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1. 发明专利

JP2006226921A SURFACE PLASMON RESONANCE MEASURING METHOD 审中-公开
公开(公告)号：JP2006226921A
公开(公告)日：2006-08-31
申请号：JP2005043209
申请日：2005-02-18
申请人： FUJI PHOTO FILM CO LTD
发明人： TSUZUKI HIROHIKO
IPC分类号： G01N21/27 , G01N21/41 , G01N33/543
摘要： PROBLEM TO BE SOLVED: To provide a method for acquiring a chromatogram by using an SPR analysis method. SOLUTION: In this method for measuring a change of surface plasmon resonance by exchanging liquid in a passage system by using a surface plasmon resonance measuring device equipped with a metal film, a light source for generating a light beam, an optical system for allowing the light beam to enter to acquire a total reflection condition at the interface with the metal film and to include various incident angle components, a passage system including a cell formed on the metal film, and a photodetection means for detecting the surface plasmon resonance state by measuring the intensity of the light beam totally reflected by the interface, measurement is performed by sending liquid in such a liquid rate that the absolute quantity of molecules adsorbed onto the metal film surface becomes smaller than a saturated adsorption quantity onto the metal film surface of the molecules. COPYRIGHT: (C)2006,JPO&NCIPI

2. 发明专利

JP2006214937A Analytical method using biosensor 审中-公开
标题翻译：使用BIOSENSOR的分析方法
公开(公告)号：JP2006214937A
公开(公告)日：2006-08-17
申请号：JP2005029458
申请日：2005-02-04
申请人： Fuji Photo Film Co Ltd , 富士写真フイルム株式会社
发明人： KUBO TOSHIAKI , TSUZUKI HIROHIKO
IPC分类号： G01N33/543 , G01N21/27 , G01N33/553
摘要： PROBLEM TO BE SOLVED: To provide an analytical method capable of simultaneously evaluating combinations of a large number of ligands and analytes through the use of a biosensor without contact between a measuring range of the sensor and a channel.
SOLUTION: After a plurality of ligands are fixed by a laminar flow to the surface of the biosensor having a metal surface or a metal film, analytes are made to flow in a laminar flow which substantially intersects with the laminar flow at right angles. The analytical method uses the biosensor and analyzes interactions between ligands and analytes.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种能够通过使用生物传感器同时评估大量配体和分析物的组合而不在传感器的测量范围和通道之间接触的分析方法。解决方案：在通过层流将多个配体固定到具有金属表面或金属膜的生物传感器的表面上之后，分析物以与直流层流基本相交的层流流动。分析方法使用生物传感器并分析配体和分析物之间的相互作用。版权所有（C）2006，JPO＆NCIPI

3. 发明专利

JP2006098204A Surface plasmon resonance measuring method 审中-公开
标题翻译：表面质谱共振测量方法
公开(公告)号：JP2006098204A
公开(公告)日：2006-04-13
申请号：JP2004284441
申请日：2004-09-29
申请人： Fuji Photo Film Co Ltd , 富士写真フイルム株式会社
发明人： TSUZUKI HIROHIKO
IPC分类号： G01N21/27
摘要： PROBLEM TO BE SOLVED: To reduce a noise caused by liquid sending during a measuring time, when measuring a specific bonding reaction between a physiologically active substance and a test substance by using a surface plasmon resonance measuring device.
SOLUTION: In this method, a change of surface plasmon resonance is measured by using the surface plasmon resonance measuring device equipped with a passage system including a cell formed on a metal film, and a photodetection means for measuring the intensity of a light beam totally reflected by the metal film surface and for detecting the surface plasmon resonance state. The method is characterized by supplying intermittently sample liquid including the test substance to be measured, and measuring and extracting the change of the surface plasmon resonance in the state where a liquid flow is stopped.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：为了减少在测量时间期间由送液引起的噪音，当通过使用表面等离子体共振测量装置测量生理活性物质和测试物质之间的特定结合反应时。解决方案：在该方法中，通过使用配备有包括形成在金属膜上的电池的通道系统的表面等离子体共振测量装置和用于测量光强度的光检测装置来测量表面等离子体共振的变化由金属膜表面全反射并用于检测表面等离子体共振状态的光束。该方法的特征在于间歇地供给包含待测物质的样品液体，并且在停止液体流动的状态下测量和提取表面等离子体共振的变化。版权所有（C）2006，JPO＆NCIPI

4. 发明专利

JP2006058072A Biosensor 审中-公开
标题翻译：生物传感器
公开(公告)号：JP2006058072A
公开(公告)日：2006-03-02
申请号：JP2004238397
申请日：2004-08-18
申请人： Fuji Photo Film Co Ltd , 富士写真フイルム株式会社
发明人： SAITO YOSHIHIRO , TSUZUKI HIROHIKO
IPC分类号： G01N21/27 , G01N33/543
摘要： PROBLEM TO BE SOLVED: To provide a detection surface for a biosensor capable of suppressing nonspecific adsorption, and performing trace amount detection.
SOLUTION: In this biosensor comprising a substrate coated with a hydrophobic polymer compound, the coating thickness of the hydrophobic polymer is 0.1 nm or more and 500 nm or less, and the number of defects with a diameter of 10 nm or more existing in the coating layer is 10 or less per 1 μm
2 .
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供能够抑制非特异性吸附的生物传感器的检测表面，并进行痕量检测。解决方案：在该生物传感器中，包含涂布有疏水性高分子化合物的基材，疏水性聚合物的涂布厚度为0.1nm以上且500nm以下，直径为10nm以上的缺陷数存在在涂层中，每1μm 2 <10/10>为10以下。版权所有（C）2006，JPO＆NCIPI

5. 发明专利

JP2005283145A Surface plasmon resonance measurement method 审中-公开
标题翻译：表面质谱共振测量方法
公开(公告)号：JP2005283145A
公开(公告)日：2005-10-13
申请号：JP2004093051
申请日：2004-03-26
申请人： Fuji Photo Film Co Ltd , 富士写真フイルム株式会社
发明人： TSUZUKI HIROHIKO
IPC分类号： G01N33/543 , G01N21/27
摘要： PROBLEM TO BE SOLVED: To acquire reliable combination detection data by suppressing variations in a measurement value, when measuring the specific combination reaction between a physiological active substance and a substance to be inspected by using a surface plasmon resonance measuring apparatus.
SOLUTION: A change in surface plasmon resonance is measured by using the surface plasmon resonance measuring apparatus, having a channel system including a cell formed on a metal film and a light detection means for detecting the state of surface plasmon resonance by measuring the intensity of light beams totally reflected from the surface of the metal film, and by exchanging liquid in the channel system. The long diameter of the metal film is ≥0.1μm and ≤100μm, a molecule interacting with a molecule to be analyzed is immobilized onto the surface of the metal film, the distance between the metal films is ≥200μm and ≤10mm, and a molecule interacting with the molecule to be analyzed is not immobilized to a part other than the metal film.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：通过使用表面等离子体共振测量装置测量生理活性物质和待检查物质之间的特定组合反应时，通过抑制测量值的变化来获取可靠的组合检测数据。解决方案：通过使用具有包括形成在金属膜上的单元的沟道系统的表面等离子体共振测量装置和用于通过测量表面等离子体共振的状态来检测表面等离子体共振的光检测装置来测量表面等离子体共振的变化从金属膜的表面全反射的光束的强度，以及通道系统中的液体的交换。金属膜的长直径≥0.1μm，≤100μm，与待分析的分子相互作用的分子固定在金属膜的表面上，金属膜之间的距离为≥200μm，≤10mm，分子与待分析的分子相互作用不会固定在金属膜以外的部分。版权所有（C）2006，JPO＆NCIPI

6. 发明专利

JP2005168436A Cell-culturing apparatus and cell-culturing method 审中-公开
标题翻译：细胞培养装置和细胞培养方法
公开(公告)号：JP2005168436A
公开(公告)日：2005-06-30
申请号：JP2003415268
申请日：2003-12-12
申请人： Fuji Photo Film Co Ltd , 富士写真フイルム株式会社
发明人： ICHIKAWA YASUNORI , TSUZUKI HIROHIKO , TODA SATORU , SHIRAISHI FUMIKO
IPC分类号： C12M3/00 , C12N5/07 , C12N5/071 , C12N5/06
摘要： PROBLEM TO BE SOLVED: To build a culturing apparatus which is most suitable for culture of animal cells. SOLUTION: In the apparatus for culturing the cells by attaching a cell to a polymer water-containing gel film for attaching the cell to be cultured and charging a culture solution therein, a liquid-pressurizing means for pressuring a liquid supplied to the culturing apparatus and a flow rate-measuring means for measuring a flow rate of the liquid are provided in this order to control the flow rate of the liquid so that the liquid supplied to the culturing apparatus becomes a prescribed flow rate. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：构建最适合于动物细胞培养的培养装置。解决方案：在用于通过将细胞附着到用于附着待培养的细胞的聚合物含水凝胶膜并向其中加入培养溶液的培养液培养细胞的装置中，加压供给到所述细胞的液体的液体加压装置依次设置用于测量液体流量的培养装置和流量测量装置，以便控制液体的流速，使供给培养装置的液体成为规定的流量。版权所有（C）2005，JPO＆NCIPI

7. 发明专利

JP2004033135A Carrier for culturing cell 有权
公开(公告)号：JP2004033135A
公开(公告)日：2004-02-05
申请号：JP2002196725
申请日：2002-07-05
申请人： Fuji Photo Film Co Ltd , 富士写真フイルム株式会社
发明人： TSUZUKI HIROHIKO , AIKAWA KAZUHIRO , KATO ATSUSHI
IPC分类号： C12N5/07 , C12N5/071 , C12N5/06
摘要： PROBLEM TO BE SOLVED: To provide a carrier for culturing cells, utilizable for a cell-culture technique, cell sheet engineering or the like. SOLUTION: The carrier for culturing the cells includes an aqueous gel containing alginic acid, and has the surface covered with a collagen. The collagen is bonded to the aqueous gel through a chitosan. The method for producing a cell culture product comprises a step of forming a cell layer on the surface of the carrier for culturing the cells, and a step of solubilizing the aqueous gel containing the alginic acid. COPYRIGHT: (C)2004,JPO

8. 发明专利

JP2004021508A Radioactive labelled substance management system, radioactive labelled substance central management server, and radioactive labelled substance management method for radioactive labelled substance management system 审中-公开
公开(公告)号：JP2004021508A
公开(公告)日：2004-01-22
申请号：JP2002174303
申请日：2002-06-14
申请人： Fuji Photo Film Co Ltd , 富士写真フイルム株式会社
发明人： TSUZUKI HIROHIKO
IPC分类号： G06Q30/06 , G06Q50/00 , G06Q50/10 , G06Q50/22 , G06F17/60
摘要： PROBLEM TO BE SOLVED: To enable an organization conducting a biochemical analysis to always conduct the biochemical analysis using a radioactive labelled substance even when the biochemical analysis is urgently requested by a hospital or the like. SOLUTION: The system includes a radioactive labelled substance management center 1, a central management server 3 transmitting and receiving data via a communication network, a plurality of analyzing organizations 4 conducting the biochemical analysis, a management server 5 transmitting and receiving data via the communication network, a supply organization 6 supplying a radioactive substance, a management server 7 transmitting and receiving data via the communication network, a radioactive labelled substance collection center 8, and a management server 9 transmitting and receiving data via the communication network. COPYRIGHT: (C)2004,JPO

9. 发明专利

JP2002272734A TWO-DIMENSIONAL PROBE, ULTRASONIC IMAGE PICKUP DEVICE AND ULTRASONIC IMAGE PICKUP METHOD 失效
公开(公告)号：JP2002272734A
公开(公告)日：2002-09-24
申请号：JP2001075584
申请日：2001-03-16
申请人： FUJI PHOTO FILM CO LTD
发明人： TSUZUKI HIROHIKO
IPC分类号： A61B8/00
摘要： PROBLEM TO BE SOLVED: To provide an ultrasonic image pickup method capable of converting the fundamental wave signal, higher harmonic signal and subharmonic signal of an echo to a three-dimensional image for a real time. SOLUTION: Arrayed vibrators 1c with an intrinsic oscillation frequency of 1 MHz, arrayed vibrators 1d with intrinsic oscillation frequency of 2 MHz and arrayed vibrators 1e with intrinsic oscillation frequency of 0.5 MHz are regularly arranged to an ultrasonic transducer 11. The arrayed vibrators 1c are used in transmission/reception to acquire the fundamental wave signal and this signal is received at the same time by the arrayed vibrators 1d and the arrayed vibrators 1e to obtain the higher harmonic signal and the subharmonic signal. These signals are subjected to image processing in an ultrasonic image pickup device to convert the echo to the three-dimensional image for a real time.

10. 发明专利

JP2002253549A ULTRASONIC IMAGE PICKUP DEVICE AND METHOD, AND PROBE 失效
公开(公告)号：JP2002253549A
公开(公告)日：2002-09-10
申请号：JP2001057947
申请日：2001-03-02
申请人： FUJI PHOTO FILM CO LTD
发明人： TSUZUKI HIROHIKO
IPC分类号： A61B8/00 , G01S7/52 , G01S7/521 , G01S15/89 , H04N7/18
摘要： PROBLEM TO BE SOLVED: To provide an ultrasonic image pickup method, etc., capable providing a wide-range image in vi-vo without deteriorating a special resolution of the image. SOLUTION: A probe is separated into a sending probe 31 and a receiving probe 41, ultrasonic wave is sent to a subject by using the sending probe 31, an echo is received by the receiving probe 41 having a plurality of transducers disposed into a two-dimensional array, signals received by the transducers of the receiving probe 41 are amplified, and waveform data 18a of the subject is provided based on the signals. In this case, the relative positions of the both probes are detected using magnetic sensors 33 and 43. The waveform data is processed referring to the relative positions so as to provide image data, the image data is processed, and the echo is three-dimensionally imaged.

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