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81. 发明专利

JP2670873B2 失效
公开(公告)号：JP2670873B2
公开(公告)日：1997-10-29
申请号：JP33679589
申请日：1989-12-27
IPC分类号： C07C69/708 , C07C59/70 , C07C229/02 , C07C233/36 , C07C233/47 , C07C271/06 , C07C311/29 , C07C327/28 , C07K1/04 , C07K1/06 , C07K1/113 , C07K17/02 , C07K17/06

82. 发明专利

JPH09235260A PRODUCTION OF PALE AMIDE GROUP CONTAINING SURFACTANT 失效
公开(公告)号：JPH09235260A
公开(公告)日：1997-09-09
申请号：JP4453896
申请日：1996-03-01
申请人： KAO CORP
发明人： KUBO MAKOTO , SAKAI TAKANARI , FUJIO AKIRA
IPC分类号： B01F17/22 , C07C231/02 , C07C233/36 , C07C233/38
摘要： PROBLEM TO BE SOLVED: To efficiently obtain a high-quality surfactant containing amide group, having good hue and smell by a simple operation. SOLUTION: A fatty acid of the formula R COOR (R is a 7-23C alkyl, alkenyl or hydroxyalkyl; R is H, a 1-3C alkyl or a residue after removing one acyloxy from glyceride) or its ester is condensed with a polyamine of the formula H2 NC2 H4 NHZ (Z is a 2-4C alkylol) and then, the reaction product is subjected to addition reaction with a monohaloalkylcarboxylic acid of the formula XR COOY (X is a halogen; R is a 1-4C alkylene; Y is H or an alkali metal) or 3-chloro-2hydroxypropylsulfonic acid or its salt to provide the objective amide group-containing surfactant of formula I or formula II [R and R are each a 1-3C alkyl; (a) is 2-3]. At this time, an inorganic reducing agent (e.g. borohydride) is added to the condensation reaction system and further, the inorganic reducing agent is added to a system after addition reaction or after adding the inorganic reducing agent in condensation reaction or without adding the inorganic reducing agent, a hypochlorite is added after addition reaction and the inorganic reducing agent is added.

83. 发明专利

JPH09216856A AMINO ALCOHOL DERIVATIVE AND ITS PRODUCTION 失效
公开(公告)号：JPH09216856A
公开(公告)日：1997-08-19
申请号：JP34238596
申请日：1996-12-09
申请人： SEIKAGAKU KOGYO CO LTD
发明人： JINBO MASAYUKI , OYAMADA HIDEKAZU , INOKUCHI JINICHI
IPC分类号： C07D295/12 , C07C215/08 , C07C215/18 , C07C215/30 , C07C231/02 , C07C233/36 , C07C271/48 , C07C309/66
摘要： PROBLEM TO BE SOLVED: To obtain an amino alcohol derivative having activity on stimulating or controlling the biosynthesis of a glycolipid, antitumor activity, and activities suppressing cancer metastasis and stimulating the growth of neurocyte, and useful as a synthetic intermediate of a PDMT analog. SOLUTION: A 2-acylaminoalcohol expressed by formula I (the mark *indicates an asymmetric carbon; R is an alkyl, a cycloalkyl, etc.; R is a group of formula II, etc.; R is a 3-18C alkyl or alkenyl), e.g. (1S,2S)-2- benzyloxycarbonylamino-1-phenyl-1,3-propanediol-3-methanesulfonyl ester. A compound of formula I is obtained by reacting an aminopropanol derivative expressed by formula III (P is an alkyl or an amino-protecting group; Y is a leaving group) with an amine, removing the P group from the reaction product to obtain an amino alcohol derivative and further reacting the amino alcohol derivative with carboxylic acid or its reactive derivative.

85. 发明专利

JPH0912521A PRODUCTION OF LIGHT COLORED AMIDOAMINO ACID OR BETAINE 失效
公开(公告)号：JPH0912521A
公开(公告)日：1997-01-14
申请号：JP15921095
申请日：1995-06-26
申请人： KAO CORP
发明人： KUBO MAKOTO , SAKAI TAKANARI
IPC分类号： C11D1/04 , C07B61/00 , C07C231/02 , C07C231/12 , C07C233/36 , C07C233/38 , C07C235/10 , C11D1/90
摘要： PURPOSE: To efficiently obtain the subject compound by a simple operation by adding a specific inorganic reducing agent at an early stage of a reaction or in the middle of the reaction, extremely excellent in hue, useful as a surfactant, etc. CONSTITUTION: In reacting (A) an amino group-containing fatty acid derivative with (B) a monohaloalkylcarboxylic acid or its salt, an inorganic reducing agent selected from (C) a borohydride of the formula M (BH4 )m (M is an alkali metal, an alkaline earth metal, aluminum, a quaternary ammonium or an amine; m is a valence of M and is 1-4) and (D) a hydride of the formula M Hn (M is an alkali metal, an alkaline earth metal, titanium or zirconium; n is a valence of M and is 1-4) (preferably NaBH4 or LiBH4 ) is added at an early stage of a reaction or in the middle of the reaction. The reaction product is preferably a reaction product obtained by reacting a fatty acid of the formula R COOR (R i a 7-23C alkyl, alkenyl, etc.; R us H, a 1-3C alkyl, etc.) or its ester with a polyamine.

86. 发明专利

JPH08333316A NEW AMIDE COMPOUND AND INTERMEDIATE FOR PRODUCING THE SAME AND THEIR PRODUCTION 失效
公开(公告)号：JPH08333316A
公开(公告)日：1996-12-17
申请号：JP13773695
申请日：1995-06-05
申请人： KAO CORP
发明人： MIYAJIMA TETSUYA , KITSUKI TOMOHITO , KITA KATSUMI
IPC分类号： A61K8/00 , A61K8/40 , A61K8/42 , A61Q5/02 , A61Q5/12 , A61Q19/10 , C07C231/12 , C07C233/35 , C07C233/36 , C07C235/10 , C11D1/52 , C11D1/62 , A61K7/075 , A61K7/50
摘要： PURPOSE: To produce a new amide compound, hardly causing skin irritation, excellent in foaming properties, capable of imparting a favorable touch to the skin, etc., and useful as a base for a hair and a skin cosmetics, a detergent, an emulsifying agent, a conditioning agent, etc. CONSTITUTION: The amide compound of formula I [R is a (OH-substituted) 1-24C (branched) alkyl or an alkenyl; R is a (OH-substituted) 1-4C alkyl or an alkenyl; X is a halogen; (m) and (n) are each 1-6; (p) is 0-2], e.g. 4,12-bls(1- oxodecyl)-1,15-di(trimethylammonium)-4,12-diaza-8-oxypentadecane dichloride. The compound of formula I is obtained by reacting a compound of formula II with a compound of the formula R -CO-Y (Y is OH, an alkoxy or a halogen).

87. 发明专利

JP2556372B2 失效
公开(公告)号：JP2556372B2
公开(公告)日：1996-11-20
申请号：JP2883389
申请日：1989-02-09
申请人： AKZO NV
发明人： BURUUSU REIMONDO BEIRII , JEEMUSU MASHUU RITSUCHIMONDO
IPC分类号： C07C231/22 , C07C231/02 , C07C233/36

88. 发明专利

JPH08295657A INTERMEDIATE FOR SURFACTANT 失效
公开(公告)号：JPH08295657A
公开(公告)日：1996-11-12
申请号：JP12922795
申请日：1995-04-27
申请人： KANEBO LTD
发明人： TSUBONE KAZUYUKI , NISHIO HIROYUKI , KUSUMARU MASAFUMI
IPC分类号： A61K8/06 , A61K8/42 , C07C231/02 , C07C233/36
摘要： PURPOSE: To obtain a compound having excellent physical properties, having such sufficient skin safety as satisfying also the consumers with sensitive skin diseases, and useful as an intermediate for various surfactants having two chains and two hydrophilic groups and used for cosmetics. CONSTITUTION: A compound of the formula [(m) is an integer of 2-3; (n) is an integer of 2-4; the number of the carbon atoms in the acyl group is 8-20]. This compound is obtained by reacting a halogenated alcohol of the formula: Br(CH2 )m OH with an alkylene diamine of the formula: NH2 (CH2 )n NH2 in the presence of sodium carbonate in ethanol as a reaction solvent under refluxing, reacting the obtained secondary diamine with a fatty acid chloride in an amount of four times equivalents that of the amine in the presence of pyridine in benzene as a reaction solvent and subsequently hydrolyzing the obtained compound having an amide group and an ester group with an alkali. The carbon atom numbers of the used halogenated alcohol, alkylenediamine and fatty acid chloride are preferably 2-3, 2-4 and 8-20, respectively.

90. 发明专利

JPH08507504A 失效
公开(公告)号：JPH08507504A
公开(公告)日：1996-08-13
申请号：JP51956894
申请日：1994-03-03
IPC分类号： B01F17/28 , C07C227/40 , C07C227/44 , C07C229/12 , C07C231/00 , C07C231/22 , C07C231/24 , C07C233/35 , C07C233/36 , C07C233/38 , C11D1/88 , C11D1/90

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