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1. 发明专利

JP2009286755A Slightly soluble amino acid microparticles, slightly soluble amino acid-containing mixture composition, method for producing the same, and external preparation for skin, and food additive 有权
标题翻译：轻微的氨基酸微量元素，轻微的含氨基酸的混合物组合物，其生产方法和外用的皮肤制剂和食品添加剂
公开(公告)号：JP2009286755A
公开(公告)日：2009-12-10
申请号：JP2008143107
申请日：2008-05-30
申请人： Nippon Rikagaku Yakuhin Kk , Tokyo Metropolitan Industrial Technology Research Institute , 地方独立行政法人東京都立産業技術研究センター , 日本理化学薬品株式会社
发明人： YANAGI SHOHAN , TAKIZAWA YUKIO , SUGIZAKI NOBUHIKO , SAWAMURA KAORI
IPC分类号： C07C227/42 , A23L29/00 , A61K8/02 , A61K8/04 , A61K8/44 , A61Q5/00 , A61Q19/00 , A61Q19/02 , C07C229/36 , C07C319/28 , C07C323/58
摘要： PROBLEM TO BE SOLVED: To provide safe and slightly soluble amino acids microparticles readily formulated in a cosmetic while maintaining properties essential to the slightly soluble amino acids without modifying the slightly soluble amino acids, easily compatible with skin, and further having excellent absorbency, to provide a method for producing the microparticles, to further provide a cosmetic having excellent skin absorbency and a transparence feeling at use concentration of the saturated cencentration or above, and to provide a food additive. SOLUTION: The method for producing the slightly soluble amino acids microparticles is characterized by physically finely dividing the slightly soluble amino acids having ≤0.5 g/100 g solubility in water at 20°C according to a wet pulverizing method, and regulating the average particle diameter which is a particle diameter where the cumulative value of frequency from the lower limit or the upper limit becomes 50% in a particle diameter distribution curve measured by using a laser diffraction/scattering type apparatus for measuring the particle size distribution to ≤1.0 μm. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：为了提供容易配制在化妆品中的安全和微溶的氨基酸微粒，同时保持对微溶性氨基酸必需的性质，而不改变容易与皮肤相容的微溶性氨基酸，并且还具有优异的吸收性提供一种微粒的制造方法，进一步提供在饱和浓度以上的使用浓度下具有优异的皮肤吸收性和透明感的化妆品，提供食品添加剂。解决方案：微溶氨基酸微粒的制造方法的特征在于，根据湿式粉碎法，将20℃下溶解度≤0.5g/ 100g溶解度的微溶性氨基酸物理上细微分解，并调节通过使用用于测量粒度分布的激光衍射/散射型装置测量的粒径分布曲线中，从下限或上限的频率的累积值的平均粒径变为50％ μm。版权所有（C）2010，JPO＆INPIT

2. 发明专利

JP2008143863A Isothiazoline compound and bactericidal composition for industrial use 有权
标题翻译：异山梨醇化合物和杀菌剂组合物用于工业应用
公开(公告)号：JP2008143863A
公开(公告)日：2008-06-26
申请号：JP2006334639
申请日：2006-12-12
申请人： Japan Enviro Chemicals Ltd , Nippon Rikagaku Yakuhin Kk , 日本エンバイロケミカルズ株式会社 , 日本理化学薬品株式会社
发明人： MIMORI TAKESHI , SUGIYAMA TAKAYUKI
IPC分类号： C07D275/02 , A01N43/80 , A01P3/00
摘要： PROBLEM TO BE SOLVED: To provide an effective component exhibiting an excellent controlling effect against harmful microorganisms such as bacteria, fungi, yeasts, algae, etc., and a bactericidal composition for an industrial use, containing such the effective component. SOLUTION: This isothiazoline compound expressed by general formula (1) [wherein, R1 is a 1-20C alkyl; and Xs are each the same or different and a halogen atom] is incorporated in the industrially used bactericidal composition. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供对包含这种有效成分的有害微生物如细菌，真菌，酵母，藻类等具有优异控制效果的有效成分和用于工业用途的杀菌组合物。解决方案：由通式（1）表示的该异噻唑啉化合物[其中，R1为1-20C烷基; 和Xs各自相同或不同，并且卤素原子]掺入工业上使用的杀菌组合物中。版权所有（C）2008，JPO＆INPIT

3. 发明专利

JPH0881437A PRODUCTION OF DL-CYSTINE 失效
公开(公告)号：JPH0881437A
公开(公告)日：1996-03-26
申请号：JP24236594
申请日：1994-09-12
申请人： NIPPON RIKAGAKU YAKUHIN KK
发明人： TAMURA YOSHIHARU , SHIYOUJI AKI
IPC分类号： C07C319/28 , C07C323/58
摘要： PURPOSE: To obtain DL-cystine having high purity useful as food additives, etc., by heating an optically active cystine together with salicylaldehyde in an aqueous solution of mineral acid with easily and quickly racemizing. CONSTITUTION: An optically active cystine (A) is racemized by heating together with salicylaldehyde (B) in an aqueous solution of mineral acid (C), neutralized and crystallized preferably in the presence of an oxidant (D) to afford the aimed compound. Preferably, e.g. hydrochloric acid having a concentration of 4-8 normal is used as the component C, the component A in an amount of 10-15wt.% of the component C is used, the component B in an amount of 5-10wt.% of the component A is added, iodine, etc., of the equal molar amount is used as the component D and the resultant mixture is neutralized and crystallized by an aqueous ammonia, etc.

4. 发明专利

JPS63112571A RACEMIZATION OF L-THIAZOLIDINE-4-CARBOXYLIC ACID 失效
公开(公告)号：JPS63112571A
公开(公告)日：1988-05-17
申请号：JP25468286
申请日：1986-10-28
申请人： NIPPON RIKAGAKU YAKUHIN KK
发明人： TAMURA YOSHIHARU , ONOE HIROTAKE , OOYOSHI KENSUKE
IPC分类号： C07D277/06
摘要： PURPOSE:To obtain the DL from of the titled compound useful as a raw material for a synthetic intermediate compound for drugs such as antibiotics, etc., simply and in an industrial scale in racemization of L-thiazolidine-4-carboxylic acid, by heating the carboxylic acid in an acetic acid. CONSTITUTION:L-Thiazolidine-4-carboxylic acid is heated in acetic acid and racemized. Acetic acid used in the racemization has preferably 0-5% water content. The amount of acetic acid used is preferably 4-6 times as much as that of L-thiazolidine-4-carboxylic acid of raw material. The concrete method of the racemization is carried out by suspending the raw material in acetic acid, heating and moderately boiling. The reaction time is properly 1-2hr after starting of boiling. After the boiling is over, the reaction solution is cooled, acetic acid is distilled away under reduced pressure, the reaction mixture is mixed with 2-3 times as much methanol as the raw material used, stirred, a substance crystallized and precipitated is collected to give the aimed compound.

5. 发明专利

JPS63112546A PRODUCTION OF HIGHLY WATER-SOLUBLE N-ACETYLAMINO ACIDS 失效
公开(公告)号：JPS63112546A
公开(公告)日：1988-05-17
申请号：JP25572886
申请日：1986-10-29
申请人： NIPPON RIKAGAKU YAKUHIN KK
发明人： SAITO MITSUAKI , IWAKAWA KATSUSHI , OOYOSHI KENSUKE
IPC分类号： C07D207/16 , C07C67/00 , C07C231/00 , C07C231/24 , C07C233/47 , C07C313/00 , C07C323/59
摘要： PURPOSE:To industrially obtain the titled compound useful as a mucilage dissolvent, etc., without containing inorganic salts in high yield, by neutralizing an acetylation reaction solution of an amino acid and removing metallic ions with an electrodialytic apparatus using cation exchange membranes as diaphragms. CONSTITUTION:An acetylation reaction solution 3 of an amino acid is circulated, neutralized and subjected to removal of metallic ions with an electrodialytic apparatus using carbon exchange membranes 4, e.g. p-styrenesulfonic acid- divinylbenzene copolymer, etc., to afford the aimed highly water-soluble N- acetylamino acids. The electrodialytic apparatus is a filter press type apparatus prepared by sandwiching diaphragms with compartment frames and providing the anode plate and the cathode plate at both ends. C, Pt, lead plate, etc., are used as the anode plate and Ag, iron, etc., are used as the cathode plate. A pole solution 1 (aqueous solution of sulfuric acid) is circulated on the side of both electrode plates and a 1-2N aqueous solution 2 of a mineral acid, e.g. HCl, H2SO4, etc., and reaction solution 3 are circulated from the anode side.

6. 发明专利

JPS6245230B2 失效
公开(公告)号：JPS6245230B2
公开(公告)日：1987-09-25
申请号：JP4876983
申请日：1983-03-25
申请人： NIPPON RIKAGAKU YAKUHIN KK
发明人： ANDO WATARU , TAMURA YOSHIHARU
IPC分类号： C07D277/06 , C07B41/02 , C07D501/08

7. 发明专利

JPS6233150A METHOD FOR OPTICAL RESOLUTION OF (R,S)-CYSTEINE 失效
公开(公告)号：JPS6233150A
公开(公告)日：1987-02-13
申请号：JP17189485
申请日：1985-08-06
申请人： NIPPON RIKAGAKU YAKUHIN KK
发明人： KATO SEIKICHI , TOMURO KEIZO , TAMURA YOSHIHARU , MORIMOTO YOKO
IPC分类号： C07B57/00 , C07B31/00 , C07C67/00 , C07C313/00 , C07C319/28 , C07C323/58
摘要： PURPOSE:To obtain R or S-cysteine inexpensively and simply in high yield, by forming two diastereomer salts from (R,S)-thiazolidine-4-carboxylic acid and an optically active amine and separating them. CONSTITUTION:Two diastereomer salts are formed from (R,S)-thiazolidine-4- carboxylic acid which is obtained by blending (R,S)-cycteine and formaldehyde in water and an optically active amine. Then, the salts are dissolved in an aqueous solution of an alkali such as NaOH, etc., a formed oil component of amine is extracted with an ether, etc., and the amine is separated. Then the water layer is adjusted to 4 pH with conc. sulfuric acid, etc., and concen trated to give the aimed substance. R-cysteine is useful for drugs, cosmetics, foods, etc., and S-cysteine is useful as an intermediate for synthesizing antibiotics. (R)-(+)-1-(alpha-Naphthyl)ethylamine, etc., may be cited as the amine.

8. 发明专利

JPS59175478A Preparation of 2,2-dimethyl-5-hydroxythiazolidine derivative 失效
标题翻译： 2,2-二甲基-5-羟基噻唑啉衍生物的制备
公开(公告)号：JPS59175478A
公开(公告)日：1984-10-04
申请号：JP4876983
申请日：1983-03-25
申请人： Nippon Rikagaku Yakuhin Kk
发明人： ANDOU WATARU , TAMURA YOSHIHARU
IPC分类号： C07D277/06 , C07B41/02 , C07D501/08
CPC分类号： Y02P20/55
摘要： PURPOSE: To obtain the titled compound useful as an intermediate for synthesizing caphalosporin, β-lactam antibiotic, by one process simply and easily, by oxidizng a 2,2-dimethylthiazolidine derivative as a raw material with oxygen in the presence of a photosensitizer.
CONSTITUTION: A 2,2-dimethylthiazolidine derivative shown by the formula I (R
1 is H, or lower alkyl; R
2 is amino-protecting group) is oxidized with oxygen in the presence of a photosensitizer in a polar solvent such as methanol, ethanol, acetonitrile, etc. to give a compound shown by the formula II. Preferably Rose Bengale, or methylene blue having good solubility in the polar solvent used in the above-mentioned reaction is used as the photosensitizer. Halogen-, tungsten-, sodium-lamp or mercury vapor lamp is used as a light irradiation lamp. An amount of the photosensitizer added is about 0.5W1wt% based on the raw material compound. The reaction is advanced smoothly by adding DMSO to it.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：通过在光敏剂存在下用氧气氧化2,2-二甲基噻唑烷衍生物作为原料，通过简单且容易的方法得到可用作合成头孢菌素β-内酰胺抗生素中间体的标题化合物。构成：式（I）所示的2,2-二甲基噻唑烷衍生物（R 1是H或低级烷基; R 2是氨基保护基））在极性溶剂中在光敏剂存在下用氧氧化如甲醇，乙醇，乙腈等，得到式Ⅱ所示的化合物。优选使用在上述反应中使用的在极性溶剂中具有良好溶解性的玫瑰色孟加拉兰或亚甲蓝作为光敏剂。卤素灯，钨灯，钠灯或水银灯被用作光照射灯。加入的光敏剂的量相对于原料化合物为约0.5-1重量％。通过向其中加入DMSO使反应顺利进行。

9. 发明专利

JPS5951763A Preparation of edible natural antioxidizing age 失效
标题翻译：可食用天然抗氧化剂的制备
公开(公告)号：JPS5951763A
公开(公告)日：1984-03-26
申请号：JP15950082
申请日：1982-09-16
申请人： Nippon Rikagaku Yakuhin Kk
发明人： TSURUIZUMI AKIE , MIYASAKA HARUO , FURUHASHI KIYOHISA
IPC分类号： C09K15/34 , A23F5/00 , A23L1/00 , A23L3/34 , A23L3/3472 , C11B5/00
摘要： PURPOSE: To prepare a natural substance for preventing oxidation in fats and oils in fat and oil foods or fat and oil-containing foods for a long period, by extracting raw coffee bean powder with water under reflux.
CONSTITUTION: Raw coffee bean powder from which fat and oil components are removed is extracted with water preferably in the presence of a basic substance such as slaked lime, etc. under reflux to give an aqueous extracted solution, which is concentrated, lyophilized, or subjected to spray drying.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：通过在回流下用水提取生咖啡豆粉，制备一种天然物质，用于预防脂肪和油性食物中脂肪和油中长时间的脂肪和油脂的氧化。构成：将去除脂肪和油成分的生咖啡豆粉末用水优选在碱性物质如熟石灰等的存在下在回流下提取，得到水提取溶液，将其浓缩，冻干或进行喷雾干燥。

10. 发明专利

JP2010001239A Composition for external use 有权
标题翻译：组合物外用
公开(公告)号：JP2010001239A
公开(公告)日：2010-01-07
申请号：JP2008160946
申请日：2008-06-19
申请人： Nippon Rikagaku Yakuhin Kk , 日本理化学薬品株式会社
发明人： TAKIZAWA YUKIO , SAWAMURA KAORI , OSHIRO HIDEAKI , TAMURA YOSHIHARU
IPC分类号： A61K8/49 , A61K31/426 , A61P17/00 , A61P17/18 , A61Q5/00 , A61Q19/00 , C07D277/06
CPC分类号： C07D277/06 , A61K8/49 , A61K31/13 , A61Q5/00 , A61Q19/02 , A61Q19/08
摘要： PROBLEM TO BE SOLVED: To provide a composition for external use having excellent active oxygen-eliminating effect, tyrosinase inhibitory effect and reducing effect, and becoming a skin preparation for external use or a cosmetic, having an anti-aging action by antioxidation effect and a whitening action by tyrosinase inhibitory effect, a hair cosmetic preventing the damage of the hair, further a permanent wave agent, curling agent and wavy hair-correcting agent by the reducing effect on disulfide bonds, and a hair dye. SOLUTION: This composition for external use is characterized by containing 1 kind or ≥2 kinds selected from 2-thiazolidine-4-carboxylic acid expressed by formula (1) or its derivative, or 2-methylthiazolidine-2,4-dicarboxylic acid expressed by formula (2) or its derivative, or their salts. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供具有优异的活性氧消除效果，酪氨酸酶抑制作用和还原效果的外用组合物，并且成为具有抗老化作用的外用皮肤制剂或化妆品效果和通过酪氨酸酶抑制作用的美白作用，通过对二硫键的还原作用，防止头发损伤的毛发化妆品，以及永久性挥发剂，卷曲剂和波浪状毛发矫正剂以及染发剂。解决方案：该外用组合物的特征在于含有1种或2种选自式（1）表示的2-噻唑烷-4-羧酸或其衍生物或2-甲基噻唑烷-2,4-二羧酸由式（2）表示的酸或其衍生物或其盐。版权所有（C）2010，JPO＆INPIT

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