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71. 发明专利

JPH0358711B2 失效
公开(公告)号：JPH0358711B2
公开(公告)日：1991-09-06
申请号：JP16899082
申请日：1982-09-27
申请人： KURARAY CO
发明人： KINUHATA KOICHI , OKADA MASAFUMI , SUGIURA TSUTOMU , ICHIHARA YOSHIHIRO , NISHIDA TAKUJI , TAKIGAWA TETSUO , MIZUNO MASAO
IPC分类号： C12P7/04 , C12R1/645 , C12R1/72 , C12R1/78 , C12R1/84 , C12R1/88

72. 发明专利

JPH0357919B2 失效
公开(公告)号：JPH0357919B2
公开(公告)日：1991-09-03
申请号：JP3125483
申请日：1983-02-25
申请人： KURARAY CO
发明人： FUMINO MASAYASU , HARADA HIDEMI , TSUJI MASAO , SUGIURA TSUTOMU , ICHIHARA YOSHIHIRO
IPC分类号： C07J7/00 , C07J31/00 , C12P33/16 , C12R1/05

73. 发明专利

JPH0147156B2 失效
公开(公告)号：JPH0147156B2
公开(公告)日：1989-10-12
申请号：JP3089882
申请日：1982-02-26
申请人： KURARAY CO
发明人： TSUJI MASAO , FUMINO MASAYASU , HARADA HIDEMI , SUGIURA TSUTOMU , ICHIHARA YOSHIHIRO
IPC分类号： C12P33/16 , C12P33/02 , C12R1/40

74. 发明专利

JPS6045174B2 失效
公开(公告)号：JPS6045174B2
公开(公告)日：1985-10-08
申请号：JP2751577
申请日：1977-03-11
申请人： KURARAY CO
发明人： OKADA MASAFUMI , ICHIHARA YOSHIHIRO , OOKAMI KATSUTOSHI
IPC分类号： C07C69/88 , A01N37/40 , A23L2/44 , A61K8/30 , A61K8/33 , A61K9/06 , C07C69/84

75. 发明专利

JPS59205396A 11beta-hydroxypregn-4-en-3-one-20-carbaldehyde and production thereof 失效
标题翻译： 11BETA-HYDROXYPREGN-4-EN-3-ONE-20-CARBALDEHYDE及其生产
公开(公告)号：JPS59205396A
公开(公告)日：1984-11-20
申请号：JP8123583
申请日：1983-05-09
申请人： Kuraray Co Ltd
发明人： TSUJI MASAO , MORI FUMIO , ICHIHARA YOSHIHIRO
IPC分类号： C12P33/16 , C07J7/00 , C07J9/00 , C12P33/00
CPC分类号： C12P33/005 , C07J9/00 , Y10S435/829
摘要： NEW MATERIAL:11β-Hydroxypregn-4-en-3-one-20-carbaldehyde.
USE: An intermediate for producing 11β-hydroxypregn-4-ene-3,20-dione which is a synthetic intermediate for corticoid based steroid as an anti-inflammatory agent.
PREPARATION: A bacterium, e.g. Alcaligenes faecalis D4020-K15 (FERM-P No. 204), belonging to the genus Alcaligenes is cultivated in a culture medium containing 11β-hydroxylithocholic acid and/or a salt thereof (preferably 2W50g/l concentration) preferably at 25W35°C for 10hrW7 days by the shaking culture or spinner culture method with aeration.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：新材料：11beta-羟基孕-4-烯-3-酮-20-甲醛。用途：制备作为抗炎剂的基于皮质类固醇的合成中间体的11β-羟基孕-4-烯-3,20-二酮的中间体。制备：细菌，例如属于产碱杆菌属的产碱杆菌D4020-K15（FERM-P No.204）在含有11β-羟基胡萝卜酸和/或其盐（优选2-50g / l浓度）的培养基中培养，优选在25-35 通过振荡培养或旋风培养法通气。

76. 发明专利

JPS59187000A Androsta-1,4,11 (12)-triene-3,17-dione 失效
标题翻译：安德罗萨-1,4,11（12） - 三烯-3,17-二酮
公开(公告)号：JPS59187000A
公开(公告)日：1984-10-23
申请号：JP6267783
申请日：1983-04-08
申请人： Kuraray Co Ltd
发明人： MORI FUMIO , TSUJI MASAO , SUGIURA TSUTOMU , ICHIHARA YOSHIHIRO
IPC分类号： C07J1/00 , C07J13/00 , C12P33/16
摘要： NEW MATERIAL:Androsta-1,4,11(12)-triene-3,17-dione of formula I .
USE: A synthetic intermediate of steroidal drugs such as sexual hormone or adrenocrotical hormone.
PREPARATION: 12-Hydroxyandrosta-1,4-diene-3,17-dione of formula II is, preferably dissolved in a solvent such as pyridine and its sulfonation is effected by adding 1W2 molar amount, per mole of the dione, of a sulfonyl chloride of the formula: RSO
2 Cl (R is alkyl) to give a sulfonate of formula III (the wavy line shows that the hydroxyl or RSO
2 O is either alpha-configuration or beta-configuration). Then the product is subjected to desulfonation to give the objective compound of formula I .
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：新材料：式I的雄甾-1,4,11（12） - 三烯-3,17-二酮。用途：类固醇药物如性激素或肾上腺皮质激素的合成中间体。制备：式II的12-羟基雄甾-1,4-二烯-3,17-二酮优选溶于溶剂如吡啶中，其磺化通过每摩尔二酮加入1-2摩尔量的下式的磺酰氯：RSO2Cl（R是烷基），得到式III的磺酸盐（波浪线表示羟基或RSO 2 O是α-构型或β-构型）。然后将产物脱磺化得到式I的目标化合物。

77. 发明专利

JPS5943453B2 JPS5943453B2 - 失效
公开(公告)号：JPS5943453B2
公开(公告)日：1984-10-22
申请号：JP2751477
申请日：1977-03-11
申请人： Kuraray Co
发明人： OKADA MASAFUMI , ICHIHARA YOSHIHIRO , OOKAMI KATSUTOSHI
IPC分类号： C07C69/88 , A01N37/10 , A01N37/40 , A23L2/44 , A23L3/34 , A23L3/3517 , A61K31/235 , A61P31/04

78. 发明专利

JPS5978698A Preparation of 12beta-hydroxyandrosta-1,4-diene-3,17-dione 失效
标题翻译： 12BETA-羟基吡喃-1,4-二烯-3,17-二酮的制备
公开(公告)号：JPS5978698A
公开(公告)日：1984-05-07
申请号：JP19057182
申请日：1982-10-28
申请人： Kuraray Co Ltd
发明人： TSUJI MASAO , FUMINO MASAYASU , HARADA HIDEMI , SUGIURA TSUTOMU , ICHIHARA YOSHIHIRO
IPC分类号： C12P33/16 , C12R1/40
摘要： PURPOSE: To collect the titled substance by cultivating a bacterium belonging to the genus Pseudomonas putida in a medium containing deoxycholic acid and/or its salt, to convert it into a raw material for synthesizing a steroid agent, etc. and to use it.
CONSTITUTION: A bacterium such as Pseudomonas putida D4014(FERM-P6325), etc., belonging to the genus Pseudomonas putida is cultivated in a medium containing deoxycholic acid/or its salt. An alkali metal salt such as potassium deoxycholate, sodium deoxycholate, etc. may be cited as the deoxycholate, and the concentration of its medium is preferably 2W50g/l. Glycose, glycerin, etc. is also preferably used as a carbon source, ammonium sulfate, peptone, etc. as a nitrogen source, and an inorganic salt are added to the medium, and the bacterium is cultivated at 25W35°C for 10hrW7 days aerobically. The culture solution is made alkali, extracted with an organic solvent, to give 12 β-hydroxyandrosta-1,4-diene-3,17-dione.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：通过在含有脱氧胆酸和/或其盐的培养基中培养属于恶臭假单胞菌属的细菌来收集标题物质，将其转化为合成类固醇剂等的原料并使用。构成：在含有脱氧胆酸/或其盐的培养基中培育属于恶臭假单胞菌的恶臭假单胞菌D4014（FERM-P6325）等细菌。可以列举脱氧胆酸钾，脱氧胆酸钠等碱金属盐作为脱氧胆酸盐，其介质浓度优选为2-50g / l。还优选使用糖，甘油等作为碳源，硫酸铵，蛋白胨等作为氮源，向无机盐中加入无机盐，将细菌在25-35℃培养， 10小时-7天有氧。培养液为碱，用有机溶剂萃取，得到12β-羟基雄甾-1,4-二烯-3,17-二酮。

79. 发明专利

JPS5959194A Preparation of beta,gamma-dihydropolyprenyl alcohol 失效
标题翻译：制备BETA，γ-二羟基丙基醇
公开(公告)号：JPS5959194A
公开(公告)日：1984-04-04
申请号：JP16899082
申请日：1982-09-27
申请人： Kuraray Co Ltd
发明人： KINUHATA KOUICHI , OKADA MASAFUMI , SUGIURA TSUTOMU , ICHIHARA YOSHIHIRO , NISHIDA TAKUJI , TAKIGAWA TETSUO , MIZUNO MASAO
IPC分类号： C12P7/04 , C12R1/645 , C12R1/72 , C12R1/78 , C12R1/84 , C12R1/88
摘要： PURPOSE: To prepare β,γ-dihydropolyprenyl alcohol by cultivating a fungus belonging to the genus Hansenula.
CONSTITUTION: A fungus such as Hansenula anomala IFO 0149 belonging to the genus Hansenula or a microorganism such as Kluyeromyces polysporus IFO 0996, etc. belonging to the genus Kluyeromyces, capable of producing β,γ-dihydropolyprenyl alcohol, is cultivated usually under aerobic conditions at about 4.0W 8.0pH at about 20W40°C for 10hr W about 5 days, and β,γ-dihydropolyprenyl alcohol is collected from a culture mold.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：通过培养属于汉逊酵母属的真菌来制备β，γ-二氢多萜烯醇。构成：通常在需氧条件下培育属于汉逊酵母属的汉逊酵母IFO 0149或属于克鲁维酵母属的克鲁维酵母属（Kluyeromyces polyporus）IFO 0996等微生物的真菌，约4.0〜8.0pH，约20-40℃，10小时〜约5天，从培养模中收集β，γ-二氢聚芘醇。

80. 发明专利

JPS58121800A PRODUCTION OF 7ALPHA-HYDROXYANDROSTA-1,4-DIENE-3,17-DIONE 失效
公开(公告)号：JPS58121800A
公开(公告)日：1983-07-20
申请号：JP208382
申请日：1982-01-08
申请人： KURARAY CO
发明人： SUGIURA TSUTOMU , ICHIHARA YOSHIHIRO
IPC分类号： C12P33/16 , C12P33/02
摘要： PURPOSE:A specific bacterium in Pseudomonas brevis is cultured in a medium containing 3alpha, 7alpha-dihydroxy-5beta-cholanic acid or its salt to produce the titled compound in high selectivity and yield. CONSTITUTION:A bacterium that produces 7alpha-hydroxyandrosta-1,4-diene-3,17- dione using 3alpha, 7alpha-dihydroxy-5beta-cholanic acid or its salt as a substrate, i.e., a strain of Pseudomonas brevis CD -21 (FERM-6275), is cultured in a medium containing 3alpha, 7alpha-dihydroxy-5beta-cholanic acid or its salt and the product, 7alpha- hydroxyandrosta-1,4-diene-3,17-dione, is collected in high selectivity and yield.

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