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81. 发明专利

JPH07163642A DEODORANT 失效
公开(公告)号：JPH07163642A
公开(公告)日：1995-06-27
申请号：JP24174594
申请日：1994-10-06
申请人： SENJU PHARMA CO
发明人： OGATA KAZUMI , KAWAHIRA OSAMU
IPC分类号： A61L9/01 , C07F9/6558
摘要： PURPOSE:To eliminate many odorous components and quickly display an effect by blending a phosphoric diester compound expressed by a specific formula, or the pharmacologically allowable salt thereof as a deodorizing component. CONSTITUTION:A deodorant is blended with a phosphoric diester expressed by the formula or the pharmacologically allowable salt thereof as a deodorizing component. In the formula, R1 and R2 are a hydrogen atom or a methyl group identically or differently. This deodorant is prepared as a liquid agent, a solid agent, a gelatinized agent or the like as appropriate, and can be applied to various industrial and household fields. The deodorant has a strong deodorizing effect, and does not stimulate the mucosa of an eye, a nose, a throat or the like. Thus, the deodorant can be applied to various industrial and household fields. For the household application, the deodorant can be used to deodorize, for example, a room, a refrigerator, a toilet, a garbage box or the like as well as for removing a body smell and preventing the occurrence thereof.

82. 发明专利

JPH07158583A MICRO-FLOW RATE PUMP 失效
公开(公告)号：JPH07158583A
公开(公告)日：1995-06-20
申请号：JP30913493
申请日：1993-12-09
申请人： SENJU PHARMA CO , TOJO KAKUJI
发明人： TOJO KAKUJI , HIRAI YOSHIAKI
IPC分类号： F04B35/00 , F04D13/02 , F04D29/22
摘要： PURPOSE:To provide a micro flow rate pump which is constituted to simply and accurately control a micro flow rate without being influenced by absorption and dissolution of a chemical. CONSTITUTION:A micro flow rate pump comprises a pump body 2 which is formed in the shape of a cylinder with a bottom and has an outflow pipe 22 formed on the outer peripheral surface thereof; a cover body 3 removable from the pump body 2 and has an inflow pipe 32 formed thereon; a magnet rotor 4 arranged in the pump body 2; and a magnet stirrer 5 arranged on the outside of the pump body 2 and rotating the magnet rotor 4 in the pump body 2 by means of a magnetic force.

83. 发明专利

JPH07126167A THERAPEUTIC AGENT FOR RENAL DISEASE AND DIALYZING FLUID FOR ARTIFICIAL KIDNEY 失效
公开(公告)号：JPH07126167A
公开(公告)日：1995-05-16
申请号：JP18428394
申请日：1994-08-05
申请人： SENJU PHARMA CO
发明人： OGATA KAZUMI , SAKAGAMI YUKIHIRO , SAITO NORIKO , MATSUURA SACHIKO , NAGAO TOSHIE , OGINO SHINYA
IPC分类号： A61M1/14 , A61K31/665 , A61P13/02 , A61P15/00 , C07F9/6558
摘要： PURPOSE:To obtain a therapeutic agent for renal disease and dialyzing fluid for artificial kidney containing a phosphoric diester compound of ascorbic acid and tocopherol or its salt, capable of effectively controlling formation of free radicals in vivo and removing free radicals. CONSTITUTION:This therapeutic agent for renal disease and dialyzing fluid for artificial kidney contains a phosphoric diester compound of the formula (R1 and R2 are H or methyl) as an active ingredient. As the therapeutic agent for renal disease, the compound is pharmaceutically manufactured into a tablet for internal use or an injection and as the dialyzing fluid for artificial kidney and the compound of the formula is adjusted to 0.001-0.05(W/V)% concentration, 270-300mOsm/kg H2O osmotic pressure and pH 6-8. The therapeutic agent for renal disease is effective for preventing and treating glomerulonephritis, acute renal insufficiency, uremia, adriamycin renal disease, puromycin renal disease, renal disorder caused by a medicine such as gentamycin, cisplatin, etc., renal, disorder caused by an agrochemical such as paraquat and various renal diseases such as immune complex nephritis. The therapeutic agent for renal disease is also useful as a dialyzing fluid for artificial kidney for preventing and treating dialysis amyloidosis.

84. 发明专利

JPH0776700A STABILIZATION OF AGENT FOR CONTACT LENS 失效
公开(公告)号：JPH0776700A
公开(公告)日：1995-03-20
申请号：JP829094
申请日：1994-01-28
申请人： SENJU PHARMA CO
发明人： NAKAYAMA HISAYUKI , KIMOTO AKIHIRO , TSUCHINO NORIKO
IPC分类号： C11D7/42 , C11D1/10 , C11D1/66 , C11D1/72 , C11D1/90 , C11D1/94 , C11D3/00 , C11D3/386 , C11D17/00 , G02C13/00
摘要： PURPOSE:To efficiently stabilize a contact lens treating agent containing a proteinase and having excellent solubility in use by compounding a surfactant to the agent. CONSTITUTION:An agent for the treatment of contact lens and containing a proteinase such as bioprase originated from a microorganism belonging to the genus Bacillus (the concentration of the enzyme is preferably 10-5,000unit/ml) is stabilized by compounding preferably 0.01-10 (W/V)% of one or more kinds of surfactants selected from anionic surfactant, ampholytic surfactant and nonionic surfactant. The contact lens treating agent is produced preferably by freeze-drying an aqueous composition containing the proteinase in the presence of the surfactant at -10 to -40 deg.C.

85. 发明专利

JPH0748262A EXTRAOCULAR APPLICATION COMPOSITION 失效
公开(公告)号：JPH0748262A
公开(公告)日：1995-02-21
申请号：JP13505394
申请日：1994-05-24
申请人： SENJU PHARMA CO
发明人： AWATA TAKASHI , DOI KOJI , NAKAYAMA HISAYUKI , SAMESHIMA SHOGO , SOGO SHUNJI , MATSUMOTO TAKAHIRO , YOKOGAKI SHUICHI
IPC分类号： A61K9/06 , A61K9/08 , A61K31/70 , A61K47/10 , A61K47/16 , A61P27/02
摘要： PURPOSE:To obtain an extraocular application composition capable of preventing the occurrence of damage of ectocornea caused e.g. by wearing of a contact lens and useful e.g. for treating xerosis corneae, etc., by compounding glucose as an active component. CONSTITUTION:This composition contains (A) glucose (for example in an amount of preferably 0.01-2.0w/v% in the case of eye drop) and further optionally (B) an antiseptic agent consisting of one or more kinds of compound selected from a group of chlorhexidine (salt) and chlorobutanol. Further, preferably the preparation is applied 3-8 times a day in an amount of one to several drops a time in the case of eye drop.

86. 发明专利

JPH0725758A OPHTHALMIC TOPICAL ANTIALLERGIC AGENT 失效
公开(公告)号：JPH0725758A
公开(公告)日：1995-01-27
申请号：JP9956194
申请日：1994-05-13
申请人： TAIHO PHARMACEUTICAL CO LTD , SENJU PHARMA CO
发明人： OMORI HITOSHI , OGAWA TAKAHIRO , TOKUMOCHI FUMINORI , OKUMURA ATSUSHI
IPC分类号： A61K9/06 , A61K9/08 , A61K31/165 , A61P27/02 , A61P27/14 , A61P37/00 , A61P37/08 , C07C381/12
摘要： PURPOSE:To obtain the novel agent containing an agent for suppressing the production of IgE antibody as an active component, exhibiting excellent IgE antibody production suppressing action simply by the topical application to the eye and effective against allergic conjunctivitis, pollenosis, etc. CONSTITUTION:This agent contains an IgE antibody production suppressing agent, preferably (+ or -)-{2-[4-(3-ethoxy-2-hydroxypropoxy)-- phenylcarbamoyl]ethyl}dimethylsulfonium p-toluenesulfonate of the formula as an active component. The compound of the formula can be produced, e.g. by reacting (+ or -)-{2-[4-(3-ethoxy-2-hydroxypropoxy)phenylcarbamoyl]ethyl}methyl sulfide with methyl p-toluenesulfonate. In the case of using the agent as an eye lotion for adult patient, an eye lotion containing 0.2-2w/v% of the compound of the formula as an active component is administered at a rate of one to several drops per dose and 1-6 doses a day.

87. 发明专利

JPH0710701A AGENT FOR ENTOPTIC PERFUSION AND WASHING AND PRESERVATIVE FOR EYEBALL 失效
公开(公告)号：JPH0710701A
公开(公告)日：1995-01-13
申请号：JP2117394
申请日：1994-02-18
申请人： SENJU PHARMA CO
发明人： MATSUMOTO TAKAHIRO , SAMEJIMA SHOGO , YOSHIDA KENICHI
IPC分类号： A01N1/02 , A61K31/665 , A61P27/02 , A61P27/04 , C07D407/12 , C07F9/6558
摘要： PURPOSE:To obtain a medicine for entoptic perfusion-washing and for preservation of an eyeball, containing a phosphoric acid diester compound of ascorbic acid and tocopherol or its pharmaceutically permissible salt as the active component and having an excellent entoptic tissue-protecting effect. CONSTITUTION:This medicine for entoptic perfusion-washing and for preservation of an eyeball contains a phosphoric acid diester compound of the formula (R1 and R2 are each H or methyl) or its pharmaceutically permissible salt. The compound of the formula is synthesized by reacting ascorbic acid with tocopherol. In addition, the compound of the formula is remarkably low in toxicity, excellent in safety and, therefore, advantageously used in various kinds of ophthalmic operations or in preservation of an eyeball. In the case a preparation containing this compound is used as an entoptic perfusion-washing agent, the concentration of the compound of the formula is about 0.5 to 10mug/ml. In the case this preparation is used as a medicine for preservation of an eyeball, the concentration of the compound of the formula is preferably 5X10 to 5X10 g/ml. The compound of the formula is especially excellent in protection of corneal (endothelial) cells which are extremely apt to receive a biological damage in an ophthalmic operation.

88. 发明专利

JPH06279453A PYRIDOTHIAZINE ACETIC ACID DERIVATIVE, ITS PRODUCTION AND USE THEREOF 失效
公开(公告)号：JPH06279453A
公开(公告)日：1994-10-04
申请号：JP9193593
申请日：1993-03-29
申请人： GREEN CROSS CORP , SENJU PHARMA CO
发明人： HOSONO HIROSHI , AOZUKA TOMOSHI , NAKAMURA YOSHIYUKI , MATSUI TETSUO , ISHIKAWA HIROTSUGU
IPC分类号： A61K31/54 , A61P3/08 , A61P3/10 , A61P13/02 , A61P15/00 , A61P25/00 , A61P27/02 , A61P27/12 , C07D513/04
摘要： PURPOSE:To obtain a novel compound having an aldose reductase-inhibiting activity, excellent in safety, and useful for the therapy of diabetic complication, especially cataract and neurosis. CONSTITUTION:A compound of formula I (either of X, Y, Z is N, and the others are CH; R -R are either H, lower alkyl, or halogen; R is carboxyl group capable of being esterified), e.g. 2-[4-(benzothiazol-2-yl)methyl-3-oxo-3,4-dihydro-2H- pyrido[2,3-b][1,4]thiazin-2-yl]butyric acid methyl ester. The compound of formula I is obtained by reacting a compound of formula II (R is esterified carboxyl group) with a compound of formula III (W is halogen, OSO2R ; R is lower alkyl, trifluoromethyl, etc.,) in the presence of a base (e.g. potassium carbonate) in a solvent (e.g. DMF) at-30 deg.C to room temperature and, if necessary, subsequently hydrolyzing the reactional product.

89. 发明专利

JPH06279423A BENZOTHIAZOLE DERIVATIVE, ITS PRODUCTION AND USE THEREOF 失效
公开(公告)号：JPH06279423A
公开(公告)日：1994-10-04
申请号：JP9055093
申请日：1993-03-26
申请人： SENJU PHARMA CO , GREEN CROSS CORP
发明人： HASE TAKEMASA , UNNAKA YASUHIRO , SHIMIZU CHIKAKO , HOSONO HIROSHI , AOZUKA TOMOSHI , NAKAMURA YOSHIYUKI , MATSUI TETSUO , ISHIKAWA HIROTSUGU
IPC分类号： A61K31/425 , A61K31/428 , A61P3/08 , A61P3/10 , A61P43/00 , C07C233/25 , C07C255/25 , C07C321/28 , C07D277/64
摘要： PURPOSE:To obtain a new benzothiazole derivative having aldose reductase inhibiting action and excellent safety and useful as an agent for the treatment of diabetic complication, especially cataract and neurosis. CONSTITUTION:A compound of formula I (R is halogen; R and R are H or halogen; R is H, halogen, lower alkyl, alkoxy or alkylmercapto; R is H or lower alkyl) or its pharmaceutically permissible salt, e.g. N-[(4,5,7- trifluorobenzothiazol-2-yl)methyl]-N-(2-methylphenyl)succinamic acid ethyl ester. The compound can be produced by reacting a compound of formula II with a compound of formula III (X is halogen; R ' is lower alkyl) and optionally hydrolyzing the obtained compound. The compound of formula II is a new substance and produced by reacting a compound of formula IV or its acid addition salt with a compound of formula V or its salt.

90. 发明专利

JPH0625062B2 失效
公开(公告)号：JPH0625062B2
公开(公告)日：1994-04-06
申请号：JP735986
申请日：1986-01-16
申请人： SENJU PHARMA CO
发明人： FUNABASHI TOMOYA , YAMAMOTO JUJIRO
IPC分类号： C07D498/04 , A61K31/535 , A61P27/02

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