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51. 发明专利

JPH0586189B2 失效
公开(公告)号：JPH0586189B2
公开(公告)日：1993-12-10
申请号：JP2348686
申请日：1986-02-05
申请人： DAICEL CHEM
发明人： TAKAO SHOICHI , MATSUYAMA AKIKAZU , KAGEYAMA SADAO , KAWAI KIMITOSHI
IPC分类号： C12P17/18 , C12R1/85 , C12R1/865

52. 发明专利

JPH0566115B2 失效
公开(公告)号：JPH0566115B2
公开(公告)日：1993-09-21
申请号：JP9909784
申请日：1984-05-17
申请人： DAICEL CHEM
发明人： KAWAI KIMITOSHI , MATSUYAMA AKIKAZU , TAKAO SHOICHI
IPC分类号： C12P25/00 , C12R1/865

53. 发明专利

JPH04152896A PRODUCTION OF OPTICALLY ACTIVE 3-PHENYL-1,3-PROPANEDIOL 失效
公开(公告)号：JPH04152896A
公开(公告)日：1992-05-26
申请号：JP27610190
申请日：1990-10-15
申请人： DAICEL CHEM
发明人： MATSUYAMA AKIKAZU , ITO MICHIO , KOBAYASHI YOSHINORI
IPC分类号： C12P41/00 , C12R1/645 , C12R1/65 , C12R1/66 , C12R1/685 , C12R1/77
摘要： PURPOSE:To economically obtain in optically high purity the title compound as an intermediate for synthesizing medicines, by allowing microorganisms to act on an enantiomer mixture of phenyl propanediol followed by collecting an optically active phenyl propanediol left. CONSTITUTION:Microorganisms or a product from their treatment is allowed to act on an enantiomer mixture of 3-phenyl-1,3-propanediol followed by collecting the objective compound left. The microorganisms is e.g. Aspergillus niger IFO 4414 having ability to leave (R)-3-phenyl-1,3-propanediol. The reaction by the microorganisms is pref. made at 20-40 deg.C and a pH of 5-9 for 1-120hr.

54. 发明专利

JPH03297394A PRODUCTION OF OPTICALLY ACTIVE 1,3-BUTANE DIOL 失效
公开(公告)号：JPH03297394A
公开(公告)日：1991-12-27
申请号：JP10411590
申请日：1990-04-18
申请人： DAICEL CHEM
发明人： FUKUNISHI KUNIO , MATSUYAMA AKIKAZU , KOBAYASHI YOSHINORI
IPC分类号： C12P41/00
摘要： PURPOSE:To obtain the title diol capable of carrying out high-concentration charge of substrate and having high productivity in the production on an industrial scale by treating an enanthiomer mixture of 1,3-butane diol with a microorganism while controlling concentration of a treating liquid of enanthiomer reverse to the aimed enanthiomer. CONSTITUTION:When an enanthiomer mixture of 1,3-butane diol is treated with a microorganism to collect residual diol, an enanthiomer mixture of 1,3- butanediol is added to the treating system and treated with a microorganism while controlling concentration in treating liquid of an enanthiomer reverse to an enanthiomer to be produced to provide the aimed diol. Furthermore, concentration in the treating liquid of the enanthiomer reverse to the enanthiomer to be produced is preferably controlled to the range of 0.5 to 1.5wt.%.

55. 发明专利

JPH03236795A PRODUCTION OF OPTICALLY ACTIVE 1,3-BUTANEDIOL 失效
公开(公告)号：JPH03236795A
公开(公告)日：1991-10-22
申请号：JP3424990
申请日：1990-02-15
申请人： DAICEL CHEM
发明人： MATSUYAMA AKIKAZU , KOBAYASHI YOSHINORI
IPC分类号： C12P41/00 , C12R1/72
摘要： PURPOSE:To accelerate reaction rate and improve productivity of the title compound by reacting a mixture (BEM) of enantiomers of 1,3-butanediol with a specific microorganism in the presence of an alcohol or ketol. CONSTITUTION:A microorganism such as Candida parapsilosis IFO 1396 bacterial strain having ability capable of asymmetrically assimilating a mixture (BEM) of enantiomers of 1,3-butanediol is inoculated into a culture medium containing glucose, yeast extract, etc., and aerobically cultured at pH3.0-9.5 and 20-45 deg.C for 5-120hr to provide the cultured product (A). Then the ingredient A is blended with 0.1-10wt.% BEM and 0.05-1wt.% alcohol such as ethanol, ethylene glycol or 1-propanol or ketol such as dihydroxyacetone to afford the reaction product liquid (B). Then the ingredient B is reacted at pH3-10 and 10-60 deg.C for 1-120hr to provide the reaction product (C). Then the ingredient C is separated from the bacterial cell and then extracted and purified with column chromatography, etc., to provide the optically active 1,3-butanediol.

56. 发明专利

JPH03228686A PRODUCTION OF OPTICALLY ACTIVE 1,3-BUTANE DIOL 失效
公开(公告)号：JPH03228686A
公开(公告)日：1991-10-09
申请号：JP2418690
申请日：1990-02-02
申请人： DAICEL CHEM
发明人： MATSUYAMA AKIKAZU , KOBAYASHI YOSHINORI
IPC分类号： C12P7/18 , C12R1/01 , C12R1/065 , C12R1/18 , C12R1/22 , C12R1/265 , C12R1/32 , C12R1/34 , C12R1/38 , C12R1/425 , C12R1/77 , C12R1/79 , C12R1/85 , C12R1/865
摘要： PURPOSE:To readily obtain high optical purity by affecting a specific microorganism to 4-hydroxy-2-butanone (HB). CONSTITUTION:A microorganism converting HB to (R)-1,3 butane diol with asymmetrically reducing is searched to obtain a group of microorganism (A) belonging to Agrobacterium, Azotobacter, Bordetella, Brettanomyces, Dekkera, Endmyces, Eremascus, Erwinia, Fusarium, Geotrichum, Gibberella, Glomerella, Gonatobotryum, Klebsiella, Micrococcus, Mycobacterium and Neosartorya, etc. Next, a microorganism selected from the group A is cultured in a medium containing glucose, etc., at pH3.0-9.5 and at 20-45 deg.C for 5-120hr and centrifuged to obtain a fungus body (B). Then, the fungus body B is added to an aqueous solution containing 0.1-10wt.% HB, etc., and subjected to reducing reaction at pH3-9 and at 10-60 deg.C for 1-120hr, then a resultant reacted solution is extracted, thus purified to produce the aimed optically active 1,3-butane diol.

57. 发明专利

JPH03183499A PRODUCTION OF OPTICALLY ACTIVE 3-HYDROXYBUTYRIC ACID 失效
公开(公告)号：JPH03183499A
公开(公告)日：1991-08-09
申请号：JP32288089
申请日：1989-12-12
申请人： DAICEL CHEM
发明人： ITO MICHIO , MATSUYAMA AKIKAZU , KOBAYASHI YOSHINORI
IPC分类号： C12P41/00
摘要： PURPOSE:To obtain the subject compound useful as a synthetic raw material for various medicines, agricultural chemicals, etc., by reacting a specific microorganism (treated substance) of the genus Candida with an enantiomeric mixture of butanediol. CONSTITUTION:A microorganism (e.g. Candida utilis IFO 1086 or 0639), belonging to the genus Candida, Pichia, Schizoblastosporium or Bacillus and having the ability to convert 1,3-butanediol into optically active (R)-3-hydroxybutyric acid or a treated substance of the aforementioned microorganism is reacted with an enantiomeric mixture of the 1,3-butanediol to afford the objective compound.

58. 发明专利

JPH0223876A PRODUCTION OF (R)-2-HYDROXY-4-PHENYL-3-BUTENOIC ACID 失效
公开(公告)号：JPH0223876A
公开(公告)日：1990-01-26
申请号：JP17347088
申请日：1988-07-12
申请人： DAICEL CHEM
发明人： MATSUYAMA AKIKAZU , TAKASE ICHIRO , UEDA YOICHIRO , KOBAYASHI YOSHINORI
IPC分类号： C12P7/42 , C12R1/01 , C12R1/225 , C12R1/46
摘要： PURPOSE:To obtain the subject butenoic acid having high optical purity and useful as pharmaceuticals, etc., by the asymmetric reduction of a specific butenoic acid with microorganism of genus Lactobacillus, Leuconostoc, etc. CONSTITUTION:The objective butenoic acid is produced by treating 2-keto-4- phenyl-3-butenoic acid with a microbial strain selected from a microbial group belonging to genus Lactobacillus, Leuconostoc, Streptococcus, Pediococcus and Sporolactobacillus and having asymmetric reduction capability or with a treated material of the microorganism.

59. 发明专利

JPS63112997A PRODUCTION OF RIBOFLAVIN 失效
公开(公告)号：JPS63112997A
公开(公告)日：1988-05-18
申请号：JP26022186
申请日：1986-10-31
申请人： DAICEL CHEM
发明人： MATSUYAMA AKIKAZU , NIKAIDO TERUYUKI , KAGEYAMA SADAO , KAWAI KIMITOSHI
IPC分类号： C12P25/00 , C12R1/85
摘要： PURPOSE:To produce the titled substance in high yield, by cultivating yeast belonging to the genus Saccharomyces by continuously adding acetic acid and a nitrogen source to a medium in a culture bath and maintaining concentration of calcium, etc., at

60. 发明专利

JPS6225996A PRODUCTION OF RIBOFLAVIN 失效
公开(公告)号：JPS6225996A
公开(公告)日：1987-02-03
申请号：JP16726085
申请日：1985-07-29
申请人： DAICEL CHEM
发明人： MATSUYAMA AKIKAZU , KAWAI KIMITOSHI , KAGEYAMA SADAO , TAKAO SHOICHI
IPC分类号： C12P25/00 , C12R1/85 , C12R1/865
摘要： PURPOSE:To obtain in high productivity riboflavin without adding an expensive demanding substance to a medium, by cultivating a purine demanding reverse variant belonging to the genus Saccharomyces, derived from a purine demanding mold capable of producing riboflavin. CONSTITUTION:A purine demanding reverse variant (variant having lost purine demanding properties) belonging to the genus Saccharomyces, derived from a purine demanding mold capable of producing riboflavin, is cultivated in a medium, riboflavin is formed, accumulated and collected. Saccharomyces cerevisiae TR-29 (FERM P-782) may be cited as the preferable strain. This strain is derived by a conventional proceduere by NTG treatment of purine demanding 3-amino-1,2-4-triazole resistant strain TP-1010 (FERM BP-565) as a parent strain.

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