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1. 发明专利

JP2004292362A Carbonic acid ester derivative containing iodoaryl group 审中-公开
公开(公告)号：JP2004292362A
公开(公告)日：2004-10-21
申请号：JP2003086857
申请日：2003-03-27
申请人： Fuji Photo Film Co Ltd , 富士写真フイルム株式会社
发明人： TAKAHASHI KAZUNOBU , AIKAWA KAZUHIRO
IPC分类号： A61K9/127 , A61K47/14 , A61K47/24 , A61K49/04 , A61K51/00 , C07C69/96
摘要： PROBLEM TO BE SOLVED: To obtain a compound useful as an X-ray contrast medium for contrast imaging of vascular smooth muscle cells abnormally grown, for example, by the influence of a foamed macrophage.
SOLUTION: The compound is represented by general formula (I) (Ar
1 and Ar
2 are each independently an aryl group containing at least one iodine atom as a substituent group; L
1 and L
2 are each independently a bifunctional connecting group containing a ≥4C main chain).
COPYRIGHT: (C)2005,JPO&NCIPI

2. 发明专利

JP2004250343A Iodoaryl group-having amino acid derivative 审中-公开
公开(公告)号：JP2004250343A
公开(公告)日：2004-09-09
申请号：JP2003039733
申请日：2003-02-18
申请人： Fuji Photo Film Co Ltd , 富士写真フイルム株式会社
发明人： TAKEUCHI KAZUYA , AIKAWA KAZUHIRO , TAKAHASHI KAZUNOBU
IPC分类号： C07D307/24 , A61K9/127 , A61K47/24 , A61K49/04 , A61K51/00 , C07C237/08
摘要： PROBLEM TO BE SOLVED: To obtain an iodo compound which is suitable for liposome-containing iodo contrast media for selectively contrasting lesions.
SOLUTION: The iodo compound represented by formula (I) (Ar
1A and Ar
2A are each independently an aryl group having at least one iodine atom as a substituent; L
1A and L
2A are each independently a divalent linkage group whose main chain has seven or more atoms; X
A is an α-amino acid residue whose nitrogen atom bound to the α-carbon is amide-bound to the left end carbonyl carbon of the group represented by the formula: -CO-L
1A -Ar
1A ) or its salt.
COPYRIGHT: (C)2004,JPO&NCIPI

3. 发明专利

JP2004231622A Pentose derivative having iodoaryl group 审中-公开
公开(公告)号：JP2004231622A
公开(公告)日：2004-08-19
申请号：JP2003025455
申请日：2003-02-03
申请人： Fuji Photo Film Co Ltd , 富士写真フイルム株式会社
发明人： NISHIGAKI JUNJI , TAKAHASHI KAZUNOBU , AIKAWA KAZUHIRO
IPC分类号： C07H15/04 , A61K9/127 , A61K47/24 , A61K49/04 , A61K51/00
摘要： PROBLEM TO BE SOLVED: To provide an iodine compound suitable as a liposome-containing iodine-imaging agent for imaging a lesion selectively.
SOLUTION: This compound is expressed by the general formula (wherein, Ar
1 , Ar
2 are independently each H or an aryl group, but at least one of the Ar
1 , Ar
2 or both of them is an aryl group having at least one iodine atom as a substituting group; L
1 , L
2 are independently each a divalent bonding group; and R
1 , R
2 are independently each H or a univalent substituting group). The liposome contains the compound or its salt as a membrane-constituting component.
COPYRIGHT: (C)2004,JPO&NCIPI

4. 发明专利

JP2003052364A Method for producing cell cultural system 审中-公开
标题翻译：生产细胞培养系统的方法
公开(公告)号：JP2003052364A
公开(公告)日：2003-02-25
申请号：JP2001248046
申请日：2001-08-17
申请人： Fuji Photo Film Co Ltd , 富士写真フイルム株式会社
发明人： AIKAWA KAZUHIRO , KITAGUCHI HIROSHI
IPC分类号： G01N33/50 , C12N1/00 , C12N5/071 , C12Q1/02 , G01N33/15 , C12N5/06
CPC分类号： C12N5/0697 , C12N2502/11 , C12N2502/28 , C12N2503/04
摘要： PROBLEM TO BE SOLVED: To provide a cell cultural system reproducing a state of a lesion of a specific disease, and useful for evaluating the usefulness and transporting property of a medicine. SOLUTION: This method for producing the cell cultural system comprises a process of simultaneously culturing >=2 kinds of cell strain (e.g. macrophage and vascular smooth muscle cell) associated with the lesion formation of a mammalian animal disease (e.g. formation of arteriosclelotic lesion) in a same cell cultural container, while separating them e.g. with a cell filter.
摘要翻译：要解决的问题：提供再现特定疾病病变状态的细胞培养系统，并且可用于评估药物的有用性和运输性质。解决方案：该细胞培养系统的制备方法包括同时培养与哺乳动物疾病的病变形成（例如形成动脉硬化病变）有关的2种细胞株（例如巨噬细胞和血管平滑肌细胞）的方法相同的细胞文化容器，而分开它们例如与一个电池过滤器。

5. 发明专利

JP2006282604A Glycerol ester derivative having metal chelate structure 审中-公开
标题翻译：具有金属螯合物结构的甘油酯衍生物
公开(公告)号：JP2006282604A
公开(公告)日：2006-10-19
申请号：JP2005105800
申请日：2005-04-01
申请人： Fuji Photo Film Co Ltd , 富士写真フイルム株式会社
发明人： TAKAHASHI KAZUNOBU , AIKAWA KAZUHIRO
IPC分类号： C07C237/10 , A61K49/00 , A61K51/00 , C07C237/08 , C07D257/02 , C07F5/00 , C07F13/00 , C07F15/02
CPC分类号： A61K49/10 , A61K49/085 , C07C229/26 , C07C237/08 , C07C237/10 , C07D257/02
摘要： PROBLEM TO BE SOLVED: To provide a compound having excellent solubility, etc., and suitable for lesion-selective liposome imaging agent.
SOLUTION: A lesion of a blood vessel is selectively contrasted by MRI imaging or scintigraphy imaging method using an imaging agent containing a liposome containing a compound expressed by general formula (I), a chelate compound having the compound or their salts. In the formula, R
1 and R
2 are each an 8-30C alkyl or alkenyl; X
1 and X
2 are each -O- or -N(Z)-; Z is a hydrogen atom or a 1-5C alkyl; L is an alkylene, an alkenylene or a bivalent linking group having an atom number of 1-10 constituting the linking group chain containing -CO-, -O- or the like; and Ch is a chelate-forming partial structure containing ≥3 nitrogen atoms and optionally having a specific substituent.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供具有优异溶解性等的化合物，并且适用于病变选择性脂质体显像剂。解决方案：使用含有含有通式（I）表示的化合物的脂质体的成像剂，具有化合物或其盐的螯合物，通过MRI成像或闪烁照相成像方法，选择性地对比血管损伤。在该式中，R“SP”1 和R 2 各自为8-30C烷基或链烯基; X 1 和X 2 分别为-O-或-N（Z） - ; Z是氢原子或1-5C烷基; L是原子数为1-10的亚烷基，亚烯基或二价连接基，构成含有-CO-，-O-等的连接基链; 并且Ch是含有≥3个氮原子并且任选地具有特定取代基的螯合形成部分结构。版权所有（C）2007，JPO＆INPIT

6. 发明专利

JP2005068053A Phosphoric diester compound containing steroid residue and iodoaryl group 审中-公开
标题翻译：含有固体残留物和碘酸盐的磷酸钙复合物
公开(公告)号：JP2005068053A
公开(公告)日：2005-03-17
申请号：JP2003298093
申请日：2003-08-22
申请人： Fuji Photo Film Co Ltd , 富士写真フイルム株式会社
发明人： TAKAHASHI KAZUNOBU , AIKAWA KAZUHIRO
IPC分类号： A61K9/127 , A61K47/24 , A61K47/28 , A61K49/04 , A61K51/00 , C07J9/00
摘要： PROBLEM TO BE SOLVED: To provide an iodine compound suitable as a liposome-containing iodine-based contrast medium for lesion-selective contrastradiography.
SOLUTION: The phosphoric diester compound ( or a salt thereof ) contains a steroid residue and 1-4 aryl groups( each having at least one iodine atom as substituent, preferably a triiodoaryl group(s) ), for example, being represented by general formula(I)( wherein, Ar
1 and Ar
2 are each an aryl group having at least one iodine atom as substituent; L
1 is a trivalent linkage group containing 3-40 carbon atoms; and Ste
1 is a steroid residue ).
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供适合作为含脂质体的碘基造影剂用于病变选择性对视镜的碘化合物。解决方案：磷酸二酯化合物（或其盐）含有类固醇残基和1-4个芳基（各自具有至少一个碘原子作为取代基，优选三碘代芳基），例如被表示通式（I）（其中，Ar 1 和Ar 2 分别是具有至少一个碘原子作为取代基的芳基; L 1 是含有3-40个碳原子的三价连接基团;并且Ste 1 是类固醇残基）。版权所有（C）2005，JPO＆NCIPI

7. 发明专利

JP2005035942A Steroid compound having iodoaryl group 审中-公开
标题翻译：具有IODOARYL集团的甾体化合物
公开(公告)号：JP2005035942A
公开(公告)日：2005-02-10
申请号：JP2003275434
申请日：2003-07-16
申请人： Fuji Photo Film Co Ltd , 富士写真フイルム株式会社
发明人： TAKAHASHI KAZUNOBU , NISHIGAKI JUNJI , AIKAWA KAZUHIRO
IPC分类号： A61K9/127 , A61K47/24 , A61K49/04 , A61K51/00 , C07J9/00
摘要： PROBLEM TO BE SOLVED: To provide an iodine compound suitable for iodine contrast medium formed into a liposome for lesion-selective contrast radiography.
SOLUTION: The compound represented by general formula (I) (wherein, Ar is an aryl group (which may have a substituent except an iodine atom) having at least one iodine atom as a substituent; L is a single bond or a divalent linking group; and Ste is a steroid residue) or a salt thereof is provided.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供适合于形成用于病变选择性对比度造影的脂质体中的碘造影剂的碘化合物。解决方案：通式（I）表示的化合物（其中，Ar为具有至少一个碘原子作为取代基的芳基（可以具有除碘原子以外的取代基）; L为单键或二价连接基团; Ste是类固醇残基）或其盐。版权所有（C）2005，JPO＆NCIPI

8. 发明专利

JP2004115378A Liposome comprising water-soluble iodine compound 审中-公开
公开(公告)号：JP2004115378A
公开(公告)日：2004-04-15
申请号：JP2002276944
申请日：2002-09-24
申请人： Fuji Photo Film Co Ltd , 富士写真フイルム株式会社
发明人： AIKAWA KAZUHIRO
IPC分类号： A61K9/127 , A61K47/24 , A61K49/04
摘要： PROBLEM TO BE SOLVED: To provide a means for selectively accumulating a water-soluble iodine compound in a diseased site, exhibiting a contrast thereof with nondiseased sites and carrying out contrastradiography.
SOLUTION: A liposome comprises a solution containing the water-soluble iodine compound and encapsulated therein and preferably a lipid selected from the group consisting of phosphatidylcholine and phosphatidylserine as a membrane constituent component. An X-ray contrast medium comprises the liposome and is preferably useful for the contrastradiography of vascular diseases such as arteriosclerosis.
COPYRIGHT: (C)2004,JPO

9. 发明专利

JP2004033135A Carrier for culturing cell 有权
公开(公告)号：JP2004033135A
公开(公告)日：2004-02-05
申请号：JP2002196725
申请日：2002-07-05
申请人： Fuji Photo Film Co Ltd , 富士写真フイルム株式会社
发明人： TSUZUKI HIROHIKO , AIKAWA KAZUHIRO , KATO ATSUSHI
IPC分类号： C12N5/07 , C12N5/071 , C12N5/06
摘要： PROBLEM TO BE SOLVED: To provide a carrier for culturing cells, utilizable for a cell-culture technique, cell sheet engineering or the like. SOLUTION: The carrier for culturing the cells includes an aqueous gel containing alginic acid, and has the surface covered with a collagen. The collagen is bonded to the aqueous gel through a chitosan. The method for producing a cell culture product comprises a step of forming a cell layer on the surface of the carrier for culturing the cells, and a step of solubilizing the aqueous gel containing the alginic acid. COPYRIGHT: (C)2004,JPO

10. 发明专利

JP2003012692A Iodobenzenes 有权
标题翻译： IODOBENZENES
公开(公告)号：JP2003012692A
公开(公告)日：2003-01-15
申请号：JP2002121214
申请日：2002-04-23
申请人： Fuji Photo Film Co Ltd , 富士写真フイルム株式会社
发明人： TAKAHASHI KAZUNOBU , KITAGUCHI HIROSHI , AIKAWA KAZUHIRO
IPC分类号： A61K49/04 , A61K51/00 , C07J9/00
摘要： PROBLEM TO BE SOLVED: To provide an iodine compound that is useful as a constituent lipid of liposome for X-ray contrast medium.
SOLUTION: The iodine compound is represented by the formula (I): A-L
1 -O- Ste (I) {wherein A is a group represented by the following general formula (II) [wherein I
3 means that the benzene ring is trisubstituted with iodine; Z
1 is H or amino group]; L
1 is -X-Y- [X is -C(R
1 )(R
2 )-, -CO-, or the like; Y is -C(R
3 )(R
4 )-, -CO-, or the like (R
1 through R
4 are each H, a 1-10C aliphatic group, or the like)]; Ste is Ste
1 (Ste
1 means a steroid residual group selected from the group consisting of cholesterol, dehydroepiandrosteron, and pregnenolone, cholic acid) or Ste
2 (Ste
2 means cholestanol, cholic acid, dehydrocholic acid, and the like)}.
COPYRIGHT: (C)2003,JPO
摘要翻译：要解决的问题：提供可用作X射线造影剂的脂质体的构成脂质的碘化合物。解决方案：碘化合物由式（I）表示：其中A是由以下通式（II）表示的基团：其中I 3表示苯环被三取代，碘; Z 1是H或氨基]; L 1是-X-Y- [X是-C（R 1）（R 2） - ， - CO-等; Y是-C（R 3）（R 4） - ， - CO-等（R 1至R 4各自为H，1-10C脂族基团等） ]; Ste为Ste <1>（Ste <1>是指选自胆固醇，脱氢表雄酮，孕烯醇酮，胆酸）或Ste <2的类固醇残留组（Ste <2>表示胆甾烷醇，胆酸，脱氢胆酸，等等）。

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