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1. 发明专利

JP2015006173A マクロファージ識別剤、該マクロファージ識別剤を用いた識別方法、分取方法、評価方法、スクリーニング方法、およびキット有权
标题翻译： MACROPHAGE识别代理，识别方法，分类方法，评估方法，筛选方法和使用大量鉴定代理的工具包
公开(公告)号：JP2015006173A
公开(公告)日：2015-01-15
申请号：JP2014111593
申请日：2014-05-29
申请人：キヤノン株式会社 , Canon Inc
发明人： KOIDE FUMIYO , NOMOTO TAKESHI , YAMAUCHI SACHIKO , WATANABE KOHEI , SHINDO TAICHI , MIYAZAKI TAKESHI , TABATA YASUHIKO , MITA ERI
IPC分类号： C12Q1/04 , C12M1/34 , C12N5/0786 , C12Q1/02 , G01N21/64 , G01N33/48
CPC分类号： G01N33/5094 , C07D209/14 , C07D209/80 , C07D277/64 , C07D401/06 , C07D403/06 , C07D403/08 , C07D413/04 , C07D413/06 , C07D413/08 , C07D417/06 , C07D417/08 , C07D417/14 , C07D498/04 , C07F5/022 , C07F5/027 , C12N5/0645 , G01N33/5005 , G01N33/52
摘要：【課題】本発明の目的は、有機化合物を用いたマクロファージのサブタイプの識別方法の提供である。また、本発明の別の目的は、付与したときに得られる分光特性がマクロファージのサブタイプによって異なることを特徴とする有機化合物から成るマクロファージ識別剤を提供することである。また、本発明の別の目的は、マクロファージ識別剤を用いたマクロファージのサブタイプの評価方法、マクロファージのサブタイプと被験物質との相関の分析方法、マクロファージのサブタイプと被験物質との相関のスクリーニング方法、およびキットを提供することにある。【解決手段】有機化合物を付与したときに、マクロファージのサブタイプによって得られる分光特性が異なることを利用した、マクロファージのサブタイプの識別方法を提供する。【選択図】図2
摘要翻译：要解决的问题：提供使用有机化合物的巨噬细胞亚型的鉴定方法，并且还提供由有机化合物组成的巨噬细胞鉴定剂，其中当给予有机化合物时获得的光谱特性不同根据巨噬细胞的亚型，还提供使用巨噬细胞识别剂的巨噬细胞亚型的评价方法，巨噬细胞亚型与检测物质之间的相关性分析方法，亚型之间的相关性筛选方法的巨噬细胞和测试物质及试剂盒。解决方案：本发明通过利用当给予有机化合物时获得的光谱特征，根据巨噬细胞的亚型而不同，提供了巨噬细胞亚型的鉴定方法。

2. 发明专利

JP2014101359A Cancer cell inhibitory drug and cancer stem-cell detection probe 有权
标题翻译：癌细胞抑制性药物和癌细胞检测探针
公开(公告)号：JP2014101359A
公开(公告)日：2014-06-05
申请号：JP2013222030
申请日：2013-10-25
申请人： Mie Univ , 国立大学法人三重大学 , Canon Inc , キヤノン株式会社
发明人： SHINDO TAICHI , NOMOTO TAKESHI , WATANABE KOHEI , MIYAZAKI TAKESHI , TANAKA TOSHIO , SHIMADA YASUTO , NISHIMURA YUHEI
IPC分类号： A61K31/404 , A61K31/405 , A61K31/423 , A61K31/427 , A61K31/428 , A61P35/00 , A61P43/00 , C07D417/06 , C07D417/14 , C12Q1/04 , G01N33/574
CPC分类号： A61K31/428 , A61K31/403 , A61K31/404 , A61K31/423 , A61K31/427 , A61K41/0038 , A61K49/0032 , C07D417/06 , C07D417/14
摘要： PROBLEM TO BE SOLVED: To provide a cancer cell inhibitory drug, particularly a cancer stem-cell inhibitory drug, or a cancer stem-cell detection probe.SOLUTION: The present invention provides a cancer cell inhibitory drug at least comprising a compound represented by the general formula (1).
摘要翻译：要解决的问题：提供癌细胞抑制药，特别是癌干细胞抑制药或癌干细胞检测探针。解决方案：本发明提供一种癌细胞抑制药，至少包含由通式（1）。

3. 发明专利

JP2014101358A Cancer cell inhibitory drug and cancer stem-cell detection probe 审中-公开
标题翻译：癌细胞抑制性药物和癌细胞检测探针
公开(公告)号：JP2014101358A
公开(公告)日：2014-06-05
申请号：JP2013222025
申请日：2013-10-25
申请人： Mie Univ , 国立大学法人三重大学 , Canon Inc , キヤノン株式会社
发明人： SHINDO TAICHI , NOMOTO TAKESHI , WATANABE KOHEI , MIYAZAKI TAKESHI , TANAKA TOSHIO , SHIMADA YASUTO , NISHIMURA YUHEI
IPC分类号： A61K31/428 , A61K31/4725 , A61P35/00 , C12Q1/02
CPC分类号： A61K31/4709 , A61K31/403 , A61K31/404 , A61K31/423 , A61K31/428 , A61K41/0038 , A61K49/0032 , C09B23/0008 , C09B23/0016 , C09B23/0025 , C09B23/0033 , C09B23/0066 , C09B23/06 , C09B23/083 , C09B23/086 , G01N33/582
摘要： PROBLEM TO BE SOLVED: To provide a cancer cell inhibitory drug, particularly a cancer stem-cell inhibitory drug, or a cancer stem-cell detection probe.SOLUTION: The present invention provides a cancer cell inhibitory drug comprising at least one compound represented by the general formula (1) as an active ingredient.
摘要翻译：要解决的问题：提供癌细胞抑制药，特别是癌干细胞抑制药或癌干细胞检测探针。解决方案：本发明提供一种癌细胞抑制药，其包含至少一种由通式（1）作为活性成分。

4. 发明专利

JP2012165715A Retinal degenerative disease model animal and method for producing the same 审中-公开
标题翻译：视网膜变性疾病模型动物及其生产方法
公开(公告)号：JP2012165715A
公开(公告)日：2012-09-06
申请号：JP2011030779
申请日：2011-02-16
申请人： Mie Univ , Canon Inc , キヤノン株式会社 , 国立大学法人三重大学
发明人： TANAKA TOSHIO , NISHIMURA YUHEI , KON TETSUO , NOMOTO TAKESHI , WATANABE KOHEI , OKANO MIE , SHINDO TAICHI , MIYAZAKI TAKESHI
IPC分类号： A01K67/027 , C12N15/09 , G01N33/15 , G01N33/50
摘要： PROBLEM TO BE SOLVED: To provide a retinal degenerative disease model animal convenient and practical, and having a reduced ethical issue, a method for producing the same, and a method for identifying a representative substance of chemical compound acting on a clinical state of a retinal degenerative disease, using the retinal degenerative disease model.SOLUTION: A small teleost fish model of retinal degenerative disease is deleted or suppressed in function of actr 1b, dynactin 3, or dynactin 4 gene. A screening method uses the small teleost fish model of retinal degenerative disease. The invention allows the identification of the representative substance of chemical compound acting on a clinical state of a retinal degenerative disease which is convenient and practical, and has a reduced ethical issue, and evaluates retinal morphology with high throughput.
摘要翻译：要解决的问题：为了提供一种方便实用的视网膜退行性疾病模型，并且具有减少的伦理问题，其生产方法以及用于鉴定作用于临床状态的化合物的代表性物质的方法的视网膜退行性疾病，使用视网膜退行性疾病模型。解决方案：在actr 1b，dynactin 3或dynactin 4基因的功能下，视网膜退行性疾病的小型硬骨鱼模型被删除或抑制。筛选方法使用视网膜退行性疾病的小型鱼类模型。本发明允许鉴定化合物的代表性物质，其作用于视网膜退行性疾病的临床状态，其方便实用，并且具有降低的伦理问题，并以高通量评估视网膜形态。版权所有（C）2012，JPO＆INPIT

5. 发明专利

JP2010273655A Cell holding method, cell testing method and cell treating device 审中-公开
标题翻译：细胞保存方法，细胞检测方法和细胞处理装置
公开(公告)号：JP2010273655A
公开(公告)日：2010-12-09
申请号：JP2009131625
申请日：2009-05-29
申请人： Canon Inc , キヤノン株式会社
发明人： NOMOTO TAKESHI , WATANABE KOHEI , MIYAZAKI TAKESHI , TANAKA TOSHIO , SHIMADA YASUTO
IPC分类号： C12N5/07 , C12M1/34 , C12Q1/02 , G01N1/04
CPC分类号： C12M23/12
摘要： PROBLEM TO BE SOLVED: To provide a method for quickly and uniformly holding cells of the number necessary for bioassay in a separately aligned state. SOLUTION: The cell holding method comprises a sheet-preparation step to prepare a sheet having a plurality of through cavities and a contact step to contact the sheet with a prepared liquid suspension of particles carrying cells, wherein the cavity holds only one particle together with the liquid in the hole. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于在单独排列状态下快速且均匀地保持生物测定所需数量的细胞的方法。解决方案：电池保持方法包括制备具有多个通孔的片材的片材制备步骤和接触步骤以使片材与制备的携带细胞的颗粒的液体悬浮液接触，其中腔体仅保持一个颗粒与孔中的液体一起。版权所有（C）2011，JPO＆INPIT

6. 发明专利

JP2010273654A Object-holding sheet, test method, and object treatment apparatus 有权
标题翻译：对象表，测试方法和对象处理设备
公开(公告)号：JP2010273654A
公开(公告)日：2010-12-09
申请号：JP2009131621
申请日：2009-05-29
申请人： Canon Inc , キヤノン株式会社
发明人： NOMOTO TAKESHI , WATANABE KOHEI , MIYAZAKI TAKESHI , TANAKA TOSHIO , SHIMADA YASUTO
IPC分类号： C12M1/34 , C12M3/00 , C12Q1/02
CPC分类号： B65D19/002 , B65D19/0002 , Y10T137/0318
摘要： PROBLEM TO BE SOLVED: To provide an object-holding sheet and an object treatment apparatus, useful for conducting operations e.g. efficiently analyzing, aliquoting biological bodies such as cells, embryos, or objects or particles of the same sizes as them while laying out the same. SOLUTION: The object-holding sheet for holding two or more objects, having a sheet member with two or more perforations and falling-proof members corresponding to the respective perforations, is provided. In this sheet, the size of any one of the perforations is such as to enable only one of the objects to be held, and the falling-proof members are laid out in the proximity of any one opening of one of the respective perforations so that one of the objects held by the corresponding one of the perforations is impassable through the above opening. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：将要解决的问题：提供一种用于进行操作的物体保持片和物体治疗装置，有效地分析生物体，如细胞，胚胎，或与其相同大小的物体或颗粒，同时铺设。解决方案：提供用于保持两个或更多个物体的物体保持片，具有具有两个或更多个穿孔的片状构件和对应于各个穿孔的防坠落构件。在该片中，任何一个穿孔的尺寸使得仅能够保持一个物体被保持，并且防坠落构件布置在相应穿孔之一的任何一个开口附近，使得由相应的一个穿孔保持的物体之一通过上述开口不能通过。版权所有（C）2011，JPO＆INPIT

7. 发明专利

JP2010270206A Water dispersion of colored fine particle, ink for inkjet recording, ink set for inkjet recording, and inkjet recording method 审中-公开
标题翻译：彩色颗粒的水分散，用于喷墨记录的墨水，用于喷墨记录的墨盒和喷墨记录方法
公开(公告)号：JP2010270206A
公开(公告)日：2010-12-02
申请号：JP2009122221
申请日：2009-05-20
申请人： Canon Inc , キヤノン株式会社
发明人： OKADA TAKESHI , WATANABE KOHEI , IDA HAYATO , KOBAYASHI YOSUKE
IPC分类号： B41J2/01 , B41M5/00 , C09D11/00 , C09D11/322 , C09D11/324 , C09D17/00
摘要： PROBLEM TO BE SOLVED: To provide a water dispersion of colored fine particles, which uses a water-insoluble color material like a pigment, and satisfies characteristics as an ink used in inkjet recording and meets high-speed fixability and higher image quality when the water dispersion is made into an ink.
SOLUTION: The water dispersion of colored fine particles includes an aqueous medium, a water-insoluble color material as the colored fine particles, and a plurality of dispersing resins to disperse the colored material in the aqueous medium. Any one of the plurality of dispersing resins is a block copolymer having at least a hydrophobic segment, and a hydrophilic segment composed of a nonionic hydrophilic unit and an ionic hydrophilic unit. When the unit number of the nonionic hydrophilic unit is denoted as B, and the unit number of the ionic hydrophilic unit is denoted as C in the respective dispersing resins, the values of X determined by X=B/(B+C) are different from each other.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供使用颜料等水不溶性色素的有色细颗粒的水分散体，并且满足喷墨记录中使用的油墨的特性，并满足高速定影性和较高图像质量当水分散体制成油墨时。解决方案：有色细颗粒的水分散体包括水性介质，作为着色微粒的水不溶性着色材料，以及将着色材料分散在水性介质中的多种分散树脂。多种分散树脂中的任何一种是至少具有疏水性链段的嵌段共聚物和由非离子亲水性单元和离子性亲水性单元构成的亲水链段。当非离子亲水单元的单元数表示为B，离子性亲水单元的单元数在各分散树脂中表示为C时，由X = B /（B + C）确定的X的值不同从彼此。版权所有（C）2011，JPO＆INPIT

8. 发明专利

JP2010169678A Labelling agent for biosample, labelling method using labelling agent, and screening method 有权
标题翻译：生物标记标签代码，使用标签代理的标签方法和筛选方法
公开(公告)号：JP2010169678A
公开(公告)日：2010-08-05
申请号：JP2009292716
申请日：2009-12-24
申请人： Canon Inc , Mie Univ , キヤノン株式会社 , 国立大学法人三重大学
发明人： SHINDO TAICHI , MIYAZAKI TAKESHI , HIROSE MASAFUMI , OKUBO TAKETOSHI , WATANABE KOHEI , NOMOTO TAKESHI , TANAKA TOSHIO , NISHIMURA YUHEI , SHIMADA YASUTO , NISHIMURA KUNIHIRO
IPC分类号： G01N21/78 , A61K49/00 , G01N21/64 , G01N33/48 , G01N33/50 , G01N33/533
CPC分类号： A61K51/0453 , A61K49/0002 , A61K49/0008 , A61K49/0021 , A61K49/006 , A61K49/10 , C07D209/08 , C07D209/86 , C07D209/94 , C07D401/08 , C07D403/06 , C07D403/08 , C07D413/08 , C07D417/06 , C07D417/14 , C09B23/0091 , C09B23/04 , C09B23/105 , G01N33/582 , G01N2333/4603 , G01N2500/10
摘要： PROBLEM TO BE SOLVED: To provide a novel labelling agent for a biosample having excellent spectroscopic characteristics, excellent in storage stability and independently labelling the specific cells or cell organ in a living body to clearly visualize the same. SOLUTION: The labelling agent for the biosample is characterized by containing a compound represented by a general formula (I) (wherein R 1 is a hydrogen atom, an alkyl group, an aralkyl group, an alkenyl group, an aryl group, a heterocyclic group or an acyl group, R 2 -R 5 are respectively independently a hydrogen atom, an alkyl group, an aryl group, a carboxylic acid group, a carboxylate group or an acyl group, R 2 and R 4 may be mutually bonded to form a ring, R 6 is a hydrogen atom, an alkyl group, an alkoxy group or a halogen atom and R 7 and R 8 are respectively independently a hydrogen atom, an alkenyl group, a cyano group, a carboxylic acid group, a carboxylate group, a sulfonic acid group, an acyl group or a heterocyclic group and may be mutually bonded to form a ring) as at least one kind of an effective component. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：为了提供具有优异的光谱特性，优异的储存稳定性和独立地标记生物体中的特定细胞或细胞器官的生物样品的新型标记试剂，以清楚地观察它们。解决方案：生物样品的标记试剂的特征在于含有由通式（I）表示的化合物（其中R SB为氢原子，烷基，芳烷基，烯基，芳基，杂环基或酰基，R SB 2 -R SB 5分别独立地为氢原子，烷基，芳基，芳基羧酸基，羧酸酯基或酰基，R SB 2和R SB 4可以相互键合形成环，R SB 6是氢原子，烷基，烷氧基或卤素原子，R SB 7和R SB 8分别独立地为氢原子，烯基，氰基，羧酸基，羧酸酯基，磺酸基，酰基或杂环基，并且可以相互键合形成环）作为至少一种有效成分。版权所有（C）2010，JPO＆INPIT

9. 发明专利

JP2010168369A Labeling composition for intraocular tissue, method for labeling intraocular tissue, and method for screening 审中-公开
标题翻译：用于内分泌组织的标记组合物，用于标记内分泌组织的方法和筛选方法
公开(公告)号：JP2010168369A
公开(公告)日：2010-08-05
申请号：JP2009292550
申请日：2009-12-24
申请人： Canon Inc , Mie Univ , キヤノン株式会社 , 国立大学法人三重大学
发明人： WATANABE KOHEI , SHINDO TAICHI , NOMOTO TAKESHI , MIYAZAKI TAKESHI , TANAKA TOSHIO , NISHIMURA YUHEI , SHIMADA YASUTO , NISHIMURA KUNIHIRO
IPC分类号： A61K49/00 , A61B3/14 , A61K51/00
CPC分类号： A61K49/0021 , A61K49/0002 , A61K49/0039 , A61K49/0041 , A61K49/006 , C07D209/70 , C07D209/96 , C07D215/00 , C07D221/14 , C07D221/18 , C07D263/54 , C07D277/34 , C07D277/36 , C07D277/64 , C07D311/82 , C07D311/86 , C07D405/04 , C07D405/06 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/14 , C07D491/052 , C07D491/12 , C07D497/10 , G01N33/5088 , G01N33/582 , G01N2333/4603
摘要： PROBLEM TO BE SOLVED: To provide a labeling composition for an intraocular tissue, which specifically labels the intraocular tissue without the need of invasive operation such as exposure of an ocular tissue or injection of a staining agent into the interior of the ocular tissue or a nerve tissue linking to the ocular tissue, to provide a method for non-invasively labeling the intraocular tissue of a living individual, and to provide a method for screening using the labeling composition for the intraocular tissue.
SOLUTION: The labeling composition for labeling the intraocular tissue of the living organic individual contains a compound labeling at least one or more photoreceptor cell layers of a retina. The compound is a staining compound having a specific structure in a partial skeleton thereof.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于眼内组织的标记组合物，其特别地标记眼内组织而无需侵入性操作，例如眼组织的暴露或注射染色剂到眼组织的内部或连接到眼组织的神经组织，以提供非侵入性标记活体个体的眼内组织的方法，并提供使用眼内组织的标记组合物进行筛选的方法。解决方案：用于标记活体有机个体的眼内组织的标记组合物含有标记视网膜的至少一个或多个光感受器细胞层的化合物。该化合物是其部分骨架中具有特定结构的染色化合物。版权所有（C）2010，JPO＆INPIT

10. 发明专利

JP2010143113A Ink set 审中-公开
标题翻译：墨盒套装
公开(公告)号：JP2010143113A
公开(公告)日：2010-07-01
申请号：JP2008323637
申请日：2008-12-19
申请人： Canon Inc , キヤノン株式会社
发明人： YAMASHITA YOSHIHISA , WATANABE KOHEI , IDA HAYATO
IPC分类号： B41M5/00 , B41J2/01 , C09D11/00 , C09D11/322 , C09D11/324 , C09D11/326 , C09D11/38 , C09D11/54
摘要： PROBLEM TO BE SOLVED: To provide an ink set which is composed of pigment ink and a reaction solution and is excellent in a color developing property, high speed printability and abrasion resistance under high temperature high humidity environment.
SOLUTION: The ink set is composed of the pigment ink and the reaction solution. The pigment ink comprises water, a water-soluble organic solvent, pigment and a resin dispersant. The reaction solution comprises water, the water-soluble organic solvent and a reactive compound which can make pigment dispersion unstable when coming into contact with the pigment ink. The resin dispersant is a polymer obtained by polymerization of a vinyl ether monomer.
COPYRIGHT: (C)2010,JPO&INPIT

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