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1. 发明专利

JP2014005206A Arylamino heterocyclic carboxamide compound 审中-公开
标题翻译： ARYLAMINO杂环碳酰胺化合物
公开(公告)号：JP2014005206A
公开(公告)日：2014-01-16
申请号：JP2010236958
申请日：2010-10-22
申请人： Astellas Pharma Inc , アステラス製薬株式会社 , Kotobuki Seiyaku Kk , 壽製薬株式会社
发明人： SHIMADA ITSURO , MATSUYA TAKAHIRO , KUROSAWA KAZUO , IIKUBO KAZUHIKO , KAMIKAWA AKIO , KUROMITSU SADAO , SHINTO NOBUAKI , FUTAMI TAKASHI , KAWASE TATSUYA , SANO YORIMASA , YAMANAKA AYA , NISHIMURA KOICHI , ASAUMI MAKOTO , TOMIYAMA YASUSHI , IWAI TATSUNORI
IPC分类号： C07D239/06 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/541 , A61P11/00 , A61P35/00 , A61P43/00 , C07D241/20 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D451/02 , C07D471/10 , C07D487/04 , C07D487/08 , C07D491/20 , C07D493/08
CPC分类号： C07D493/08 , C07D239/06 , C07D241/20 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D451/02 , C07D471/10 , C07D487/04 , C07D487/08 , C07D491/20
摘要： PROBLEM TO BE SOLVED: To provide a compound useful as an inhibitor of a kinase activity of EML4-ALK fusion protein.SOLUTION: The present inventors conducted intensive studies about a compound having an inhibitory activity of the kinase activity of EML4-ALK fusion protein and found that the arylamino heterocyclic carboxamide compound of the present invention has the inhibitory activity of the kinase activity of EML4-ALK fusion protein, and completed the present invention. The compound of the present invention may be used for a pharmaceutical composition for preventing and/or treating cancer, lung cancer, non-small cell lung cancer, small cell lung cancer and the like.
摘要翻译：要解决的问题：提供可用作EML4-ALK融合蛋白的激酶活性抑制剂的化合物。解决方案：本发明人对具有EML4-ALK融合蛋白激酶活性抑制活性的化合物进行了深入研究，发现本发明的芳基氨基杂环羧酰胺化合物具有EML4-ALK融合蛋白的激酶活性的抑制活性，完成了本发明。本发明的化合物可以用于预防和/或治疗癌症，肺癌，非小细胞肺癌，小细胞肺癌等的药物组合物。

2. 发明专利

JP2014087258A Method for detecting fgfr4 mutant in breast cancer 审中-公开
标题翻译：检测乳腺癌中FGFR4突变体的方法
公开(公告)号：JP2014087258A
公开(公告)日：2014-05-15
申请号：JP2011034218
申请日：2011-02-21
申请人： Astellas Pharma Inc , アステラス製薬株式会社
发明人： FUTAMI TAKASHI , KAWASE TATSUYA , SUZUKI TOMOYUKI , SHINTO NOBUAKI
IPC分类号： C12N15/09 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/156
摘要： PROBLEM TO BE SOLVED: To provide a method for detecting presence of breast cancer in a subject, a method for diagnosing the breast cancer in the subject by elucidating a novel gene mutation which is a cause of breast cancer and detecting the gene mutation or a protein based on the mutation, and to provide a primer set, a probe, and a detection kit which are used for these methods.SOLUTION: A method for detecting presence of breast cancer in a subject includes a step of detecting presence of a mutation of asparagine at position 82 in the tyrosine kinase domain of fibroblast growth factor receptor 4 (FGFR4) to aspartic acid or lysine in a sample collected from the subject.
摘要翻译：要解决的问题：提供一种检测受试者乳腺癌存在的方法，通过阐明作为乳腺癌的原因的新基因突变和检测基因突变或蛋白质来诊断受试者的乳腺癌的方法基于突变，并提供用于这些方法的引物组，探针和检测试剂盒。解决方案：用于检测受试者乳腺癌存在的方法包括检测天冬酰胺突变的存在的步骤在成纤维细胞生长因子受体4（FGFR4）的酪氨酸激酶结构域中的位置82与从受试者收集的样品中的天冬氨酸或赖氨酸。

3. 发明专利

JP2013226108A Method for detecting new ntrk2 activating mutation 审中-公开
标题翻译：用于检测新NTRK2激活突变的方法
公开(公告)号：JP2013226108A
公开(公告)日：2013-11-07
申请号：JP2012102098
申请日：2012-04-27
申请人： Astellas Pharma Inc , アステラス製薬株式会社
发明人： KAWASE TATSUYA , KADOYAMA KAZUHISA , ASAMI MAKOTO
IPC分类号： C12Q1/68 , C12Q1/04
摘要： PROBLEM TO BE SOLVED: To provide a method for detecting presence of cancer in a subject by clarifying new gene mutation causing the cancer and detecting the new gene mutation or protein in response to the mutation, a method for diagnosing the cancer in the subject, and a method for identifying a cancer patient who is positive to the mutation, and to provide a primer set, a probe, and a detection kit, which are used for these methods.SOLUTION: A method for detecting presence of cancer in a subject includes a step of detecting presence of mutation from 138th arginine of neurotrophic tyrosine receptor kinase 2 (NTRK2) tyrosine kinase domain in a sample received from the subject to cysteine.
摘要翻译：要解决的问题：提供一种通过澄清引起癌症的新基因突变和检测针对突变的新基因突变或蛋白质来检测受试者中癌症存在的方法，用于诊断受试者中的癌症的方法，以及用于鉴定对突变呈阳性的癌症患者的方法，以及提供用于这些方法的引物组，探针和检测试剂盒。解决方案：用于检测受试者中癌症存在的方法包括：从受试者接受半胱氨酸的样品中检测出第138位神经营养性酪氨酸受体激酶2（NTRK2）酪氨酸激酶结构域的精氨酸的突变存在的步骤。

4. 发明专利

JP2014082984A Method for detecting novel ntrk2 activating mutation 审中-公开
标题翻译：检测新型NTRK2激活突变的方法
公开(公告)号：JP2014082984A
公开(公告)日：2014-05-12
申请号：JP2012233934
申请日：2012-10-23
申请人： Astellas Pharma Inc , アステラス製薬株式会社
发明人： KAWASE TATSUYA , TSUNOYAMA KAZUHISA , ASAUMI MAKOTO
IPC分类号： C12Q1/68 , C12N15/09 , G01N33/68
摘要： PROBLEM TO BE SOLVED: To provide a method for detecting presence of cancer in a subject, a method for diagnosing the cancer in the subject, and a method for identifying a cancer patient who is positive to the mutation by elucidating a novel gene mutation which is a cause of cancer and detecting the gene mutation or a protein based on the mutation, and to provide a primer set, a probe, and a detection kit which are used for these methods.SOLUTION: A method for detecting presence of cancer in a subject includes a step of detecting presence of a mutation of arginine at position 138 in the tyrosine kinase domain of neurotrophic tyrosine kinase receptor, type 2 (NTRK2) to cysteine in a sample collected from the subject.
摘要翻译：要解决的问题：提供一种用于检测受试者中癌症存在的方法，用于诊断受试者中的癌症的方法，以及通过阐明新的基因突变来鉴定对该突变呈阳性的癌症患者的方法癌症的原因和基于突变的基因突变或蛋白质，以及提供用于这些方法的引物组，探针和检测试剂盒。解决方案：用于检测受试者中癌症存在的方法包括在从受试者收集的样品中检测神经营养性酪氨酸激酶受体2型（NTRK2）至半胱氨酸的酪氨酸激酶结构域中138位精氨酸突变的存在的步骤。

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