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52. 发明专利

JP3760287B2 Cosmetics 失效
公开(公告)号：JP3760287B2
公开(公告)日：2006-03-29
申请号：JP31416494
申请日：1994-11-24
申请人：株式会社コーセー
发明人：徹清水 , 留佳鈴木
IPC分类号： A61K8/60 , C07H5/06 , A61K8/00 , A61Q1/00 , A61Q1/10 , A61Q3/02 , A61Q19/00 , C07H13/02

53. 发明专利

JP2006503848A How to bifunctional heterocyclic compound and making them use 审中-公开
公开(公告)号：JP2006503848A
公开(公告)日：2006-02-02
申请号：JP2004540011
申请日：2003-09-26
申请人：リブ−エックスファーマシューティカルズ,インコーポレイテッドRib−X Pharmaceuticals, Inc.
发明人：ジョンエヌ．アベルソン， , ジョセフエー．イポリト， , アデグボイエガケー．オイエレア， , ジョエルエー．ゴールドバーグ， , ジョイスエー．サトクリッフェ， , ジョセフエム．サルビノ， , デーンエム．スプリンガー， , エリンエム．ダフィー， , アショークバッタチャルジー， , ジェージェイ．ファーマ， , ティモシーエス．マッコーネル， , ロンリャンルー， , デピンワン，
IPC分类号： C07D413/06 , A61K31/5377 , A61K31/7056 , A61K31/706 , A61P1/00 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/00 , A61P35/00 , C07D413/02 , C07D417/02 , C07H5/06 , C07H17/00 , C07H17/08
CPC分类号： A61K31/42 , A61K31/44 , A61K31/497 , A61K31/5375 , A61K31/7048 , C07H17/00
摘要：本発明は、抗感染薬、抗増殖薬、抗炎症薬およびプロキネチック薬として有用な系統の二官能性複素環化合物を提供する。本発明はまた、該二官能性複素環化合物を製造する方法、および抗感染薬、抗増殖薬、抗炎症薬および／またはプロキネチック薬としてこのような化合物を使用する方法を提供する。１つの実施形態において、次式を有する化合物、またはそれらの薬学的に受容可能な塩、エステルまたはプロドラッグ：
【化１】

を提供する。Ａは、各出現例にて、別個に、炭素、カルボニルまたは窒素であるが、但し、少なくとも１個のＡは、炭素である；Ｚは、炭素、窒素、酸素またはイオウである；Ｂは、Ｏ、ＮＲ
２、Ｓ（Ｏ）
ｒ、Ｃ＝Ｏ、Ｃ＝ＳおよびＣ＝ＮＯＲ
３からなる群から選択される。

54. 发明专利

JP2005533057A Synthetic c- glycolipids, as well as cancer, the use of synthetic c- glycolipid for the treatment of infectious disease and autoimmune disease 审中-公开
公开(公告)号：JP2005533057A
公开(公告)日：2005-11-04
申请号：JP2004512677
申请日：2003-06-13
申请人：ニューヨーク・ユニバーシティNew York University
发明人：グァング・チェン , グァングリ・ヤング , リチャード・ダブリュ・フランク , 守哉辻
IPC分类号： C07D309/10 , A61K31/351 , A61K31/70 , A61P31/00 , A61P31/14 , A61P31/18 , A61P33/06 , A61P35/00 , A61P37/06 , A61P43/00 , C07D407/06 , C07H5/06 , C07H7/00 , C07H15/10
CPC分类号： C07H5/06 , C07H7/00 , C07H15/10
摘要：本発明は、式(I)の化合物に関し、式中、XはO、OR、NHであり;R
1 は炭化水素鎖であり;R
3 およびR
4 は、水素、OHまたは単糖であり;R
5 は水素または単糖であり;Q
1 は場合により存在し、かつC
1〜10 炭化水素であり得;X'は場合により存在し、かつO、SまたはNR
8 であり得;そしてQ
3 は炭化水素または水素であり得る。本発明はまた、癌、感染性疾患および自己免疫疾患を処置するためのこの化合物の使用に関する。本発明はまた、式(I)の化合物の合成に関する。

55. 发明专利

JP3615397B2 Food composition 有权
公开(公告)号：JP3615397B2
公开(公告)日：2005-02-02
申请号：JP23637298
申请日：1998-08-07
申请人：株式会社ファンケル
发明人：雅昭小野 , 健一石渡 , 典宏重松
IPC分类号： A23L1/30 , A61K31/70 , A61K31/7008 , A61P17/00 , C07H5/04 , C07H5/06

56. 发明专利

JP2004352672A New disaccharide, composition containing the same and method for producing the same 有权
公开(公告)号：JP2004352672A
公开(公告)日：2004-12-16
申请号：JP2003153627
申请日：2003-05-30
申请人： Yaizu Suisankagaku Industry Co Ltd , 焼津水産化学工業株式会社
发明人： MISAWA YOSHITOMO , KIKUCHI KAZUAKI , HOSOMI OSAMU
IPC分类号： A23L1/30 , A61K8/60 , A61K8/73 , A61K31/7016 , A61P35/00 , C07H5/06 , C12P19/26 , A61K7/00
摘要： PROBLEM TO BE SOLVED: To provide a non-natural type new disaccharide, in which new bioactivity and function can be expected, having galactose at the non-reducing terminal, and a composition containing the new disaccharide and to provide a method for producing the composition.
SOLUTION: The disaccharide represented by formula (1) is obtained by dissolving α-bonded galactooligosaccharide or its derivative in which one or a plurality of galactoses are bonded in α pattern to a non-reducing terminal, a glucosamine salt or N-acetylglucosamine into a buffer solution or water and making α-galactosidase act on the solution. It is preferable to use melibiose or raffinose or its hydrate as the α-bonded galactooligosaccharide or its derivative. It is preferable to use glucosamine hydrochloride as the glucosamine salt. The disaccharide can be utilized as a raw material for foods, medicines, cosmetics, etc.
COPYRIGHT: (C)2005,JPO&NCIPI

57. 发明专利

JP2003292444A Insulin secretion promoting agent 有权
标题翻译：胰岛素分泌促进剂
公开(公告)号：JP2003292444A
公开(公告)日：2003-10-15
申请号：JP2003026881
申请日：2003-02-04
申请人： Kyowa Hakko Kogyo Co Ltd , 協和醗酵工業株式会社
发明人： TAKADA YOSHIO , KAMIYA SHUNICHI , ENDO TETSUO , KOIZUMI SOJI
IPC分类号： A23K1/16 , A23L1/30 , A61K31/7012 , A61K31/7016 , A61K31/702 , A61P3/02 , A61P3/08 , A61P3/10 , A61P5/50 , C07H5/06 , C07H7/027
摘要： PROBLEM TO BE SOLVED: To provide an agent having insulin secretion promoting activity for effectively treating diabetes, and foods, drinks or animal feeds effective for ameliorating, preventing or treating diabetes by daily administration. SOLUTION: The insulin secretion promoting agent, a blood sugar level increase suppressing agent, a diabetes improving agent, a growth promoting agent and an agent for increasing insulin level in breast milk contain galactose and one or more substances selected from a carbohydrate comprising a di- or polysaccharide and its derivative, and a carbohydrate containing N- acetylneuraminic acid and its derivative. The invention further relates to foods, drinks, feeds, food and drink additives or feed additives having insulin secretion promoting action, blood sugar level suppressing action, diabetes improving action, growth promoting action and action to increase insulin level in breast milk. COPYRIGHT: (C)2004,JPO
摘要翻译：待解决的问题：提供一种有效治疗糖尿病的胰岛素分泌促进活性的药剂，以及通过日常给药有效改善，预防或治疗糖尿病的食品，饮料或动物饲料。解决方案：胰岛素分泌促进剂，血糖增加抑制剂，糖尿病改善剂，生长促进剂和用于增加母乳中胰岛素水平的试剂含有半乳糖和一种或多种选自碳水化合物的物质，包括二糖或多糖及其衍生物，以及含有N-乙酰神经氨酸及其衍生物的碳水化合物。本发明还涉及具有胰岛素分泌促进作用的食品，饮料，饲料，食品添加剂或饲料添加剂，血糖水平抑制作用，糖尿病改善作用，生长促进作用和增加母乳中胰岛素水平的作用。版权所有（C）2004，JPO

58. 发明专利

JP2003183296A METHOD FOR PRODUCING GLUCOSAMINE OR (AND) CHITOSAN OLIGOMER COMPOSITION 审中-公开
公开(公告)号：JP2003183296A
公开(公告)日：2003-07-03
申请号：JP2001381281
申请日：2001-12-14
申请人： PROD DEV RES INST , STELLA CHEMIFA CORP
发明人： FUJIMURA HAJIME , KITANO HISAO , TANIMOTO FUMIO , KIKUYAMA HIROHISA , WAKI MASAHIDE , HASHIGUCHI SHINJI
IPC分类号： C07H5/06
摘要： PROBLEM TO BE SOLVED: To provide a method for industrially advantageously producing a glucosamine or (and) a chitosan oligomer composition from a chitin-based material. SOLUTION: The glucosamine or (and) the chitosan oligomer composition is easily produced by reacting the chitin-based material with a concentrated hydrofluoric acid containing 75-95% hydrogen fluoride under a mild condition and dehydrofluorinating the product. COPYRIGHT: (C)2003,JPO

59. 发明专利

JP2003137789A NITROGEN MONOXIDE ELIMINATOR 审中-公开
公开(公告)号：JP2003137789A
公开(公告)日：2003-05-14
申请号：JP2001337858
申请日：2001-11-02
申请人： YAIZU SUISANKAGAKU IND CO LTD
发明人： KIKUCHI KAZUAKI
IPC分类号： A23L2/38 , A23L1/30 , A23L2/52 , A61K8/00 , A61K8/60 , A61K8/73 , A61K8/96 , A61K31/7008 , A61K31/7016 , A61K31/702 , A61K31/722 , A61P3/10 , A61P9/00 , A61P11/06 , A61P25/00 , A61P29/00 , A61P39/02 , A61P43/00 , A61Q1/00 , A61Q1/02 , A61Q1/12 , C07H5/06 , A61K7/00 , A61K7/02
摘要： PROBLEM TO BE SOLVED: To obtain a nitrogen monoxide eliminator that has high safety to human bodies and can effectively eliminate nitrogen monoxide. SOLUTION: This nitrogen monoxide eliminator contains, as an active ingredient, at least one selected from glucosamine, chitosan oligosaccharides with a polymerization degree of 2-10, low-molecular-weight chitosan with a polymerization degree of 11-100 and their salts. The nitrogen monoxide eliminator is preferably used by adding to at least one selected from drinks, foods, medicines or cosmetics. Particularly, in the cases that glucosamine and/or salts thereof are used as an active ingredient, they may be used as one component for tobacco filers, air cleaner filters, air conditioner filters and car mufflers.

60. 发明专利

JP2003128703A METHOD FOR PRODUCING SUGAR CHAIN ASPARAGINE DERIVATIVE 有权
公开(公告)号：JP2003128703A
公开(公告)日：2003-05-08
申请号：JP2002178032
申请日：2002-06-19
申请人： KAJIWARA YASUHIRO , TAIYO KAGAKU KK
发明人： KAJIWARA YASUHIRO , SASAKI MASARU
IPC分类号： C12P19/26 , C07H5/06 , C07K7/06 , C08B37/00 , C12P13/04 , C12P19/04 , C12P19/28
摘要： PROBLEM TO BE SOLVED: To provide a method for producing sugar chain asparagine derivatives by which various isolated sugar chain asparagine derivatives which are useful in the field of development of medicines can be easily obtained in a large amount compared with the existing methods, a method for producing a sugar chain asparagine via the method for producing these sugar chain asparagine derivatives and a method for producing sugar chains and to provide new sugar chain asparagine derivatives, sugar chain asparagines and sugar chains. SOLUTION: This method for producing the sugar chain asparagine derivatives derived from the sugar chain asparagine comprises (a) a step for introducing a fat- soluble protective group into the sugar chain asparagine contained in a mixture containing one or more kinds of sugar chain asparagines and obtaining a sugar chain asparagine derivative mixture and (b) a step for chromatographing the sugar chain asparagine derivative mixture or a mixture obtained by hydrolyzing sugar chain asparagine derivative contained in the sugar chain asparagine derivative mixture and separating each sugar chain asparagine derivative. The method for producing sugar chain asparagine including the production method, the method for producing sugar chains and the sugar chain asparagine derivatives obtained therefrom, the sugar chain asparagines and the sugar chains are also provided.

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