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1. 发明专利

JP2005130851A Method for measuring specimen in liquid and apparatus for the same 有权
标题翻译：用于测量液体样品的方法及其设备
公开(公告)号：JP2005130851A
公开(公告)日：2005-05-26
申请号：JP2004249094
申请日：2004-08-27
申请人： F Hoffmann La Roche Ag , エフ.ホフマン−ラロシュアーゲーF. Hoffmann−La Roche Aktiengesellschaft
发明人： WAHL HANS-PETER
IPC分类号： G01N35/08 , B01L3/00 , B01L7/00 , C12M1/00 , C12M1/34 , C12N15/09 , C12Q1/68 , G01N37/00
CPC分类号： B01L3/502792 , B01L7/52 , B01L7/525 , B01L2200/10 , B01L2300/089 , B01L2400/0415 , B01L2400/0436
摘要： PROBLEM TO BE SOLVED: To provide a method for measuring a specimen in a liquid, and to provide an apparatus for measuring the specimen in the liquid in accordance with the method.
SOLUTION: The method for measuring the specimen in the liquid comprises applying a small volume of the testing liquid to a base plate of a transportation surface, then transferring the volume of the testing liquid to a testing position on the base plate and bringing the liquid into contact with only the base plate of the transportation surface, and further bringing the testing liquid into contact with a sensor element which is arranged in a detection surface of an opposite side of the base plate in the testing position, so that the specimen in the volume of the testing liquid is directly or indirectly measured with the sensor element. Further, the apparatus for measuring the specimen in the liquid in accordance with the method is provided.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供一种用于测量液体中的样本的方法，并提供一种根据该方法测量液体中的样本的装置。
解决方案：液体中测定样品的方法包括将小体积的测试液体施加到运输表面的底板，然后将测试液体的体积传送到底板上的测试位置，并将液体仅与输送面的基板接触，进一步使检测液体与设置在检查位置的基板的相对侧的检测面的传感器元件接触，使得检体在用传感器元件直接或间接地测量测试液体积。此外，提供了根据该方法测量液体中的样本的装置。版权所有（C）2005，JPO＆NCIPI

2. 发明专利

JP2008020457A Device equipped with insert for analysis system 审中-公开
标题翻译：装备有分析系统插件
公开(公告)号：JP2008020457A
公开(公告)日：2008-01-31
申请号：JP2007182949
申请日：2007-07-12
申请人： F Hoffmann La Roche Ag , エフ.ホフマン−ラロシュアーゲーF. Hoffmann−La Roche Aktiengesellschaft
发明人： SAROFIM EMAD , WAHL HANS-PETER
IPC分类号： G01N35/10
CPC分类号： B01L3/502715 , B01L3/5025 , B01L2400/0622 , B01L2400/0633
摘要： PROBLEM TO BE SOLVED: To provide a device permitting simple fluid flow, without carrying various reagents over final mixture for measuring during sample regulating stage. SOLUTION: In the analytical device possessing a main body equipped with a fluidic unit including a first chamber with a delivery aperture and a first channel exiting through the delivery aperture, the first chamber containing also an insert equipped with recesses between each limb contacting wall section of the first chamber concerned and a second channel, while the insert is prepared at a first position where the insert concerned is not engaged from the delivery aperture, is movable from the aforementioned first position to a second position in the first chamber, where the insert is engaged to the delivery aperture so as to extend the first channel into interior of the first chamber by the second channel, and has the same shape as the first chamber at a part pointing to the delivery aperture. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供允许简单流体流动的装置，而不在最终混合物中携带各种试剂以在样品调节阶段进行测量。解决方案：在具有配备有流体单元的主体的分析装置中，流体单元包括具有输送孔的第一室和通过输送孔离开的第一通道，第一室还包含在每个肢体接触之间的凹槽所述第一腔室和所述第二通道的壁部分，并且所述插入件准备在所述插入件未与所述输送孔接合的第一位置处，可从所述第一位置移动到所述第一腔室中的第二位置，其中插入件接合到输送孔，以便通过第二通道将第一通道延伸到第一室的内部，并且在指向输送孔的部分处具有与第一室相同的形状。版权所有（C）2008，JPO＆INPIT

3. 发明专利

JP2010115647A Method and device for separating component bound to magnetic particle by applying centrifugal force 有权
标题翻译：通过应用离心力分离与磁性颗粒接触的组分的方法和装置
公开(公告)号：JP2010115647A
公开(公告)日：2010-05-27
申请号：JP2009256430
申请日：2009-11-09
申请人： F Hoffmann-La Roche Ag , エフホフマン−ラロッシュアクチェンゲゼルシャフト
发明人： HEIN HEINZ-MICHAEL , SAROFIM EMAD , SCHENK LOTAR , WAHL HANS-PETER
IPC分类号： B03C1/30 , B04B5/10
CPC分类号： B03C1/01 , B03C1/288 , B03C2201/18 , B03C2201/26 , Y10T436/111666
摘要： PROBLEM TO BE SOLVED: To provide a method for separating a component of interest bound to magnetic particles from a solution. SOLUTION: The method includes the following steps: providing a container device having one or more flat chamber(s) each composed of an angular bottom ascending to the outer part 25 of the compartment and means for trapping fluids 10, the means being positioned inside the outer part of the compartment of the container 11 and a magnet 12 for capturing the magnetic particles 21 and the component of interest bound to the magnetic particles; disposing the solution including the component of interest in the interior volume of the chamber(s), while the container is rotating around an axis 19 located outside the inner part of the container and adjacent to the magnet; adding to the solution the magnetic particles coated with a reaction component that binds the component of interest; mixing the solution with the magnetic particles to produce a mixture composed of magnetic particles and a supernatant liquid; and separating the magnetic particles and the liquid by rotating the container, wherein the liquid is trapped by centrifugal forces into the trapping means and a magnetic field is applied such that magnetic particles bind to the inner side of the inner part of the interior volume. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种从溶液中分离与磁性颗粒结合的感兴趣成分的方法。解决方案：该方法包括以下步骤：提供一种具有一个或多个平坦室的容器装置，每个平坦室由沿着隔室的外部部分25上升的角度底部构成，并且用于捕获流体10的装置位于容器11的隔室的外部部分的内部;磁体12，用于捕获与磁性颗粒结合的磁性颗粒21和感兴趣的组分; 将包含感兴趣的部件的溶液放置在室的内部容积中，同时容器围绕位于容器的内部部分外部并且与磁体相邻的轴线19旋转; 向溶液中加入涂覆有结合感兴趣组分的反应组分的磁性颗粒; 将溶液与磁性颗粒混合以产生由磁性颗粒和上清液组成的混合物; 并且通过旋转容器来分离磁性颗粒和液体，其中液体被离心力捕获到捕获装置中，并且施加磁场，使得磁性颗粒结合到内部体积的内部部分的内侧。版权所有（C）2010，JPO＆INPIT

4. 发明专利

JP2010133952A Mwp lid separation 有权
标题翻译： MWP LID分离
公开(公告)号：JP2010133952A
公开(公告)日：2010-06-17
申请号：JP2009256431
申请日：2009-11-09
申请人： F Hoffmann-La Roche Ag , エフホフマン−ラロッシュアクチェンゲゼルシャフト
发明人： SAROFIM EMAD , SCHENK LOTAR , WAHL HANS-PETER
IPC分类号： G01N1/10 , B04B5/02 , G01N33/543 , G01N33/553 , G01N35/00
CPC分类号： G01N35/04 , B01L3/5025 , B01L2200/026 , B01L2300/048 , B01L2300/069 , B01L2300/0829 , B01L2300/0858 , B01L2400/0409 , G01N21/03 , G01N21/07 , G01N21/253 , G01N2021/0328 , G01N2035/0449
摘要： PROBLEM TO BE SOLVED: To provide a separation device for separating a supernatant from a solid phase, a separation method, and an analytical and sample preparation system.
SOLUTION: The separation device for separating the supernatant from the solid phase includes a multiwell plate for holding a liquid including at least one analyte and a solid phase to which the analyte can be bound. The multiwell plate includes: at least two purification chambers which hold the liquid and the solid phase, and in which the at least one analyte is bound to the solid phase; at least one waste chamber to which the liquid is transferred after the bond of the analyte to the solid phase; and a lid for covering a vessel. An interface between the vessel and the lid is dimensioned such that the liquid can be transferred from the purification chambers holding the solid phase to the waste chamber when the at least one analyte is under centrifugal force after being bound to the solid phase while the solid phase remains the purification chambers.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于从固相中分离上清液的分离装置，分离方法以及分析和样品制备系统。解决方案：用于将上清液与固相分离的分离装置包括用于保持包含至少一种分析物和固相的液体的多孔板，分析物可以与其结合。所述多孔板包括：至少两个保持液体和固相的净化室，并且其中所述至少一种分析物与固相结合; 至少一个废物室，在将分析物结合到固相之后液体被转移到该废物室; 以及用于覆盖容器的盖子。容器和盖子之间的界面的尺寸使得当至少一个分析物在与固相结合之后处于离心力下时，液体可以从保持固相的净化室转移到废物室，而固相仍然是净化室。版权所有（C）2010，JPO＆INPIT

5. 发明专利

JP2014178333A Mwp lid separation 有权
标题翻译： MWP LID分离
公开(公告)号：JP2014178333A
公开(公告)日：2014-09-25
申请号：JP2014115181
申请日：2014-06-03
申请人： F Hoffmann-La Roche Ag , エフホフマン−ラロッシュアクチェンゲゼルシャフト
发明人： SAROFIM EMAD , SCHENK LOTAR , WAHL HANS-PETER
IPC分类号： G01N1/10 , G01N1/00 , G01N33/48
CPC分类号： G01N35/04 , B01L3/5025 , B01L2200/026 , B01L2300/048 , B01L2300/069 , B01L2300/0829 , B01L2300/0858 , B01L2400/0409 , G01N21/03 , G01N21/07 , G01N21/253 , G01N2021/0328 , G01N2035/0449
摘要： PROBLEM TO BE SOLVED: To provide a separation device for separating a floating matter from a solid phase, a separation method, analysis and a sample preparation device.SOLUTION: A separation device uses a multi-well plate 12 and a lid 3 as a container, and can process plural analytes simultaneously. After a liquid 5 including the analytes, reagent and magnetic particles is incubated in a refinement chamber 1, the liquid 5 is separated into magnetic particles to which the analytes are bonded by centrifugal separation and floating matters such as liquid, and then the floating matters are discharged to a disposal chamber 2 through the lid.
摘要翻译：要解决的问题：提供一种用于从固相中分离漂浮物质的分离装置，分离方法，分析和样品制备装置。解决方案：分离装置使用多孔板12和盖3作为容器，并可同时处理多种分析物。在包含分析物的液体5之后，将试剂和磁性颗粒在精制室1中孵育，将液体5分离成磁性颗粒，通过离心分离和浮选物质如液体将分析物结合到其中，然后浮选物质通过盖排出到处理室2。

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