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1. 发明专利

JP2014008329A Diagnostic system for presence/absence of mild cognitive impairment, cognitive function testing terminal and cognitive function testing program 有权
标题翻译：诊断误差诊断系统，认知功能测试终端和认知功能测试程序
公开(公告)号：JP2014008329A
公开(公告)日：2014-01-20
申请号：JP2012148680
申请日：2012-07-02
申请人： National Center For Geriatrics & Gerontology , 独立行政法人国立長寿医療研究センター
发明人： SUZUKI TAKAO , SHIMADA HIROYUKI , PARK HYUN-TAE , MAKISAKO HYUMA
IPC分类号： A61B10/00
摘要： PROBLEM TO BE SOLVED: To comprehensively test a cognitive function of a subject and diagnose the presence/absence of mild cognitive impairment by considering age of the subject.SOLUTION: A diagnostic system for presence/absence of mild cognitive impairment includes: means (32) for acquiring test data, with respect to each of a test for logical immediately-memorizing ability, a test for visual space cognition ability, a test for word immediately-memorizing ability, a test for cognitive function including orientation, memorizing ability, calculating ability, linguistic ability and figurative ability, a test for attention function, a test for performance function, a test for information processing ability, a test for suppressing function, a test for word subsequently-reproducing ability and a test for logical subsequently-recognizing ability; means (31) for acquiring age data for a subject; and means (22) for diagnosing whether the subject has mild cognitive impairment by comparing the test data for at least one of the tests with the test data obtained by executing the at least one of the tests for multiple persons in an age range corresponding to the age data.
摘要翻译：要解决的问题：通过考虑受试者的年龄来全面测试受试者的认知功能并诊断轻度认知障碍的存在/不存在。解决方案：存在/不存在轻度认知障碍的诊断系统包括：手段（32）用于获取测试数据，关于逻辑立即记忆能力的测试，视觉空间认知能力测试，单词记忆能力测试，认知功能测试，包括方向，记忆能力，计算能力，语言能力和比喻能力，注意功能测试，性能测试功能，信息处理能力测试，抑制功能测试，后续再现能力测试和逻辑后续识别能力测试; 用于获取受试者年龄数据的（31）以及用于通过将所述测试中的至少一个的测试数据与通过对应于所述测试的年龄范围中的多个人执行所述至少一个测试获得的测试数据来诊断所述受试者是否具有轻度认知障碍的装置（22）年龄数据。

2. 发明专利

JP2012179123A Root canal filling material containing mesenchymal stem cell and dental tissue regeneration method using the same 有权
标题翻译：使用含有MESENCHYMAL STEM细胞和牙齿组织再生方法的ROOT CANAL FILLING MATERIAL OF THE MESENCHYMAL STEM CELL AND DENTAL TISSUE REGENERATION METHOD WITH THE SAME
公开(公告)号：JP2012179123A
公开(公告)日：2012-09-20
申请号：JP2011042862
申请日：2011-02-28
申请人： National Center For Geriatrics & Gerontology , 独立行政法人国立長寿医療研究センター
发明人： NAKAJIMA MISAKO , IOHARA KOICHIRO
IPC分类号： A61L27/00
CPC分类号： A61C5/04 , A61C5/40 , A61C5/50 , A61K6/0035 , A61K6/0041 , A61L27/3633 , A61L27/3834 , A61L27/54 , A61L2300/412 , A61L2430/12
摘要： PROBLEM TO BE SOLVED: To provide a root canal filling material for use in a tooth extraction or non-tooth extraction treatment, which is easily obtained, can be clinically applied, and can efficiently promote dental tissue regeneration, and to provide a dental tissue regeneration method using the same.SOLUTION: This root canal filling material 200, which contains mesenchymal stem cells 220 except dental pulp stem cells and an extracellular matrix 210, is inserted into the apical side of the root canal after pulpectomy or after the enlargement and cleaning of an infected root canal. The dental tissue regeneration method by the tooth extraction or non-tooth extraction treatment includes a step of injecting the root canal filling material into the apical side of the root canal of a non-extracted tooth after the pulpectomy or after the enlargement and cleaning of the infected root canal.
摘要翻译：要解决的问题：为了提供容易获得的用于拔牙或非牙齿提取处理的根管填充材料，可以临床应用，并且可以有效地促进牙齿组织再生，并且提供一种牙组织再生方法使用相同。解决方案：除了牙髓干细胞和细胞外基质210之外，将含有间充质干细胞220的根管填充材料200插入到根管切除术后的根管顶端或扩大和清洁感染牙根。通过牙齿拔牙或非牙齿拔出处理的牙齿组织再生方法包括将根管填充材料注入到未切除牙齿的根管的顶端侧的步骤，或者在扩大和清洁之后感染根管。版权所有（C）2012，JPO＆INPIT

3. 发明专利

JP2014054482A Imaging probe for oct apparatus 审中-公开
标题翻译： OCT装置成像探头
公开(公告)号：JP2014054482A
公开(公告)日：2014-03-27
申请号：JP2012202402
申请日：2012-09-14
申请人： Sanyo Engineer & Construction Inc , サンテック株式会社 , National Center For Geriatrics & Gerontology , 独立行政法人国立長寿医療研究センター
发明人： SUMI YASUNORI , NISHIDA ISAO , CHUNG CHANG-HO
IPC分类号： A61C19/04 , A61C8/00
摘要： PROBLEM TO BE SOLVED: To provide an imaging probe for OCT that can be safely inserted into a living body, and scan and emit light and receive the reflected light.SOLUTION: A probe 30 is attached with a transparent attachment 38. When the probe emits and scans laser light and receives the reflected light, the emitted light and the received light pass through the inside of the attachment 38. The attachment attached to the imaging probe is inserted into a hole drilled in the lower jawbone for implant treatment. Thus a cross-sectional image of the section scanned by an OCT apparatus can be acquired, and the canalis mandibulae can be prevented from being damaged during drilling for implant treatment.
摘要翻译：要解决的问题：提供可以安全地插入生物体中的OCT的成像探针，并且扫描和发射光并接收反射光。解决方案：探针30附接有透明附件38.当探针发射时并且扫描激光并接收反射光，发射的光和接收到的光通过附件38的内部。附接到成像探针的附件被插入到钻在下颚骨中的孔中用于植入治疗。因此，可以获得由OCT设备扫描的部分的横截面图像，并且可以防止在用于植入物治疗的钻孔期间损伤管状下颌骨。

4. 发明专利

JP2014008250A Standing/seating movement support device 审中-公开
标题翻译：定位/座椅运动支持设备
公开(公告)号：JP2014008250A
公开(公告)日：2014-01-20
申请号：JP2012147280
申请日：2012-06-29
申请人： Harada Vehicle Design Co Ltd , 原田車両設計株式会社 , National Center For Geriatrics & Gerontology , 独立行政法人国立長寿医療研究センター
发明人： MATSUI YASUMOTO , HARADA HISAMITSU , AOKI FUMIO
IPC分类号： A61G7/10 , A61H3/04
摘要： PROBLEM TO BE SOLVED: To provide a support device used for supporting standing motion, seating motion and walking movement motion of a care-receiver having difficulty in standing up and walking.SOLUTION: A standing/seating movement support device includes: armrest plate bodies 100 on which the elbows, the fore-arms and the hands of a care-receiver are placed and to which the body weight is applied; lifting/lowering frames 300 that slidingly lift the armrest plate bodies 100 diagonally upward or lower the armrest plate bodies 100 diagonally backward with respect to the body axis of the care-receiver, while retaining the armrest plate bodies 100 horizontally; and bases 400 that are movable on a floor face by having wheels 430 between their selves and the floor face. The armrest plate bodies 100 include, on the upper faces thereof, hand holds 120 that can be held with the hands of the care-receiver and extend in the vertically direction.
摘要翻译：要解决的问题：提供一种支撑装置，其用于支撑难以站立和行走的护理接收器的站立运动，座椅运动和步行运动。解决方案：立式/座椅运动支撑装置包括：扶手板体100 在其上放置护理者的肘部，前臂和手，并且施加体重; 同时将扶手板体100保持在水平状态的同时，使扶手板体100向上或向下倾斜地将扶手板体100相对于护理人体的身体轴向对角地向上或向下提升扶梯板体100，以及通过在其自身和地板面之间具有轮430而可在地板表面上移动的基座400。扶手板体100在其上表面上包括能够被护理人员的手握住并且在垂直方向上延伸的护手120。

5. 发明专利

JP2009249344A Drug for promoting formation of dental pulp and/or dentine and its application 有权
标题翻译：促进形成牙髓和/或丁烯的药物及其应用
公开(公告)号：JP2009249344A
公开(公告)日：2009-10-29
申请号：JP2008099814
申请日：2008-04-07
申请人： Aichi Gakuin , National Center For Geriatrics & Gerontology , 国立長寿医療センター総長 , 学校法人愛知学院
发明人： NAKAJIMA MISAKO , NAKAMURA HIROSHI
IPC分类号： A61K38/46 , A61K6/02 , A61K35/12 , A61P1/02 , G01N33/15 , G01N33/50
CPC分类号： A61K35/32 , A61K6/0017 , A61K6/0067 , A61K6/02 , A61K35/36 , A61K35/44 , A61K38/4886 , G01N33/5023 , G01N33/5064 , G01N33/5073 , G01N2333/96494 , G01N2800/18
摘要： PROBLEM TO BE SOLVED: To provide a biological pulp capping agent for treating dental caries and pulpitis and a drug for treating pulpitis.
SOLUTION: In dental caries or pulpitis, after removing the dental caries, MMP3 is applied to the dentine within a cavity or applied to the surface of exposed pulp or the amputated surface of vital pulp together with a scaffold. By so doing, the migration of dental pulp stem cells or endothelial precursor cells to the surface of wounded dental pulp and their multiplication are promoted to inhibit the apoptosis of damaged cells, and angiogenesis and regeneration of dentine and dental pulp are promoted.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于治疗龋齿和牙髓炎的生物牙膏封端剂和用于治疗牙髓炎的药物。解决方案：在龋齿或牙髓炎中，在去除龋齿后，将MMP3施用于空腔内的牙质，或者与支架一起应用于暴露的纸浆或生物纸浆的截肢表面。通过这样做，促进牙髓干细胞或内皮前体细胞向受伤牙髓表面的迁移及其增殖，抑制受损细胞的凋亡，促进牙本质和牙髓的血管生成和再生。版权所有（C）2010，JPO＆INPIT

6. 发明专利

JP2005080629A Anti-inflammatory agent, cytokine-inducing agent and method for screening by utilizing cytokine induction 审中-公开
标题翻译：抗炎剂，细胞因子诱导剂和利用细胞因子诱导筛选的方法
公开(公告)号：JP2005080629A
公开(公告)日：2005-03-31
申请号：JP2003319755
申请日：2003-09-11
申请人： Applied Cell Biotechnologies Inc , National Center For Geriatrics & Gerontology , 国立長寿医療センター総長 , 株式会社エーシーバイオテクノロジーズ
发明人： ISHIZUKA YASUYUKI , NIIDA SHUNPEI
IPC分类号： G01N33/50 , A61K31/713 , A61K38/00 , A61K38/45 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/02 , A61P1/04 , A61P1/16 , A61P9/04 , A61P9/10 , A61P11/02 , A61P17/00 , A61P19/02 , A61P19/10 , A61P25/02 , A61P25/28 , A61P29/00 , A61P31/12 , A61P31/16 , A61P31/18 , A61P35/00 , A61P37/04 , C12N9/10 , C12Q1/48 , G01N33/15
摘要： PROBLEM TO BE SOLVED: To provide an anti-inflammatory agent and a cytokine-inducing agent based on a new action mechanism and having a high safety, and further a method for screening a substance inducing and suppressing the expression of an inflammatory cytokine.
SOLUTION: The new anti-inflammatory agent and cytokine-inducing agent based on a new finding that γ-GTP (γ-glutamyltranspeptidase) induces the inflammatory cytokines (MIP-1, IL-6, IL-1, etc.) are provided. Also, the screening method based on the new finding is also provided.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供基于新的作用机理并具有高安全性的抗炎剂和细胞因子诱导剂，以及进一步筛选诱导和抑制炎性细胞因子表达的物质的方法。解决方案：基于γ-GTP（γ-谷氨酰转肽酶）诱导炎症细胞因子（MIP-1，IL-6，IL-1等）的新发现的新型抗炎剂和细胞因子诱导剂，被提供。此外，还提供了基于新发现的筛选方法。版权所有（C）2005，JPO＆NCIPI

7. 发明专利

JP2014016159A Method for predicting crisis of alzheimer disease 有权
标题翻译：预测阿尔茨海默病危害的方法
公开(公告)号：JP2014016159A
公开(公告)日：2014-01-30
申请号：JP2012151620
申请日：2012-07-05
申请人： Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho , 国立医薬品食品衛生研究所長 , National Center For Geriatrics & Gerontology , 独立行政法人国立長寿医療研究センター
发明人： MAEKAWA KYOKO , TAJIMA YOKO , ISHIKAWA MASAKI , SAITO YOSHIAKI , AKUNO ARATO , NIIDA SHUNPEI , TAKIGAWA OSAMU
IPC分类号： G01N33/53
摘要： PROBLEM TO BE SOLVED: To provide a simple method for predicting a crisis of alzheimer disease.SOLUTION: As a result of identification of metabolites whose abundances are significantly different between an alzheimer disease model mouse and a wild type mouse, it is found that (±)17,18-dihydroxy-eicosa-5Z,8Z,11Z,14Z-tetraenoic acid (17,18-DiHETE) and (±)19,20-dihydroxy-4Z,7Z,10Z,13Z,16Z-docosapentaenoic acid (19,20-DiHDoPE) exist at a significantly high level in a brain and plasma of the alzheimer disease model mouse. That is, it is possible to predict a crisis of alzheimer disease by detecting at least one of 17,18-DiHETE and 19,20-DiHDoPE.
摘要翻译：要解决的问题：提供一种预测阿尔茨海默病危机的简单方法。解决方案：通过鉴定阿尔茨海默病模型小鼠和野生型小鼠之间的丰度显着不同的代谢物，结果发现（± ）17,18-二羟基 - 二十碳-5Z，8Z，11Z，14Z-四烯酸（17,18-DiHETE）和（±）19,20-二羟基-4Z，7Z，10Z，13Z，16Z-二十二碳五烯酸，20-DiHDoPE）在阿尔茨海默病模型小鼠的脑和血浆中以显着高的水平存在。也就是说，可以通过检测17,18-DiHETE和19,20-DiHDoPE中的至少一种来预测阿尔茨海默病的危机。

8. 发明专利

JP2013063976A ANTIBODY THAT SPECIFICALLY BINDS TO Aβ OLIGOMER AND USE THEREOF 有权
标题翻译：特殊的抗菌药物低分子及其使用
公开(公告)号：JP2013063976A
公开(公告)日：2013-04-11
申请号：JP2012226553
申请日：2012-10-12
申请人： Immunas Pharma Inc , イムナス・ファーマ株式会社 , National Center For Geriatrics & Gerontology , 独立行政法人国立長寿医療研究センター
发明人： MATSUBARA ETSURO , SHIBATA MASAO , YOKOZEKI TATSUMI
IPC分类号： C07K16/18 , A61K39/395 , A61P17/00 , A61P25/28 , C12P21/08 , G01N33/53
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： PROBLEM TO BE SOLVED: To provide an antibody that specifically binds to Aβ oligomers and uses thereof, and more particularly, an antibody that specifically binds to Aβ oligomers, a method of measuring Aβ oligomers using the antibody, a method of diagnosing Alzheimer disease using the antibody, and a drug containing the antibody.SOLUTION: A monoclonal antibody specific to only soluble Aβ oligomers but that does not recognize soluble Aβ monomers which are physiological molecules can be successfully manufactured. The antibody is found to be useful as a monoclonal antibody for the diagnosis and treatment of Alzheimer disease.
摘要翻译：要解决的问题：提供特异性结合Aβ寡聚体的抗体及其用途，更具体地，涉及特异性结合Aβ寡聚体的抗体，使用该抗体测量Aβ寡聚体的方法，诊断阿尔茨海默病的方法使用抗体的疾病和含有该抗体的药物。解决方案：可以成功地制造仅对可溶性Aβ寡聚体特异但不识别作为生理分子的可溶性Aβ单体的单克隆抗体。发现该抗体可用作用于诊断和治疗阿尔茨海默病的单克隆抗体。版权所有（C）2013，JPO＆INPIT

9. 发明专利

JP2010184884A Dementia-preventing effect by anti-e-selectin antibody 审中-公开
标题翻译：抗E-SELECTIN抗体的预防作用
公开(公告)号：JP2010184884A
公开(公告)日：2010-08-26
申请号：JP2009029179
申请日：2009-02-10
申请人： Katayama Kagaku Kogyo Kk , National Center For Geriatrics & Gerontology , 国立長寿医療センター総長 , 片山化学工業株式会社
发明人： WAKITA HIDEAKI , ADACHI KAYO , IGARASHI KOICHI , OYA KAZUNORI
IPC分类号： A61K39/395 , A61P25/02 , A61P25/28
摘要： PROBLEM TO BE SOLVED: To provide a composition useful for preventing damage of cerebral white matter and memory disorder induced by ischemia, and to provide a preventing method and the like. SOLUTION: There is provided the composition containing an anti-E-selectin antibody for preventing the damage of the cerebral white matter and the reduction of memory function induced by the ischemia. In one embodiment, the composition is administered before the occurrence of the ischemia, during the ischemia, or within about two hours after the occurrence of the ischemia. The method for preventing the damage of the cerebral white matter and the reduction of the memory function induced by the ischemia is also provided. COPYRIGHT: (C)2010,JPO&INPIT

10. 发明专利

JP2009131314A Nondestructive examination method of false tooth by using optical coherence tomography (oct) 审中-公开
标题翻译：使用光学相干图（OCT）的假牙的非结合检查方法
公开(公告)号：JP2009131314A
公开(公告)日：2009-06-18
申请号：JP2007307712
申请日：2007-11-28
申请人： National Center For Geriatrics & Gerontology , Sun Tec Kk , サンテック株式会社 , 国立長寿医療センター総長
发明人： SUMI YASUNORI , NEMOTO TETSUYA , TERASAWA FUMIYO , CHONG CHANGHO , MOROSAWA ATSUSHI
IPC分类号： A61B10/00 , A61C19/04 , G01N21/17
摘要： PROBLEM TO BE SOLVED: To solve such problems that a conventional nondestructive examination of false teeth is proposed by using X-rays or ultrasound and does not make an accurate evaluation and that images of surfaces and internal parts of the false tooth are not obtained especially in an non-invasive and simultaneous manner since the secular variations of the false tooth on which repair or lining are performed are determined by the status inside the oral cavity of a wearer or doctor's questions/a visual inspection and are not evaluated by objective evaluation methods.
SOLUTION: This invention provides an apparatus for making an evaluation inexpensively and instantly by using OCT or optical coherence tomography and the method for obtaining damage of the internal part of the false tooth by an image in order to contribute to dental treatments and for evaluating by capturing three-dimensional images of the false tooth by using the method when manufacturing the false tooth or at a place of adjusting to fix the false tooth.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：为了解决通过使用X射线或超声波提出常规的假牙的非破坏性检查并且不能进行准确评估并且假牙的表面和内部部件的图像不是的问题特别是以非侵入性和同时方式获得，因为执行修复或衬里的假牙的长期变化由穿戴者的口腔内的状态或医生的问题/目视检查确定，并且不被客观评估评估方法。解决方案：本发明提供一种通过使用OCT或光学相干断层摄影来廉价且即时地进行评价的装置，以及通过图像获得假牙内部的损伤的方法，以便有助于牙科治疗，并且通过在制造假牙时或在调整位置固定假牙时使用该方法来捕获假牙的三维图像来评估。版权所有（C）2009，JPO＆INPIT

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