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61. 发明专利

JP2012509283A Method for the treatment or prevention of pancreatic dysfunction 有权
标题翻译：空值
公开(公告)号：JP2012509283A
公开(公告)日：2012-04-19
申请号：JP2011536703
申请日：2009-11-19
申请人：アンジオブラストシステムズ,インコーポレーテッド
发明人：イテスク，シルビウ , クリシュナン，ラビ
IPC分类号： A61K35/12 , A61P1/18 , A61P3/10 , A61P5/48 , A61P35/00 , A61P37/02 , A61P43/00 , C12N5/071
CPC分类号： A61K35/545 , A61K35/12 , A61K45/06 , C12N5/0676 , G01N33/66 , G01N33/6893 , G01N33/74 , G01N2333/47 , G01N2333/62 , G01N2800/042
摘要：本発明は、それを必要とする被験体において膵機能を改善する方法を提供し、本方法は、被験体にＳＴＲＯ−１
＋細胞および／またはその子孫細胞および／またはそれらに由来する可溶性因子を投与するステップを含む。本発明の方法は、膵機能障害によりもたらされる、または膵機能障害に関連する障害、例えば、膵臓の内分泌機能または外分泌機能の異常によりもたらされる障害の治療および／または予防および／または発症もしくは進行の遅延のために有用である。
摘要翻译：本发明提供了一种在有需要的受试者中改善胰腺功能的方法，所述方法包括给予受试者STRO-1 +细胞和/或其后代细胞和/或由其衍生的可溶性因子。本发明的方法可用于治疗和/或预防和/或延缓由胰腺功能障碍引起或与胰腺功能障碍相关的疾病的发作或进展，例如由胰腺的内分泌或外分泌功能异常引起。

62. 发明专利

JP2012027008A Method for measuring blood plasma glucose 有权
标题翻译：测量血浆血浆葡萄糖的方法
公开(公告)号：JP2012027008A
公开(公告)日：2012-02-09
申请号：JP2011127853
申请日：2011-06-08
申请人： Arkray Inc , アークレイ株式会社
发明人： TAKAGI TAKESHI , OKUMURA KOJI
IPC分类号： G01N33/66 , G01N21/78 , G01N27/327 , G01N27/416 , G01N33/48 , G01N33/72
CPC分类号： G01N33/66 , C12Q1/006 , G01N33/726
摘要： PROBLEM TO BE SOLVED: To provide a technology for raising accuracy of measurement of concentration of blood plasma glucose.SOLUTION: The blood plasma glucose is measured through the following steps. The steps are: sample preparation steps (S101, S102) of hemolyzing blood cells in blood to prepare a sample for measurement; whole blood glucose measurement steps (S103-S105) of measuring glucose concentration of the whole blood using the measurement sample; and a whole blood liquid component ratio calculation step (S109) of calculating liquid component ratio of the whole blood from ratio between the blood cells and the blood plasma, liquid component ratio of the blood cells and liquid component ratio of the blood plasma which are known values in the blood.
摘要翻译：要解决的问题：提供一种提高血浆葡萄糖浓度测量精度的技术。
解决方案：通过以下步骤测量血浆葡萄糖。步骤是：血液中血细胞溶血的样品制备步骤（S101，S102），以制备用于测量的样品; 使用测定样品测定全血的葡萄糖浓度的全血糖值测定步骤（S103〜S105）以及全血液成分比率计算步骤（S109），其计算全血的血液成分比例，血细胞与血浆之间的比例，血细胞的液体成分比和已知的血浆的液体组分比血液中的价值观版权所有（C）2012，JPO＆INPIT

63. 发明专利

JP2011169913A Method and product related to low molecular weight heparin 有权
标题翻译：低分子量肝素相关的方法和产品
公开(公告)号：JP2011169913A
公开(公告)日：2011-09-01
申请号：JP2011098811
申请日：2011-04-26
申请人： Massachusetts Inst Of Technology , マサチューセッツインスティテュートオブテクノロジー
发明人： SUNDARAM MALLIKARJUM , VENKATARAMAN GANESH , SHRIVER ZACHARY , LIU DONGFANG , QI YIWEI , SASISEKHARAN RAM
IPC分类号： G01N27/447 , G01N33/50 , A61K31/715 , A61K31/727 , A61P7/02 , A61P9/10 , A61P35/00 , C12Q1/34 , C12Q1/48 , G01N27/26 , G01N30/88 , G01N33/00 , G01N33/15 , G01N33/66 , G01N33/86
CPC分类号： G01N33/66 , A61K31/727 , C08B37/0075 , C12P19/26 , G01N33/86 , G01N2400/10 , G01N2400/40 , Y10T436/143333
摘要： PROBLEM TO BE SOLVED: To provide a method and product for characterizing and using polysaccharide. SOLUTION: There are provided a method and product for characterizing and using polysaccharide. Low molecular weight heparin product and method of use are described. The method for characterizing purity and activity of polysaccharid preparations including glycosaminoglycans such as heparin are also described. The method is for analyzing includes: (A) a step of generation the decorated polysaccharide applying an experimental restriction to the polysaccharide in a sample and having signature component; (B) a step of detecting existence of the signature component in the sample as an index showing that the polysaccharide exists in the sample; and (C) a step of determining the existence or nonexistence of the signature component and analyzing the sample. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供用于表征和使用多糖的方法和产品。解决方案：提供了表征和使用多糖的方法和产品。描述了低分子量肝素产品和使用方法。还描述了包括糖胺聚糖如肝素在内的多糖制剂的纯度和活性的表征方法。所述分析方法包括：（A）在样品中对所述多糖进行实验限制并具有特征成分的装饰多糖的生成步骤; （B）检测样品中特征成分的存在的步骤作为示出样品中存在多糖的指标; 和（C）确定签名组件的存在或不存在并分析样本的步骤。版权所有（C）2011，JPO＆INPIT

64. 发明专利

JP2011522231A Means and methods to evaluate the liver enzyme induction 审中-公开
公开(公告)号：JP2011522231A
公开(公告)日：2011-07-28
申请号：JP2011510975
申请日：2009-05-25
申请人：ビーエーエスエフソシエタス・ヨーロピアBasf Se
发明人：ヴィーマー，ヤン，ツェー． , ウォーク，ティルマン，ベー． , カンプ，ヘニッケ , パレルモクーニャ，ジョージアコエーリョ , シュトラウス，フォルカー , ファビアン，エリック , プロコディーヌ，アレクサンドル , ヘロルド，ミヒャエル，マンフレッド , メラート，ヴェルナー , ヴァンラヴェンツヴァーイ，ベナード , ルーサー，ラルフ , レイボルド，エドガー
IPC分类号： G01N33/50 , G01N27/62 , G01N30/72 , G01N33/15 , G01N33/92
CPC分类号： G01N33/66 , G01N33/84 , G01N33/92 , G01N2405/00 , G01N2500/00 , G01N2800/085 , G01N2800/50 , G01N2800/60
摘要： The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing the pro-pathological effect of compounds which are inducing liver enzymes. It also relates to a method of determining whether a compound is capable of exhibiting pro-pathological effects on the liver by enzyme induction in a subject and to a method of identifying a drug for treating the pro-pathological effect of liver enzyme induction. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five analytes, a data storage medium comprising said data collection, and a system and a device for diagnosing the pro-pathological effect of liver enzyme induction. Finally, the present invention pertains to the use of a group of analytes or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing the pro-pathological effect of liver enzyme induction in a subject. For each sex, a different metabolome pattern, i.e. a different set of analytes is disclosed. The liver enzyme induction markers are mainly selected from free fatty acids, but also include various phosphatidylcholines, galactose, 3- and 5-Methoxysphingosine, Cholesterol, Threonic acid, 1,2-Dioleoyl-sn-glycero-3-phosphatidyl-L-serine, Glycerol, Glycerophosphate, Dodecanol, myo-Inositol-2-monophosphate.

65. 发明专利

JP4665235B2 Fad-binding glucose dehydrogenase gene 有权
公开(公告)号：JP4665235B2
公开(公告)日：2011-04-06
申请号：JP2008522658
申请日：2007-06-29
申请人：池田食研株式会社
发明人：浩士宮本 , 通済本田 , 貴子矢田
IPC分类号： C12N15/09 , C12N1/15 , C12N9/04 , C12Q1/32
CPC分类号： C12N9/0006 , C12Q1/006 , C12Q1/32 , C12Q1/54 , C12Y101/9901 , G01N27/301 , G01N27/302 , G01N27/3271 , G01N33/66 , G01N2333/902 , G01N2333/904 , Y10T29/49117
摘要： Disclosed herein are a gene (polynucleotide) encoding an FAD-conjugated glucose dehydrogenase which can be characterized by reactivity to glucose, thermal stability, substrate-recognition performance, and low activity for maltose; a process for the production of the enzyme using a transformant cell transfected with the gene; a method for the determination of glucose; a reagent composition for use in the determination of glucose; and a biosensor for use in the determination of glucose. An embodiment is a polynucleotide encoding an FAD-conjugated glucose dehydrogenase, comprising a polypeptide whose amino acid sequence comprises X1-X2-X3-X4-X5-X6, wherein X1 and X2 independently represent an aliphatic amino acid residue; X3 and X6 independently represent a branched amino acid residue; and X4 and X5 independently represent a heterocyclic amino acid residue or an aromatic amino acid residue.

66. 发明专利

JP2011055836A Fad-conjugated glucose dehydrogenase gene 有权
标题翻译： FAD-结合葡萄糖脱氢酶基因
公开(公告)号：JP2011055836A
公开(公告)日：2011-03-24
申请号：JP2010232518
申请日：2010-10-15
申请人： Ikeda Shokken Kk , 池田食研株式会社
发明人： YADA TAKAKO , MIYAMOTO HIROSHI , HONDA MICHINARI
IPC分类号： C12M1/34 , C12N15/09
CPC分类号： C12N9/0006 , C12Q1/006 , C12Q1/32 , C12Q1/54 , C12Y101/9901 , G01N27/301 , G01N27/302 , G01N27/3271 , G01N33/66 , G01N2333/902 , G01N2333/904 , Y10T29/49117
摘要： PROBLEM TO BE SOLVED: To provide: a novel gene (polynucleotide) encoding an FAD-conjugated glucose dehydrogenase having excellent properties that it has excellent reactivity to glucose, excellent thermal stability, and excellent substrate-recognition performance and also has a low activity for maltose; a process for the production of the enzyme using a transformant cell transfected with the gene; and a method for the determination of glucose, a reagent composition for use in the determination of glucose, a biosensor for use in the determination of glucose and others, each characterized by using the enzyme obtained. SOLUTION: An FAD-conjugated glucose dehydrogenase, comprises a polypeptide containing an amino acid sequence: X1-X2-X3-X4-X5-X6 (wherein X1 and X2 independently represent an aliphatic amino acid; X3 and X6 independently represent a branched amino acid; and X4 and X5 independently represent a heterocyclic amino acid or an aromatic amino acid). The FAD-conjugated glucose dehydrogenase is used for the biosensor for use in the determination of glucose. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供：编码与葡萄糖具有优异的反应性，优异的热稳定性和优异的底物识别性能的优异性质的FAD-缀合的葡萄糖脱氢酶的新型基因（多核苷酸），并且还具有低麦芽糖活动使用用该基因转染的转化体细胞来生产酶的方法; 和测定葡萄糖的方法，用于测定葡萄糖的试剂组合物，用于测定葡萄糖的生物传感器等，其特征在于使用所得的酶。解决方案：FAD-缀合的葡萄糖脱氢酶包含含有氨基酸序列的多肽：X1-X2-X3-X4-X5-X6（其中X1和X2独立地表示脂族氨基酸; X3和X6独立地表示支链氨基酸; X4和X5独立地表示杂环氨基酸或芳香族氨基酸）。 FAD-共轭葡萄糖脱氢酶用于生物传感器用于测定葡萄糖。版权所有（C）2011，JPO＆INPIT

67. 发明专利

JP4656731B2 Polysaccharides structure and sequencing 有权
公开(公告)号：JP4656731B2
公开(公告)日：2011-03-23
申请号：JP2000616422
申请日：2000-05-04
申请人：プロコグニア (イスラエル) リミテッド
发明人：オファーマークマン，
IPC分类号： G01N33/53 , C12M1/40 , C12Q1/34 , C12Q1/48 , G01N33/02 , G01N33/15 , G01N33/50 , G01N33/543 , G01N33/66
CPC分类号： G01N33/66 , C12Q1/34 , G01N33/5308 , G01N2333/42 , G01N2333/924 , G01N2400/00 , G01N2400/02 , G01N2400/10 , Y10T436/143333

68. 发明专利

JP2011506966A Gradient-based correction 有权
公开(公告)号：JP2011506966A
公开(公告)日：2011-03-03
申请号：JP2010538067
申请日：2008-12-06
申请人：バイエル・ヘルスケア・エルエルシーBayer HealthCare LLC
发明人：ウ，ホァン−ピン
IPC分类号： G01N27/26 , G01N21/76 , G01N27/416 , G01N33/48 , G01N33/66
CPC分类号： G01N33/66 , G01N27/3273
摘要：バイオセンサシステムは、被分析物の光識別可能な種またはレドックス反応から生成された出力信号から、被分析物濃度を判定する。バイオセンサシステムは、出力信号から抽出された１つ以上の指数関数で、出力信号から被分析物濃度を判定するために、相関関係を調整する。指数関数は、１つ以上のエラーパラメータからの、少なくとも１つの勾配偏差値ΔＳまたは正規化勾配偏差を決定する。被分析物濃度と出力信号との間の勾配調整された相関関係は、バイアスに起因する成分を含む出力信号から、改善された確度および／または精度を有する被分析物濃度を判定するために使用されてもよい。

69. 发明专利

JP2010237199A Method for analysis of saccharides 有权
标题翻译：分析方法
公开(公告)号：JP2010237199A
公开(公告)日：2010-10-21
申请号：JP2010054203
申请日：2010-03-11
申请人： Jcr Pharmaceuticals Co Ltd , 日本ケミカルリサーチ株式会社
发明人： YOKOYAMA TETSUO
IPC分类号： G01N30/88 , G01N21/64 , G01N30/26 , G01N30/54 , G01N30/74 , G01N30/84
CPC分类号： G01N33/66 , G01N30/02 , G01N30/30 , G01N30/34 , G01N30/74 , G01N30/84 , G01N30/96 , G01N2030/8435 , G01N2030/8836 , Y10T436/143333 , Y10T436/144444 , B01D15/363
摘要： PROBLEM TO BE SOLVED: To provide a post-column fluorimetric determination-boric acid complex anion exchange method, capable of analyzing mannose-6-phosphate.
SOLUTION: The disclosed method is a method for separation analysis of reducing sugars using column chromatography, comprising loading a sample onto an anion exchange column, cleaning the column by allowing to flow a sufficient volume of a first mobile phase consisting of an aqueous solution of boric acid containing a water-soluble inorganic salt through the column concerned; supplying a second mobile phase with an elevated concentration of the salt concerned to elute the reducing sugars; adding a basic amino acid to the eluate, heating; and containing to measure continuously and to record the intensity of fluorescent light emitted under irradiation with an exciting light.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供能够分析甘露糖-6-磷酸的柱后荧光测定 - 硼酸络合物阴离子交换法。解决方案：所公开的方法是使用柱色谱法分离分析还原糖的方法，其包括将样品加载到阴离子交换柱上，通过允许将足够体积的由水溶液通过相关柱含有水溶性无机盐的硼酸溶液; 提供具有提高浓度的相关盐的第二流动相以洗脱还原糖; 向洗脱液中加入碱性氨基酸，加热; 并且包含连续测量并记录用激发光照射的荧光的强度。版权所有（C）2011，JPO＆INPIT

70. 发明专利

JP2010148515A METHOD FOR MEASURING HEMOGLOBIN A1c, ENZYME TO BE USED THEREFOR, AND METHOD FOR PRODUCING THE SAME 有权
标题翻译：用于测量HEMOGLOBIN A1c的方法，其使用的酶及其生产方法
公开(公告)号：JP2010148515A
公开(公告)日：2010-07-08
申请号：JP2010035797
申请日：2010-02-22
申请人： Asahi Kasei Pharma Kk , Ichibiki Kk , イチビキ株式会社 , 旭化成ファーマ株式会社
发明人： MATSUOKA TAKESHI , KOGA SHINJI , TAKATSUMA TAKUJI , YOSHIOKA ISSEI , NISHIMURA ATSUHISA , ITO HOMARE , KUMAZAWA TOSHIHIKO , AZEYANAGI TAKASHI
IPC分类号： C12N15/09 , C12N1/20 , C12N1/21 , C12N9/02 , C12N9/06 , C12N9/50 , C12N9/52 , C12N15/53 , C12Q1/26 , C12Q1/37 , G01N33/66 , G01N33/72
CPC分类号： C12N9/0004 , C12N9/50 , C12Q1/37 , C12R1/01 , C12R1/07 , G01N33/66 , G01N33/723 , G01N2333/95
摘要： PROBLEM TO BE SOLVED: To provide a method for specifically measuring a glycated β-chain N-terminal of glycated hemoglobin using an enzyme without performing separating operation, and to provide a determination reagent kit therefor. SOLUTION: The method for specifically measuring the glycated β-chain N-terminal of the glycated hemoglobin includes using a protease obtained by screening the protease cleaving a glycated amino acid and/or a glycated peptide from the glycated β-chain N-terminal without substantially cleaving the glycated amino acid or glycated peptide from a glycated α-chain N-terminal of the glycated hemoglobin or a fragment thereof. Furthermore, the determination reagent kit therefor is provided. Thereby, the glycated β-chain N-terminal of the glycated hemoglobin can specifically be measured without performing the separating operation. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种使用酶进行糖基化的β-链N-末端糖基化血红蛋白的分离方法，并且提供其测定试剂盒。解决方案：特异性测定糖化血红蛋白的糖基化β-链N-末端的方法包括使用通过筛选从糖基化的β-链N-末端切割糖基化氨基酸和/或糖化肽的蛋白酶获得的蛋白酶，不从糖化血红蛋白的糖化α-链N末端或其片段基本上切割糖基化氨基酸或糖化肽。此外，提供了其测定试剂盒。由此，可以在不进行分离操作的情况下，具体地测定糖化血红蛋白的糖化β-链N-末端。版权所有（C）2010，JPO＆INPIT

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