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71. 发明专利

JPH03215484A PRODUCTION OF 2',3'-DIDEOXY-BETA-RIBONUCLEOSIDE 失效
公开(公告)号：JPH03215484A
公开(公告)日：1991-09-20
申请号：JP697090
申请日：1990-01-16
申请人： JAPAN TOBACCO INC , YUKI GOSEI YAKUHIN KOGYO KK
发明人： KAWAKAMI HIROSHI , KOSEKI YUKIFUMI , EHATA TAKASHI , MATSUSHITA HAJIME , ITO KAZUO , NAOI YOSHITAKA
IPC分类号： C07D405/04 , A61K31/505 , A61P31/12 , A61P31/18
摘要： PURPOSE:To readily obtain the subject compound having an anti-AIDS virus effect and useful as a raw material of related compounds by carrying out a condensation reaction between a substituted pyrimidine derivative and a halogenodideoxy-pentofuranose derivative in the presence of a tertiary amine. CONSTITUTION:A condensation reaction is carried out between a 5-substituted pyrimidine derivative of formula I [R -R are (substituted)alkyl or phenyl; X is O or N having atoms or atomic groups; Y is H, (halogen-substituted)alkyl or alkenyl] and a 1-halogeno-2,3-dideoxy-pentofuranose derivative of formula II (R is OH-protecting group; Z is halogen) in the presence of a tertiary amine (e.g. triethylamine or pyridine) to obtain the objective 1-(2,3-deoxy-beta-D- pentofuranosyl)-pyrimidine derivative of formula III.

72. 发明专利

JPH03157388A PREPARATION OF SILANOLS 失效
公开(公告)号：JPH03157388A
公开(公告)日：1991-07-05
申请号：JP29540089
申请日：1989-11-14
申请人： YUKI GOSEI YAKUHIN KOGYO KK
发明人： KOSUGI YOKO , KOIKE HITOSHI , HIGUCHI SHIGEKI , NAOI YOSHITAKA
IPC分类号： C07F7/08
摘要： PURPOSE:To profitably prepare the subject compound useful for silicone products and used as a raw material for polyesters, etc., by hydrolyzing a hydrosilane in the coexistence of a platinum group metal catalyst and an aromatic nitro compound. CONSTITUTION:A hydrosilane having two or more silyl groups, 0.002-2wt.% (preferably 0.02-0.5wt.%) of a platinum group metal catalyst such as palladium catalyst, >=1/3 equivalent (per H group bonded to the silyl group of the hydrosilane) of an aromatic nitro compound such as nitrobenzene and 0.05-100wt.% of water are added to a solvent such as THF, subjected to a reaction at 0-100 deg.C for 0.1-24 hours and subsequently purified by a method such as a distillation method to provide the objective compound.

73. 发明专利

JPH03109384A PRODUCTION OF (S)-4-HYDROXYMETHYL-GAMMA-LACTONE 失效
公开(公告)号：JPH03109384A
公开(公告)日：1991-05-09
申请号：JP24494589
申请日：1989-09-22
申请人： JAPAN TOBACCO INC , YUKI GOSEI YAKUHIN KOGYO KK
发明人： KOSEKI YUKIFUMI , EBATA TAKASHI , KAWAKAMI HIROSHI , MATSUSHITA HAJIME , ITO KAZUO , NAOI YOSHITAKA
IPC分类号： C07D307/33 , C07D493/08
摘要： PURPOSE:To obtain the title compound useful as a feed additive for domestic animal and a synthetic raw material for nucleic acid as drug in high optical purity by oxidizing dihydrolevoglucosenone with a peracid in an organic solvent. CONSTITUTION:Dihydrolevoglucosenone shown by formula I is oxidized with a peracid (e.g. performic acid, peracetic acid, perbenzoic acid or perphthalic acid) to give the objective compound shown by formula II. The compound shown by formula I is preferably obtained by catalytically reducing levoglucosenone shown by formula III.

74. 发明专利

JPH0296653A DETERMINATION OF NUCLEIC ACID BASE SEQUENCE AND REAGENT KIT THEREFOR 失效
公开(公告)号：JPH0296653A
公开(公告)日：1990-04-09
申请号：JP24748088
申请日：1988-10-03
申请人： YUKI GOSEI YAKUHIN KOGYO KK , HITACHI ELECTR ENG
发明人： TAIRA MICHIO , TAKANO YUJI
IPC分类号： G01N33/58 , G01N27/447
摘要： PURPOSE:To improve the precision in determination of the sequence of bases of a deoxyribonucleic acid by a method wherein a pigment for coloring which is neutral electrically or charged in plus and different in behavior from a fragment of the nucleic acid in a sample thereof at the time of electrophoresis and does not have a functional power being active on the nucleic acid, is added to a solution of the sample of the nucleic acid. CONSTITUTION:A pigment for coloring which is neutral electrically or charged in plus and different in behavior from a fragment of a deoxyribonucleic acid in a sample thereof at the time of electrophoresis and does not have a functional power being active on the nucleic acid is added to a solution of the sample of the nucleic acid. Nile blue A, pararosaniline, neutral red or the like is used as this pigment. The addition of the pigment is made in such a manner that a formamide solution of the pigment of 0.05 to 0.1% is added, in a quantity of 1/3 to an equal quantity, to the sample for electrophoresis. By this method, an improvement in the precision of the quantity of a collected sample and the prevention of a human mistake at the time of injection of the sample are attained, and an improvement in the precision of determination of the sequence of bases of the nucleic acid can be attained.

75. 发明专利

JPS6251695A SYNTHESIS OF PHOSPHOROAMIDITE 失效
公开(公告)号：JPS6251695A
公开(公告)日：1987-03-06
申请号：JP19150785
申请日：1985-08-29
申请人： YUKI GOSEI YAKUHIN KOGYO KK
发明人： TANAKA TOSHIKI , TAMATSUKURI SHIGERU , IKEHARA MORIO
IPC分类号： C07H19/10 , C07H1/02 , C07H19/20 , C07H21/00
摘要： PURPOSE:To obtain the titled compound useful as a synthetic raw material for oligonucleotide in high yield, enabling the free and easy introduction of a phosphoric acid protecting group, by phosphatizing a nucleoside with a specific phosphatizing agent and reacting with an alcohol, etc. CONSTITUTION:The objective compound of formula (B is nucleic acid base residue which may have protecting group; R is OH-protecting group) can be produced by (1) reacting phosphorus trichloride with diisopropylamine to obtain N,N-diisopropylaminophosphodichloridite as a phosphatizing agent, (2) reacting the phosphatizing agent with a nucleoside having protected 5'-OH group to phosphatize the 3'-OH group and (3) reacting the obtained reaction intermediate with an alcohol, phenol, thiol or amine of formula R -XH [X is O, S or NH; R is (substituted) alkyl or aryl which can protect phosphoric acid group]. The compound of formula containing P-S bond or P-N bond is novel.

76. 发明专利

JPS6172791A Production of dialkoxydiphenylsilane 失效
标题翻译：对二氧代二苯基硅烷的生产
公开(公告)号：JPS6172791A
公开(公告)日：1986-04-14
申请号：JP19256984
申请日：1984-09-17
申请人： Toshiba Silicone Co Ltd , Yuki Gosei Yakuhin Kogyo Kk
发明人： IKOMA YOSHIHARU , ZENBAYASHI MICHIO , HIGUCHI SHIGEKI , NAOI YOSHITAKA
IPC分类号： C07F7/18
摘要： PURPOSE: An alkoxycyclodiphenylsilane obtained from dichlorophenylsilane and a monohydric saturated alcohol is subjected to reaction with a solvent amount of a monohydric saturated alcohol at a specific temperature to enable high-yield production of the titled compound of high purity in a shortened reaction time.
CONSTITUTION: An alkoxydiphenylsilane resulting from reaction of dichloro diphenylsilane with a monohydric saturated alcohol, preferably methanol such as chloromethoxydiphenylsilane is allowed to react with a monohydric saturated alcohol, preferably in an amount of 1.5W20 times the silane at -10W30°C using the same alcohol as a reaction solvent for 5W60min. Then, the reaction mixture is stood until it separates into 2 layers and the objective compound is obtained from the lower phase, e.g., in more than 97% purity and more than 90% yield.
COPYRIGHT: (C)1986,JPO&Japio
摘要翻译：目的：将由二氯苯基硅烷和一元饱和醇得到的烷氧基环烷基二甲硅烷与特定温度下的一元饱和醇的溶剂量反应，从而能够在缩短的反应时间内高产率制备高纯度的标题化合物。构成：使二氯二苯基硅烷与一元饱和醇（优选甲醇如氯甲氧基二苯基硅烷）反应得到的烷氧基二苯基硅烷与一元饱和醇反应，优选在-10-30℃下，硅烷的1.5-20倍使用相同的醇作为反应溶剂5-60分钟。然后，将反应混合物直到分离成2层，目标化合物从下相获得，例如纯度大于97％，产率高于90％。

77. 发明专利

JPS6144352A Method for fluorescent marking of polydeoxyribonucleotide or polyribonucleotide 失效
标题翻译：氟代二氧化碳或聚氨酯的荧光标记方法
公开(公告)号：JPS6144352A
公开(公告)日：1986-03-04
申请号：JP16536184
申请日：1984-08-07
申请人： Yuki Gosei Yakuhin Kogyo Kk
发明人： KOBAYASHI MAKOTO , SUGIMOTO NOBUTAKA
IPC分类号： G01N33/50 , C07H21/00 , C07H21/04 , C12Q1/68 , G01N21/76 , G01N21/78 , G01N33/52 , G01N33/533
CPC分类号： C12Q1/68
摘要： PURPOSE:To enhance the detection sensitivity of marked polynucleotide by an optical marking method, by introducing an optical marking compound into the thiophosphoric acid group of a nucleic acid constitutional element. CONSTITUTION:The fluorescent marking of polynucleotide is performed by converting the phosphoric acid bond of polynucleotide to a thiophosphoric acid bond and reacting the thiol group of the thiophosphoric acid bond with a covalently bondable fluorescent marking compound specifically reacting said thiol group. The above-mentioned polynucleotide having the thiophosphoric acid bond can be synthesized by an org. synthesis method or enzymatic method. Especially, in the former org. synthesis method, it is easiest to introduce the thiophosphoric group into both terminal hydroxyl groups of polynucleotide and thiophosphoric acid, thiophosphoryl chloride or derivatives thereof may be reacted under a known condition.
摘要翻译：目的：通过光学标记法提高标记多核苷酸的检测灵敏度，通过将光学标记化合物引入核酸结构元件的硫代磷酸基团。构成：多核苷酸的荧光标记通过将多核苷酸的磷酸键转化为硫代磷酸键，并使硫代磷酸键的硫醇基与与所述硫醇基特别反应的共价键合的荧光标记化合物反应来进行。上述具有硫代磷酸键的多核苷酸可以通过组织合成。合成方法或酶法。特别是在前组织。合成方法中，最好将硫代磷酸引入多核苷酸和硫代磷酸的两个末端羟基，硫代磷酰氯或其衍生物可以在已知条件下反应。

78. 发明专利

JPS59156290A Preparation of optically active alkyl or alkenylaryl sulfoxide 失效
标题翻译：光学活性亚烷基或亚乙基硫代氧化物的制备
公开(公告)号：JPS59156290A
公开(公告)日：1984-09-05
申请号：JP3208183
申请日：1983-02-28
申请人： Yuki Gosei Yakuhin Kogyo Kk
发明人： OOTA HIROMICHI , OKAMOTO YASUSHI , DOBASHI GENICHI
IPC分类号： C12P11/00 , C12R1/15
摘要： PURPOSE: To obtain the titled substance in high concentration of substrate in high optical yield in high reaction yield, by cultivating a specific mold in a medium containing an alkyl or alkenylaryl sulfide under aerobic culture conditions.
CONSTITUTION: A bacterium belonging to the genus Corynebacterium, capable of oxidizing sulfide in a medium containing an Alkyl or alkenylaryl sulfide. The cultivation is carried out by shaking culture under aerobic conditions at 20W 30°C, and a concentration of substrate used is preferably about 0.1W5.0wt%. An optically active alkyl or alkenylaryl sulfoxide is collected from the culture.
USE: A starting substance for synthesis of optically active hydroxy acid, synthesis of optically active secondary alcohol, and synthesis of optically active steroid.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：通过在需氧培养条件下在含有烷基或烯基芳基硫醚的培养基中培养特定的模具，以高的反应产率，以高光学收率获得高浓度底物的标题物质。构成：属于棒杆菌属的细菌，能够在含有烷基或烯基芳基硫醚的介质中氧化硫化物。通过在需氧条件下在20-30℃振荡培养进行培养，所用底物的浓度优选为约0.1-5.0重量％。从培养物中收集光学活性的烷基或链烯基芳基亚砜。用途：合成光学活性羟基酸的起始物质，光学活性仲醇的合成和光学活性类固醇的合成。

79. 发明专利

JPS59144760A Preparation of pyridinecarboxylic acid amide 1-oxide 失效
标题翻译：吡啶羧酸酰胺1-氧化物的制备
公开(公告)号：JPS59144760A
公开(公告)日：1984-08-18
申请号：JP1755583
申请日：1983-02-07
申请人： Yuki Gosei Yakuhin Kogyo Kk
发明人： NAOI YOSHITAKA , ITOU KAZUO , TAKIGUCHI TOSHIMI
IPC分类号： C07D213/89
摘要： PURPOSE: To prepare the titled substance useful as a preparation intermediate of pharmaceuticals, in high yield, by reacting pyridinecarbonitrile with hydrogen peroxide in an aqueous medium in the presence of a metal oxide.
CONSTITUTION: The objective compound of formula II can be prepared by reacting the compound of formula I with hydrogen peroxide at a molar ratio of 1:(1W2.5) in an aqueous solvent in the presence of a metal oxide at 60W90°C for 2W6hr. The metal oxide is e.g. tungstic acid, molybdic acid, vanadic acid, selenic acid, titanic acid, their alkali metal salts, ammonium salts, etc., and its amount is 0.1W5mol% based on the compound of formula I . The reaction product can be precipitated and separated easily by cooling the reaction liquid. The mother liquid of the reaction can be used as the reaction solvent for the next reaction.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：通过使吡啶腈与过氧化氢在金属氧化物的存在下在水性介质中反应，以高产率制备可用作药物制剂中间体的标题物质。构成：式II的目标化合物可以通过使式I化合物与摩尔比为1：（1-2.5）的过氧化氢在水溶液中在金属氧化物存在下在60-90℃下反应来制备。 C为2-6小时。金属氧化物是例如。钨酸，钼酸，钒酸，硒酸，钛酸，其碱金属盐，铵盐等，其量为基于式I化合物的0.1-5mol％。通过冷却反应液可以容易地沉淀和分离反应产物。反应的母液可以用作下一反应的反应溶剂。

80. 发明专利

JPS5776099A Antioxidation for oils and fats 失效
标题翻译：油和脂肪的抗氧化
公开(公告)号：JPS5776099A
公开(公告)日：1982-05-12
申请号：JP15331380
申请日：1980-10-31
申请人： Yuki Gosei Yakuhin Kogyo Kk
发明人： NIIMI ICHIOU , FUNAZASHI SHIGENOBU
IPC分类号： A23B4/03 , A23B4/14 , A23B4/20 , A23L3/34 , A23L3/3544 , A23L17/00 , C11B5/00

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