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1. 发明专利

JP2012010706A Expression system 审中-公开
标题翻译：表达系统
公开(公告)号：JP2012010706A
公开(公告)日：2012-01-19
申请号：JP2011180293
申请日：2011-08-22
申请人： Uk Government , イギリス国The Secretary Of State For Defence In Her Britannic Majesty’S Government Of The Uneted Kingdom Of Great Britain And Northern Ireland
发明人： WILLIAMSON ETHEL DIANE , MILLER JULIE , WALKER NICOLA JANE , BAILLIE LESLIE WILLIAM JAMES , HOLDEN PAULA THOMSON , FLICK-SMITH HELEN CLAIRE , BULLIFENT HELEN LISA , TITBALL RICHARD WILLIAM , TOPPING ANDREW WILLIAM
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61P31/04 , C07K14/32 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/31 , C12P21/02
CPC分类号： C07K14/32 , A61K39/00 , C07K2319/00 , C12N15/70
摘要： PROBLEM TO BE SOLVED: To provide an immunogenic reagent causing a protective immune response against Bacillus anthracis.SOLUTION: This immunogenic reagent is provided by comprising one or more polypeptides occupying up to the three domains of full length protective antigen (PA) of the Bacillus anthracis or their variants, wherein at least one of the domains comprise the domain 1 or domain 4 of the PA, or its variant. In a method the polypeptides of the immunogenic reagents as well as the full length PA are produced by the expression from E. coli. By the method, the polypeptides in high yields are obtained.
摘要翻译：要解决的问题：提供引起针对炭疽芽孢杆菌的保护性免疫应答的免疫原性试剂。解决方案：该免疫原性试剂通过包含占据至多炭疽芽孢杆菌或其变体的全长保护性抗原（PA）的三个结构域的一种或多种多肽，其中至少一个结构域包含结构域1或 PA的域4或其变体。在一种方法中，通过来自大肠杆菌的表达产生免疫原性试剂的多肽以及全长PA。通过该方法，获得高产率的多肽。版权所有（C）2012，JPO＆INPIT

2. 发明专利

JP2010198030A Liquid crystal device 审中-公开
标题翻译：液晶装置
公开(公告)号：JP2010198030A
公开(公告)日：2010-09-09
申请号：JP2010092643
申请日：2010-04-13
申请人： Sharp Corp , Uk Government , イギリス国The Secretary Of State For Defence In Her Britannic Majesty’S Government Of The Uneted Kingdom Of Great Britain And Northern Ireland , シャープ株式会社
发明人： JONES JOHN CLIFFORD , PAUL EDWARD DUNN , HASLAM SIMON DAVID
IPC分类号： G02B5/20 , G02F1/1335 , G02B5/30 , G02F1/1333 , G02F1/1337 , G02F1/141 , G09F9/35
CPC分类号： G02F1/133528 , G02F1/141 , G02F2001/133519 , G02F2001/133565
摘要： PROBLEM TO BE SOLVED: To provide a liquid crystal device capable of reducing transmission light in the dark state to improve the performance of the liquid crystal device by reducing scattered light generated by depolarizing linearly polarized light made incident on a color filter layer.
SOLUTION: The color ferroelectric liquid crystal device has a ferroelectric liquid crystal material 2 between two glass substrates 3, 4 arranged at a fixed gap by spacers. The glass substrate 3 is provided with a color filter layer 5, wherein the surface of the color filter layer 5 is covered with a planarizing layer 6 made of a material which planarizes the surface. Surfaces inside the glass substrates 3, 4 are provided with electrode structures 7, 8, barrier layers 9, 10 and alignment layers 11, 12. Further, in order for the light linearly polarized by a polarizer 14 to reduce the transmission light in the dark state, a polarizing layer 16 is disposed between the color filter layer 5 and the liquid crystal material 2.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：解决问题的方案：提供一种能够通过减少入射到滤色器层上的线偏振光去偏振产生的散射光，从而降低暗态透光的液晶装置，从而提高液晶装置的性能。彩色铁电液晶装置在两个玻璃基板3,4之间具有铁电液晶材料2，两个玻璃基板3,4间隔开地以固定的间隙排列。玻璃基板3设置有滤色器层5，其中滤色器层5的表面被由平坦化表面的材料制成的平坦化层6覆盖。玻璃基板3,4内的表面设置有电极结构7,8，阻挡层9,10和取向层11,12。此外，为了使偏振器14线性偏振的光减少黑暗中的透射光状态下，偏光层16设置在滤色器层5和液晶材料2之间。版权所有（C）2010，JPO＆INPIT

3. 发明专利

JP2010148506A Analytical method and kit 审中-公开
标题翻译：分析方法和试剂盒
公开(公告)号：JP2010148506A
公开(公告)日：2010-07-08
申请号：JP2009286010
申请日：2009-12-17
申请人： Uk Government , イギリス国The Secretary Of State For Defence In Her Britannic Majesty’S Government Of The Uneted Kingdom Of Great Britain And Northern Ireland
发明人： SQUIRRELL DAVID JAMES , LEE MARTIN ALAN
IPC分类号： C12N15/09 , C12Q1/68 , C12Q1/26 , C12Q1/34 , C12Q1/48 , C12Q1/66 , G01N21/76
CPC分类号： C12Q1/686 , C12Q1/6874 , C12Q2563/103 , C12Q2521/301
摘要： PROBLEM TO BE SOLVED: To provide analytical methods using RNA probes for the detection or analysis of nucleic acid sequences. SOLUTION: RNA probes 3 are contacted with a sample 1 suspected of containing the nucleic acid sequence and if they form duplexes, they are hydrolysed. This may be done, for example during an amplification reaction. AMP generated as a result of the hydrolysis is converted to ATP. The ATP may then be detected by using bioluminescent reagents. RNA hydrolysed probes 2 are usable as much versatile means for producing signals indicating existence of very specific nucleic acid sequences in the sample. The sensitivity of the assay using such a probe combinedly with the bioluminescent detection system is high and the signals can be produced quickly. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供使用RNA探针进行核酸序列检测或分析的分析方法。解决方案：RNA探针3与疑似含有核酸序列的样品1接触，如果它们形成双链体，则它们被水解。这可以例如在扩增反应期间完成。作为水解产生的AMP被转化为ATP。然后可以通过使用生物发光试剂检测ATP。 RNA水解探针2可用作产生指示样品中非常特异性核酸序列存在的信号的通用手段。使用这种探针与生物发光检测系统组合的测定的灵敏度高，并且可以快速产生信号。版权所有（C）2010，JPO＆INPIT

4. 发明专利

JP2009148303A Antibiotic sensitivity testing 审中-公开
标题翻译：抗生素敏感性测试
公开(公告)号：JP2009148303A
公开(公告)日：2009-07-09
申请号：JP2009092366
申请日：2009-04-06
申请人： Uk Government , イギリス国The Secretary Of State For Defence In Her Britannic Majesty’S Government Of The Uneted Kingdom Of Great Britain And Northern Ireland
发明人： MURPHY MELANIE JANE , PRICE RACHEL LOUISE , SQUIRRELL DAVID JAMES
IPC分类号： C12Q1/48 , C12Q1/02 , C12Q1/18 , C12Q1/34 , C12Q1/70
摘要： PROBLEM TO BE SOLVED: To provide a test in particular for the sensitivity of bacteria to an antibiotic or a biostatic agent, a test to assess the growth stage of the bacteria and the health state, and to provide methods of carrying out these tests and kits for achieving them. SOLUTION: The invention relates to the use of an assay for adenylate kinase in an in vitro test for the effect of external conditions on the growth characteristics of bacterial cells. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：特别提供细菌对抗生素或生物静力剂的敏感性的测试，评估细菌生长阶段和健康状态的测试，以及提供进行这些试验的方法测试和试剂盒来实现它们。解决方案：本发明涉及在外部条件对细菌细胞生长特性的影响的体外试验中腺苷酸激酶测定的用途。版权所有（C）2009，JPO＆INPIT

5. 发明专利

JP2003035918A Signal routing device 审中-公开
标题翻译：信号路由设备
公开(公告)号：JP2003035918A
公开(公告)日：2003-02-07
申请号：JP2002159769
申请日：2002-05-31
申请人： Uk Government , イギリス国
发明人： JENKINS RICHARD M , HEATON JOHN M
IPC分类号： G02B6/12 , G02B6/126 , G02B6/28 , G02F1/21 , G02F1/313
CPC分类号： G02B6/2813 , G02F1/313 , G02F2001/212 , G02F2001/217
摘要： PROBLEM TO BE SOLVED: To provide a signal routing device different from a conventional form. SOLUTION: The signal routing device (10) includes a multimode beamsplitter waveguide (20) connected to a multimode recombiner waveguide (24) by a set of parallel relay waveguides (22). Each relay waveguide (22) contains each electro-optic phase shifter (36). Sets of input and output waveguides (18, 28) are connected to the beamsplitter and the recombiner waveguides (20, 24), respectively. The input and the output waveguides (18, 28) are periodically spaced at off-center positions across each multimode waveguide transverse cross-section associated therewith. Different sets of phase shifts provide for radiation in any one of the input waveguides (18) being transferred selectively to any one or more of the output waveguides (28) according to selectable signal routing.
摘要翻译：要解决的问题：提供与传统形式不同的信号路由设备。解决方案：信号路由设备（10）包括通过一组并行中继波导（22）连接到多模重组波导（24）的多模分束器波导（20）。每个中继波导（22）包含每个电光移相器（36）。输入和输出波导的组（18,28）分别连接到分束器和重组波导（20,24）。输入和输出波导（18,28）在跨越与其相关联的每个多模波导横截面上的偏心位置周期性地间隔开。根据可选择的信号路由，不同组的相移提供任何一个输入波导（18）中的辐射被选择性地传送到任何一个或多个输出波导（28）。

6. 发明专利

JP2010032536A Apparatus for directing particles in fluid 审中-公开
标题翻译：用于指导流体中的颗粒的装置
公开(公告)号：JP2010032536A
公开(公告)日：2010-02-12
申请号：JP2009249881
申请日：2009-10-30
申请人： Uk Government , イギリス国The Secretary Of State For Defence In Her Britannic Majesty’S Government Of The Uneted Kingdom Of Great Britain And Northern Ireland
发明人： HAWKES JEREMY JOHN , LONG MICHEAL J , COAKLEY WILLIAM TERENCE , MCDONNELL MARTIN BERNARD
IPC分类号： G01N15/14 , B01D21/00 , B01D43/00 , B01J19/10
CPC分类号： B01D21/283 , B01D43/00 , B01J19/10
摘要： PROBLEM TO BE SOLVED: To provide an apparatus for directing particles entrained in a fluid.
SOLUTION: This apparatus for directing particles entrained in the fluid comprises a chamber having a first wall, including means for generating a sound wave having a frequency ν, and a second, opposite wall capable of reflecting the sound wave. The first and second walls define a conduit for the passage of the fluid, and the thickness of the second wall is such that the path length of the standing wave in the second wall is a multiple of about 1/2 the wavelength λ
r of the sound wave therein.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于引导夹带在流体中的颗粒的装置。用于引导夹带在流体中的颗粒的该装置包括具有第一壁的室，包括用于产生具有频率v的声波的装置和能够反射声波的第二相对的壁。第一和第二壁限定用于流体通过的导管，并且第二壁的厚度使得第二壁中的驻波的路径长度为波长λ的1/2的倍数，其中的声波的r 。版权所有（C）2010，JPO＆INPIT

7. 发明专利

JP2009284912A Fluid sample-processing device 有权
标题翻译：流体样品处理装置
公开(公告)号：JP2009284912A
公开(公告)日：2009-12-10
申请号：JP2009207809
申请日：2009-09-09
申请人： Uk Government , イギリス国The Secretary Of State For Defence In Her Britannic Majesty’S Government Of The Uneted Kingdom Of Great Britain And Northern Ireland
发明人： SQUIRRELL DAVID JAMES , BOWN KEVIN JOHN , WALSH PHILIP
IPC分类号： C12M1/00 , G01N35/00
CPC分类号： G01N35/0098 , G01N35/0099
摘要： PROBLEM TO BE SOLVED: To provide a device capable of giving a series of continuous chemical or physical treating stages by a prescribed sequence to a fluid sample for purifying and also concentrating the fluid sample prior to a nucleic acid amplification reaction. SOLUTION: This fluid sample-processing device is provided by having (i) a platform comprising (a) a chamber suitable for receiving the sample and (b) a functional component, (ii) an arm capable of being raised and lowered, and equipping a means for mounting to the functional component as demountable so that the functional component may be raised or lowered with the arm, and (iii) further a means for moving the platform so that any chamber or functional component may be aligned with respect to the arm. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种能够通过规定的顺序将一系列连续的化学或物理处理阶段提供给用于纯化的流体样品并且在核酸扩增反应之前浓缩流体样品的装置。解决方案：该流体样品处理装置通过具有（i）平台来提供，该平台包括（a）适合于接收样品的室和（b）功能部件，（ii）能够升高和降低的臂并且装备用于将功能部件安装到可拆卸的装置，使得功能部件可以用臂升高或降低，以及（iii）另外的移动平台的装置，使得任何室或功能部件可以相对于到手臂。版权所有（C）2010，JPO＆INPIT

8. 发明专利

JP2003050330A Optical device 有权
标题翻译：光学装置
公开(公告)号：JP2003050330A
公开(公告)日：2003-02-21
申请号：JP2002159768
申请日：2002-05-31
申请人： Uk Government , イギリス国
发明人： JENKINS RICHARD M , HEATON JOHN M
IPC分类号： G02B6/122 , G02B6/126 , G02B6/28 , G02B6/34 , G02F1/225 , G02F1/313 , H01S3/00 , H01S3/03 , H01S3/06 , H01S5/00 , H01S5/22 , H01S5/40
CPC分类号： G02B6/12007 , G02B6/2813 , G02B6/29352 , G02F1/225 , H01S3/005 , H01S3/0315 , H01S5/005 , H01S5/4068
摘要： PROBLEM TO BE SOLVED: To provide an optical device used for a beam splitting, a beam recombining and a related applications thereof. SOLUTION: The optical device (10) includes a rectangular multimode waveguide (20) which connects a first coupling waveguide (18) to two second coupling waveguides (22 and 24). The first coupling waveguide (18) is operated at its basic mode and gives an input which excites a series of symmetry modes of the multimode waveguide (20). The modal dispersion along the multimode waveguide (20) enables an input excitation (70a) transformed into separate output excitations (75a and 75b) of which the center is located on respective second coupling waveguides (22 and 24). A radiation intensity distribution (75) becomes zero in the end wall region of the multimode waveguide between the second coupling waveguides (22 and 24). Thus, a reflection is minimized and a beam splitting efficiency is increased.
摘要翻译：要解决的问题：提供用于分束，光束复合的光学装置及其相关应用。解决方案：光学装置（10）包括将第一耦合波导（18）连接到两个第二耦合波导（22和24）的矩形多模波导（20）。第一耦合波导（18）在其基本模式下操作并且给出激励多模波导（20）的一系列对称模式的输入。沿着多模波导（20）的模态色散使得能够将输入激励（70a）转换成分离的输出激励（75a和75b），其中心位于相应的第二耦合波导（22和24）上。辐射强度分布（75）在第二耦合波导（22和24）之间的多模波导的端壁区域中变为零。因此，反射被最小化并且分束效率增加。

9. 发明专利

JP2009195238A Fluorimetric detection system of nucleic acid 审中-公开
标题翻译：核酸荧光检测系统
公开(公告)号：JP2009195238A
公开(公告)日：2009-09-03
申请号：JP2009103044
申请日：2009-04-21
申请人： Uk Government , イギリス国The Secretary Of State For Defence In Her Britannic Majesty’S Government Of The Uneted Kingdom Of Great Britain And Northern Ireland
发明人： LEE MARTIN ALAN , FUERST RODERICK
IPC分类号： C12Q1/68 , G01N33/50 , C12N15/09 , C12Q1/00
CPC分类号： C12Q1/6818 , C12Q1/6823 , Y10S436/80 , Y10T436/143333 , C12Q2563/107 , C12Q2561/113 , C12Q2527/107 , C12Q2563/173
摘要： PROBLEM TO BE SOLVED: To provide a chain specific system for detecting the presence of a specific target nucleic acid sequence useful for PCR reaction, determination of an amount of a target sequence present in a sample, to generate duplex destabilization data such as a melt hysteresis information for amplification monitoring or for detection and quantitation of polymorphisms or allelic variation, and useful for general diagnosis. SOLUTION: Provided is the method for detecting the presence of the target nucleic acid sequence in the sample, the method comprising, (a) adding to the sample suspected of containing the target nucleic acid sequence, a probe specific for the target sequence and DNA duplex binding agent, the probe comprising a reactive molecule able to absorb fluorescence from or donate fluorescent energy to the DNA duplex binding agent, (b) subjecting thus formed mixture to an amplification reaction in which target nucleic acid is amplified, (c) subjecting the sample to conditions under which the probe hybridizes to the target sequence, and (d) monitoring fluorescence from the sample. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供用于检测有用于PCR反应的特异性目标核酸序列的存在的链特异性系统，确定样品中存在的靶序列的量，以产生双相不稳定数据，例如用于扩增监测或用于多态性或等位基因变异的检测和定量的熔融滞后信息，并且可用于一般诊断。提供了用于检测样品中靶核酸序列的存在的方法，所述方法包括：（a）向疑似含有靶核酸序列的样品中加入靶序列特异性的探针和DNA双链体结合剂，所述探针包含能够吸收荧光能量或向DNA双链体结合剂提供荧光能的反应性分子，（b）使由此形成的混合物经受其中扩增靶核酸的扩增反应，（c）对样品进行与靶序列杂交的条件，（d）监测来自样品的荧光。版权所有（C）2009，JPO＆INPIT

10. 发明专利

JP2009034104A Method for determining presence of bacteria resistant to cell lysing antibiotic 审中-公开
标题翻译：用于确定抗细菌耐药性的细菌存在的方法
公开(公告)号：JP2009034104A
公开(公告)日：2009-02-19
申请号：JP2008188908
申请日：2008-07-22
申请人： Uk Government , イギリス国The Secretary Of State For Defence In Her Britannic Majesty’S Government Of The Uneted Kingdom Of Great Britain And Northern Ireland
发明人： SQUIRRELL DAVID JAMES , LESLIE RACHEL LOUISE , BOWN KEVIN J
IPC分类号： C12Q1/04 , C12Q1/14 , G01N21/76 , G01N21/78 , G01N33/569
CPC分类号： G01N33/56938 , C12Q1/14
摘要： PROBLEM TO BE SOLVED: To provide a method for determining the presence of a target bacteria based on its resistance to a cell lysing antibiotic of the target bacteria. SOLUTION: The method for determining the presence of a target bacteria in a sample, which target bacteria shows the resistance to a cell lysing antibiotic, is provided, wherein the method comprises following serial steps: (i) a step for incubating a sample in an incubating medium including the cell lysing antibiotic; (ii) a step for capturing unlysed cells of the target bacteria on a solid support comprising a capture agent; (iii) a step for exposing the cells to an agent capable of causing lysis of the unlysed cells of the target bacteria; and (iv) a step for determining the presence of intracellular material derived from the lysed cells of the target bacteria. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种基于其对目标细菌的细胞裂解抗生素的抗性来确定靶细菌的存在的方法。提供了用于确定样品中目标细菌存在的方法，其靶向细菌显示出对细胞裂解抗生素的抗性，其中所述方法包括以下连续步骤：（i）用于孵育在包括细胞裂解抗生素的培养基中的样品; （ii）在包含捕获剂的固体支持物上捕获目标细菌的未分解细胞的步骤; （iii）将细胞暴露于能够引起目标细菌未分解细胞裂解的试剂的步骤; 和（iv）确定源自目标细菌裂解细胞的细胞内物质的存在的步骤。版权所有（C）2009，JPO＆INPIT

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