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1. 发明专利

JP2013123426A Method for producing aldonic acid characterized by containing fatty acid 审中-公开
标题翻译：生产含有脂肪酸的二酸的方法
公开(公告)号：JP2013123426A
公开(公告)日：2013-06-24
申请号：JP2011275365
申请日：2011-12-16
申请人： Daiso Co Ltd , ダイソー株式会社
发明人： UTSUGI YOSHIKI , IDOGAKI HIDESATO
IPC分类号： C12P7/58
摘要： PROBLEM TO BE SOLVED: To provide a method for producing aldonic acid characterized by including a process for culturing acetic acid bacteria using a medium that contains fatty acid, and/or a process for adding fatty acid to a reaction liquid for reaction.SOLUTION: Aldonic acid can be efficiently produced by using the medium containing fatty acid such as stearic acid or oleic acid, and/or adding fatty acid into the reaction liquid.
摘要翻译：待解决的问题：提供一种生产醛糖酸的方法，其特征在于包括使用含有脂肪酸的培养基培养乙酸菌的方法和/或向反应液中添加脂肪酸的方法。解决方案：通过使用含有脂肪酸的介质如硬脂酸或油酸，和/或向反应液中加入脂肪酸，可以有效地制备Aldonic酸。版权所有（C）2013，JPO＆INPIT

2. 发明专利

JP2015027265A 細胞培養用培地有权
标题翻译：细胞培养基
公开(公告)号：JP2015027265A
公开(公告)日：2015-02-12
申请号：JP2013157651
申请日：2013-07-30
申请人：ダイソー株式会社 , Daiso Co Ltd
发明人： MADONO KEIKO , KIDO MASAHIDE , IDOGAKI HIDESATO
IPC分类号： C12N1/00 , C12P21/08
CPC分类号： Y02P10/234
摘要：【課題】細胞培養用培地、および当該培地の有用物質製造のための使用を提供する。【解決手段】疎水性D-アミノ酸を含む動物細胞培養用培地、疎水性D-アミノ酸を含む細胞培養用培地を用いて細胞を培養する行程を含む有用物質の製造方法。疎水性D−アミノ酸が、バリン、ロイシン、フェニルアラニン、及びメチオニンからなる群より選択される少なくとも1種であり、含有量が0.002〜1%(w/v)である。培用する細胞が、形質転換細胞であり、CHO細胞である。生産される有用物質がIgG抗体である。【選択図】図1
摘要翻译：要解决的问题：提供用于细胞培养的培养基和用于制备有用物质的培养基的使用。解决方案：用于细胞培养的动物培养基包括疏水性D-氨基酸，并且有用物质的制造方法包括培养步骤使用包含疏水性D-氨基酸的细胞培养基的细胞。疏水性D-氨基酸是选自缬氨酸，亮氨酸，苯丙氨酸和甲硫氨酸中的至少一种，其含量为0.002〜1％（w / v）。待培养的细胞是转化体和CHO细胞。待产生的有用物质是IgG抗体。

3. 发明专利

JP2013053094A Skin texture improving agent and skin barrier function improving agent 审中-公开
标题翻译：皮肤纹理改善剂和皮肤障碍功能改善剂
公开(公告)号：JP2013053094A
公开(公告)日：2013-03-21
申请号：JP2011191834
申请日：2011-09-02
申请人： Daiso Co Ltd , ダイソー株式会社
发明人： SUZUKI TOSHIO , NAKAI TOMOHIRO , IDOGAKI HIDESATO
IPC分类号： A61K8/73 , A61K8/99 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide a new application of β-1,3-1,6-glucan.SOLUTION: The skin texture improving agent and the skin barrier function improving agent contain β-1,3-1,6-glucan.
摘要翻译：要解决的问题：提供β-1,3-1,6-葡聚糖的新应用。皮肤纹理改善剂和皮肤屏障功能改善剂含有β-1,3-1,6-葡聚糖。版权所有（C）2013，JPO＆INPIT

4. 发明专利

JP2004147646A Chlorohydrin and hydroxycarboxylic ester asymmetric hydrolase gene 有权
标题翻译：氯羟菊酯和羟基羧酸酯不对称水解酶基因
公开(公告)号：JP2004147646A
公开(公告)日：2004-05-27
申请号：JP2003347866
申请日：2003-10-07
申请人： Daiso Co Ltd , ダイソー株式会社
发明人： NAKAGAWA ATSUSHI , SUZUKI TOSHIO , NIINA ATSUHIKO , KATO AKIRA , IDOGAKI HIDESATO
IPC分类号： C12N15/09 , C12N1/21 , C12N9/18 , C12P41/00
CPC分类号： Y02P20/52
摘要： PROBLEM TO BE SOLVED: To provide an asymmetric hydrolase gene useful for synthesizing an optically active carboxylic acid, an enantiomer ester thereof, and a lactone. SOLUTION: A hydroxycarboxylic ester asymmetric hydrolase (EnHCH) derived from an Enterobactor sp. DS-S-75 strain (FERM BP-5494) which is a bacterium belonging to Enterobacter genus, an EnHCH gene expressed by a base sequence of sequence number 1, a gene encoding a protein containing an amino acid sequence of sequence number 2, and Escherichia coli DH5α (pKK-EnHCH) deposited in Incorporated Administrative Agency, National Institute of Advanced Industrial Science and Technology, International Patent Organism Depositary as a deposit number of FERM BP-08466 are provided, respectively. COPYRIGHT: (C)2004,JPO
摘要翻译：要解决的问题：提供可用于合成光学活性羧酸的非对称水解酶基因，其对映异构体酯和内酯。解决方案：衍生自Enterobactor sp。的羟基羧酸酯不对称水解酶（EnHCH）属于肠杆菌属的细菌的DS-S-75菌株（FERM BP-5494），由序列号1的碱基序列表达的EnHCH基因，编码含有序列号2的氨基酸序列的蛋白质的基因，以及保藏号为FERM BP-08466的保藏号为FERM BP-08466的大肠杆菌DH5α（pKK-EnHCH）保藏在国家先进工业科学技术研究所，国际专利生物保藏中心的公司行政机构。版权所有（C）2004，JPO

5. 发明专利

JP2004041076A Method for producing optically active 1,2-propanediol compounds by continuous culture method 有权
公开(公告)号：JP2004041076A
公开(公告)日：2004-02-12
申请号：JP2002202756
申请日：2002-07-11
申请人： Daiso Co Ltd , ダイソー株式会社
发明人： NISHIKAWA KOJI , SUZUKI TOSHIO , SUZUKI KEIKO , IDOGAKI HIDESATO , HIGAMI MOTOKO
IPC分类号： C12P41/00 , C12N1/20 , C12R1/38
摘要： PROBLEM TO BE SOLVED: To provide a method for producing optically active 1, 2-propanediol compounds, by which the highly optically pure 1, 2-propanediol R and S isomers or 3-halogeno-1, 2-propanediol R and S isomers can extremely simply, effectively and massively be produced from an inexpensive raw material.
SOLUTION: This method for producing the optically active 1, 2-propanediol compound is characterized by continuously culturing a microorganism which belongs to the genus Pseudomonas or Alcaligenes, has an ability for assimilating the 1, 2-propanediol R or S isomer, and can grow using the optical isomer as a single carbon source, while adding a culture medium containing the enantiomer mixture of the 1, 2-propanediol compound as a single carbon source to a culture tank, thus assimilating and degrading the optical isomer, and then collecting the left optically active 1, 2-propanediol compound from the culture product discharged from the culture tank.
COPYRIGHT: (C)2004,JPO

6. 发明专利

JP2000287696A PRODUCTION OF OPTICALLY ACTIVE 1-ACETOXY-3-HALOGENO-2- PROPANOL 失效
公开(公告)号：JP2000287696A
公开(公告)日：2000-10-17
申请号：JP9999199
申请日：1999-04-07
申请人： DAISO CO LTD
发明人： KASAI NAOYA , SUZUKI TOSHIO , IDOGAKI HIDESATO , HATADA MIKI , TAKEUCHI MOTOKO
IPC分类号： C12P7/62
摘要： PROBLEM TO BE SOLVED: To provide an easy method for producing an optically active 1- acetoxy-3-chloro-2-propanol. SOLUTION: An optically active 1-acetoxy-3-chloro-2-propanol is obtained by acting an enzyme able to hydrolyze an ester of an optically active 1,2- diacetoxy-3-chloropropane, a microorganism capable of producing the enzyme or an fermentation product of the microorganism on the optically active 1,2- diacetoxy-3-chloropropane. The objective substance can be used as a raw material for pharmaceuticals, agricultures, ferroelectric liquid crystals, optically active polymers or the like.

7. 发明专利

JP2000350594A OPTICAL RESOLUTION OF 4-HALOGENO-3- ALKANOYLOXYBUTYRONITRILE 失效
公开(公告)号：JP2000350594A
公开(公告)日：2000-12-19
申请号：JP2000082045
申请日：2000-03-23
申请人： DAISO CO LTD
发明人： KASAI NAOYA , SUZUKI TOSHIO , IDOGAKI HIDESATO , HATADA MIKI , TAKEUCHI MOTOKO
IPC分类号： C12P41/00 , C12N1/20 , C12R1/38
摘要： PROBLEM TO BE SOLVED: To optically resolve the subject compound for producing a raw material for medicines, agrochemicals, liquid crystals, etc., by making a microorganism having the stereoselective ester hydrolytic activity, its cultured product, an enzyme, etc., act on a racemic specific nitrile compound. SOLUTION: A microorganism having the stereoselective ester hydrolytic activity such as a microorganism belonging to the genus Pseudomonas [e.g. Pseudomonas sp. DS-K-717 strain (FERM BP-7077)] or a microorganism belonging to the genus Enterobacter [e.g. Enterobacter sp. DS-S-75 strain (FERM BP-5494)], a cultured product of the microorganism or an enzyme derived from the microorganism is made to act on a racemic 4-halogeno-3- alkanoyloxybutyronitrile represented by formula I (R is a 2-4C alkanoyl group) (e.g. 4-chloro-3-acetoxybutyronitrile) to produce the objective optically active compounds represented by formulae II and III and useful as a raw material, etc., for medicines, agrochemicals, ferroelectric liquid crystals, optically active polymers, etc.

8. 发明专利

JP2002000292A METHOD FOR PRODUCING OPTICALLY ACTIVE 1,2-DIOLS BY MICROBIOLOGICAL CULTURE METHOD 失效
公开(公告)号：JP2002000292A
公开(公告)日：2002-01-08
申请号：JP2000194316
申请日：2000-06-28
申请人： DAISO CO LTD
发明人： SUZUKI TOSHIO , IDOGAKI HIDESATO , NAKAGAWA ATSUSHI
IPC分类号： C07C31/20 , C07C31/22 , C07C33/02 , C12P7/18 , C12P7/42 , C12P41/00 , C12R1/05
摘要： PROBLEM TO BE SOLVED: To provide a method for obtaining optically active 1,2-diols in high optical purity by a simple and inexpensive method. SOLUTION: This method for producing the optically active 1,2-diols represented by the following formula [2] (wherein, R is an alkyl group, a hydroxy-substituted alkyl group or an alkenyl group) is characterized by making racemic 1,2-diols represented by the following formula [1] act on a microbial cell of a microorganism belonging to the genus Alcaligenes during culture and proliferation under aerobic conditions and recovering the optically active 1,2-diols from the resultant culture solution.

9. 发明专利

JPH0947296A OPTICAL RESOLUTION OF CHLOROHYDRIN BY MICROORGANISM 失效
公开(公告)号：JPH0947296A
公开(公告)日：1997-02-18
申请号：JP12824296
申请日：1996-05-23
申请人： DAISO CO LTD
发明人： KASAI NAOYA , SUZUKI TOSHIO , IDOGAKI HIDESATO
IPC分类号： C12P7/18 , C07C31/36 , C07C69/675 , C07C255/12 , C07D307/33 , C12P17/04 , C12P41/00 , C12R1/01 , C12R1/07 , C12R1/38
摘要： PROBLEM TO BE SOLVED: To optically resolve the subject compound useful as a raw material for medicines and agrochemicals, physiologically active substances, liquid crystals, etc., by reacting racemic chlorohydrins with a cultured solution, microbial cell (treated material), etc., of a microorganism to decompose either one of optical isomers and leave the other isomer. SOLUTION: A racemic chlorohydrin compound [e.g. racemic 4-chloro-3- hydroxybutylonitrile] of the formula [R is H or a lower alkyl; R' is a (substituted) lower alkyl (excluding hydroxymethyl group) when R is H or R is H when R is a lower alkyl group] is reacted with a culture solution, or microbial cell of a microorganism [e.g. Pseudomonas sp. OS-K-29 (FERM BP-994), etc.] or its treated material. Thereby, either one of optical isomers is decomposed and either one of the optical isomers is left to provide the objective optically active chlorohydrin capable of providing chiral building blocks, intermediates, etc., useful in synthesis of optically active compounds such as medicines, agrochemicals, physiologically active substances and ferroelectric liquid crystals.

10. 发明专利

JP2003250595A METHOD FOR OPTICALLY RESOLVING CARBOXYLIC ACID ESTER BY USING MICROORGANISM 审中-公开
公开(公告)号：JP2003250595A
公开(公告)日：2003-09-09
申请号：JP2002372675
申请日：2002-12-24
申请人： DAISO CO LTD
发明人： SUZUKI TOSHIO , IDOGAKI HIDESATO , NAKAGAWA ATSUSHI , HIGAMI MOTOKO
IPC分类号： C12P41/00 , C12R1/01
摘要： PROBLEM TO BE SOLVED: To provide a method for producing an optically active hydroxycarboxylic acid alkyl ester or an optically active hydroxycarboxylic acid, or an optically active tetrahydrofuran-2-carboxylic acid alkyl ester or an optically active tetrahydrofuran-2-carboxylic acid, capable of simply producing the esters or the acids at low costs in an industrially advantageous manner. SOLUTION: This method for producing the optically active hydroxycarboxylic acid alkyl ester or the optically active hydroxycarboxylic acid, or the optically active tetrahydrofuran-2-carboxylic acid alkyl ester or the optically active tetrahydrofuran-2-carboxylic acid comprises making a microorganism belonging to Enterobacter or Citrobacter act on a racemic hydroxycarboxylic acid ester expressed by the formula: R 1 -(CH 2 ) n -CHOH-(CH 2 ) m - COOR 2 (R 1 is methyl or benzyl; R 2 is an alkyl; and (n) is 0 or 1 when (m) is 0, and (n) is 0 when (m) is 1) or a racemic tetrahydrofuran-2-carboxylic acid alkyl ester so as to optically resolving the ester, and collecting one of the optically active carboxylic acid alkyl esters which is remained or another optically active carboxylic acid alkyl ester which is formed. COPYRIGHT: (C)2003,JPO

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