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1. 发明专利

JPS6156196A Monoclonal antibody 失效
标题翻译：单克隆抗体
公开(公告)号：JPS6156196A
公开(公告)日：1986-03-20
申请号：JP14735584
申请日：1984-07-16
申请人： Fujirebio Inc , Mitsubishi Chem Ind Ltd , Isao Ono , Toshio Shikata , Yoko Shimizu
发明人： ONO ISAO , SHIKATA TOSHIO , SHIMIZU YOKO
IPC分类号： G01N33/576 , A61K39/29 , A61K39/395 , C07K14/005 , C07K14/195 , C07K16/00 , C07K16/18 , C12N15/02 , C12P21/08 , G01N33/577
CPC分类号： C07K16/18
摘要： PURPOSE:To provide the titled human and chimpanzee-type antibody reactive specifically with the antigen developed in hepatic cell in the crisis of a non-A non-B hapatitis of chimpanzee and man, and prepared by using the cloned cell of lymphocyte positive to the antibody relating to the chimpanzee and human non-A non-B hepatitis. CONSTITUTION:The peripheral blood lymphocyte of convalescent chimpanzee or man of non-A non-B hepatitis is transformed by Epstin-Barr virus to obtain culture cell positive to the antibody relating to non-A non-B hepatitis, and the cell is cloned by a soft agar method, critical dilution method, etc. to obtain a cell strain (cloned strain) capable of producing the objective antibody. The obtained cloned strain is proliferated in e.g. a serum-free medium containing 0.5% bovine serum albumin, and the supernatant liquid is collected, subjected to ultrafiltration (to remove a fraction having a molecular weight of
摘要翻译：目的：提供黑猩猩和男性非甲非乙型脑炎病毒危害下在肝细胞发育的抗原中特异性反应的人类和黑猩猩型抗体，并通过使用克隆的淋巴细胞细胞，与黑猩猩和人类非A非乙型肝炎有关的抗体。构成：恢复期的黑猩猩的外周血淋巴细胞或非A非乙型肝炎的人由Epstin-Barr病毒转化，得到与非A非乙型肝炎有关的抗体阳性的培养细胞，并且通过软琼脂法，临界稀释法等，以获得能够产生目的抗体的细胞株（克隆株）。获得的克隆菌株在例如，收集含有0.5％牛血清白蛋白的无血清培养基，收集上清液，进行超滤（去除分子量<= 300,000的级分），并通过凝胶过滤色谱法（用0.2M硼酸缓冲溶液为9.0pH），得到目标抗体。

2. 发明专利

JPS6136229A Selectively carcinostatic substance 失效
标题翻译：选择性致癌物质
公开(公告)号：JPS6136229A
公开(公告)日：1986-02-20
申请号：JP15987284
申请日：1984-07-30
申请人： Kayaku:Kk , Isao Ono , Toshio Takahashi
发明人： KOIDE YOSHIO , NAGATA KINYA , ONO ISAO , TAKAHASHI TOSHIO
IPC分类号： G01N33/574 , A61K39/395 , C07K14/005 , C07K14/195 , C07K16/00 , C07K19/00 , C12N15/00 , C12N15/02 , C12P21/00 , C12P21/08 , G01N33/577
摘要： PURPOSE: The titled carcinostatic substance having high affinity for CEA-forming cancer, showing no affinity for normal cells at all, consisting of a reaction product of an anti-human CEA monoclonal antibody and neocarzinostatin.
CONSTITUTION: A chemical reaction product of an anti-human CEA monoclonal antibody (e.g., anti-human colon cancer monoclonal antibody) and neocarzinostatin (NCS for short). NCS is a compound wherein a chromophore having about 700 molecular weight is bonded to an acidic protein having about 10,700 molecular weight consisting of 109 amino acid, shows strong carcinostatic action, but has side effect to have actions on normal cell simultaneously. Bonding of the monoclonal antibody having selective affinity for CEA-forming cancer to it provides the selective carcinostatic substance having high selectivity only for cancerous cells, longer durability in blood than NCS, and lower toxicity. Colon cancer, stomach cancer, etc. may be cited as the human CEA-forming cancer.
COPYRIGHT: (C)1986,JPO&Japio
摘要翻译：目的：针对CEA形成癌症具有高亲和力，对正常细胞无亲和力的标题抗癌物质，由抗人CEA单克隆抗体与新辅佐丁抑制素的反应产物组成。构成：抗人CEA单克隆抗体（例如抗人结肠癌单克隆抗体）和新卡那霉素（简称NCS）的化学反应产物。 NCS是其中具有约700分子量的发色团与具有109个氨基酸组成的约10,700分子量的酸性蛋白质结合的化合物，显示出强的致癌作用，但具有同时对正常细胞具有作用的副作用。具有对CEA形成癌症具有选择性亲和力的单克隆抗体的结合提供了对于癌细胞具有高选择性的选择性制癌物质，血液中耐久性比NCS更长，毒性更低。可能引用结肠癌，胃癌等作为人CEA形成癌。

3. 发明专利

JPS6125484A Cell strain producing antibody 失效
标题翻译：细胞株生产抗体
公开(公告)号：JPS6125484A
公开(公告)日：1986-02-04
申请号：JP14735484
申请日：1984-07-16
申请人： Fujirebio Inc , Mitsubishi Chem Ind Ltd , Isao Ono , Toshio Shikata
发明人： ONO ISAO , SHIKATA TOSHIO , SHIMIZU YOKO
IPC分类号： G01N33/576 , A61K39/29 , A61K39/395 , C07K14/005 , C07K14/195 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/02 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/577
摘要： PURPOSE: To provide a cell strain originated from human and chimpanzee, capable of producing a monoclonal antibody reactive specifically to an antigen developing in the hepatic cell of non-A non-B hepatitis and the screening of serum, etc.
CONSTITUTION: The peripheral blood lymphocyte of chimpanzee or human of the covalescence of non-A non-B hepatitis is transformed with Epstein-Barr virus (EB virus), and the obtained culture cell positive to the antibody relating to non-A non-B hepatitis is cloned to obtain the cell strain capable of producing the objective antibody. For example, the peripheral blood of a chimpanzee or human of the covalescence of non-A non-B hepatitis is collected and added with heparin, and lymphocyte is separated from the blood by centrifugal separation. Separately, the cell producing and releasing EB virus is cultured in a medium, and the supernatant liquid of the culture product is separated to obtain a virus source. The virus source is made to contact with the above lymphocyte, inoculated in a micro-titer plate for tissue culture at various cultivation densities, and cultured to obtain the objective strain.
COPYRIGHT: (C)1986,JPO&Japio
摘要翻译：目的：提供源自人和黑猩猩的细胞株，能够产生对非A非乙型肝炎肝细胞中发生的抗原特异性反应的单克隆抗体，并筛选血清等。构成：外周血利用爱泼斯坦 - 巴尔病毒（EB病毒）转染非A非B型肝炎病毒的黑猩猩或人类的淋巴细胞，克隆得到的与非A非B型肝炎相关的抗体阳性的培养细胞，得到能够产生目标抗体的细胞株。例如，收集非A非乙型肝炎的黑猩猩或人的外周血，并加入肝素，通过离心分离将淋巴细胞与血液分离。另外，在培养基中培养细胞产生和释放EB病毒，分离培养产物的上清液，得到病毒源。将病毒源与上述淋巴细胞接触，接种在微滴定板中，以各种培养密度进行组织培养，并培养以获得目标菌株。

4. 发明专利

JPS6124523A Preparation of monoclonal antibody 失效
标题翻译：单克隆抗体的制备
公开(公告)号：JPS6124523A
公开(公告)日：1986-02-03
申请号：JP14585284
申请日：1984-07-12
申请人： Isao Ono , Toshio Shikata
发明人： SHIKATA TOSHIO , ONO ISAO , SHIMIZU YOKO
IPC分类号： G01N33/577 , A61K39/395 , C07K14/005 , C07K14/02 , C07K14/10 , C07K14/18 , C07K14/195 , C07K14/41 , C07K14/52 , C07K14/555 , C07K16/00 , C07K16/08 , C12N15/02 , C12P21/08
CPC分类号： C07K16/082
摘要： PURPOSE:To obtain the titled antibody of an animal other than humans useful as a diagnosis, prevention and treatment for diseases, by immunizing a chimpanzee with an antigen to give sensitized B-lymphocytes, and transforming the resultant lymphocytes with lymphotropic viruses. CONSTITUTION:A chimpanzee is immunized with an antigen, e.g. virus, hepatitis B antigen, tumorous cell, interferon or urokinase, to give sensitized B-lymphocytes, which are then transformed with lymphotropic viruses, e.g. Epstein Barr virus, to afford multiplicative B-lymphocytes. The resultant B-lymphocytes are then cultivated to produce monoclonal antibodies. The above-mentioned antibodies can be used not only for detecting the corresponding antigens but also for protecting diseases involving the above-mentioned antigens. The immunological source to be used is preferably highly purified before use.
摘要翻译：目的：通过用抗原免疫黑猩猩以获得致敏的B淋巴细胞，并用淋巴细胞病毒转化所得淋巴细胞，获得人类以外的动物的标题抗体，可用作疾病的诊断，预防和治疗。构成：黑猩猩用抗原免疫，例如病毒，乙型肝炎抗原，肿瘤细胞，干扰素或尿激酶，以产生致敏的B淋巴细胞，然后用淋巴细胞病毒例如，爱泼斯坦巴尔病毒，以提供倍增的B淋巴细胞。然后培养所得的B淋巴细胞以产生单克隆抗体。上述抗体不仅可用于检测相应的抗原，而且可用于保护涉及上述抗原的疾病。使用的免疫源优选在使用前被高度纯化。

5. 发明专利

JP2005280376A Fin for surfboard 审中-公开
标题翻译： FIN FOR SURFBOARD
公开(公告)号：JP2005280376A
公开(公告)日：2005-10-13
申请号：JP2004093175
申请日：2004-03-26
申请人： Isao Ono , 功小野
发明人： ONO ISAO
IPC分类号： B63B35/79
摘要： PROBLEM TO BE SOLVED: To stabilize and enhance motion performance and to make linear advancement property, rotation property and acceleration operation property good by mounting to a back surface of a rear part of a surfboard.
SOLUTION: Two mounting pieces 1, 1 for mounting to a back surface of the surfboard; a fin base part 2 extending from the two mounting pieces 1, 1; an obliquely downward fin part 3 extending from a rear end of the fin base part 2; and an obliquely upward fin part 4 extending from the rear end of the fin base part 2 are integrally constituted by carbon fiber. The obliquely downward fin part 3 and the obliquely upward fin part 4 are constituted so as to become thin toward rear ends and have resiliency.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：通过安装到冲浪板的后部的后表面，来稳定和提高运动性能，并且使线性前进性，旋转性和加速操作性良好。
解决方案：两个用于安装到冲浪板后表面的安装件1,1; 从两个安装件1,1延伸的翅片基部2; 从翅片基部2的后端延伸的倾斜向下的翅片部3; 并且从翅片基部2的后端延伸的倾斜向上的翅片部分4由碳纤维一体地构成。倾斜向下的翅片部分3和倾斜向上的翅片部分4被构造成朝向后端变薄并具有弹性。版权所有（C）2006，JPO＆NCIPI

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