in the thickening treatment to the liquid component by ultrafiltrating, containing substantially no uronic acid, but containing a polysaccharide consisting of xylose, arabinose and glucose, obtaining a thickened liquid having the activating action of the NK cell, and obtaining the composition comprising the thickened liquid. The producing method of the activated NK cell-containing composition comprises containing the activated NK cell with the composition having the activating action of the NK cell. COPYRIGHT: (C)2004,JPO&NCIPI
摘要翻译：解决问题的方法：提供从大麦烧酒蒸馏残留液中分配的NK细胞的活化作用的组合物的制造方法，提供含活性NK细胞的组合物的制造方法。解决方案：具有NK细胞活化作用的组合物的制备方法至少包括以下步骤：通过以下方法获得液体成分：将生产的副产的大麦烧酒蒸馏残余液体固液分离，使用大麦作为原料的烧酒，通过使用超滤膜进行超滤处理，对液体成分进行增稠处理，在通过超滤的液体成分的粗化处理中，基本上不含糖醛酸，但含有由木糖，阿拉伯糖和葡萄糖，得到具有NK细胞活化作用的增稠液，得到包含增稠液体的组合物。活化的含有NK细胞的组合物的制备方法包括含有具有NK细胞活化作用的组合物的活化的NK细胞。版权所有（C）2004，JPO＆NCIPI

5. 发明专利

JP2005104957A Composition having activity for activating natural killer cell, method for producing the same, activated natural killer cell-containing composition and method for producing the same 审中-公开
标题翻译：具有用于激活自然杀伤细胞的活性的组合物，其生产方法，活化的自然杀伤细胞含有组合物及其生产方法
公开(公告)号：JP2005104957A
公开(公告)日：2005-04-21
申请号：JP2003429972
申请日：2003-12-25
申请人： National Institute Of Advanced Industrial & Technology , Omugi Hakko Kenkyusho:Kk , Sanwa Shiyurui Kk , 三和酒類株式会社 , 株式会社大麦発酵研究所 , 独立行政法人産業技術総合研究所
发明人： OMORI TOSHIRO , UMEMOTO YASUSHI , FURUTA YOSHIFUMI , SOTOZONO HIDEKI , KODERA MIHOKO , OBA HIDEKI
IPC分类号： A61K31/716 , A61K35/14 , A61K36/00 , A61K36/06 , A61K36/899 , A61P1/16 , A61P31/12 , A61P35/00 , A61P35/02 , A61P37/02 , A61P43/00 , C12N5/0783 , C12P1/00 , A61K35/78 , A61K35/72 , C12N5/06
CPC分类号： C12N5/0646 , A61K36/8998 , C12N2500/34
摘要： PROBLEM TO BE SOLVED: To obtain a composition fractionated from a barley-distilled white liquor residual liquid and having an activity of activating natural killer (NK) cells, and an activated NK cell-containing composition. SOLUTION: The composition having the activity for activating the NK cells consisting of a fraction insoluble to an organic solvent is obtained by the solid-liquid separation of the barley-distilled white liquor residual liquid produced as a byproduct in the distilled white liquor production by using the barley as a raw material to obtain a liquid portion, performing an ion exchange treatment to the liquid portion or a non-adsorbed fraction obtained by performing an adsorptive separation of the liquid portion by using a synthetic adsorbent, by using an ion-exchanging resin to obtain a non-adsorbed fraction to the ion-exchanging resin, performing a concentrating treatment of the non-adsorbed fraction to the ion-exchanging resin by an ultrafiltration using an ultrafiltration membrane to obtain concentrated liquid and adding the above organic solvent to the concentrated liquid, and a method for producing the same is also provided. The activated NK cell-containing composition containing the NK cells activated by the above composition, and a method for producing the same are also provided. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：获得从大麦蒸馏白液残液中分级分离并具有活化自然杀伤（NK）细胞活性的组合物和活化的含有NK细胞的组合物。解决方案：通过将蒸馏白液中作为副产物产生的大麦蒸馏白液残留液体的固液分离，获得具有活化由不溶于有机溶剂的级分组成的NK细胞活性的组合物通过使用大麦作为原料以获得液体部分，通过使用合成吸附剂对液体部分进行离子交换处理或通过使用合成吸附剂进行液体部分的吸附分离而获得的非吸附级分来生产改性树脂，以获得离子交换树脂的非吸附级分，通过使用超滤膜进行超滤，对离子交换树脂进行非吸附级分的浓缩处理，得到浓缩液，加入上述有机溶剂与浓缩液相同，也提供了其制造方法。还提供了含有通过上述组合物活化的NK细胞的活化的含有NK细胞的组合物及其制备方法。版权所有（C）2005，JPO＆NCIPI

6. 发明专利

JP2004359608A Composition exhibiting medicinal activity for improving memory learning ability and fractionated from distillation residual liquid of barley shochu (white distilled liquor) 有权
$Composition exhibiting medicinal activity for improving memory learning ability and fractionated from distillation residual liquid of barley shochu (white distilled liquor)$
标题翻译：组合物展示药物活性，用于提高记录学习能力，并分离出来的BARLEY SHOCHU（白色液体）的蒸馏残留液体
公开(公告)号：JP2004359608A
公开(公告)日：2004-12-24
申请号：JP2003160353
申请日：2003-06-05
申请人： Omugi Hakko Kenkyusho:Kk , Sanwa Shiyurui Kk , 三和酒類株式会社 , 株式会社大麦発酵研究所
发明人： SUZUKI HIRAMITSU , SOTOZONO HIDEKI , OMORI TOSHIRO , UMEMOTO YASUSHI , TAKESHIMA NAOKI
IPC分类号： C12F3/10 , A61K36/00 , A61K36/899 , A61P25/28 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To provide a composition exhibiting medicinal activities for improving memory learning ability, and fractionated from a distillation residual liquid of barley Shochu. SOLUTION: The composition exhibiting the excellent medicinal activities for improving the memory learning ability in an evaluation test of the memory learning ability comprises a desorbed fraction. The desorbed fraction is obtained by subjecting the distillation residual liquid by-produced in the production of the Shochu using barley as a raw material to solid-liquid separation to provide a liquid component, subjecting the liquid component to adsorption treatment using a synthetic adsorbent to provide an adsorbed fraction on the synthetic adsorbent, and eluting the adsorbed fraction on the synthetic adsorbent by using an alkali or ethanol. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供一种表现出用于提高记忆学习能力的药用活性的组合物，并从大麦烧酒的蒸馏残余液中分离出来。解决方案：在记忆学习能力的评价试验中表现出用于提高记忆学习能力的优异药物活性的组合物包括解吸组分。脱附馏分是通过使用大麦生产Shochu中的副产的蒸馏残余液体作为原料进行固液分离，得到液体成分，使用合成吸附剂对液体成分进行吸附处理，得到合成吸附剂上的吸附级分，并通过使用碱或乙醇洗脱合成吸附剂上的吸附级分。版权所有（C）2005，JPO＆NCIPI

7. 发明专利

JP2004210686A Composition having inhibitory action on crisis of alcoholic hepatopathy and healing action, and method for producing the same 有权
公开(公告)号：JP2004210686A
公开(公告)日：2004-07-29
申请号：JP2002380677
申请日：2002-12-27
申请人： Omugi Hakko Kenkyusho:Kk , Sanwa Shiyurui Kk , 三和酒類株式会社 , 株式会社大麦発酵研究所
发明人： OMORI TOSHIRO , UMEMOTO YASUSHI , FURUTA YOSHIFUMI , SOTOZONO HIDEKI , KODERA MIHOKO
IPC分类号： A23L1/30 , A61K31/738 , A61P1/16
摘要： PROBLEM TO BE SOLVED: To obtain a composition which is collected from barley Shochu (Japanese distilled spirits) distillation residual liquid and has inhibitory action on crisis of alcoholic hepatopathy and healing action. SOLUTION: The composition having inhibitory action on crisis of alcoholic hepatopathy and healing action comprises an organic solvent-insoluble fraction which is collected by subjecting barley Shochu distillation residual liquid produced as a by-product in Shochu production using barley as a raw material to solid-liquid separation to give a liquid, subjecting the liquid to ion exchange treatment using an ion exchange resin to give a non-adsorbed fraction on the ion exchange resin, ultrafiltering the non-adsorbed fraction on the ion exchange resin by using an ultrafilter to give a concentrate and adding an organic solvent to the concentrate. COPYRIGHT: (C)2004,JPO&NCIPI

8. 发明专利

JP2007084503A Composition containing ingredient originated from grain as active ingredient and having neovascularization inhibitory action 有权
标题翻译：含有成分作为活性成分并具有新生血管抑制作用的成分组成
公开(公告)号：JP2007084503A
公开(公告)日：2007-04-05
申请号：JP2005277652
申请日：2005-09-26
申请人： National Institute Of Advanced Industrial & Technology , Omugi Hakko Kenkyusho:Kk , Sanwa Shiyurui Kk , 三和酒類株式会社 , 株式会社大麦発酵研究所 , 独立行政法人産業技術総合研究所
发明人： OMORI TOSHIRO , SOTOZONO HIDEKI , KODERA MIHOKO , UMEMOTO YASUSHI , HAYASHI KEI , OBA HIDEKI , TAKESHIMA NAOKI
IPC分类号： A61K36/899 , A23K1/16 , A23K1/18 , A23L1/30 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a composition having an excellent neovascularization inhibitory action from an inexpensive and relatively easily available material not having a problem on safety, preferably barley, by a simple treatment method suitable for practical production in a factory scale without passing through a troublesome purification process. SOLUTION: This composition for inhibiting neovascularization contains an ingredient originated from a gramineae plant, preferably an ingredient originated from barley, as active ingredient having a neovascularization inhibitory action. The ingredient originated from barley is selected from the group consisting of an unmilled barley ethyl alcohol extraction fraction and an unmilled barley alkali extraction fraction. The composition for inhibiting the neovascularization is a composition for treating or preventing diseases having neovascularization to be inhibited, concretely diseases caused by abnormal neovascularization in tumors or cancers, chronic inflammations or retinopathy. The composition is in a form selected from the group consisting of food additives, food materials, foods, drinks, medicines/quasi-drugs, and feeds for inhibiting neovascularization. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：通过适用于工厂规模的实际生产的简单的处理方法，从不具有安全性问题的廉价且相对容易获得的材料，优选大麦提供具有优异的新血管形成抑制作用的组合物，没有通过一个麻烦的净化过程。解决方案：用于抑制新生血管形成的组合物含有起源于禾本科植物，优选来自大麦的成分的成分，作为具有新血管形成抑制作用的活性成分。起源于大麦的成分选自未熟化的大麦乙醇提取级分和未熟化的大麦碱提取级分。用于抑制新血管形成的组合物是用于治疗或预防具有新血管形成被抑制的疾病的组合物，具体是由肿瘤或癌症中的异常新血管形成引起的疾病，慢性炎症或视网膜病变。组合物为选自食品添加剂，食品材料，食品，饮料，药物/准药物和用于抑制新血管形成的饲料的形式。版权所有（C）2007，JPO＆INPIT

9. 发明专利

JP2004238453A Anti-oxidizing action-having composition and method for producing the same composition 有权
公开(公告)号：JP2004238453A
公开(公告)日：2004-08-26
申请号：JP2003027902
申请日：2003-02-05
申请人： Omugi Hakko Kenkyusho:Kk , Sanwa Shiyurui Kk , 三和酒類株式会社 , 株式会社大麦発酵研究所
发明人： UCHIUMI TOSHIHIKO , OMORI TOSHIRO , UMEMOTO YASUSHI , FURUTA YOSHIFUMI , SOTOZONO HIDEKI , KODERA MIHOKO
IPC分类号： C12F3/08 , A61K9/19 , A61K36/06 , A61K36/899 , A61P1/04 , A61P3/10 , A61P9/10 , A61P9/12 , A61P17/00 , A61P17/10 , A61P35/00 , A61P39/06 , C09K15/06 , C09K15/08 , C09K15/34 , A61K35/72 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To obtain an anti-oxidizing action-having composition fractionated from a barley Shochu (Japanese white distilled liquor) distillation residual liquid. SOLUTION: The method for producing the excellent anti-oxidizing action-having composition comprises subjecting the barley shochu distillation residual liquid by-produced on the production of the Shochu using barley as a raw material to a solid-liquid separation to obtain a liquid fraction, subjecting the liquid fraction to an adsorption treatment using a synthetic adsorbent to obtain a synthetic adsorbent non-adsorbable fraction, and then eluting the synthetic adsorbent non-adsorbable fraction with an alkali or ethanol to fractionate the anti-oxidizing action-having composition. COPYRIGHT: (C)2004,JPO&NCIPI

10. 发明专利

JP2004244318A Composition having antioxidizing action and method of producing the same composition 有权
标题翻译：具有抗氧化作用的组合物及其制备方法
公开(公告)号：JP2004244318A
公开(公告)日：2004-09-02
申请号：JP2003032585
申请日：2003-02-10
申请人： Omugi Hakko Kenkyusho:Kk , Sanwa Shiyurui Kk , 三和酒類株式会社 , 株式会社大麦発酵研究所
发明人： UCHIUMI TOSHIHIKO , OMORI TOSHIRO , UMEMOTO YASUSHI , FURUTA YOSHIFUMI , SOTOZONO HIDEKI , KODERA MIHOKO
IPC分类号： A23L1/30 , A61K9/19 , A61K31/05 , A61K31/19 , A61K31/194 , A61K31/7004 , A61K31/716 , A61K36/899 , A61K38/00 , A61P9/10 , A61P39/06 , C09K15/34 , C12F3/10 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To provide a composition separated from a distillation residue of barley Shochu (Japanese distilled spirit) and having antioxidizing actions. SOLUTION: In the production of a Shochu made from barley as a raw material, the distillation residue of the barley Shochu formed as a by-product is subjected to liquid-solid separation to provide a liquid component which is then subjected to an ion exchange treatment with an ion exchange resin to afford a fraction unadsorbed on the ion exchange resin. The resultant fraction unadsorbed on the ion exchange resin is subjected to an ultrafiltration treatment with an ultrafiltration membrane to provide a concentrate. An organic solvent is added to the concentrate to separate a fraction (A) insoluble in the organic solvent. The distillation residue of the barley Shochu is subjected to the solid-liquid separation to afford the liquid component which is then subjected to an adsorption treatment with a synthetic adsorbent to provide a fraction adsorbed on the synthetic adsorbent. The resultant fraction adsorbed on the synthetic adsorbent is eluted with an alkali or ethanol to afford a desorbed fraction (B) which is mixed with the fraction (A) insoluble in the organic solvent in a prescribed proportion. The composition is composed of a mixture (A+B) and assumes excellent antioxidizing actions with in vitro tests related to in vivo oxidation. COPYRIGHT: (C)2004,JPO&NCIPI
摘要翻译：待解决的问题：提供从大麦烧酒（日本蒸馏酒）的蒸馏残渣中分离并具有抗氧化作用的组合物。解决方案：在以大麦为原料制作的烧酒的生产中，将作为副产物形成的大麦烧酒的蒸馏残渣进行液固分离，得到液体成分，然后将其进行用离子交换树脂进行离子交换处理，得到未吸附在离子交换树脂上的馏分。将未吸附在离子交换树脂上的所得部分用超滤膜进行超滤处理以提供浓缩物。向浓缩物中加入有机溶剂以分离不溶于有机溶剂的级分（A）。将大麦Shochu的蒸馏残余物进行固液分离，得到液体成分，然后用合成吸附剂进行吸附处理，以提供吸附在合成吸附剂上的级分。用碱或乙醇洗脱吸附在合成吸附剂上的所得级分，得到与不溶于有机溶剂的级分（A）以规定比例混合的脱附级分（B）。该组合物由混合物（A + B）组成，并且与体内氧化相关的体外试验具有优异的抗氧化作用。版权所有（C）2004，JPO＆NCIPI

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