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1. 发明专利

JP2014206544A 試料ろ過フィルターを用いる簡易メンブレンアッセイ方法及びキット有权
标题翻译：使用样品过滤器进行简单膜分析的方法和工具包
公开(公告)号：JP2014206544A
公开(公告)日：2014-10-30
申请号：JP2014149854
申请日：2014-07-23
申请人：デンカ生研株式会社 , Denka Seiken Co Ltd
发明人： SHIMIZU HIDEHARU , INANO KOICHI , GONDAIRA FUMIO
IPC分类号： G01N33/543 , G01N33/545 , G01N33/569
摘要：【課題】本発明の目的は、メンブレンアッセイ法を用いた検体の簡易な検査方法において、感度を保ちながら偽陽性や詰まりを防止できる検体試料のろ過法を提供し、被検出物の精度の高い検出又は定量を可能にする方法及びそのような方法において使用されるキットの提供。【解決手段】被検出物を含む検体試料をろ過フィルターによってろ過した後に、被測定物を捕捉するための捕捉試薬が結合したメンブレンを備えたアッセイ装置上で検体試料中の被測定物の存在を検出又は定量することを含む簡易メンブレンアッセイ法において、上記ろ過フィルターを構成するフィルターに強剛性フィルターが含まれることを特徴とする簡易メンブレンアッセイ方法。【選択図】なし
摘要翻译：要解决的问题：为了提供能够在保持灵敏度的同时防止假阳性或拥塞的分析物样品的过滤方法，能够高精度地检测或定量测定待检测物体的方法，以及用于该方法的试剂盒，在使用膜测定方法的简单分析物检查方法中。解决方案：简单的膜测定方法包括用于在测定装置上的分析物样品中进行检测或定量测定待测物体的存在的步骤，其包括与在包含待检测物体的分析物样品已经通过过滤器过滤后，捕获被测物体的捕获试剂。在简单的膜测定方法中，构成过滤器的过滤器中包含强烈的刚性过滤器。

2. 发明专利

JP2014085208A Method of increasing sensibility of immunoassay system by pre-treating urine with denaturant 有权
标题翻译：通过预处理尿素来增加免疫系统的敏感性的方法
公开(公告)号：JP2014085208A
公开(公告)日：2014-05-12
申请号：JP2012233891
申请日：2012-10-23
申请人： Denka Seiken Co Ltd , デンカ生研株式会社
发明人： KUROSAWA HIROYUKI , HIRAYAMA YOSHIRO
IPC分类号： G01N33/531 , G01N33/53
CPC分类号： G01N33/5306 , G01N33/6893 , G01N2333/705
摘要： PROBLEM TO BE SOLVED: To provide a method of increasing the sensibility of immunoassay of protein existing in a urine specimen.SOLUTION: One or two of compounds made of a reducer, a chaotropic reagent, and a surfactant are added as a denaturant to a urine specimen. By pre-treating the urine specimen using these compounds, the sensibility of an immunoassay system, namely the measurement sensibility of protein in urine as a measuring object, is improved.
摘要翻译：要解决的问题：提供增加存在于尿液样品中的蛋白质的免疫测定的敏感性的方法。溶液：将一种或两种由还原剂，离液剂和表面活性剂制成的化合物作为变性剂加入到尿液中标本。通过使用这些化合物预处理尿标本，提高了免疫测定系统的灵敏度，即作为测量对象的尿液中蛋白质的测量灵敏度。

3. 发明专利

JP2013205408A Immunity analysis method and reagent 有权
标题翻译：免疫分析方法和试剂
公开(公告)号：JP2013205408A
公开(公告)日：2013-10-07
申请号：JP2012078449
申请日：2012-03-30
申请人： Denka Seiken Co Ltd , デンカ生研株式会社
发明人： KANO MAYUMI , TACHIBANA RITSUKO , IIZUKA MASAYUKI
IPC分类号： G01N33/531 , G01N33/543 , G01N33/545
CPC分类号： G01N33/54393 , C08F210/14 , C08F222/02 , G01N33/5306 , G01N33/54313
摘要： PROBLEM TO BE SOLVED: To provide an immunity analysis method which allows antigens to be accurately measured with high sensitivity, and a reagent for the method.SOLUTION: In an immunity analysis method, an antigen-antibody reaction and/or measurement is carried out in the presence of a polycarboxylic acid type surfactant. An immunity analysis reagent used in the method contains the polycarboxylic acid type surfactant. Accordingly, by using simple means allowing the presence of the polycarboxylic acid type surfactant in a reaction and/or measurement system, a nonspecific reaction is efficiently suppressed even in high-sensitivity immunity analysis, and the antigens are accurately measured and specificity is improved in immunity analysis.
摘要翻译：要解决的问题：提供一种能够高灵敏度地准确测定抗原的免疫分析方法和该方法的试剂。解决方案：在免疫分析方法中，进行抗原 - 抗体反应和/或测定存在多元羧酸型表面活性剂。该方法中使用的免疫分析试剂含有多元羧酸型表面活性剂。因此，通过使用在反应和/或测定体系中存在多元羧酸型表面活性剂的简单方法，即使在高灵敏度免疫分析中也能有效抑制非特异性反应，能够准确测定抗原，提高抗原特异性分析。

4. 发明专利

JP2013152147A Method for quantifying cholesterol in high-density lipoprotein 3 有权
标题翻译：在高密度脂蛋白中量化胆固醇的方法3
公开(公告)号：JP2013152147A
公开(公告)日：2013-08-08
申请号：JP2012013145
申请日：2012-01-25
申请人： Denka Seiken Co Ltd , デンカ生研株式会社
发明人： SATO NORIYUKI , HIRAO HIROKO , ITO YASUKI
IPC分类号： G01N33/92 , C12Q1/26 , C12Q1/42 , G01N33/48 , G01N33/50
CPC分类号： G01N33/92 , C12Q1/60
摘要： PROBLEM TO BE SOLVED: To provide a method for quantifying HDL3 in a test sample without requiring complicated operation.SOLUTION: A method for quantifying cholesterol in high-density lipoprotein 3 includes making an interfacial active agent peculiarly reacting to the high-density lipoprotein 3 react to the test sample, and quantifying cholesterol and the interfacial active agent is at least one kind selected from among a group composed of polyoxyethylene polycyclic phenyl ether and polyoxyethylene styrenated phenyl ether.
摘要翻译：要解决的问题：提供一种在测试样品中定量HDL3的方法，而不需要复杂的操作。解决方案：一种用于定量高密度脂蛋白3中的胆固醇的方法包括制备与高密度脂蛋白3特异性反应的界面活性剂反应测定样品，定量胆固醇和界面活性剂为选自聚氧乙烯多环苯基醚和聚氧乙烯苯乙烯化苯基醚中的至少一种。

5. 发明专利

JP2013126952A Method for preparing immunogen and method for producing antibody using the same 审中-公开
标题翻译：用于制备免疫原的方法和使用其生产抗体的方法
公开(公告)号：JP2013126952A
公开(公告)日：2013-06-27
申请号：JP2010078920
申请日：2010-03-30
申请人： Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho , 国立医薬品食品衛生研究所長 , Denka Seiken Co Ltd , デンカ生研株式会社
发明人： KAMATA YOICHI , GONDAIRA FUMIO
IPC分类号： C07K14/32 , C07K16/12 , G01N33/53 , G01N33/569
CPC分类号： C07K16/1278 , A61K39/07 , A61K2039/6006 , G01N33/56911 , G01N33/6893 , G01N2333/32 , G01N2800/06
摘要： PROBLEM TO BE SOLVED: To provide a method for preparing an immunogen that can produce an antibody even if an antigen is a hydrophobic small molecule such as cereulide, and to provide a method for producing an antibody using the same.SOLUTION: The method for preparing an immunogen includes: a step for dissolving an antigen such as cereulide in a water-soluble organic solvent such as methanol; a step for mixing the antigen solution obtained with a carrier having antigenicity itself, such as dead Salmonella cells; and a step for vaporizing the water-soluble organic solvent. The method of preparing an immunogen is the first to provide an anti-cereulide antibody.
摘要翻译：待解决的问题：提供一种制备即使抗原是疏水性小分子如大肠杆菌也能产生抗体的免疫原的制备方法，并提供使用其制备抗体的方法。解决方案：用于制备免疫原的方法包括：将抗原如大脑溶解在水溶性有机溶剂如甲醇中的步骤; 将由具有抗原性本身的载体获得的抗原溶液如死沙门氏菌细胞混合的步骤; 以及使水溶性有机溶剂蒸发的工序。制备免疫原的方法是首先提供抗大脑功能抗体。版权所有（C）2013，JPO＆INPIT

6. 发明专利

JP2012100581A Method for quantification of remnant-like lipoprotein cholesterol and kit for the same 有权
标题翻译：用于定量分离类似脂蛋白胆固醇和其它药盒的方法
公开(公告)号：JP2012100581A
公开(公告)日：2012-05-31
申请号：JP2010251511
申请日：2010-11-10
申请人： Denka Seiken Co Ltd , デンカ生研株式会社
发明人： HIRAO HIROKO
IPC分类号： C12Q1/44 , C12Q1/28 , C12Q1/30 , G01N33/92
CPC分类号： C12Q1/60 , C12Q1/44 , G01N33/92 , G01N2333/918
摘要： PROBLEM TO BE SOLVED: To provide a method for simply and accurately quantifying RLP cholesterol in a specimen material without requiring separation and to provide a kit for the same.SOLUTION: The method for quantifying remnant-like lipoprotein cholesterol in a specimen containing a plurality of lipoprotein types, including a remnant-like lipoprotein, includes: a step (1) for eliminating cholesterol in lipoproteins other than the remnant-like lipoprotein; and a step (2) for quantifying the cholesterol in the remaining remnant-like lipoprotein. In the step (1), the specimen is acted upon by a cholesterol esterase with a molecular weight of more than 40 kDa and which does not contain a subunit with a molecular weight of 40 kDa or less. In the step (2), the specimen is acted upon by a cholesterol esterase with a molecular weight of 40 kDa or less or a cholesterol esterase with a subunit with a molecular weight of 40 kDa or less.
摘要翻译：要解决的问题：提供一种用于简单且准确地量化样品材料中的RLP胆固醇而不需要分离并提供用于其的试剂盒的方法。解决方案：含有多种脂蛋白类型（包括残余样脂蛋白）的标本中的残留样脂蛋白胆固醇的定量方法包括：除残留物脂蛋白以外的脂蛋白中的胆固醇消除的步骤（1） ; 和用于定量残留的类似脂蛋白中的胆固醇的步骤（2）。在步骤（1）中，样本被分子量大于40kDa的胆固醇酯酶作用，并且不含分子量为40kDa以下的亚单位。在步骤（2）中，通过分子量为40kDa以下的胆固醇酯酶或分子量为40kDa以下的亚单位的胆固醇酯酶作用于试样。版权所有（C）2012，JPO＆INPIT

7. 发明专利

JP2012083370A Membrane assay method and kit using colored latex particle 审中-公开
标题翻译：膜分析方法和使用有色LATEX颗粒的工具包
公开(公告)号：JP2012083370A
公开(公告)日：2012-04-26
申请号：JP2012018426
申请日：2012-01-31
申请人： Denka Seiken Co Ltd , デンカ生研株式会社
发明人： SHIMIZU HIDEHARU , INANO KOICHI , MIYAZAWA YASUSHI , SAITO TAKEHIKO , HIROSE TAKANORI
IPC分类号： G01N33/543 , G01N33/531 , G01N33/545 , G01N33/569
摘要： PROBLEM TO BE SOLVED: To provide a method for discriminating positive from false positive in a method of easily inspecting a plurality of detection objects by a membrane assay method using colored latex particles as a marker reagent.SOLUTION: First capture substances that specifically couple to the respective detection objects are rendered into solid phases in different positions on a membrane; two or more kinds of marker reagents are prepared by coupling colored latex particles having different tones by each detection object to a second capture substance; a mixture of a specimen liquid and the marker reagents is supplied and spread on the membrane; and the specimen liquid is determined in each determination section in the following way. When the color of the marker reagent corresponding to each determination section is detected, the detection object is determined as 'positive'; when the color of the marker reagent corresponding to each determination section is not detected, the detection object is determined as 'negative'; and when a tone (halftone) of the mixture of the marker reagents is detected in any one of the determination sections, the inspection is determined as 'invalid'.
摘要翻译：要解决的问题：提供一种通过使用着色胶乳颗粒作为标记试剂的膜测定方法在容易地检查多个检测对象的方法中鉴别阳性与假阳性的方法。解决方案：首先将特定耦合到各个检测对象的物质在膜上的不同位置变成固相; 通过将每个检测对象具有不同色调的着色胶乳颗粒与第二捕获物质偶联制备两种或更多种标记试剂; 将样品液体和标记试剂的混合物供给并铺展在膜上; 在各判断部中，以下述方式确定试样液。当检测到与每个确定部分相对应的标记试剂的颜色时，检测对象被确定为“正”; 当没有检测到与每个确定部分相对应的标记试剂的颜色时，将检测对象确定为“阴性”; 并且当在任何一个确定部分中检测到标记试剂的混合物的色调（半色调）时，检查被确定为“无效”。版权所有（C）2012，JPO＆INPIT

8. 发明专利

JP2012016452A Swab for collecting specimen having shaft part formed with material having flexibility 有权
标题翻译：用于收集具有弹性的材料形成的轴的样品的SWAB
公开(公告)号：JP2012016452A
公开(公告)日：2012-01-26
申请号：JP2010155129
申请日：2010-07-07
申请人： Denka Seiken Co Ltd , デンカ生研株式会社
发明人： INANO KOICHI , SHIBANO NOBUKO , SHIMIZU HIDEHARU , SHIRAI YASUO
IPC分类号： A61B10/02 , G01N1/04 , G01N33/48
摘要： PROBLEM TO BE SOLVED: To provide a swab that can surely, efficiently and safely collect a specimen.SOLUTION: The swab includes: a shaft part 1 formed with a flexible material such as a crystalline resin; a collecting part 2 with a brush piloerection body on one end to a longitudinal direction of the shaft part 1; and a grip part 3 on one end to an opposite direction. When the shaft part 1 is bent, the swab can be bent without breaking the shaft 1 and can collect specimens from pharynx, nasal cavity, middle ear, internal ear, horny coat, urethra, anus, rectum, vagina or skin.
摘要翻译：要解决的问题：提供可以可靠，高效和安全地收集样本的拭子。解决方案：拭子包括：形成有诸如结晶树脂的柔性材料的轴部1; 在轴部1的纵向方向上的一端具有刷毛体的收集部2; 以及在一端朝向相反方向的把手部分3。当轴部分1弯曲时，拭子可以弯曲而不破坏轴1，并且可以从咽，鼻腔，中耳，内耳，角质衣，尿道，肛门，直肠，阴道或皮肤收集标本。版权所有（C）2012，JPO＆INPIT

9. 发明专利

JP2010060571A Measured value lowering suppressor for immunoassay, and immunoassay using the same 有权
标题翻译：测量值降低抑制剂进行免疫，并进行免疫测定
公开(公告)号：JP2010060571A
公开(公告)日：2010-03-18
申请号：JP2009273151
申请日：2009-12-01
申请人： Denka Seiken Co Ltd , デンカ生研株式会社
发明人： MINAGAWA YASUNORI , SAITO MICHIE , MATSUI HIROSHI
IPC分类号： G01N33/531 , G01N33/543
摘要： PROBLEM TO BE SOLVED: To provide a measured value lowering suppressor for an immunoassay capable of restraining an influence caused by an interfering substance in an examined sample to enhance accuracy in an immunonephelometry, and the immunoassay restrained in the lowering of a measured value caused by the interfering substance, and a reagent for the immunoassay using the suppressor.
SOLUTION: This measured value lowering suppressor for the immunoassay capable of restraining the lowering of the measured value caused by the interfering substance includes an ionic surfactant of a polymer polymerized with a hydrophobic cyclic monomer having an ionic functional group, and having a molecular weight of 1,000 to 100,000.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供能够抑制检查样品中由干扰物质引起的影响的免疫测定值的降低值的降低抑制剂，以提高免疫比浊法的精度，并且在降低测定值时抑制免疫测定由干扰物质引起的免疫测定试剂和使用抑制剂的免疫测定用试剂。解决方案：能够抑制由干扰物质引起的测量值降低的免疫测定值的该测量值降低抑制剂包括与具有离子官能团的疏水性环状单体聚合的聚合物的离子表面活性剂，并且具有分子重量为1,000至100,000。版权所有（C）2010，JPO＆INPIT

10. 发明专利

JP2009145357A Simplified measurement method of enterohemorrhagic escherichia coli 有权
标题翻译：肠易激综合征的简化测量方法
公开(公告)号：JP2009145357A
公开(公告)日：2009-07-02
申请号：JP2009021918
申请日：2009-02-02
申请人： Denka Seiken Co Ltd , デンカ生研株式会社
发明人： SATO YOSHIHIRO
IPC分类号： G01N33/569 , G01N33/543 , G01N33/545
摘要： PROBLEM TO BE SOLVED: To provide a detecting method of enterohemorrhagic escherichia coli producing verotoxin.
SOLUTION: This detecting method of enterohemorrhagic escherichia coli includes the step to react anti-verotoxin antibody sensitized particles with escherichia coli fungus body, and to measure an aggregation level of a reactant mixture from a change in absorbance or change in scattered light intensity. It also includes the step to destroy the cell wall of the escherichia coli fungus body, and uses an analytical measuring device to perform measurement. It also includes the step to process the escherichia coli fungus body by using polymyxin B, and to react anti-verotoxin antibody sensitized particles with escherichia coli fungus body in which verotoxin is bound to its surface, to measure the aggregation level of the reactant mixture.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供产生肠毒素的大肠杆菌生产的毒素的检测方法。解决方案：这种肠出血大肠杆菌的检测方法包括使大肠杆菌真菌体内的抗痘苗毒素抗体致敏颗粒反应的步骤，从吸光度的变化或散射光强度的变化来测定反应物混合物的凝集水平。它还包括破坏大肠杆菌真菌体的细胞壁的步骤，并使用分析测量装置进行测量。它还包括通过使用多粘菌素B处理大肠杆菌真菌体的步骤，并使抗毒素毒素抗体致敏颗粒与其中毒素与其表面结合的大肠杆菌真菌体反应，以测量反应物混合物的聚集水平。版权所有（C）2009，JPO＆INPIT

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