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81. 发明专利

JPS6136512B2 失效
公开(公告)号：JPS6136512B2
公开(公告)日：1986-08-19
申请号：JP2711878
申请日：1978-03-07
申请人： KURARAY CO
发明人： OONISHI TAKASHI , FUJITA YOSHIJI , NISHIDA TAKUJI
IPC分类号： C07C403/16 , C07C67/00 , C07C401/00

82. 发明专利

JPS61148120A ANALGESIC AGENT 失效
公开(公告)号：JPS61148120A
公开(公告)日：1986-07-05
申请号：JP27028684
申请日：1984-12-20
申请人： KURARAY CO
发明人： SHIONO MANZO , FUJITA YOSHIJI , NISHIDA TAKUJI
IPC分类号： C07D311/58 , A61K31/35 , A61K31/352 , A61P25/04
摘要： NEW MATERIAL:A compound expressed by formula I (R is H, hydroxymethyl or carboxyl; n is an integer 0 or 1), ester and salt thereof. EXAMPLE:beta-( 2,3-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-H-benzopyran-2-y l)alanine hydrochloride. USE:An analgesic agent, having better analgesic action than aspirin with high safety. The agent is administered particularly preferably by oral routes or intravenous injection, and the dose thereof is preferably 100-500mg/day for adults. PREPARATION:An aldehyde expressed by formula II (R' is H or protecting group of OH) is reacted with ammonium carbonate and an alkali metal cyanide, e.g. sodium cyanide, to give a hydantoin expressed by formula III, which is then hydrolyzed to afford the aimed compound expressed by formula I (R is COOH).

83. 发明专利

JPS6121941B2 JPS6121941B2 - 失效
公开(公告)号：JPS6121941B2
公开(公告)日：1986-05-29
申请号：JP20684684
申请日：1984-10-01
申请人： Kuraray Co
发明人： FUJITA YOSHIJI , OOMURA SUKEAKI , NISHIDA TAKUJI , ITOI KAZUO
IPC分类号： C07C227/12 , C07C67/00 , C07C227/00 , C07C227/02 , C07C229/30

84. 发明专利

JPS6039059B2 失效
公开(公告)号：JPS6039059B2
公开(公告)日：1985-09-04
申请号：JP1504576
申请日：1976-02-12
申请人： KURARAY CO
发明人： OONISHI TAKASHI , FUJITA YOSHIJI , WADA TOMIO , NISHIDA TAKUJI , OOMURA SUKEAKI , MORI FUMIO , HOSOGAI TAKEO , AIHARA FUKUJI
IPC分类号： C07C45/51 , C07C45/00 , C07C49/20 , C07C49/203 , C07C49/24 , C07C49/255 , C07C67/00

85. 发明专利

JPS6032635B2 失效
公开(公告)号：JPS6032635B2
公开(公告)日：1985-07-29
申请号：JP233376
申请日：1976-01-08
申请人： KURARAY CO
发明人： FUJITA YOSHIJI , OOMURA SUKEAKI , NISHIDA TAKUJI , ITOI KAZUO
IPC分类号： C07C57/03 , C07C51/00 , C07C57/26 , C07C67/00 , C07C69/533 , C07C69/587 , C07D263/10 , C07D263/12

86. 发明专利

JPS6029365B2 失效
公开(公告)号：JPS6029365B2
公开(公告)日：1985-07-10
申请号：JP6203677
申请日：1977-05-25
申请人： KURARAY CO
发明人： OONISHI TAKASHI , FUJITA YOSHIJI , ISHIGURO MICHIHIRO , NISHIDA TAKUJI
IPC分类号： C07C29/136 , C07C27/00 , C07C29/00 , C07C29/143 , C07C33/02 , C07C67/00 , C11B9/00

87. 发明专利

JPS6028814B2 失效
公开(公告)号：JPS6028814B2
公开(公告)日：1985-07-06
申请号：JP30576
申请日：1976-01-01
申请人： KURARAY CO
发明人： NISHIDA TAKUJI , NINAGAWA YOICHI , ITOI KAZUO , OOMURA SUKEAKI , MORI FUMIO , TAMAI HIRONOBU , HOSOGAI TAKEO , FUJITA YOSHIJI
IPC分类号： C07C5/03 , C07C1/00 , C07C1/22 , C07C9/22 , C07C27/00 , C07C29/00 , C07C31/20 , C07C67/00

88. 发明专利

JPS6021139B2 失效
公开(公告)号：JPS6021139B2
公开(公告)日：1985-05-25
申请号：JP6011377
申请日：1977-05-23
申请人： KURARAY CO
发明人： OONISHI TAKASHI , FUJITA YOSHIJI , ISHIGURO MICHIHIRO , NISHIDA TAKUJI
IPC分类号： C07C29/42 , C07C27/00 , C07C27/18 , C07C33/05 , C07C33/14 , C07C67/00 , C07C401/00 , C07C403/08 , C07C403/16

89. 发明专利

JPS6084255A PRODUCTION OF UNSATURATED NITRILE 失效
公开(公告)号：JPS6084255A
公开(公告)日：1985-05-13
申请号：JP19317883
申请日：1983-10-14
申请人： KURARAY CO
发明人： NOGAMI JIYUNZOU , OONISHI TAKASHI , FUJITA YOSHIJI , SHIONO MANZOU
IPC分类号： C07C255/07 , C07C67/00 , C07C253/00 , C07C253/30 , C07C255/31
摘要： PURPOSE:To produce an unsaturated nitrile useful as a synthetic intermediate of vitamin A, alphabeta.gammadelta.epsilonzeta-unsaturated carboxylic acid, etc., easily, in high yield, by the dehydrohalogenation reaction or decarboxylation reaction of an alpha,beta-unsaturated nitrile. CONSTITUTION:The objective compound of formula II is produced by reacting the alpha,beta-unsaturated nitrile of formula I (R is hydrocarbon group; A is CH -CH or CH=CH; n is 0-10; X is halogen or acyloxy) at 10-150 deg.C using a strong roganic base compound such as 1,8-diazabicyclo(5,4,0)-7-undecene, etc. as the dehydrohalogenation agent. The amount of the dehydrohalogenation agent is preferably 1-10 equivalent based on the alpha,beta-unsaturated nitrile. If necessary, the reaction is carried out in a hydrocarbon solvent such as benzene, toluene, etc.

90. 发明专利

JPS59161373A Dicarboxylic acid diester and its preparation 失效
标题翻译：二氧化硅酸及其制备方法
公开(公告)号：JPS59161373A
公开(公告)日：1984-09-12
申请号：JP3559983
申请日：1983-03-03
申请人： Kuraray Co Ltd
发明人： SHIONO MANZOU , FUJITA YOSHIJI , NISHIDA TAKUJI
IPC分类号： C08K5/00 , C07D311/72 , C07D311/92 , C07F7/18 , C08K5/15 , C08K5/1545 , C08K5/36 , C08K5/37 , C08L7/00 , C08L21/00 , C09K15/08
CPC分类号： Y02P20/55
摘要： NEW MATERIAL:The compound of formula I [R
1 is H or alkyl; R
2 is R
1 , alkoxy or together with R
1 form CH=CH-CH=CH; R
4 is H or protecting group; A is S, CH
2 S, S-S, CH
2 S-SCH
2 , SCH
2 S, or CH
2 SCH
2 SCH
2 ].
EXAMPLE: Di[2-( 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-benzopyranyl )-ethyl] thiodiacetate.
USE: An antioxidant or its precursor. It has higher antioxidation activity than vitamine E.
PREPARATION: The compound of formula I is prepared by reacting the 2-substituted ethyl alcohol of formula II (R is H or protecting group) with the dicarboxylic acid of formula IIIin an inert solvent in the presence of a dehydrative condensation agent or under azeotropic dehydration condition. The starting compound of formula II can be obtained easily by reacting hydroquinone of formula IV with 4-methyl-5,6-dihydro-2H-pyrane in the presence of a Lewis acid.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：新材料：式I化合物[R 1]为H或烷基; R 2是R 1，烷氧基或与R 1一起形成CH = CH-CH = CH; R 4是H或保护基; A是S，CH2S，S-S，CH2S-SCH2，SCH2S或CH2SCH2SCH2]。实施例：二[2-（3,4-二氢-6-羟基-2,5,7,8-四甲基-2H-苯并吡喃基） - 乙基]硫代二乙酸酯。使用：抗氧化剂或其前体。它具有比维生素E更高的抗氧化活性。制剂：式Ⅰ化合物是通过式Ⅱ的2-取代乙醇（R为H或保护基）与式Ⅲ二羧酸在惰性溶剂中反应来制备的，的脱水缩合剂或共沸脱水条件。在路易斯酸存在下，式IV的氢醌与4-甲基-5,6-二氢-2H-吡喃反应可以容易地得到式II的起始化合物。

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