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1. 发明专利

JP2012184217A Evaluation probe for central nervous system permeability, evaluation method for central nervous system permeability, and screening method using the evaluation probe for central nervous system permeability 有权
标题翻译：用于中央神经系统渗透性的评估探针，用于中央神经系统渗透性的评估方法和使用评估探针进行中央神经系统渗透性的筛选方法
公开(公告)号：JP2012184217A
公开(公告)日：2012-09-27
申请号：JP2011187500
申请日：2011-08-30
申请人： Mie Univ , Canon Inc , キヤノン株式会社 , 国立大学法人三重大学
发明人： TANAKA TOSHIO , NISHIMURA YUHEI , SHIMADA YASUTO , WATANABE KOHEI , NOMOTO TAKESHI , OKANO MIE , SHINDO TAICHI , MIYAZAKI TAKESHI
IPC分类号： A61K49/00 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/58
CPC分类号： C07D417/06 , C07D417/14 , C09B23/04 , C09B23/06 , G01N33/5082 , G01N33/5088 , G01N2333/4603 , G01N2800/28
摘要： PROBLEM TO BE SOLVED: To provide an evaluation probe capable of optically evaluating permeability of a substance through a central nervous system tissue, to provide an evaluation method for permeability of a substance through a central nervous system tissue using an evaluation probe for central nervous system permeability, and to provide a screening method using the evaluation probe for central nervous system permeability.SOLUTION: The evaluation probe for the central nervous system permeability includes, as an active ingredient, at least one kind of compounds represented by general formula (1).
摘要翻译：要解决的问题：提供能够通过中枢神经系统组织光学评价物质的渗透性的评价探针，通过中枢神经系统组织使用中央评价探针提供物质的渗透性的评价方法神经系统通透性，并提供使用评估探针进行中枢神经系统渗透性的筛选方法。解决方案：用于中枢神经系统渗透性的评估探针包括作为活性成分的至少一种由通式（1）表示的化合物。版权所有（C）2012，JPO＆INPIT

2. 发明专利

JP2011148794A Composition for labeling tissue of central nervous system, method for labeling tissue of central nervous system, and screening method using the composition for labeling tissue of central nervous system 有权
标题翻译：用于标记中枢神经系统组织的组合物，用于标记中枢神经系统组织的方法，以及使用组合物用于标记中枢神经系统的组织的筛选方法
公开(公告)号：JP2011148794A
公开(公告)日：2011-08-04
申请号：JP2010288573
申请日：2010-12-24
申请人： Canon Inc , Mie Univ , キヤノン株式会社 , 国立大学法人三重大学
发明人： WATANABE KOHEI , NOMOTO TAKESHI , SHINDO TAICHI , MIYAZAKI TAKESHI , OKANO MIE , TANAKA TOSHIO , NISHIMURA YUHEI , SHIMADA YASUTO
IPC分类号： A61K49/00 , A61K51/00 , G01T1/161
CPC分类号： A61K49/0032 , A61K49/0039 , A61K49/006 , C07D417/06 , G01N33/15 , G01N33/50 , G01N33/58 , G01T1/161
摘要： PROBLEM TO BE SOLVED: To provide a central nervous system tissue labeling composition which can label tissues of the central nervous system, a method for labeling tissues of the central nervous system in a non-invasive manner, and to provide a screening method using the central nervous system tissue labeling composition. SOLUTION: There is disposed a composition for labeling tissues of the central nervous system in vivo, which contains at least either one of compounds represented by formulae (1) and (7) as an active ingredient. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供可以标记中枢神经系统的组织的中枢神经系统组织标记组合物，以非侵入性方式标记中枢神经系统的组织的方法，并提供筛选方法使用中枢神经系统组织标签组成。本发明提供一种用于在体内标记中枢神经系统组织的组合物，其含有式（1）和（7）表示的化合物中的至少一种作为有效成分。版权所有（C）2011，JPO＆INPIT

3. 发明专利

JP2011148793A Transnasal labeling composition for tissue of central nervous system, labeling method and screening method using transnasal labeling composition for tissue of central nervous system 有权
标题翻译：用于组织中枢神经系统的标签标签组合物，标记方法和筛选方法使用跨标签组合物用于组织中央神经系统
公开(公告)号：JP2011148793A
公开(公告)日：2011-08-04
申请号：JP2010288514
申请日：2010-12-24
申请人： Canon Inc , Mie Univ , キヤノン株式会社 , 国立大学法人三重大学
发明人： NOMOTO TAKESHI , WATANABE KOHEI , SHINDO TAICHI , MIYAZAKI TAKESHI , TANAKA TOSHIO , NISHIMURA YUHEI , SHIMADA YASUTO
IPC分类号： A61K49/00
CPC分类号： A61K49/0004 , A61K49/0032 , A61K49/0041 , A61K51/0446
摘要： PROBLEM TO BE SOLVED: To provide a transnasal labeling composition for tissue of the central nervous system for labeling the central nervous system from the olfactory epithelium through the olfactory bulb by transnasal administration, and a method for non-invasively labeling tissues of the central nervous system through a route of administration causing less migration throughout the whole body, in addition, a screening method using the transnasal labeling composition for tissues of the central nervous system.
SOLUTION: The composition includes at least one kind of compounds expressed by formula (1) or (2) as an active ingredient [in formula (1), R
1 represents alkyl; R
3 to R
6 independently represent each a hydrogen atom, alkyl, aryl, alkoxy, a carboxylic acid group, sulfonic acid group, hetero ring group, amino or a halogen atom; R
5 and R
6 may mutually bond to form a ring; X
1
- represents an anionic group; A represents formula (3) or (4)], and [in formula (2), R
11 to R
15 independently represent each a hydrogen atom or alkyl; X
2
- represents an anionic group].
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供一种用于中枢神经系统组织的经鼻标记组合物，用于通过经鼻给药从嗅上皮通过嗅球标记中枢神经系统，以及用于非侵入性地标记组织的方法通过施用途径的中枢神经系统导致整个身体的迁移较少，另外，使用用于中枢神经系统组织的经鼻标记组合物的筛选方法。组合物包含至少一种由式（1）或（2）表示的化合物作为活性成分[在式（1）中，R SB 1表示烷基; R SB 3与R SB 6独立地表示氢原子，烷基，芳基，烷氧基，羧酸基，磺酸基，杂环基，氨基或卤素原子 ; R 5 和R SB 6可以相互键合形成环; X - 表示阴离子基团; A表示式（3）或（4）]，[式（2）中R 17与R 15 独立地表示氢原子或烷基; X - 表示阴离子基团]。版权所有（C）2011，JPO＆INPIT

4. 发明专利

JP2010276559A System and method for observing sample 有权
标题翻译：用于观察样品的系统和方法
公开(公告)号：JP2010276559A
公开(公告)日：2010-12-09
申请号：JP2009131628
申请日：2009-05-29
申请人： Canon Inc , キヤノン株式会社
发明人： NOMOTO TAKESHI , WATANABE KOHEI , MIYAZAKI TAKESHI , TANAKA TOSHIO , SHIMADA YASUTO
IPC分类号： G01N21/84
CPC分类号： G01N35/00
摘要： PROBLEM TO BE SOLVED: To provide a system and method for observing a sample to easily observe a sample from an angle greater than that of the conventional way without requiring special operation and treatment to limit sample's movement and adjust a direction in the observation of the sample. SOLUTION: The system for observing a sample with a vertical direction defined by gravity includes at least, a sample holder with a vacancy penetrating to hold a liquid containing the sample, an observing means for observing the sample, and an angle adjusting means for varying the angle of the observing means to the direction of gravity acting on the sample in the condition that the relative angle between the sample holder and the observing means is fixed. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于观察样品的系统和方法，以便从大于常规方式的角度容易地观察样品，而不需要特殊的操作和处理来限制样品的运动并调整观察方向的样品。解决方案：用于观察由重力限定的垂直方向的样品的系统至少包括具有穿透以保持含有样品的液体的空隙的样品保持器，用于观察样品的观察装置和角度调节装置用于在样品保持器和观察装置之间的相对角度被固定的条件下，将观察装置的角度改变为作用在样品上的重力方向。版权所有（C）2011，JPO＆INPIT

5. 发明专利

JP2009148249A Method for holding living body, method for testing living body, method for growing living body, sheet for holding living body, and apparatus for processing living body 有权
标题翻译：用于保存生命体的方法，用于测试生命体的方法，用于生长生命体的方法，用于控制生命体的植物和用于处理生命体的装置
公开(公告)号：JP2009148249A
公开(公告)日：2009-07-09
申请号：JP2008297990
申请日：2008-11-21
申请人： Canon Inc , Mie Univ , キヤノン株式会社 , 国立大学法人三重大学
发明人： MIYAZAKI TAKESHI , WATANABE KOHEI , NOMOTO TAKESHI , TANAKA TOSHIO , SHIMADA YASUTO , NISHIMURA KUNIHIRO
IPC分类号： C12N5/06 , C12M3/04 , C12Q1/02
CPC分类号： C12M21/06 , C12M23/12 , C12M25/01 , C12M25/06 , C12M35/08 , G01N21/6456 , G01N2021/0339 , G01N2021/0342 , G01N2021/0378 , G01N2021/174
摘要： PROBLEM TO BE SOLVED: To provide a method for rapidly individually arranging a large number of living bodies such as cells, embryos, or individuals one by one, to provide a sheet for holding the living bodies, and to provide an apparatus for processing the living bodies.
SOLUTION: The method for arranging and holding the living bodies comprises using the sheet having a plurality of through-holes of a size capable of holding one living body to be the object, but incapable of holding two or more of the living bodies and arranged therein, and thereby holding the living bodies one by one, in each of the plurality of through-holes in the sheet.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：为了提供一种一个地快速单独排列诸如细胞，胚胎或个体的大量活体的方法，以提供用于保持活体的片材，并且提供一种用于加工活体。解决方案：用于布置和保持活体的方法包括使用具有多个能够容纳一个活体的尺寸的通孔作为对象的片材，但不能容纳两个或更多个生物体并且布置在其中，从而在片材中的多个通孔中的每一个中一个接一个地保持活体。版权所有（C）2009，JPO＆INPIT

6. 发明专利

JP2010169677A Probe for hair cell, and labelling method for hair cell using same 有权
标题翻译：头发细胞探针和使用其的头发细胞的标记方法
公开(公告)号：JP2010169677A
公开(公告)日：2010-08-05
申请号：JP2009292551
申请日：2009-12-24
申请人： Canon Inc , Mie Univ , キヤノン株式会社 , 国立大学法人三重大学
发明人： NOMOTO TAKESHI , MIYAZAKI TAKESHI , WATANABE KOHEI , SHINDO TAICHI , TAKAHASHI KAORU , TANAKA TOSHIO , NISHIMURA YUHEI , SHIMADA YASUTO , NISHIMURA KUNIHIRO
IPC分类号： G01N33/48 , G01N21/64 , G01N33/15 , G01N33/50
CPC分类号： G01N33/5005 , A61K49/0032 , A61K49/0041 , A61K49/006 , C09B11/24 , C09B23/0016 , C09B23/0058 , C09B23/0066 , C09B23/0075 , C09B23/06 , C09B23/105 , C09B23/107 , G01N33/5044 , G01N33/6893 , G01N2800/14 , G01N2800/20
摘要： PROBLEM TO BE SOLVED: To provide a novel probe for a hair cell for clearly identifying various conditions of the hair cell, and a labelling method for a hair cell using the probe for the hair cell. SOLUTION: This probe for the hair cell contains, as an effective component, at least one kind selected from compounds represented by one of general formulae (I) and (II). The labelling method for the hair cell uses the probe for the hair cell. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：为了清楚地识别毛细胞的各种条件，提供一种用于毛细胞的新型探针，以及使用毛细胞探针的毛细胞的标记方法。解决方案：毛细胞的该探针作为有效成分含有选自通式（I）和（II）中的一个表示的化合物中的至少一种。毛细胞的标记方法使用毛细胞的探针。版权所有（C）2010，JPO＆INPIT

7. 发明专利

JP2010148447A Composition for staining retinal tissue and method for staining retinal tissue 有权
标题翻译：用于染色后组织的组合物和用于染色后组织的方法
公开(公告)号：JP2010148447A
公开(公告)日：2010-07-08
申请号：JP2008330980
申请日：2008-12-25
申请人： Canon Inc , Mie Univ , キヤノン株式会社 , 国立大学法人三重大学
发明人： WATANABE KOHEI , SHINDO TAICHI , NOMOTO TAKESHI , MIYAZAKI TAKESHI , TANAKA TOSHIO , NISHIMURA YUHEI , SHIMADA YASUTO , NISHIMURA KUNIHIRO
IPC分类号： C12Q1/02 , G01N1/30 , G01N33/48
摘要： PROBLEM TO BE SOLVED: To provide a staining composition for retinal tissue enabling staining of the retinal tissue of a bio-specimen by a simple exposure without needing a complicate operation, and to provide a method for selectively staining the retinal tissue. SOLUTION: The staining composition for staining the retinal tissue of the bio-specimen contains a compound capable of staining the retinal tissue by being exposed to the retinal tissue of the bio-specimen. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供一种视网膜组织的染色组合物，其能够通过简单的曝光使生物标本的视网膜组织染色而不需要复杂的操作，并提供用于选择性染色视网膜组织的方法。解决方案：用于染色生物样本的视网膜组织的染色组合物含有能够通过暴露于生物标本的视网膜组织来染色视网膜组织的化合物。版权所有（C）2010，JPO＆INPIT

8. 发明专利

JP2014101359A Cancer cell inhibitory drug and cancer stem-cell detection probe 有权
标题翻译：癌细胞抑制性药物和癌细胞检测探针
公开(公告)号：JP2014101359A
公开(公告)日：2014-06-05
申请号：JP2013222030
申请日：2013-10-25
申请人： Mie Univ , 国立大学法人三重大学 , Canon Inc , キヤノン株式会社
发明人： SHINDO TAICHI , NOMOTO TAKESHI , WATANABE KOHEI , MIYAZAKI TAKESHI , TANAKA TOSHIO , SHIMADA YASUTO , NISHIMURA YUHEI
IPC分类号： A61K31/404 , A61K31/405 , A61K31/423 , A61K31/427 , A61K31/428 , A61P35/00 , A61P43/00 , C07D417/06 , C07D417/14 , C12Q1/04 , G01N33/574
CPC分类号： A61K31/428 , A61K31/403 , A61K31/404 , A61K31/423 , A61K31/427 , A61K41/0038 , A61K49/0032 , C07D417/06 , C07D417/14
摘要： PROBLEM TO BE SOLVED: To provide a cancer cell inhibitory drug, particularly a cancer stem-cell inhibitory drug, or a cancer stem-cell detection probe.SOLUTION: The present invention provides a cancer cell inhibitory drug at least comprising a compound represented by the general formula (1).
摘要翻译：要解决的问题：提供癌细胞抑制药，特别是癌干细胞抑制药或癌干细胞检测探针。解决方案：本发明提供一种癌细胞抑制药，至少包含由通式（1）。

9. 发明专利

JP2014101358A Cancer cell inhibitory drug and cancer stem-cell detection probe 审中-公开
标题翻译：癌细胞抑制性药物和癌细胞检测探针
公开(公告)号：JP2014101358A
公开(公告)日：2014-06-05
申请号：JP2013222025
申请日：2013-10-25
申请人： Mie Univ , 国立大学法人三重大学 , Canon Inc , キヤノン株式会社
发明人： SHINDO TAICHI , NOMOTO TAKESHI , WATANABE KOHEI , MIYAZAKI TAKESHI , TANAKA TOSHIO , SHIMADA YASUTO , NISHIMURA YUHEI
IPC分类号： A61K31/428 , A61K31/4725 , A61P35/00 , C12Q1/02
CPC分类号： A61K31/4709 , A61K31/403 , A61K31/404 , A61K31/423 , A61K31/428 , A61K41/0038 , A61K49/0032 , C09B23/0008 , C09B23/0016 , C09B23/0025 , C09B23/0033 , C09B23/0066 , C09B23/06 , C09B23/083 , C09B23/086 , G01N33/582
摘要： PROBLEM TO BE SOLVED: To provide a cancer cell inhibitory drug, particularly a cancer stem-cell inhibitory drug, or a cancer stem-cell detection probe.SOLUTION: The present invention provides a cancer cell inhibitory drug comprising at least one compound represented by the general formula (1) as an active ingredient.
摘要翻译：要解决的问题：提供癌细胞抑制药，特别是癌干细胞抑制药或癌干细胞检测探针。解决方案：本发明提供一种癌细胞抑制药，其包含至少一种由通式（1）作为活性成分。

10. 发明专利

JP2010273655A Cell holding method, cell testing method and cell treating device 审中-公开
标题翻译：细胞保存方法，细胞检测方法和细胞处理装置
公开(公告)号：JP2010273655A
公开(公告)日：2010-12-09
申请号：JP2009131625
申请日：2009-05-29
申请人： Canon Inc , キヤノン株式会社
发明人： NOMOTO TAKESHI , WATANABE KOHEI , MIYAZAKI TAKESHI , TANAKA TOSHIO , SHIMADA YASUTO
IPC分类号： C12N5/07 , C12M1/34 , C12Q1/02 , G01N1/04
CPC分类号： C12M23/12
摘要： PROBLEM TO BE SOLVED: To provide a method for quickly and uniformly holding cells of the number necessary for bioassay in a separately aligned state. SOLUTION: The cell holding method comprises a sheet-preparation step to prepare a sheet having a plurality of through cavities and a contact step to contact the sheet with a prepared liquid suspension of particles carrying cells, wherein the cavity holds only one particle together with the liquid in the hole. COPYRIGHT: (C)2011,JPO&INPIT

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