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1. 发明专利

JP2004298630A Tissue catching machine and method 有权
公开(公告)号：JP2004298630A
公开(公告)日：2004-10-28
申请号：JP2004092799
申请日：2004-03-26
申请人： Depuy Mitek Inc , デピュイ・ミテック・インコーポレイテッドDePuy Mitek,Inc.
发明人： BINETTE FRANCOIS , HWANG JULIA , ORR KEITH M , LEPKE STEVE , HYMAN ERIC , PERKINS ASHLEY
IPC分类号： A61L27/00 , A61B10/00 , A61F2/28 , A61F2/46 , A61L27/38
CPC分类号： A61L27/36 , A61B10/0096 , A61F2/4644 , A61F2002/2835
摘要： PROBLEM TO BE SOLVED: To offer a tissue support body preparation machine, which is efficient and effective, and a method. SOLUTION: A biological tissue catching machine (10) having a housing (12) equipped with a fluid holding internal chamber having come to hold a fluid permeable tissue support body (16a), in which a living body can be implanted, is offered. The support body is preferably held within the housing so as to separate the fluid holding internal chamber into a primary chamber (14a) and a second chamber (14b). The catching machine is combined with the housing and further has a driver mechanism which can produce within the housing force which pushes away fluid within the second chamber into the primary chamber. If the fluid is pushed away, biological tissue, which deposits on the support body, disperses in the fluid. If the force is excluded, the fluid returns to the inside of the second chamber and thereby, more preferably the tissue is uniformly deposited on the support body. COPYRIGHT: (C)2005,JPO&NCIPI

2. 发明专利

JP2012077089A Chondrocyte therapeutic agent delivery system 有权
标题翻译： CHONDROCYTE治疗药物递送系统
公开(公告)号：JP2012077089A
公开(公告)日：2012-04-19
申请号：JP2012001248
申请日：2012-01-06
申请人： Depuy Mitek Inc , デピュイ・ミテック・インコーポレイテッドDePuy Mitek,Inc.
发明人： BINETTE FRANCOIS , STORY BROOKS J
IPC分类号： A61K35/32 , A61K48/00 , A61K9/06 , A61K35/12 , A61K38/22 , A61K45/00 , A61K47/36 , A61P1/00 , A61P1/16 , A61P1/18 , A61P3/00 , A61P3/10 , A61P5/00 , A61P5/48 , A61P7/00 , A61P9/00 , A61P11/00 , A61P13/12 , A61P15/00 , A61P15/08 , A61P17/00 , A61P17/02 , A61P19/00 , A61P19/08 , A61P19/10 , A61P21/00 , A61P25/00 , A61P25/16 , A61P25/28 , A61P27/02 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C12N5/077 , C12N5/10
CPC分类号： C12N5/0655 , A61K35/12 , C12N2510/00 , C12N2533/74 , C12N2533/76
摘要： PROBLEM TO BE SOLVED: To provide a method and composition for producing various therapeutic agents using chondrocytes.SOLUTION: The chondrocytes genetically engineered chondrocytes can be used to express a therapeutic agent in a certain subject, including in a constant environment typically associated with chondrocytes and in a constant environment not typically associated with chondrocytes.
摘要翻译：待解决的问题：提供使用软骨细胞生产各种治疗剂的方法和组合物。解决方案：软骨细胞基因工程软骨细胞可用于在特定受试者中表达治疗剂，包括在通常与软骨细胞相关的恒定环境中，并且在通常不与软骨细胞相关的恒定环境中。版权所有（C）2012，JPO＆INPIT

3. 发明专利

JP2005152653A Tissue restoration implant, production method therefor, and tissue restoration method 有权
标题翻译：组织恢复植物，其生产方法和组织恢复方法
公开(公告)号：JP2005152653A
公开(公告)日：2005-06-16
申请号：JP2004340887
申请日：2004-11-25
申请人： Depuy Mitek Inc , デピュイ・ミテック・インコーポレイテッド
发明人： BINETTE FRANCOIS , HAMMER JOSEPH J , MUKHOPADHYAY KRISH , ROSENBLATT JOEL
IPC分类号： A61L27/00 , A61F2/02 , A61F2/08 , A61F2/10 , A61F2/28 , A61L27/38 , A61L27/58
CPC分类号： A61L27/3604 , A61L27/3683 , A61L27/38 , A61L27/3852 , A61L27/58
摘要： PROBLEM TO BE SOLVED: To provide a tissue restoration implant which can be sent out to an affected region by a minimal invasive procedure and conform to the configuration of the affected region, a production method therefor, and a tissue restoration method. SOLUTION: A tissue integrity implant is provided in order to use when restoring and reinforcing the affected or damaged region of a tissue. The tissue implant includes a tissue-supporting matrix. This matrix includes a plurality of granules with biological compatibility and biological reabsorption and at least one tissue fragment related to this granule. The tissue fragment contains one or more living cells which move outside from a tissue and are firmly fixed on the tissue-supporting matrix. A method to send out the tissue implant in a state capable of being accepted is also provided. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供可以通过最小侵入性程序发送到受影响区域并符合受影响区域的构造，其生产方法和组织恢复方法的组织修复植入物。解决方案：提供组织完整性植入物，以便在恢复和加强组织的受影响或受损区域时使用。组织植入物包括组织支撑基质。该基质包括具有生物相容性和生物再吸收的多个颗粒和与该颗粒相关的至少一个组织片段。组织片段含有从组织向外移动并且牢固地固定在组织支撑基质上的一个或多个活细胞。还提供了一种在能够被接受的状态下发送组织植入物的方法。版权所有（C）2005，JPO＆NCIPI

4. 发明专利

JP2005082599A Chondrocyte therapeutic agent delivery system 有权
标题翻译： CHONDROCYTE治疗药物递送系统
公开(公告)号：JP2005082599A
公开(公告)日：2005-03-31
申请号：JP2004260041
申请日：2004-09-07
申请人： Depuy Mitek Inc , デピュイ・ミテック・インコーポレイテッド
发明人： BINETTE FRANCOIS , STORY BROOKS J
IPC分类号： A61K48/00 , A61K35/12 , A61P3/00 , A61P5/00 , A61P7/00 , A61P9/00 , A61P15/08 , A61P17/00 , A61P19/10 , A61P25/00 , A61P35/00 , A61P37/00 , C12N5/077
CPC分类号： C12N5/0655 , A61K35/12 , C12N2510/00 , C12N2533/74 , C12N2533/76
摘要： PROBLEM TO BE SOLVED: To provide a method and to obtain a composition for producing a therapeutic agent using chondrocyte. SOLUTION: The genetically engineered chondrocyte can be used to exhibit the therapeutic agent in a subject, in an environment typically associated with chondrocyte and in an environment not typically associated with chondrocyte. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供一种方法并获得使用软骨细胞产生治疗剂的组合物。解决方案：基因工程软骨细胞可用于在受试者中，在通常与软骨细胞相关的环境中以及通常不与软骨细胞相关的环境中显示治疗剂。版权所有（C）2005，JPO＆NCIPI

5. 发明专利

JP2005131365A Tissue repair implant 审中-公开
标题翻译：组织修复植入物
公开(公告)号：JP2005131365A
公开(公告)日：2005-05-26
申请号：JP2004233655
申请日：2004-08-10
申请人： Depuy Mitek Inc , デピュイ・ミテック・インコーポレイテッド
发明人： BINETTE FRANCOIS , LU ED YILING
IPC分类号： A61L27/00 , A61B17/00 , A61B17/064 , A61F2/00 , A61F2/02 , A61F2/30 , A61F2/38 , A61L27/36 , A61L27/38
CPC分类号： A61L27/3654 , A61B17/00491 , A61B17/0642 , A61B2017/00004 , A61F2/30756 , A61F2/3859 , A61F2002/30062 , A61F2002/30225 , A61F2002/30677 , A61F2002/30751 , A61F2002/30764 , A61F2002/30766 , A61F2210/0004 , A61F2230/0069 , A61L27/38
摘要： PROBLEM TO BE SOLVED: To provide a biocompatible bioresorbable implantable tissue implant for resurfacing and functionally repairing a joint surface for delaying the progression of damage of a cartilage caused by a degenerative joint disease such as a metatypical joint disease. SOLUTION: A biocompatible bioresorbable tissue repair implant 30 or a skeleton device 32 is provided for resurfacing and/or repairing a damaged or diseased cartilage particularly for use in repairing an injury of a variety of cartilage tissues. A repairing procedure is performed by using the tissue repair implant including a biological component that assists in delaying or arresting the deterioration of the degenerative joint disease, and assists in enhancing healing or repair of the tissue. The biocompatible bioresorbable tissue repair implant includes a skeleton and a particle of a viable tissue derived from the cartilage tissue, and the tissue and the skeleton become associated. The particle of a living tissue contains one or more viable cells livable in the skeleton by migrating from the tissue. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供生物相容性生物可再吸收的可植入组织植入物，用于表面重建和功能性修复关节表面，用于延迟由诸如复位性关节疾病之类的退行性关节疾病引起的软骨损伤的进展。解决方案：提供生物相容性生物可吸收组织修复植入物30或骨架装置32用于重建和/或修复受损或患病的软骨，特别是用于修复各种软骨组织的损伤。通过使用包括协助延缓或阻止退行性关节疾病的恶化的生物成分的组织修复植入物进行修复过程，并且有助于增强组织的愈合或修复。生物相容性生物可吸收组织修复植入物包括衍生自软骨组织的骨组织和活组织的颗粒，并且组织和骨骼变得相关联。生物体组织的颗粒含有一种或多种通过从组织迁移而在骨骼中居住的活细胞。版权所有（C）2005，JPO＆NCIPI

6. 发明专利

JP2005152652A Arthroscopic tissue scaffold delivery device 有权
标题翻译： ARTHROSCOPIC组织SCAFFOLD交付设备
公开(公告)号：JP2005152652A
公开(公告)日：2005-06-16
申请号：JP2004340876
申请日：2004-11-25
申请人： Depuy Mitek Inc , デピュイ・ミテック・インコーポレイテッド
发明人： ORR KEITH M , HYMAN ERIC , BINETTE FRANCOIS , MCRURY IAN D , LEPKE STEVE , PERKINS ASH , HWANG JULIA
IPC分类号： A61B17/56 , A61B17/00 , A61B17/12 , A61F2/30
CPC分类号： A61F2/46 , A61B17/00234 , A61B2017/00575 , A61B2017/1205 , A61F2002/30281 , A61F2002/30426 , A61F2002/30604 , A61F2002/30772 , A61F2002/30878 , A61F2002/30881 , A61F2002/30897 , A61F2002/4022 , A61F2002/4085
摘要： PROBLEM TO BE SOLVED: To provide a device for delivering a tissue-loaded scaffold in a perfect arthroscopic surgery.
SOLUTION: A small diameter delivery device capable of arthroscopically delivering the tissue-loaded scaffold to a tissue defect or tissue injury site without reducing the pressure at the injury site is provided. The scaffold delivery device comprises a plunger system having two main components, namely an insertion tube and an insertion rod. The insertion tube has a flared proximal end for holding the tissue scaffold prior to delivery. An elongate, hollow body extends from the flared proximal end to the distal end of the insertion tube, and defines a passage penetrating through the hollow body for delivering the tissue scaffold. The insertion rod has a handle at the proximal end and an elongate body extending to the tip of the distal end. The insertion rod is configured to be removably arranged within the insertion tube for sliding along the passage to effect delivery of the tissue scaffold through the insertion tube.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供一种用于在完美的关节镜手术中输送组织装载的支架的装置。提供了一种小直径输送装置，其能够关节镜地将组织装载的支架递送到组织缺损或组织损伤部位，而不会降低损伤部位的压力。支架输送装置包括具有两个主要部件即插入管和插入杆的柱塞系统。插入管具有用于在输送之前保持组织支架的扩张近端。细长的中空体从扩张的近端延伸到插入管的远端，并且限定穿过中空体的通道，用于输送组织支架。插入杆在近端具有手柄和延伸到远端的尖端的细长主体。插入杆构造成可移除地布置在插入管内，用于沿着通道滑动以实现组织支架通过插入管的输送。版权所有（C）2005，JPO＆NCIPI

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