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1. 发明专利

JP2007314483A Preparation for external use and method for producing the same 审中-公开
标题翻译：用于外部使用的制备及其生产方法
公开(公告)号：JP2007314483A
公开(公告)日：2007-12-06
申请号：JP2006148002
申请日：2006-05-29
申请人： Amino Up Chemical Co Ltd , Ichimaru Pharcos Co Ltd , 一丸ファルコス株式会社 , 株式会社アミノアップ化学
发明人： TSUBOI TAKAYUKI , KAWASAKI YUJI , WAKAMEI KOJI
IPC分类号： A61K8/49 , A61K8/34 , A61K8/97 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide a preparation for external use obtained by elevating the stability and content of a sulfur-containing proanthocyanidine oligomer which has almost not been examined conventionally, or a method for producing the same. SOLUTION: This preparation for external use obtained by elevating the stability and content of the sulfur-containing proanthocyanidine oligomer is provided by blending a polyhydric alcohol in the preparation for external use containing the sulfur-containing proanthocyanidine oligomer for showing that the sulfur-containing proanthocyanidine oligomer which is an active ingredient, shows a good stability for a long period in the preparation, and also improving the solubility of the sulfur-containing proanthocyanidine oligomer by blending the polyhydric alcohol to increase the content of the sulfur-containing proanthocyanidine oligomer in the preparation, and the method for producing the same is also provided. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供通过提高几乎未经常规检查的含硫原花色素寡聚物的稳定性和含量而获得的外部用途制剂或其制备方法。解决方案：通过提高含硫原花色素低聚物的稳定性和含量而获得的这种外用制剂是通过在含有含硫原花色素低聚物的外用制剂中混合多元醇来提供的，含有原花青素低聚物作为活性成分，在制备中长时间显示出良好的稳定性，并且还通过混合多元醇来提高含硫原花青素低聚物的溶解度，从而提高含硫原花色素低聚物的含量还提供了制备方法及其制备方法。版权所有（C）2008，JPO＆INPIT

2. 发明专利

JP2015017051A メタボリックシンドローム治療剤审中-公开
标题翻译：代谢综合征治疗剂
公开(公告)号：JP2015017051A
公开(公告)日：2015-01-29
申请号：JP2013144667
申请日：2013-07-10
申请人：和久前田 , Kazuhisa Maeda , 和久前田 , 株式会社アミノアップ化学 , Amino Up Chemical Co Ltd , ロッテ健康産業株式会社 , Lotte Kenko Sangyo:Kk
发明人： MAEDA KAZUHISA , WAKAMEI KOJI , TAKANARI JUN , YASUDA HIDEYUKI , IMAI KEIJI
IPC分类号： A61K36/18 , A61K36/00 , A61P3/04 , A61P3/06 , A61P3/10
摘要：【課題】メタボリックシンドローム治療剤の提供【解決手段】本願発明者らは、マンゴスチン果皮抽出物を含むことを特徴とするメタボリックシンドローム治療剤、さらには、ライチ抽出物を含む治療剤を提供する。【選択図】図1
摘要翻译：要解决的问题：提供代谢综合征治疗剂。解决方案：本发明提供了一种包含绞胃芒果果皮提取物的代谢综合征治疗剂和包含荔枝提取物的治疗剂。

3. 发明专利

JP2013165732A Method for screening gene product 有权
标题翻译：筛选基因产物的方法
公开(公告)号：JP2013165732A
公开(公告)日：2013-08-29
申请号：JP2013101558
申请日：2013-05-13
申请人： Amino Up Chemical Co Ltd , 株式会社アミノアップ化学 , Kansai Medical Univ , 学校法人関西医科大学
发明人： OKUMURA TADAYOSHI , NISHIZAWA MIKIO , KAMIYAMA YASUO , WAKAMEI KOJI , MIURA TAKETO
IPC分类号： C12Q1/68 , C12N15/09
CPC分类号： C12Q1/6811 , A61K38/4866 , C12N15/111 , C12N15/67 , C12N2310/113
摘要： PROBLEM TO BE SOLVED: To provide a method for effectively screening gene products such as cytokine.SOLUTION: A method for screening gene products includes a step of determining the presence or absence of an antisense transcript containing a sequence complementary to the base sequence of 3' untranslated region of mRNA corresponding to the gene products. The determination of the presence and absence of the antisense transcript is carried out by, for example, conducting reverse transcription from intracellular mRNA by using a primer containing sense sequence of the 3' untranslated region of mRNA corresponding to the gene product, and thereby confirming the presence or absence of products of the reverse transcription.
摘要翻译：要解决的问题：提供有效筛选基因产物如细胞因子的方法。解决方案：筛选基因产物的方法包括确定含有与3'碱基序列互补的序列的反义转录物的存在或不存在的步骤对应于基因产物的mRNA的非翻译区。通过使用含有对应于该基因产物的mRNA的3'非翻译区的正义序列的引物，通过例如从细胞内mRNA进行逆转录来进行反义转录物的存在和不存在的测定，从而确认存在或不存在逆转录产物。

4. 发明专利

JP2008013550A COMPOSITION HAVING ACTIVITY FOR REGULATING EXPRESSION OF iNOS 有权
标题翻译：具有调节iNOS表达活性的组合物
公开(公告)号：JP2008013550A
公开(公告)日：2008-01-24
申请号：JP2007151892
申请日：2007-06-07
申请人： Amino Up Chemical Co Ltd , Univ Kansai Medical , 学校法人関西医科大学 , 株式会社アミノアップ化学
发明人： OKUMURA TADAYOSHI , NISHIZAWA MIKIO , KAMIYAMA YASUO , WAKAMEI KOJI , MIURA TAKETO
IPC分类号： A61K36/07 , A61P7/00 , A61P29/00 , A61P35/00 , A61P43/00 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide a composition targeting the regulation of the expression of iNOS (inducible nitric oxide synthase) and originated from a culture product of basidiomycete.
SOLUTION: The expression of the iNOS can be regulated by using the composition originated from the culture product of the basidiomycete, and the composition is useful for biophylaxis, and therapy and prophylaxis of a disease associated with the excess production of NO, e.g. carcinogenesis, inflammatory disease, endotoxin shock caused by bacterial infection or the like.
COPYRIGHT: (C)2008,JPO&INPIT

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