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1. 发明专利

JP2012040380A Sub-threshold voltage priming of inkjet device to minimize first drop dissimilarity in drop on demand mode 有权
标题翻译：喷墨设备的子阈值电压调整，以最小化需求模式下的第一个DROP DISSIMILARITY
公开(公告)号：JP2012040380A
公开(公告)日：2012-03-01
申请号：JP2011175631
申请日：2011-08-11
申请人： Cordis Corp , コーディス・コーポレイションCordis Corporation
发明人： BALDY JR WILLIAM J , FAMILI AMIN , PALKAR SAURABH A
IPC分类号： A61F2/84 , A61L31/00 , B05D1/26 , B05D3/00
CPC分类号： B41J2/04596 , A61F2/91 , B41J2/04575 , B41J2/04581 , B41J2/04588 , B41J2/04598
摘要： PROBLEM TO BE SOLVED: To provide a method for precisely depositing the same amount of a particular substance at one or more locations on an object.SOLUTION: The establishment of a stable acoustic environment within the individual channels of an inkjet printing device functions to allow the inkjet printing device to precisely deposit the same amount of a particular substance at one or more locations on an object. This is particularly relevant when the inkjet printing device is operated in the on-demand mode of operation.
摘要翻译：要解决的问题：提供一种用于在物体上的一个或多个位置处精确地沉积相同量的特定物质的方法。解决方案：在喷墨打印装置的各个通道内建立稳定的声学环境起作用，以允许喷墨打印装置在物体上的一个或多个位置处精确地沉积相同量的特定物质。当喷墨打印装置以按需操作模式操作时，这是特别相关的。版权所有（C）2012，JPO＆INPIT

2. 发明专利

JP2011245297A Drug coated expandable device 有权
标题翻译：药物涂层可扩展装置
公开(公告)号：JP2011245297A
公开(公告)日：2011-12-08
申请号：JP2011113076
申请日：2011-05-20
申请人： Cordis Corp , コーディス・コーポレイションCordis Corporation
发明人： ZHAO JONATHON Z
IPC分类号： A61F2/82 , A61K31/436 , A61K47/10 , A61K47/14 , A61K47/22 , A61K47/32 , A61K47/34 , A61L29/00 , A61M25/00
CPC分类号： A61L29/16 , A61K31/337 , A61K31/4355 , A61K31/436 , A61K31/4745 , A61L31/16 , A61L2300/416
摘要： PROBLEM TO BE SOLVED: To provide an expandable medical device.SOLUTION: The medical device may be utilized for local and regional therapeutic agent delivery. These therapeutic agents or compounds may reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the prevention of thrombosis. The drugs, agents, and/or compounds may also be utilized to treat specific disorders, including restenosis, vulnerable plaque, and atherosclerosis in type 2 diabetic patients.
摘要翻译：要解决的问题：提供可扩展医疗装置。解决方案：医疗设备可用于局部和区域治疗剂递送。这些治疗剂或化合物可以减少生物体对将生物体引入医疗装置的反应。此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括预防血栓形成。药物，药剂和/或化合物也可用于治疗2型糖尿病患者中的特定疾病，包括再狭窄，易损斑块和动脉粥样硬化。版权所有（C）2012，JPO＆INPIT

3. 发明专利

JP2011156377A Vessel coupling device 有权
标题翻译：船舶联轴器
公开(公告)号：JP2011156377A
公开(公告)日：2011-08-18
申请号：JP2011085115
申请日：2011-04-07
申请人： Cordis Corp , コーディス・コーポレイションCordis Corporation
发明人： BONSIGNORE CRAIG
IPC分类号： A61B17/00 , A61B17/11 , A61F2/06 , A61M25/01
CPC分类号： A61F2/064
摘要： PROBLEM TO BE SOLVED: To provide a device for coupling two vessels seamlessly. SOLUTION: The device includes: a main vessel 10; a bypass vessel 80; a coupling graft 70 disposed within the main vessel end and the bypass vessel end; a main vessel internal stent-anchor 116 and a bypass vessel internal stent-anchor 115 configured to exert an outward force to seal each vessel with the coupling graft; and an external anchor 142 to seal the main vessel end and the bypass vessel end around the coupling graft. The main vessel and the bypass vessel are held in fluid communication via the coupling graft. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种无缝连接两个容器的装置。解决方案：该装置包括：主容器10; 旁路容器80; 设置在主容器端和旁路容器端内的联接移植物70; 主容器内部支架锚定件116和旁路容器内部支架锚定件115，其构造成施加向外的力以用联接移植物密封每个容器; 以及外部锚固件142，以密封联接移植物周围的主容器端部和旁路容器端部。主容器和旁路容器通过联接移植物保持流体连通。版权所有（C）2011，JPO＆INPIT

4. 发明专利

JP2011104369A Electron beam sterilization of medical device with bioactive coating 有权
标题翻译：具有生物涂层的医疗设备的电子束灭菌
公开(公告)号：JP2011104369A
公开(公告)日：2011-06-02
申请号：JP2010254523
申请日：2010-11-15
申请人： Cordis Corp , コーディス・コーポレイションCordis Corporation
发明人： FALOTICO ROBERT , LI CHENGXUE , NGUYEN THAI MINH , PARKER THEODORE L , ZHAO JONATHON Z
IPC分类号： A61L2/08 , A61M37/00
CPC分类号： B65B31/00 , A61L2/087 , A61L2202/21 , B65B55/00 , B65B55/16 , B65D81/266
摘要： PROBLEM TO BE SOLVED: To provide a method for single-step terminal sterilization process for bioactive heparin coatings on materials and biomaterials containing heparin used in medical devices, such as catheters, tissue engineering scaffolds, or drug delivery carrier materials. SOLUTION: The present invention may include a medical device or an implant that could benefit from improved antithrombotic and biocompatible heparin surfaces. Other relevant device examples may include heparin or a heparin derivative-coated stents for reducing clotting and restenosis, dental or ophthalmological implants. These materials may, in cases, include additional polymeric compositions, such as polyethyleneimine, dextran sulfate, or their modified forms. These polymers together with heparin coatings may be applied to other substrate of medical devices such as metal, ceramics, or biologically derived materials. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于医疗装置（例如导管，组织工程支架或药物递送载体材料）中含有肝素的材料和生物材料上的生物活性肝素涂层的一步终端灭菌方法。解决方案：本发明可以包括可以从改进的抗血栓形成和生物相容性肝素表面中受益的医疗装置或植入物。其它有关的装置实例可包括肝素或用于减少凝血和再狭窄的肝素衍生物涂层的支架，牙科或眼科植入物。在这些情况下，这些材料可以包括另外的聚合物组合物，例如聚乙烯亚胺，硫酸葡聚糖或其改性形式。这些聚合物与肝素涂层一起可以应用于诸如金属，陶瓷或生物衍生材料的医疗装置的其它基底。版权所有（C）2011，JPO＆INPIT

5. 发明专利

JP2011019918A Coating for medical device having anti-thrombotic conjugate 审中-公开
标题翻译：具有抗凝血药物的医疗器械涂层
公开(公告)号：JP2011019918A
公开(公告)日：2011-02-03
申请号：JP2010161311
申请日：2010-07-16
申请人： Cordis Corp , コーディス・コーポレイションCordis Corporation
发明人： ZHAO JONATHON Z , FALOTICO ROBERT
IPC分类号： A61L31/00
CPC分类号： A61L31/16 , A61L31/10 , A61L31/148 , A61L33/0029 , C08L67/04
摘要： PROBLEM TO BE SOLVED: To provide a coating material for application to at least a portion of one surface of an article. SOLUTION: A method is provided for applying a coating comprising an anti-thrombotic agent and bioabsorbable polymer conjugate to at least some of an implantable device to prevent formation of thrombosis on the surface 10 of the device 50. A first or sub layer 20 of the coating is prepared by mixing polymeric material and a biologically active agent with a solvent, thereby forming a homogeneous solution. A second or outer layer 30 comprises an anti-thrombotic heparin 40-bioabsorbable polymer conjugate. This coating is applied in dip coating or spray coating processes. After drying, the anti-thrombotic heparin 40-bioabsorbable polymer conjugate remains in the outer layer of coating, allowing agent from the inner layer to elute therethrough. Also, the outermost layer prevents thrombosis, and modulates release kinetics of agent(s) contained within inner layer(s) of the coating. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于制品的一个表面的至少一部分的涂料。解决方案：提供了一种用于将包含抗血栓形成剂和生物可吸收聚合物缀合物的涂层施用于至少一些可植入装置以防止在装置50的表面10上形成血栓形成的方法。第一或第二层通过将聚合物材料和生物活性剂与溶剂混合制备涂层20，从而形成均匀的溶液。第二层或外层30包含抗血栓形成肝素40-生物可吸收聚合物缀合物。该涂层用于浸涂或喷涂工艺。干燥后，抗血栓形成的肝素40-生物可吸收聚合物缀合物保留在涂层的外层中，允许来自内层的试剂从其中洗脱。此外，最外层防止血栓形成，并且调节包被在内层内的药剂的释放动力学。版权所有（C）2011，JPO＆INPIT

6. 发明专利

JP2010148876A Adhesion promoting temporary mask for coated surfaces 有权
标题翻译：粘合促进涂层表面的临时掩模
公开(公告)号：JP2010148876A
公开(公告)日：2010-07-08
申请号：JP2009290189
申请日：2009-12-22
申请人： Cordis Corp , コーディス・コーポレイションCordis Corporation
发明人： DAVE VIPUL , FALOTICO ROBERT , LI CHENGXUE , NGUYEN THAI M , PARKER THEODORE L , ZHAO JONATHON Z
IPC分类号： A61L31/00 , A61F2/82 , A61L33/10
CPC分类号： A61F2/91 , A61F2250/0068 , A61L31/10 , A61L31/16 , A61L33/0011 , A61L2300/00
摘要： PROBLEM TO BE SOLVED: To provide a heparin coated stent having reservoirs or openings therein. SOLUTION: An expandable medical device 10 includes a plurality of elongated struts 18, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings 30a within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different agents may also be used to address different diseases from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供在其中具有储存器或开口的肝素涂层支架。解决方案：可扩张医疗装置10包括多个细长支柱18，其形成从第一直径扩展到第二直径的基本上圆柱形的装置。多个不同的有益剂可以被装载到支柱内的不同的开口30a中，以输送到组织。为了治疗诸如再狭窄的病症，将不同的药剂装入装置中的不同开口以解决与再狭窄相关的不同生物过程，并且以与所治疗的生物过程相匹配的不同释放动力学递送。不同的药剂也可用于解决来自同一药物递送装置的不同疾病。此外，抗血栓形成剂可以附着在医疗装置的至少一部分表面上，以防止亚急性血栓形成。版权所有（C）2010，JPO＆INPIT

7. 发明专利

JP2010104788A Catheter system and method for filter retrieval 有权
标题翻译：导管系统和滤波器检索方法
公开(公告)号：JP2010104788A
公开(公告)日：2010-05-13
申请号：JP2009249916
申请日：2009-10-30
申请人： Cordis Corp , コーディス・コーポレイションCordis Corporation
发明人： FLEMING JAMES A III
IPC分类号： A61B17/50 , A61B17/00
摘要： PROBLEM TO BE SOLVED: To provide a filter catheter system for retrieving a previously implanted medical filter and a method of using the retrieval system. SOLUTION: This filter retrieval system 10 includes a flexible shaft 12, a retrieval element 14, and a handle 16 with an actuator 18. The flexible shaft which may be catheter-based, has a proximal and a distal end, with an opening near its distal end. The handle is affixed to the shaft near the proximal end of the shaft, and the actuator is adapted to manipulate the retrieval element. When an operator manipulates the actuator, the retrieval element is adapted to protrude slightly from the shaft opening. As the actuator is operated, the retrieval element can grasp or hook or otherwise engage a portion of the filter, and then pull the filter in through the opening into a lumen in a proximal or distal space defined by the flexible shaft. The retrieval system is capable of retrieving a filter like this. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于检索先前植入的医疗过滤器的过滤器导管系统和使用该检索系统的方法。解决方案：该过滤器回收系统10包括柔性轴12，回收元件14和具有致动器18的手柄16.可以是基于导管的柔性轴具有近端和远端，在其远端附近开放。手柄固定在靠近轴的近端的轴上，并且致动器适于操纵检索元件。当操作者操纵致动器时，取出元件适于从轴孔略微突出。当致动器被操作时，回收元件可以抓住或钩住或以其他方式接合过滤器的一部分，然后将过滤器通过开口拉入到由柔性轴限定的近端或远端空间中的内腔中。检索系统能够检索这样的过滤器。版权所有（C）2010，JPO＆INPIT

8. 发明专利

JP2009136672A Medical device including thin metallic film component attached to polymeric component and associated methods 有权
标题翻译：包括连接到聚合物组分和相关方法的薄金属薄膜组件的医疗装置
公开(公告)号：JP2009136672A
公开(公告)日：2009-06-25
申请号：JP2008275585
申请日：2008-10-27
申请人： Cordis Corp , コーディス・コーポレイションCordis Corporation
发明人： VELASCO REGINA , BONSIGNORE CRAIG
IPC分类号： A61M25/00 , A61F2/958 , A61L29/00
CPC分类号： A61M25/10 , A61M25/1034 , B29C65/64 , B29C66/1122 , B29C66/30325 , B29C66/304 , B29C66/5344 , B29C66/742 , B29K2305/00 , B29L2022/022 , B29L2031/7542
摘要： PROBLEM TO BE SOLVED: To provide a comparatively low-profile medical device despite the presence of a region to engage a medical device polymeric component.
SOLUTION: The medical device includes a medical device thin metallic film component (such as a thin metallic angioplasty balloon 310), with perforations 340 therethrough, and a medical device polymeric component (e.g., a polymeric tubular catheter 320) abutting the thin metallic film component. The medical device also includes a polymeric sleeve 330 covering the perforations and at least a portion of the polymeric component abutting the thin metallic film component. Moreover, the polymeric sleeve intrudes into the perforations and joins the thin metallic film component to the polymeric component.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：为了提供一种比较薄型的医疗装置，尽管存在与医疗装置聚合物组分接合的区域。解决方案：医疗装置包括医疗装置薄金属膜部件（例如薄金属血管成形术球囊310），穿孔穿过其中的340以及邻接薄片的医疗装置聚合物部件（例如，聚合物管状导管320）金属膜成分。医疗装置还包括覆盖穿孔的聚合物套筒330和邻接薄金属膜部件的聚合物部件的至少一部分。此外，聚合物套管侵入穿孔并将薄金属膜组分连接到聚合物组分上。版权所有（C）2009，JPO＆INPIT

9. 发明专利

JP2008264527A Short term sustained drug-delivery system for implantable medical devices and method of making the same 审中-公开
标题翻译：用于可植入医疗装置的短期持续的药物递送系统及其制造方法
公开(公告)号：JP2008264527A
公开(公告)日：2008-11-06
申请号：JP2008082882
申请日：2008-03-27
申请人： Cordis Corp , コーディス・コーポレイションCordis Corporation
发明人： ZHAO JONATHON Z
IPC分类号： A61F2/84 , A61L31/00
CPC分类号： A61L31/16 , A61F2/91 , A61F2/915 , A61F2002/91558 , A61F2250/0068 , A61L2300/416 , A61L2300/602
摘要： PROBLEM TO BE SOLVED: To provide a short-term sustained drug eluting coating for implantable medical devices. SOLUTION: The coating comprises a biocompatible matrix and at least one pharmacologically or biologically active agent and releases substantially one of all of its payloads within four to six weeks post-implantation. When a combination of pharmacological agents are incorporated in the disclosed sustained drug eluting matrix of a drug/device combination, at least one agent is preferred to substantially release in a short duration. Medical devices benefiting from such a desired sustained drug eluting coating include drug eluting cardiovascular, peripheral, and neurovascular stents, abdominal aortic aneurysm prosthesis, anastomosis shunt, arterial/venous shunts etc. One embodiment of the invention is a sustained release coating or depot on or in a stent that releases substantially all of its payload for ischemic myocardial injury after a heart attack. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供用于可植入医疗器械的短期持续药物洗脱涂层。解决方案：涂层包括生物相容性基质和至少一种药理学或生物活性剂，并且在植入后四至六周内释放其全部有效载荷中的其中一个。当所公开的药物/装置组合的持续药物洗脱基质中并入药理学试剂的组合时，优选至少一种试剂在短时间内基本上释放。受益于这种期望的持续药物洗脱涂层的医疗装置包括药物洗脱心血管，外周和神经血管支架，腹主动脉瘤假体，吻合分流，动脉/静脉分流等。本发明的一个实施方案是持续释放包衣或在支架中，其在心脏病发作后基本上释放缺血性心肌损伤的所有有效载荷。版权所有（C）2009，JPO＆INPIT

10. 发明专利

JP2008110204A Bioabsorbable device having composite structure for accelerating degradation 有权
标题翻译：具有加速降解的复合结构的生物可降解装置
公开(公告)号：JP2008110204A
公开(公告)日：2008-05-15
申请号：JP2007262362
申请日：2007-10-05
申请人： Cordis Corp , コーディス・コーポレイションCordis Corporation
发明人： DAVE VIPUL , LANDAU GEORGE
IPC分类号： A61L31/00
CPC分类号： B32B27/32 , A61F2/82 , A61L27/18 , A61L27/58 , A61L31/06 , A61L31/148 , Y10T428/31725 , Y10T428/31786 , C08L67/04
摘要： PROBLEM TO BE SOLVED: To provide new and useful bioabsorbable medical devices that are capable of achieving a desired mass loss through accelerated degradation after the medical device has achieved its desired functional effect or achieved the end of its functional purpose or useful life. SOLUTION: The medical device has a structure made of a first biodegradable and/or bioabsorbable material and a second biodegradable and/or bioabsorbable material. The first biodegradable and/or bioabsorbable material has a degradation rate that is faster than a degradation rate of the second biodegradable and/or bioabsorbable material. The structure experiences a period of accelerated degradation upon exposure of the first biodegradable and/or bioabsorbable material. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供新的和有用的生物可吸收医疗装置，其能够在医疗装置达到其期望的功能效果之后通过加速降解实现期望的质量损失或达到其功能目的或使用寿命的终止。解决方案：医疗装置具有由第一可生物降解和/或生物可吸收材料和第二可生物降解和/或生物可吸收材料制成的结构。第一可生物降解和/或生物可吸收材料具有比第二可生物降解和/或生物可吸收材料的降解速度更快的降解速率。该结构体经历第一可生物降解和/或生物可吸收材料暴露时加速降解的时期。版权所有（C）2008，JPO＆INPIT

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