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1. 发明专利

JP2006217918A Transgenic arthritic mouse 有权
标题翻译：转基因小鼠
公开(公告)号：JP2006217918A
公开(公告)日：2006-08-24
申请号：JP2006084234
申请日：2006-03-24
申请人： Centre National De La Recherche Scientifique , Er Squibb & Sons Inc , Inst National De La Sante & De La Recherche Medicale , Univ Louis Pasteur Strasbourg 1 , アンスティチュナシオナルドゥラサントゥエデュラルシェルシュメディカル , イー.アール. スキッブアンドサンズ, インコーポレイテッド , ウニベルシットゥルイパストゥール, ストラスブール 1 , サルトゥルナシオナルドゥラルシェルシュシアンティフィック
发明人： BENOIST CHRISTOPHE O , MATHIS DIANE J , KOUSKOFF VALERIE
IPC分类号： A01K67/027 , C12N15/09 , A61K38/00 , A61K48/00 , A61K49/00 , A61P29/00 , C07K14/47 , C07K14/705 , C07K14/725 , C07K16/18 , C12N5/10 , C12N9/22 , C12N15/00 , C12N15/02 , C12N15/12 , C12N15/85 , C12P21/02 , C12P21/08 , G01N33/53 , G01N33/577
CPC分类号： A01K67/0278 , A01K67/0275 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/0325 , A01K2267/0368 , C07K14/705 , C07K14/7051 , C12N9/22 , C12N15/8509
摘要： PROBLEM TO BE SOLVED: To provide an animal model developing severe arthritic symptoms in a reproducible and thus predictable manner for promptly characterizing and controlling an immunological phenomenon such as autologousimmunity arthritis especially chronic rheumatoid arthritis. SOLUTION: The present invention relates to the transgenic mouse having one or more chronic inflammation of synoviale arthrosis and plasmodia phenotype, wherein the mouse is produced by introducing a virus vector including following (a), (b) and (c), (a) a first DNA sequence encoding T cell receptor α subunit containing variable regions originating from functionally rearranged TCR α gene of hybridoma R28, (b) a second DNA sequence encoding T cell receptor β subunit including variable regions originating from T cell receptor β gene of a hybidoma R28, and (c) a means which expresses the first DNA sequence and the second DNA sequence in vivo. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供以可重复且可预测的方式开发严重关节炎症状的动物模型，以及时表征和控制免疫学现象，例如自身免疫性关节炎，特别是慢性类风湿性关节炎。解决方案：本发明涉及具有滑膜关节病和疟原虫表型的一种或多种慢性炎症的转基因小鼠，其中通过引入包含以下（a），（b）和（c）的病毒载体来产生小鼠，（a）编码含有来自杂交瘤R28的功能重排的TCRα基因的可变区的T细胞受体α亚基的第一DNA序列，（b）编码T细胞受体β亚基的第二DNA序列，其包含源自T细胞受体β基因的可变区杂交瘤R28，和（c）在体内表达第一DNA序列和第二DNA序列的方法。版权所有（C）2006，JPO＆NCIPI

2. 发明专利

JP2003276056A Coupling member and coupling 有权
标题翻译：联系会员和联系
公开(公告)号：JP2003276056A
公开(公告)日：2003-09-30
申请号：JP2003028877
申请日：2003-02-05
申请人： Er Squibb & Sons Inc , イー.アール.スクィブアンドサンズ,インコーポレイテッド
发明人： KILGOUR RICHARD DEREK
IPC分类号： B65D41/16 , A61F20060101 , A61F5/44 , A61F5/445 , A61F5/448 , A61M27/00 , B29C20060101 , B29C33/44 , B29C45/26 , B29C45/44 , B29L31/24 , B29L31/56 , B65D20060101 , B65D43/10 , B65D55/02
CPC分类号： B29C45/4407 , A61F5/448 , B29L2031/565
摘要： PROBLEM TO BE SOLVED: To solve the problems of conventional coupling member that an undercut is shallow and inevitably slanted and witness lines are generated.
SOLUTION: A coupling member (110) of medical appliance for ostomy, incontinence or wound which comprises an annular body equipped with a continuous circumferential wall (112) having an undercut structure (130). The undercut structure (130) has multiple undercut arc parts (130) alternately corresponding to multiple voids. The multiple undercut arc parts (130) have respective planes (132) radially protruded at an angle with the axis line of the circular body so that they provide enough reliability required for loading the coupling member (110) to a corresponding press fit coupling member (160).
COPYRIGHT: (C)2003,JPO
摘要翻译：要解决的问题：为了解决传统的联结构件的问题，即底切浅而不可避免地倾斜并产生见证线。解决方案：一种用于造口术，失禁或伤口的医疗器具的联接构件（110），其包括设置有具有底切结构（130）的连续周壁（112）的环形体。底切结构（130）具有交替地对应于多个空隙的多个底切弧部分（130）。多个底切弧部分（130）具有与圆形体的轴线成一定角度径向突出的相应平面（132），使得它们提供足够的可靠性以将联接构件（110）装载到相应的压配合联接构件 160）。版权所有（C）2003，JPO

3. 发明专利

JP2716501B2 失效
公开(公告)号：JP2716501B2
公开(公告)日：1998-02-18
申请号：JP50683588
申请日：1988-07-15
申请人： SQUIBB & SONS INC
IPC分类号： A61B19/00 , A61M25/01 , A61M25/02 , A61M25/08

4. 发明专利

JP2572413B2 失效
公开(公告)号：JP2572413B2
公开(公告)日：1997-01-16
申请号：JP4181888
申请日：1988-02-24
申请人： SQUIBB & SONS INC
发明人： OORI AARU JENSEN , UORUTAA EFU RENZU , FURANKU EMU FURIIMAN
IPC分类号： A61F5/448 , A61F5/44 , A61F5/445 , A61F5/451 , A61F5/453

5. 发明专利

JPH0653713B2 失效
公开(公告)号：JPH0653713B2
公开(公告)日：1994-07-20
申请号：JP23163391
申请日：1991-09-11
申请人： SQUIBB & SONS INC
发明人： SASHA AI NATARAJAN , ERITSUKU EMU GOODON
IPC分类号： C07C233/36 , A61K31/40 , A61K31/42 , A61K38/00 , A61P9/12 , A61P25/04 , C07C67/00 , C07C233/30 , C07C233/62 , C07C235/34 , C07C237/12 , C07C237/20 , C07C239/00 , C07C279/04 , C07C313/00 , C07C323/59 , C07C323/60 , C07D205/04 , C07D207/16 , C07D207/22 , C07D209/14 , C07D211/60 , C07D213/54 , C07D213/81 , C07D217/26 , C07D231/14 , C07D233/64 , C07D277/06 , C07D307/54 , C07D333/24 , C07D401/12 , C07D405/12 , C07D409/12 , C07D495/10 , C07K1/113 , C07K5/06 , C07K5/062 , C07K14/81

6. 发明专利

JPH03501087A 失效
公开(公告)号：JPH03501087A
公开(公告)日：1991-03-14
申请号：JP50683588
申请日：1988-07-15
申请人： SQUIBB & SONS INC
IPC分类号： A61B19/00 , A61M25/01 , A61M25/02 , A61M25/08

7. 发明专利

JPH02261448A COUPLING FOR ARITIFICAL ANAL 失效
公开(公告)号：JPH02261448A
公开(公告)日：1990-10-24
申请号：JP2500190
申请日：1990-02-02
申请人： SQUIBB & SONS INC
发明人： PIITAA RESURII SUTEA , DEBITSUDO JIYON OURUDO
IPC分类号： A61F5/448
摘要： PURPOSE: To obtain a safe lock system by setting up so that the shape and the mounting position of an arm so as to deform the seam in the radial inside direction when a locking material rotates against a body-side coupling element, and overlaid on a part of a bag-side coupling element. CONSTITUTION: A coupling system for an artificial anus bag consists of a bag- side coupling element 100, a body-side coupling element 200 and a locking member 300. In order to assemble the locking member 300 in the body-side coupling element 200, a rib-shaped member 204 is inserted in an opening 302 for small hole formed by an inner face 314 of a blade part 310, and a roof part 212 of the lug 210 is crossed with the lower side of the blade part 310 to bend upward. In this case, the lug 210 may be installed between the blade part 310 corresponding to one arm 306 and the leg part of an obliquely adjacent arm. After the lock member 300 and the body-side coupling element 200 are assembled, a rib- shaped member 204 is inserted into a grooved member 104, and finally snap- interfits the bag-side coupling element 100.

8. 发明专利

JPH02221278A 7-OXABICYCLOHEPTYL-SUBSTITUTED HETEROCYCLIC AMIDEPROSTAGLANDIN ANLOGUE 失效
公开(公告)号：JPH02221278A
公开(公告)日：1990-09-04
申请号：JP33803389
申请日：1989-12-25
申请人： SQUIBB & SONS INC
发明人： FUIRITSUPU EMU SHIYAA , FUIRITSUPU DEII SUTEIN , DEBITSUDO FUROIDO , SUTEIIBUN II HOORU
IPC分类号： A61K31/34 , A61K31/557 , A61P7/02 , A61P11/08 , A61P43/00 , C07C45/29 , C07D493/08

9. 发明专利

JPH0237345B2 失效
公开(公告)号：JPH0237345B2
公开(公告)日：1990-08-23
申请号：JP21607581
申请日：1981-12-23
申请人： SQUIBB & SONS INC
发明人： ADORIAN NAN , MITSUSHERU ROBEEGU
IPC分类号： A61K31/165 , A61K31/19 , A61K51/00 , A61K51/04 , C07C237/04 , C07C237/06

10. 发明专利

JPH02109560A IMPROVED BANDAGE 失效
公开(公告)号：JPH02109560A
公开(公告)日：1990-04-23
申请号：JP23453189
申请日：1989-09-08
申请人： SQUIBB & SONS INC
发明人： OURI ROJIYAA JIENSEN
IPC分类号： A61F13/00 , A61F13/02 , A61F13/15 , A61L15/58
摘要： PURPOSE: To make a bandage with excellent absorption and retention, and keep good contact with skin even when curved against the skin, by wrapping a super-absorbing pad with a nonwoven fabric sheet, fastening it with an acrylic adhesive to a side of a base material, and edging the pad with the adhesive. CONSTITUTION: A pad material is punched into a square pad and placed on a nonwoven fabric sheet 20, the same material as the sheet 10, Then, the super- absorbing pad 18 is wrapped with the nonwoven fabric sheet 20, where the flaps 20a and 20b are overlapped and folded neatly. Then, the both sides of the pad unit is crimped along a line 22, cut and sealed. The wrapped pad (the flaps are folded but not sealed) is placed at the center of the adhesive-coated base B, and firmly stuck to a plastic film 12. The adhesive layer 16 keeps unsealed flaps 20a, 20b in a sealed state. The super-absorbing pad 18 is encompassed by an edging of skin-sticking adhesive layers 11, 16.

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