专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 发明专利

JPH11286486A NEW PHYSIOLOGICALLY ACTIVE SUBSTANCE AND ITS PRODUCTION 失效
公开(公告)号：JPH11286486A
公开(公告)日：1999-10-19
申请号：JP8858498
申请日：1998-04-01
申请人： SNOW BRAND MILK PROD CO LTD
发明人： KUROSAWA KAZUHIKO , TAKAHASHI KIMISAKI , OINUMA TOSHIO , WASHIDA NAOHIRO , TOO KANJI
IPC分类号： C12P17/08 , A61K31/335 , A61K31/357 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/00 , A61P37/06 , A61P37/08 , C07D323/00 , C12N1/20 , C12R1/465
摘要： PROBLEM TO BE SOLVED: To obtain a new compound having immunosuppression activity, antiallergic activity, antitumor activity and multidrug resistance overcoming action and useful as an inhibitor for immunorejection due to organ transplantation, etc., a therapeutic agent for allergic diseases such as atopic dermatitis and a therapeutic agent, etc., for autoimmune diseases such as chronic rheumatoid arthritis. SOLUTION: This compound is represented by the formula (R is H or a 1-5C lower alkyl). The compound of the formula is obtained by culturing a microorganism, preferably Streptomyces sp.-SNA15896 strain (FERM P-16667), preferably at pH of culture medium of 4-8 and 25-30 deg.C culture temperature for 96-144 hr culturing time by a method of shaking culture, deep submerged culture, etc., using a medium comprising carbon source such as glucose or soluble starch, a nitrogen source such as soybean flour or ammonium sulfate, an inorganic salt such as magnesium sulfate or potassium primary phosphate to produce a compound of the formula in the culture solution and collecting the compound by utilizing usual separation means.

62. 发明专利

JPH11196862A NEW STRAIN OF STREPTOMYCES AND ITS UTILIZATION 失效
公开(公告)号：JPH11196862A
公开(公告)日：1999-07-27
申请号：JP22969498
申请日：1998-08-14
申请人： DEV CENTER FOR BIOTECHNOL
发明人： MIN SHAN , MAN YAN KOO , KEI CHII CHU , HAI PIN LEE , PAO CHI CHAN , SHU IN CHAN
IPC分类号： C12P17/08 , A01N43/22 , A01N63/00 , A01N63/02 , C07D313/00 , C12N1/20 , C12R1/51
摘要： PROBLEM TO BE SOLVED: To obtain a prepared medium effective for a fungus, capable of promoting germination of a seed and useful as a biological agrochemical agent by culturing a specific strain of Streptomyces candidus. SOLUTION: This prepared medium containing borrelidin as an active component is obtained by culturing a microorganism, Streptomyces candidus Y21007-2 (ATCC 202148) or its mutant or its variant isolated from a soil sample collected in Peng-Hu islands, Taiwan.

63. 发明专利

JP2897834B2 失效
公开(公告)号：JP2897834B2
公开(公告)日：1999-05-31
申请号：JP23824789
申请日：1989-09-13
申请人： KITAZATO KENKYUSHO
发明人： OOMURA SATOSHI , IKEDA HARUO
IPC分类号： C12P17/08 , C12N1/20 , C12P17/18 , C12R1/465

64. 发明专利

JPH09224687A POLYKETIDE-SYNTHASE GENE 失效
公开(公告)号：JPH09224687A
公开(公告)日：1997-09-02
申请号：JP3602097
申请日：1997-02-20
申请人： LILLY CO ELI
发明人： BURATSUDORII SUCHIYUAATO DEIHO , SUCHIYUAATO AREN KUSUTOSU , POORU ROBAATO ROSUTETSUKU JIYU , KINBARII RIN SATSUTON
IPC分类号： C12N15/09 , C12N9/00 , C12N15/00 , C12N15/52 , C12P17/08 , C12P19/62 , C12R1/465 , C12R1/54

65. 发明专利

JPH08182496A SUBSTANCE FO-2942 AND ITS PRODUCTION 失效
公开(公告)号：JPH08182496A
公开(公告)日：1996-07-16
申请号：JP53495
申请日：1995-01-06
申请人： KITASATO INST
发明人： OMURA SATOSHI , KODA HIROSHI , MASUMA ROKUROU
IPC分类号： C12P13/02 , A61K31/235 , A61P3/04 , A61P3/06 , C12P17/08 , C12R1/645
摘要： PURPOSE: To obtain the subject new substance capable of manifesting the inhibiting activities against a diacylglycerolacyltransferase and useful for prevention, treatment, etc., of obesity, hyperlipemia, arteriosclerosis, etc., by culturing a microorganism, belonging to the genus Humicola and having the ability to produce a substance FO-2942. CONSTITUTION: This new substance FO-2942 is represented by the formula (R is methyl or isopropyl when R is H; R is methyl when R is methyl). The substance FO-2942 is useful for prevention and treatment, etc., of various adult diseases caused by accumulation of triacylglycerols in humans, e.g. diseases such as obesity, hyperlipemia and further arteriosclerosis based thereon due to the manifestation of inhibiting activities thereof against a diacylglycerolacyltransferase. This substance is obtained by culturing a microorganism, belonging to the genus Humicola and having the ability to produce the substance FO-2942 [e.g. Humicola sp. FO-2942 strain (FERM P-14671)] in a culture medium and then recovering the resultant product from the cultured product.

66. 发明专利

JPH0692414B2 失效
公开(公告)号：JPH0692414B2
公开(公告)日：1994-11-16
申请号：JP19894590
申请日：1990-07-26
IPC分类号： C12P17/18 , A01N43/90 , A23K20/195 , A61K31/365 , A61P3/00 , A61P33/00 , A61P33/10 , C07D493/22 , C12N1/20 , C12P17/08 , C12R1/465

67. 发明专利

JPH0637501B2 失效
公开(公告)号：JPH0637501B2
公开(公告)日：1994-05-18
申请号：JP17747386
申请日：1986-07-28
IPC分类号： C07D493/22 , A01N43/90 , A23K20/195 , A61K31/365 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P33/00 , A61P33/10 , C07H17/08 , C07H19/01 , C12P17/08 , C12P17/18 , C12P19/62 , C12R1/465 , A61K31/71
摘要： The invention provides novel compounds having the formula:wherein the broken line at the 22-23 position represents an optional double bond and wherein R' is H or OH and the double bond is absent, or, the double bond is present and R' is absent; R 2 is an alpha-branched C 3 -C 8 alkyl, alkenyl, alkynyl, alkoxyalkyl or alkylthioalkyl group; a C 3 -C 8 cycloalkyl, C 5 -C 8 cycloalkenyl or C 5 -C 8 cycloalkylalkyl group, any of which may optionally be substituted by methylene or one or more C 1 -C 4 alkyl groups or halo atoms; or a 3 to 6 membered oxygen or sulphur containing heterocyclic ring which may optionally be substituted by one or more C 1 -C 4 alkyl groups or halo atoms; R 3 is hydrogen or methyl; R 4 is H or 4'-(alpha-L-oleandrosyl)-alpha-L-oleandrosyloxy, with the proviso that when R 2 is alkyl it is not isopropyl or sec-butyl, and when R 4 is H, R 1 is OH, and the double bond is absent, R 2 is not 2-buten-2-yl, 2-pentene-2-yl or 4-methyl-2-pentene-2-yl. The compounds are broad spectrum antiparasitic agents having utility as anthelmintics, ectoparasiticides, insecticides and acaricides. The invention also provides a process for producing the novel avermectin and milbemycin derivatives by adding a carboxylic acid or derivative thereof to a fermentation of an avermectin or milbemycin producing organism.

68. 发明专利

JPH0690772A PREPARATION OF OPTICALLY ACTIVE GAMMA- HYDROXYDECANOIC ACID 失效
公开(公告)号：JPH0690772A
公开(公告)日：1994-04-05
申请号：JP8558993
申请日：1993-03-18
申请人： FRITZSCHE DODGE & OLCOTT INC
发明人： MOHAMADO AI FUAABUDO , BURAIAN JIEI UIRISU
IPC分类号： C12P7/42 , C12P17/02 , C12P17/08 , C12R1/645 , C12R1/69 , C12R1/72 , C12R1/725 , C12R1/74 , C12R1/85

69. 发明专利

JPH069514B2 失效
公开(公告)号：JPH069514B2
公开(公告)日：1994-02-09
申请号：JP18747987
申请日：1987-07-27
申请人： UNILEVER NV
发明人： PIITAA SAMUERU JEEMUSU CHIISAMU , KYASARIIN AN MOOME , YOHANESU FURANSHISUKASU MARIA DE ROOIYU
IPC分类号： C07D307/33 , C07D307/32 , C07D315/00 , C12N1/38 , C12P7/42 , C12P17/04 , C12P17/08 , C12R1/645

70. 发明专利

JPH05306271A 失效
公开(公告)号：JPH05306271A
公开(公告)日：1993-11-19
申请号：JP28995892
申请日：1992-10-28
申请人： LILLY CO ELI , UNIV HAWAI
发明人： ROZANNU BONJIYOUKURIAN , RICHIYAADO ERIOTSUTO MUUA , GUREGORII MASHIYUU REON PATAAS , TEIMU AREN SUMITOKA
IPC分类号： A61K31/40 , A01N43/38 , A01N43/90 , A61K31/403 , A61P31/04 , A61P35/00 , C07D209/56 , C07D209/70 , C07D209/80 , C07D491/06 , C07D491/08 , C12N1/12 , C12P17/08 , C12P17/10 , C12P17/18 , C12R1/89

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式