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1. 发明专利

JP2014061398A Polymer material for medical device 审中-公开
标题翻译：医疗器械用聚合物材料
公开(公告)号：JP2014061398A
公开(公告)日：2014-04-10
申请号：JP2013223177
申请日：2013-10-28
申请人： Cordis Corp , コーディス・コーポレイションCordis Corporation
发明人： ZHAO JONATHON Z
IPC分类号： A61L31/00 , A61F2/82 , A61K31/436 , A61K45/00 , A61P7/02 , A61P29/00
CPC分类号： A61L31/10 , A61L27/16 , A61L27/34 , A61L27/54 , A61L29/041 , A61L29/085 , A61L29/16 , A61L31/048 , A61L31/16 , A61L2300/216 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2300/606 , A61L2420/06 , C08L27/12
摘要： PROBLEM TO BE SOLVED: To provide a polymer material for a medical device.SOLUTION: This invention comprises a polymer coating, a film, a matrix and a coat with biocompatibility used together with an implantable medical device. The medical device comprising the above material and applied to the surface of the medical device comprises a fluorous homopolymer or copolymer for film formation having the polymerization residue of a fluorous part, and the relative amount of the polymerization residues of one or more fluorous parts is effective for imparting effective characteristics for using upon coating the implantable medical device.
摘要翻译：要解决的问题：提供用于医疗器械的聚合物材料。解决方案：本发明包括与植入式医疗装置一起使用的具有生物相容性的聚合物涂层，膜，基质和涂层。包含上述材料并施加到医疗装置的表面的医疗装置包括具有氟部分的聚合残基的成膜用氟均聚物或共聚物，并且一个或多个氟部分的聚合残留物的相对量是有效的用于在涂覆可植入医疗装置时赋予使用有效特性。

2. 发明专利

JP2010142638A Adhesion promoting primer for coated surfaces 有权
标题翻译：涂层表面的粘合剂促进剂
公开(公告)号：JP2010142638A
公开(公告)日：2010-07-01
申请号：JP2009283706
申请日：2009-12-15
申请人： Cordis Corp , コーディス・コーポレイションCordis Corporation
发明人： DAVE VIPUL , FALOTICO ROBERT , LI CHENGXUE , NGUYEN THAI M , PARKER THEODORE L , ZHAO JONATHON Z
IPC分类号： A61F2/82
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91558 , A61F2250/0043 , A61F2250/0068 , A61L31/10 , A61L31/16
摘要： PROBLEM TO BE SOLVED: To provide primer compositions and configurations for improving the adhesion of a drug delivery matrix, e.g. therapeutic agent and polymer combination, to openings of a medical device. SOLUTION: An expandable medical device 10 includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings 30 within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different agents are loaded into different openings 30 in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different agents may also be used to address different diseases from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis. To ensure that the different agents remain affixed to the device as well as to each other, primer layers may be utilized. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供用于改善药物递送基质的粘附的底漆组合物和构型，例如，治疗剂和聚合物组合，用于医疗装置的开口。解决方案：可扩张医疗装置10包括多个细长的支柱，形成从第一直径扩展到第二直径的大致圆柱形的装置。多个不同的有益剂可以被装载到支柱内的不同开口30中，以便输送到组织。为了治疗诸如再狭窄的病症，将不同的药剂装入装置中的不同开口30中以解决与再狭窄有关的不同生物过程，并且以与所治疗的生物过程相匹配的不同释放动力学递送。不同的药剂也可用于解决来自同一药物递送装置的不同疾病。此外，抗血栓形成剂可以附着在医疗装置的至少一部分表面上，以防止亚急性血栓形成。为了确保不同的试剂保持固定在装置上以及彼此之间，可以使用底漆层。版权所有（C）2010，JPO＆INPIT

3. 发明专利

JP2009073811A Coating using antithrombotic conjugate 有权
标题翻译：使用抗凝血剂涂覆
公开(公告)号：JP2009073811A
公开(公告)日：2009-04-09
申请号：JP2008178681
申请日：2008-07-09
申请人： Cordis Corp , コーディス・コーポレイションCordis Corporation
发明人： ZHAO JONATHON Z
IPC分类号： A61K45/00 , A61K9/00 , A61K31/337 , A61K31/436 , A61K31/706 , A61K31/727 , A61K47/34 , A61K47/48 , A61L31/00
CPC分类号： A61L31/10 , A61K47/55 , A61K47/593 , A61L31/148 , A61L31/16 , A61L33/0029 , A61L2300/42 , A61L2300/80 , C08G63/08 , C08G63/912
摘要： PROBLEM TO BE SOLVED: To provide a material for coating at least a part of subject surface or implanting in a subject. SOLUTION: A biodegradable antithrombotic conjugate having heparin and other antithrombotic part is introduced in a main chain of a polymer modified by click chemistry as a side chain. Various bioabsorbable monomers and dimers, e.g. valerolactone can be used for monomer derivation, homo- and co-polymerization, and conjugation with a biologically active molecule by click chemistry. A coating containing a biocompatible and bioabsorbable polymeric antithrombotic conjugate is applied to at least a part of surface of implantable tool to prevent or reduce the formation of thrombosis. The first coating layer that is the base layer is prepared by mixing a polymer material and a biologically active drug with a solvent to form a homogeneous solution. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供用于涂覆受试者表面的至少一部分或植入受试者的材料。解决方案：将具有肝素和其他抗血栓形成部分的生物可降解抗血栓缀合物引入到通过点击化学改性的聚合物的主链中作为侧链。各种生物可吸收单体和二聚体，例如戊内酯可用于单体衍生，均聚和共聚，以及通过点击化学与生物活性分子缀合。将包含生物相容性和生物可吸收的聚合物抗血栓形成缀合物的涂层施用于可植入工具的至少一部分表面以防止或减少血栓形成。作为基层的第一涂层是通过将聚合物材料和生物活性药物与溶剂混合以形成均匀溶液来制备的。版权所有（C）2009，JPO＆INPIT

4. 发明专利

JP2008200492A Antithrombotic and anti-restenosis drug eluting stent 有权
标题翻译：抗生素和抗静脉药物治疗手术
公开(公告)号：JP2008200492A
公开(公告)日：2008-09-04
申请号：JP2008020742
申请日：2008-01-31
申请人： Cordis Corp , コーディス・コーポレイションCordis Corporation
发明人： ZHAO JONATHON Z
IPC分类号： A61F2/06 , A61F2/84
CPC分类号： A61F2/856 , A61F2/91 , A61F2/915 , A61F2002/9155 , A61F2002/91558 , A61F2250/0035 , A61F2250/0068 , A61L31/146 , A61L31/16 , A61L2300/416 , A61L2300/42
摘要： PROBLEM TO BE SOLVED: To send comparatively large amount of useful medicaments to a section in which a blood vessel cavity is injured. SOLUTION: An expansible medical device has two or more support struts, forming a substantially cylindrical device which can be extended from a cylinder having the first diameter to a cylinder having the second diameter. In order to send to tissue, two or more different useful agents can be filled into the different openings within the struts. When a status like restinosis is treated, the different useful agents are filled into the different openings of the device in order to treat different biological processes accompanying the restinosis and are sent on different release kinetics according to the biological processes to treat. The different useful agents are also utilized for treating different diseases like the restinosis and acute myocardial infarction with the same drug delivery apparatus. Further, in order to prevent a subacute thrombus, an antithrombotic agent can also be adhered to at least a part of the surface of the medical device. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：将较大量的有用药物发送到血管腔受伤的部位。解决方案：可扩展医疗装置具有两个或更多个支撑支柱，形成基本上圆柱形的装置，其可以从具有第一直径的圆柱体延伸到具有第二直径的圆柱体。为了发送到组织，可以将两种或更多种不同的有用试剂填充到支柱内的不同开口中。当治疗状态如再狭窄时，将不同的有用试剂填充到装置的不同开口中，以便治疗伴随再狭窄的不同生物过程，并根据生物过程进行不同释放动力学的治疗。不同的有用试剂也用于用相同的药物输送装置治疗不同的疾病，如再狭窄和急性心肌梗塞。此外，为了防止亚急性血栓，还可以将抗血栓剂粘附在医疗装置的表面的至少一部分上。版权所有（C）2008，JPO＆INPIT

5. 发明专利

JP2007190379A Photoactive biocompatible coating composition 有权
标题翻译：光泽生物成分涂料组合物
公开(公告)号：JP2007190379A
公开(公告)日：2007-08-02
申请号：JP2006355418
申请日：2006-12-28
申请人： Cordis Corp , コーディス・コーポレイションCordis Corporation
发明人： FALOTICO ROBERT , ZHAO JONATHON Z
IPC分类号： A61L33/00 , C09D139/06 , C09D201/00
CPC分类号： A61L27/34 , A61L27/50 , A61L27/54 , A61L2300/236 , A61L2300/41 , A61L2300/418 , A61L2300/434 , A61L2300/606
摘要： PROBLEM TO BE SOLVED: To provide a biocompatible coating composition for improving retention of the biological activity of therapeutic agents embedded therein.
SOLUTION: The present invention discloses the biocompatible coating composition that can be photo crosslinked when exposed to long wavelength ultraviolet light. The biocompatible coating composition comprises at least one biocompatible polymer having a photoactive moiety covalently attached thereto, and a biologically active molecule having a photoactive moiety covalently attached thereto. The photoactive moiety covalently attached to the biologically active molecule and the photoactive moiety covalently attached to the at least one biocompatible polymer are the same or different, and absorb and respond to ultraviolet light having a wavelength band of about 300 nm or above. Preferably, the photoactive moiety is a chemical moiety derived from thioxanthone. The inventive biocompatible coating composition can be applied on at least a portion of one surface of an article.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种生物相容性涂料组合物，用于改善嵌入其中的治疗剂的生物活性的保留。解决方案：本发明公开了当暴露于长波长紫外光时可以光交联的生物相容性涂料组合物。生物相容性涂料组合物包含至少一种具有共价连接于其上的光活性部分的生物相容性聚合物和具有共价连接于其上的光活性部分的生物活性分子。共价连接到生物活性分子和共价连接到至少一种生物相容性聚合物的光活性部分的光活性部分相同或不同，并且吸收并响应波长带约为300nm或更高的紫外光。优选地，光活性部分是衍生自噻吨酮的化学部分。本发明的生物相容性涂料组合物可以施用在制品的一个表面的至少一部分上。版权所有（C）2007，JPO＆INPIT

6. 发明专利

JP2007153895A Organic contrast agent for radiography for medical tool 审中-公开
标题翻译：有机对照药物用于医疗工具的放射学
公开(公告)号：JP2007153895A
公开(公告)日：2007-06-21
申请号：JP2006329761
申请日：2006-12-06
申请人： Cordis Corp , コーディス・コーポレイションCordis Corporation
发明人： ZHAO JONATHON Z
IPC分类号： C07C233/69 , A61F2/06 , A61F2/84 , A61L27/00 , C07C69/76 , C08K5/101 , C08K5/20 , C08L101/00
CPC分类号： A61K49/0442 , A61K49/0433 , A61K49/0447
摘要： PROBLEM TO BE SOLVED: To provide a contrast agent for radiography compatible with a polymer material and improving contrast intensity. SOLUTION: The organic contrast agent for the radiography comprises an aliphatic main chain or an alicyclic main chain and a plurality of halogen-substituted aromatic groups. Each of the halogen-substituted aromatic groups in the contrast agent for the radiography is substituted with at least 3 halogen atoms and covalently bonded to the aliphatic main chain or alicyclic main chain. Furthermore, a radiation-non-transmitting polymer material comprising the contrast agent for the radiography and at least one kind of polymer is disclosed. The contrast agent for the radiography is physically mixed with at least the one kind of polymer or physically embedded or dispersed in at least the one kind of polymer. The radiation-non-transmitting polymer material can be applied to at least a part of one surface of a medical tool. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供与聚合物材料相容的放射线造影剂并提高对比度强度。解决方案：用于放射摄影的有机造影剂包括脂族主链或脂环族主链和多个卤素取代的芳族基团。用于放射照相术的造影剂中的每个卤素取代的芳族基团被至少3个卤素原子取代并且共价键合到脂族主链或脂环族主链上。此外，公开了包含用于放射照相的造影剂和至少一种聚合物的辐射非透射性聚合物材料。用于放射照相术的造影剂与至少一种聚合物物理混合，或物理地嵌入或分散在至少一种聚合物中。辐射非透射性聚合物材料可以应用于医疗工具的一个表面的至少一部分。版权所有（C）2007，JPO＆INPIT

7. 发明专利

JP2006298904A Dendritic star-shaped contrast agent for medical device, bioabsorbable radiopaque bulk material, and method of producing the same 审中-公开
标题翻译：用于医疗装置的生物形星形造影剂，生物可降解散装材料及其制造方法
公开(公告)号：JP2006298904A
公开(公告)日：2006-11-02
申请号：JP2006075049
申请日：2006-03-17
申请人： Cordis Corp , コーディス・コーポレイションCordis Corporation
发明人： ZHAO JONATHON Z
IPC分类号： C07C271/16 , A61K49/04 , A61L31/00 , C08G63/08 , C08L101/16
CPC分类号： C08G83/003 , A61K31/785 , A61K49/0442 , A61L31/06 , A61L31/18 , C08G63/08 , C08L101/005 , C08L101/04
摘要： PROBLEM TO BE SOLVED: To provide a high intensity radiopaque contrast agent. SOLUTION: This contrast agent can be applied on or incorporated in a bulk material and after that, the material can be used for the preparation of a radiopaque medical device. The main action by its chemical properties is to comparatively heighten the radiopaque concentrations per unit weight of the radiopaque element or substance, and the secondary action is to enable selective placement of the radiopaque element. Thus, the radiopacity of the device can be enhanced with reduced amounts of the radiopaque substance. The radiopaque contrast agent can be produced in various forms such as a dendrimer and/or be incorporated as the end groups of polymeric chain. Further, biological and/or medicinal substances can be incorporated in combination of the agent. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供高强度不透射线造影剂。解决方案：该造影剂可以施加在散装材料上或并入其中，然后该材料可用于制备不透射线的医疗装置。其化学性质的主要作用是相对增加不透射线元件或物质的每单位重量的不透射线浓度，并且次要作用是使得能够选择性地放置不透射线的元件。因此，可以通过减少不透射线物质的量来增强装置的射线不透性。不透射线的造影剂可以以各种形式生产，例如树枝状大分子和/或作为聚合物链的端基引入。此外，生物和/或药物可以并入该药剂的组合中。版权所有（C）2007，JPO＆INPIT

8. 发明专利

JP2011245297A Drug coated expandable device 有权
标题翻译：药物涂层可扩展装置
公开(公告)号：JP2011245297A
公开(公告)日：2011-12-08
申请号：JP2011113076
申请日：2011-05-20
申请人： Cordis Corp , コーディス・コーポレイションCordis Corporation
发明人： ZHAO JONATHON Z
IPC分类号： A61F2/82 , A61K31/436 , A61K47/10 , A61K47/14 , A61K47/22 , A61K47/32 , A61K47/34 , A61L29/00 , A61M25/00
CPC分类号： A61L29/16 , A61K31/337 , A61K31/4355 , A61K31/436 , A61K31/4745 , A61L31/16 , A61L2300/416
摘要： PROBLEM TO BE SOLVED: To provide an expandable medical device.SOLUTION: The medical device may be utilized for local and regional therapeutic agent delivery. These therapeutic agents or compounds may reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the prevention of thrombosis. The drugs, agents, and/or compounds may also be utilized to treat specific disorders, including restenosis, vulnerable plaque, and atherosclerosis in type 2 diabetic patients.
摘要翻译：要解决的问题：提供可扩展医疗装置。解决方案：医疗设备可用于局部和区域治疗剂递送。这些治疗剂或化合物可以减少生物体对将生物体引入医疗装置的反应。此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括预防血栓形成。药物，药剂和/或化合物也可用于治疗2型糖尿病患者中的特定疾病，包括再狭窄，易损斑块和动脉粥样硬化。版权所有（C）2012，JPO＆INPIT

9. 发明专利

JP2011104369A Electron beam sterilization of medical device with bioactive coating 有权
标题翻译：具有生物涂层的医疗设备的电子束灭菌
公开(公告)号：JP2011104369A
公开(公告)日：2011-06-02
申请号：JP2010254523
申请日：2010-11-15
申请人： Cordis Corp , コーディス・コーポレイションCordis Corporation
发明人： FALOTICO ROBERT , LI CHENGXUE , NGUYEN THAI MINH , PARKER THEODORE L , ZHAO JONATHON Z
IPC分类号： A61L2/08 , A61M37/00
CPC分类号： B65B31/00 , A61L2/087 , A61L2202/21 , B65B55/00 , B65B55/16 , B65D81/266
摘要： PROBLEM TO BE SOLVED: To provide a method for single-step terminal sterilization process for bioactive heparin coatings on materials and biomaterials containing heparin used in medical devices, such as catheters, tissue engineering scaffolds, or drug delivery carrier materials. SOLUTION: The present invention may include a medical device or an implant that could benefit from improved antithrombotic and biocompatible heparin surfaces. Other relevant device examples may include heparin or a heparin derivative-coated stents for reducing clotting and restenosis, dental or ophthalmological implants. These materials may, in cases, include additional polymeric compositions, such as polyethyleneimine, dextran sulfate, or their modified forms. These polymers together with heparin coatings may be applied to other substrate of medical devices such as metal, ceramics, or biologically derived materials. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于医疗装置（例如导管，组织工程支架或药物递送载体材料）中含有肝素的材料和生物材料上的生物活性肝素涂层的一步终端灭菌方法。解决方案：本发明可以包括可以从改进的抗血栓形成和生物相容性肝素表面中受益的医疗装置或植入物。其它有关的装置实例可包括肝素或用于减少凝血和再狭窄的肝素衍生物涂层的支架，牙科或眼科植入物。在这些情况下，这些材料可以包括另外的聚合物组合物，例如聚乙烯亚胺，硫酸葡聚糖或其改性形式。这些聚合物与肝素涂层一起可以应用于诸如金属，陶瓷或生物衍生材料的医疗装置的其它基底。版权所有（C）2011，JPO＆INPIT

10. 发明专利

JP2011019918A Coating for medical device having anti-thrombotic conjugate 审中-公开
标题翻译：具有抗凝血药物的医疗器械涂层
公开(公告)号：JP2011019918A
公开(公告)日：2011-02-03
申请号：JP2010161311
申请日：2010-07-16
申请人： Cordis Corp , コーディス・コーポレイションCordis Corporation
发明人： ZHAO JONATHON Z , FALOTICO ROBERT
IPC分类号： A61L31/00
CPC分类号： A61L31/16 , A61L31/10 , A61L31/148 , A61L33/0029 , C08L67/04
摘要： PROBLEM TO BE SOLVED: To provide a coating material for application to at least a portion of one surface of an article. SOLUTION: A method is provided for applying a coating comprising an anti-thrombotic agent and bioabsorbable polymer conjugate to at least some of an implantable device to prevent formation of thrombosis on the surface 10 of the device 50. A first or sub layer 20 of the coating is prepared by mixing polymeric material and a biologically active agent with a solvent, thereby forming a homogeneous solution. A second or outer layer 30 comprises an anti-thrombotic heparin 40-bioabsorbable polymer conjugate. This coating is applied in dip coating or spray coating processes. After drying, the anti-thrombotic heparin 40-bioabsorbable polymer conjugate remains in the outer layer of coating, allowing agent from the inner layer to elute therethrough. Also, the outermost layer prevents thrombosis, and modulates release kinetics of agent(s) contained within inner layer(s) of the coating. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于制品的一个表面的至少一部分的涂料。解决方案：提供了一种用于将包含抗血栓形成剂和生物可吸收聚合物缀合物的涂层施用于至少一些可植入装置以防止在装置50的表面10上形成血栓形成的方法。第一或第二层通过将聚合物材料和生物活性剂与溶剂混合制备涂层20，从而形成均匀的溶液。第二层或外层30包含抗血栓形成肝素40-生物可吸收聚合物缀合物。该涂层用于浸涂或喷涂工艺。干燥后，抗血栓形成的肝素40-生物可吸收聚合物缀合物保留在涂层的外层中，允许来自内层的试剂从其中洗脱。此外，最外层防止血栓形成，并且调节包被在内层内的药剂的释放动力学。版权所有（C）2011，JPO＆INPIT

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