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82. 发明专利

JPH01112981A SUPEROXIDE DISMUTASE DERIVATIVE AND COMPOSITION FOR ORAL ADMINISTRATION THEREOF 失效
公开(公告)号：JPH01112981A
公开(公告)日：1989-05-01
申请号：JP12970688
申请日：1988-05-26
申请人： MAEDA HIROSHI , KURARAY CO
发明人： MAEDA HIROSHI , SUZUKI FUJIO , ODA TATSUYA
IPC分类号： C07D309/08 , A61K38/45 , A61K47/00 , A61P9/00 , A61P9/10 , A61P29/00 , C12N9/02
摘要： NEW MATERIAL:A superoxide dismutase derivative expressed by formula I {[SOD] is superoxide dismutase having 1-22 or 24 groups obtained by removing one hydrogen atom from amino groups in place of the amino groups; [Z] is a monofunctional group of a copolymer having 500-200000 average molecular weight containing formula II (R1-R4 are H, provided that either of R1 and R2 and either of R3 and R4 each are H, or 1-8C alkanol, etc.) as constituent units, etc., n is an integer of 1-22 or 24 corresponding to the number of groups after removing one H from amino groups of the [SOD]; group CO free of OR -OR of COOR -COOR is bonded to the [SOD]} or a pharmacologically acceptable salt thereof. USE:A remedy for various inflammations and ischemic diseases capable of remarkably prolonging half-life in blood. PREPARATION:[SOD] is reacted with [Z]n in an aqueous solution of an alkali at pH7-11.

83. 发明专利

JPS63168468A HEAT-RESISTANT COATING COMPOSITION 失效
公开(公告)号：JPS63168468A
公开(公告)日：1988-07-12
申请号：JP31566286
申请日：1986-12-29
申请人： MAEDA HIROSHI
发明人： NAKAO ISATO
IPC分类号： C08K3/02 , C08G59/00 , C08G59/18 , C08L63/00 , C09D163/00
摘要： PURPOSE:To provide the title compsn. having excellent resistance to heat and corrosion, by blending a polyfunctional epoxy resin with fine powders of a specified natural mineral. CONSTITUTION:A polyfunctional epoxy resin (A) (e.g., a novolak epoxy resin having a novolak content of 40-60%) is blended with fine powder of a natural mineral (B) having a high K content and a low Ca content.

84. 发明专利

JPS6261926A CARCINOSTATIC AGENT 失效
公开(公告)号：JPS6261926A
公开(公告)日：1987-03-18
申请号：JP20160785
申请日：1985-09-13
申请人： MAEDA HIROSHI , AMANO PHARMA CO LTD
发明人： MAEDA HIROSHI , MATSUMURA YASUHIRO
IPC分类号： A61K38/46 , A61K35/74 , A61K38/48 , A61P35/00
摘要： PURPOSE:To provide a carcinostatic agent containing a microorganism-originated protease as an active component, exhibiting remarkable carcinostatic activity against various tumors, keeping the carcinostatic effect for a long period at the local point of the cancer and having low cytotoxicity to normal cell. CONSTITUTION:A protease originated from microorganism (e.g. neutral protease originated from Serratia marcescens) is used as an active component. The behavior of a polymeric carcinostatic agent applied locally to the tumor tissue is completely different from that of low-molecular carcinostatic agent. The polymeric substance is retained for a long period at the local tumor without being recovered and secreted either hematogenically nor lymphogenically. Accordingly, when the microorganism-originated polymeric protease is applied to the local position of cancer, an excellent carcinostatic effect can be attained and the drug action is continued for a long period. Furthermore, it has been found that the cytotocity against normal cell is considerably lower than the cytotoxity against cancer cell.

85. 发明专利

JPS60100522A CARCINOSTATIC AGENT 失效
公开(公告)号：JPS60100522A
公开(公告)日：1985-06-04
申请号：JP19367784
申请日：1984-09-14
申请人： MAEDA HIROSHI , ISHIDA NAKAO
发明人： MAEDA HIROSHI , KANAMARU RIYUUNOSUKE , ISHIDA NAKAO
IPC分类号： A61K38/00 , A61P35/00
摘要： PURPOSE:A carcinostatic agent containing a neocarzinostatin derivative having low toxicity, being accumulated specifically in lymphocyte. CONSTITUTION:A carcinostatic agent containing a compound shown by the formula (ring N is neocarzinostatin residue; R1+R2 is residue of styrene-maleic acid copolymer having 2,500-80,000mol.wt) as an active ingredient. Administration in tissue of affected part such as primary site of cancer, site from which cancer is extracted after operation, etc., intracutaneous, hypodermic, intramuscular, intravenous, and oral medication, etc., application to the affected part, and administration of external use such as suppository may be used as the administration. A dose is 0.1-10mg/kg/time/day, preferably once-twice per week or daily administration. The compound shown by the formula as the active ingredient is obtained by reacting neocarzinostatin with a styrene-maleic acid copolymer containing at least one maleic anhydride residue in the molecule in neutrality or in weak basicity at 0-40 deg.C.

89. 发明专利

JPS5635997A FLUORESCENT LYSOZYME BASE 失效
公开(公告)号：JPS5635997A
公开(公告)日：1981-04-08
申请号：JP11066779
申请日：1979-08-30
申请人： MAEDA HIROSHI
发明人： MAEDA HIROSHI
IPC分类号： G01N33/68 , C12Q1/34
摘要： PURPOSE:To obtain a lysozyme base capable of measuring lysozyme activity in high sensitivity quickly, by bonding a fluorescent dyestuff to a free amino group of peptide part of peptideglycane. CONSTITUTION:Peptideglycane obtained from the cell wall of mold of Micrococcus lysodeikticus, for example, is reacted with a fluorescent substance, e.g., fluoresein isothiocyanate, tetramethyl Rhodamine isocyanate, Dansyl Chloride, etc. so that the fluorescent dyestuff is bonded to the free amino group of the peptide part of peptideglycane, to give a fluorescent lysozyme base. The measurement of lysozyme activity is carried out by treating a lysozyme-containing sample with the fluorescent base and measuring fluorescent polarization value and fluorescence intensity with time.

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