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1. 发明专利

JPH10201742A CAP FOR VACUUM BLOOD COLLECTION TUBE 失效
公开(公告)号：JPH10201742A
公开(公告)日：1998-08-04
申请号：JP2215297
申请日：1997-01-21
申请人： S R L KK
发明人： KANBAYASHI TOSHIRO
IPC分类号： B65D39/04 , A61B5/153 , A61B5/14
摘要： PROBLEM TO BE SOLVED: To obtain a cap for vacuum blood drawing tube, which is excellent in the engagement and air-tightness, good at operating sticking a needle and available to nip a blood vessel exactly by a chuck of the automatic inspection unit by making the barrel of rigid plastics, both the needle sticking part and seal of flexible plastic, and by a monolithic molding in two-color mold. SOLUTION: The barrel 4 of this cap D1 for vacuum blood collection tube C is made of solid plastics, consisting of a flange 1 covering the opening end at the mouth 6 of a blood collection tube C, a leg 2 with a smaller diameter and a needle sticking bearer 3 formed in a V-shape at the center side from a stepped section. Both the needle sticking part 6 with a thin thickness formed by penetrating through the center of the needle sticking bearer 3 and the seal 7 n contact with the mouth 6 of the blood collection tube C, are made of soft plastics. The barrel 4, the needle sticking part 5 and the seal 7 are subjected to a simultaneous monolithic molding by injection molding, etc.

2. 发明专利

JPH1099099A DIAGNOSIS OF ABNORMITY OF HUMAN LDL RECEPTOR GENE AND PROBE USED THEREFOR AND OLIGONUCLEOTIDE PRIMER 失效
公开(公告)号：JPH1099099A
公开(公告)日：1998-04-21
申请号：JP27715396
申请日：1996-09-27
申请人： S R L KK
发明人： SAKURABAYASHI IKUNOSUKE , HATA YOSHIYA , AOSAKI RIYOUJI
IPC分类号： C12N15/09 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To diagnose the subject genetic abnormity causing familial hypercholesterolemia, etc., by probing whether the base sequence of the codon 109 of the exon of human LDL receptor gene is TCA or TCCA. SOLUTION: This method for diagnosing the abnormity of human LDL receptor gene by probing whether the base sequence of the codon 109 of the exon 4 of the human LDL receptor gene is TCA or TCCA comprises annealing a normal probe and an abnormal probe with a gene region containing the codon 109 of the exon 4 of the human LDL receptor gene and subsequently detecting the hybridized probe. The normal probe has a base sequence complementary to the codon 109-containing region of a normal gene in which the codon 109 of the exon 4 of the human LDL(low density lipoprotein) receptor gene is TCA, and an abnormal probe has a base sequence complementary to the codon 109- containing region of an abnormal gene in which the codon 109 is TCCA produced by the insertion of C into the codon 109.

3. 发明专利

JPH1066600A PRIMER FOR DETECTING HUMAN CYTOCHROME P450 2C9 GENE 失效
公开(公告)号：JPH1066600A
公开(公告)日：1998-03-10
申请号：JP24568396
申请日：1996-08-28
申请人： S R L KK
发明人： MURAMATSU KAYOKO , KUBOTA TAKAHIRO
IPC分类号： C12Q1/68
摘要： PROBLEM TO BE SOLVED: To obtain the subject new primer, comprising an oligonucleotide having a specific base sequence and capable of amplifying a human cytochrome P450 2C9 gene without amplifying human cytochrome P450 2C17, 2C18 and 2C19 genes. SOLUTION: This new primer comprises an oligonucleotide having a base sequence represented by the formula and is useful for amplifying a human cytochrome P450 2C9 gene. Since the primer is capable of specifically amplifying only the human cytochrome P450 2C9 gene without amplifying human cytochrome P450 2C17, 2C18 and 2C19 genes, the polymorphism of the human cytochrome P450 2C9 gene can accurately be diagnosed. The primer is obtained by chemically synthesizing an oligonucleotide having a base sequence capable of hybridizing with a 245-267nt region counted from the first base of the 7th exon of the human cytochrome P450 2C9 gene as 1nt with a DNA synthesizer, etc.

4. 发明专利

JPH09182586A RECOMBINANT VECTOR, CELL TRANSFORMED THEREBY, AND MEASUREMENT OF BONE METABOLISM CONTROL ACTIVITY OF VITAMIN D DERIVATIVE USING THE SAME CELL 失效
公开(公告)号：JPH09182586A
公开(公告)日：1997-07-15
申请号：JP35281795
申请日：1995-12-29
申请人： S R L KK
发明人： NEGISHI YOICHI , KAJIYAMA NAOKI , KAWAGUCHI RYUJI
IPC分类号： G01N33/82 , C12N5/10 , C12N15/09 , C12P21/02 , C12R1/91
摘要： PROBLEM TO BE SOLVED: To obtain the subject new vector containing a vitamin D responding sequence and a promoter sequence of an osteocalcin gene, connecting a transcriptional control region of the gene to a structural gene and capable of measuring bone metabolism of vitamin Ds. SOLUTION: This new recombinant vector contains a transcriptional control region of a human osteocalcin gene containing a vitamin D responding sequence and a promoter sequence of the osteocalcin gene and a structural gene functionally connected to the downstream of the transcriptional control region and coding for a detectable compound. A bone metabolism activity of a vitamin D derivative can be measured by adding the vitamin D derivative to a cell transformed with the and measuring a compound for which the structural gene which the cell produces as a method for evaluating activity of a vitamin D derivative which is a bone metabolism controlling medicine codes. Furthermore, a β-galactosidase gene, a chloramphenicolacetyl transferase gene, a luciferase gene, etc., are preferably used as the structural gene.

5. 发明专利

JPH0968532A MICROPLATE 失效
公开(公告)号：JPH0968532A
公开(公告)日：1997-03-11
申请号：JP22388595
申请日：1995-08-31
申请人： TOPPAN PRINTING CO LTD , S R L KK
发明人： HIROSE KIICHIRO , MITSUMA TOSHIO , TOUNO TAKATOSHI , TAKANASHI NAOKI , MORIMOTO TAEKO
IPC分类号： G01N33/543 , A61J1/00
摘要： PROBLEM TO BE SOLVED: To improve an antigen or antibody adsorbing characteristic and to provide an immunological assay result of high sensitivity by forming the bottom part plane shape of wells, formed numerously in array, into square shape with specific area. SOLUTION: A large number of wells 3 of square cylinder shape are formed at a plane part 2 of a microplate 1, and the area of a bottom part 5 of the well is to be 29-43mm . The wall thickness of a side wall part 4 or the bottom part 5 of the well 3 is substantially equal to that of the plane part 2, and the plane part 2 and the side wall part 4 and bottom part 5 of the well 3 are transparent like colorless glass. An opening edge part 3a of the well 3 is slightly swollen from the upper part of the plane part 2. In order to prevent the slip-off of a sample or a reagent such as antigen and an antibody, the surface of the side wall part 4 of the well 3 is roughened by matting. Polystyrene, polycarbonate, or the like is used as material for the specific adsorption of the antigen and antibody.

6. 发明专利

JPH0947286A MYELOPEROXIDASE AND ANTIBACTERIAL AGENT AND ANTIVIRAL AGENT CONTAINING THE ENZYME AS ACTIVE COMPONENT 失效
公开(公告)号：JPH0947286A
公开(公告)日：1997-02-18
申请号：JP22260195
申请日：1995-08-08
申请人： S R L KK
发明人： KAWASAKI MAYUMI , ISHIKAWA HIROSHI , KAWAGUCHI RYUJI , HIKICHI KAZUMASA
IPC分类号： C12N15/09 , A61K38/44 , A61P31/04 , A61P31/12 , C12N9/08 , C12R1/91
摘要： PROBLEM TO BE SOLVED: To obtain the subject new enzyme consisting of a glycoprotein having a specific amino acid sequence, exhibiting lectin bonding property, antibacterial action, antiviral action and peroxidase activity and useful as an antibacterial agent, antiviral agent, etc. SOLUTION: This new myeloperoxidase contains the amino acid sequence of the formula as the protein part of the glycoprotein, has a molecular weight of about 9×10 Dalton determined by SDS-PAGE, an optimum pH of 6, a lectin bonding property, an absorbance ratio of 430nm wavelength to 280nm wavelength of 0.61 and exhibits antibacterial action, antiviral action and peroxidase activity. It has broad antibacterial spectrum and antiviral spectrum and is useful as an antibacterial agent, antiviral agent, etc. The enzyme can be produced by collecting leucocyte from a patient of osteomyelodysplasia syndrome, subculturing the leucocyte, extracting mRNA from the subcultured strain, preparing a cDNA library, screening the library and expressing the DNA.

7. 发明专利

JPH0943237A HYBRIDOMA BORN FROM ANTI-PIKA-2 ANTIBODY AND IMMUNOLOGICAL MEASURING METHOD 失效
公开(公告)号：JPH0943237A
公开(公告)日：1997-02-14
申请号：JP21655995
申请日：1995-08-03
申请人： S R L KK
发明人： SAKAUCHI SATOKO , KUBOTA TAKAHIRO , TAKANASHI NAOKI
IPC分类号： G01N33/53 , G01N33/577
摘要： PROBLEM TO BE SOLVED: To quickly, accurately and simply measure PIVKA-2 in a specimen by using at least two kinds of monoclonal antibodies for PIVKA-2. SOLUTION: A monoclonal antibody which does not react with prothrombin and reacts only with PIVKA-2, and another nomoclonal antibody which reacts with both of them are combined and used to obtain excellent responsibility. In the production of these antibodies, an animal is immunized by making an immune source of human PIVKA-2, and cells born from the obtained antibody is cell-fused with myeloma cells, and detained antigen-forming cell is fused with myeloma cell. For instance, spleen cell suspension of an immunized mouse and the myeloma cell stocks are set in cultivation ground, and a cell fusion agent is added thereto. After fusion reaction processing, centrifuged cells are removed to another cultivation ground for selection, aimedhybridoma (cell fusion) is selected and cloned. The cloned hybridoma is cultivated in a suitable cultivation ground for breeding and a desired monoclonal antibody can be obtained from the supernatant of the cultivation ground.

8. 发明专利

JPH0912060A SEALING MATERIAL FOR PRESERVATION CONTAINER 失效
公开(公告)号：JPH0912060A
公开(公告)日：1997-01-14
申请号：JP18477195
申请日：1995-06-28
申请人： TOPPAN PRINTING CO LTD , S R L KK , SASAKI KAGAKU YAKUHIN KK
发明人： SAKAIRI KOJI , TOMITA TAKEHITO , SATO TSUYOSHI , TAKANASHI NAOKI , MORIMOTO TAEKO , ISOJIMA EIJI
IPC分类号： B65D77/20 , B32B27/00 , B32B27/18 , B65D65/40
摘要： PURPOSE: To maintain activity for a long period of time for antigem, antibody or the like put in the state of a solid phase in a preservation container like a microplate. CONSTITUTION: This sealing material 100 for a preservation container is mainly composed of a film base 2, a humidity controlling composition layer 10, made up by mixing 5-400wt.pts. of magnesium sulfate represented by a chemical formula MgSO4 .nH2 O (0

9. 发明专利

JPH08338845A METHOD AND SYSTEM FOR SETTING INSPECTION NUMBER 失效
公开(公告)号：JPH08338845A
公开(公告)日：1996-12-24
申请号：JP14591695
申请日：1995-06-13
申请人： S R L KK
发明人： MATSUDA KENICHI
IPC分类号： G01N35/02 , G01N1/00 , G01N33/49 , G01N35/10 , G06Q50/22
摘要： PURPOSE: To obtain a system for setting an inspection number and an inspection item number after finishing the dispensation by identifying the inspection room from the inspection item of a specimen for which the dispensation is finished and storing the inspection number being set for each inspection room in relation to the inspection number of specimen. CONSTITUTION: Upon finishing precise dispensation, the CPU 21a in a dispensation unit management computer 21 reads out dispensation information from a memory section 21c and identifies an inspection room for inspecting the specimen based on the inspection items in the information. An inspection number. is then set for each inspection room based on the identified inspection room. At the same time, currently stored inspection numbers are read out from counters provided for each inspection group of inspection room and the inspection numbers are updated. Subsequently, an inspection item number is set based on the inspection item in dispensation information and the inspection item number stored in the counter is updated. Since sorting or arrangement of specimen is not required prior to dispensation, efficiency of dispensation work is enhanced.

10. 发明专利

JPH08304409A APPARATUS AND METHOD FOR SORTING SPECIMEN 失效
公开(公告)号：JPH08304409A
公开(公告)日：1996-11-22
申请号：JP10861195
申请日：1995-05-02
申请人： S R L KK
发明人： IMAMURA SATOSHI
IPC分类号： G01N35/02 , G01N35/04
摘要： PURPOSE: To provide a method and apparatus for sorting specimens which enable sorting of the specimens accurately and quickly. CONSTITUTION: A sorting apparatus 56 is provided with a DCR7b to read out sorting information from a DC of a specimen rack 40 being conveyed on a branch conveyor 64, an LED7e to display a sorting destination determined based on the sorting information and a gate sensor 7f to detect the sorting destination of a specimen 22. In addition, a label printer 7c is provided to print out a label to display an inspection number of the specimen 22.

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