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51. 发明专利

JP2004191106A Screening method of hair cultivating agent effective component and its utilization 有权
公开(公告)号：JP2004191106A
公开(公告)日：2004-07-08
申请号：JP2002357383
申请日：2002-12-10
申请人： Ichimaru Pharcos Co Ltd , 一丸ファルコス株式会社
发明人： ITO KENICHI , MAEDA MUNENORI , HASEGAWA JUNICHI , OTSU HIROSHI , UENO HIROSHI
IPC分类号： G01N33/50 , A61K8/00 , A61K8/44 , A61K8/97 , A61K31/4172 , A61K36/18 , A61K36/23 , A61K36/48 , A61K36/53 , A61K36/73 , A61K45/00 , A61P17/14 , A61P43/00 , A61Q5/00 , A61Q5/02 , A61Q7/00 , A61K7/06 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To provide a new and useful screening method for developing a hair cultivating agent effective component, and the hair cultivating agent effective component evaluated through the screening method and a hair cultivating agent composition wherein the component is mixed. SOLUTION: This invention includes a screening method of the hair cultivating agent effective component by using histamine biosynthesis inhibition action, especially activation inhibition of a histidine decarbonization enzyme, as an evaluation index, and a hair cultivating agent composition containing the hair cultivating agent effective component acquired by using the histamine biosynthesis inhibition action as the evaluation index. COPYRIGHT: (C)2004,JPO&NCIPI

52. 发明专利

JP2003342123A Collagenase activity inhibitor, elastase activity inhibitor and cosmetic composition 审中-公开
标题翻译：胶原活化抑制剂，弹性酶活性抑制剂和化妆品组合物
公开(公告)号：JP2003342123A
公开(公告)日：2003-12-03
申请号：JP2002159266
申请日：2002-05-31
申请人： Ichimaru Pharcos Co Ltd , 一丸ファルコス株式会社
发明人： NISHIBE YUKINAGA , WAKAMATSU KANAE
IPC分类号： A61K8/96 , A61K8/00 , A61K8/97 , A61K36/00 , A61K36/18 , A61K36/73 , A61K36/75 , A61P17/16 , A61P43/00 , A61Q1/00 , A61Q1/12 , A61Q5/02 , A61Q19/00 , A61Q19/08 , A61K7/00 , A61K7/48 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To provide a new and safe collagenase activity inhibitor, an elastase activity inhibitor and a cosmetic composition. SOLUTION: The collagenase activity inhibitor, the elastase activity inhibitor and the cosmetic composition each comprises extracts of one or more kinds of plants selected from Vitis vinifera L., Zanthoxylum piperitum DC., and Filipendula ulmaria Maxim. Since these inhibitors and the cosmetic composition each have collagenase activity-inhibiting action and elastase activity-inhibiting action and impart tenseness and gloss to the skin, they are effective in preventing aging of the skin and can be applied to preparations (medicines, quasi-drugs and cosmetics) in various forms. In addition, they can be utilized also to general foods and beverages. COPYRIGHT: (C)2004,JPO
摘要翻译：要解决的问题：提供新的和安全的胶原酶活性抑制剂，弹性蛋白酶活性抑制剂和化妆品组合物。解决方案：胶原酶活性抑制剂，弹性蛋白酶活性抑制剂和化妆品组合物各自包含选自葡萄葡萄（Vitis vinifera L.），花椒（Zanthoxylum piperitum DC）和菲兰（Filipendula ulmaria Maxim）的一种或多种植物的提取物。由于这些抑制剂和化妆品组合物各自具有胶原酶活性抑制作用和弹性蛋白酶活性抑制作用，并且对皮肤赋予张力和光泽，因此它们有效地防止皮肤老化，并且可以应用于制剂（药物，准药物和化妆品）。此外，它们也可以用于一般食品和饮料。版权所有（C）2004，JPO

53. 发明专利

JP2003321379A Antiallergic agent 审中-公开
标题翻译：抗真菌剂
公开(公告)号：JP2003321379A
公开(公告)日：2003-11-11
申请号：JP2002131255
申请日：2002-05-07
申请人： Ichimaru Pharcos Co Ltd , 一丸ファルコス株式会社
发明人： OHARA MITSUHARU , NABA YOSHIHIKO
IPC分类号： A61K8/96 , A61K8/00 , A61K8/02 , A61K8/06 , A61K8/97 , A61K36/18 , A61K36/53 , A61P37/08 , A61P43/00 , A61Q1/00 , A61Q1/02 , A61Q1/12 , A61Q5/00 , A61Q5/02 , A61Q5/06 , A61Q5/12 , A61Q7/00 , A61Q17/04 , A61Q19/10 , A61K35/78 , A61K7/00 , A61K7/021 , A61K7/06 , A61K7/075 , A61K7/08 , A61K7/11 , A61K7/42 , A61K7/50
摘要： PROBLEM TO BE SOLVED: To provide an antiallergic agent, a histamine release inhibitor and a cosmetic composition which are new and safe. SOLUTION: The antiallergic agent, the histamine release inhibitor and a cosmetic composition comprise plant extracts from at least one selected from Coleus forskhlii. and Yerba Santa. The antiallergic agent, the histamine release inhibitor and the cosmetic composition have a histamine release inhibiting action and can be used for prevention and improvement of skins and scalps suffering from troubles such as allergic or atopic skin inflammatory disease (for example, flare, eczema, edema, swelling and the like), skin roughness, itch, and the like. The antiallergic agent, the histamine release inhibitor and the cosmetic composition can also be utilized for general foods and drinks. COPYRIGHT: (C)2004,JPO
摘要翻译：要解决的问题：提供新的和安全的抗过敏剂，组胺释放抑制剂和化妆品组合物。解决方案：抗过敏剂，组胺释放抑制剂和化妆品组合物包含选自柯氏梭菌中的至少一种的植物提取物。和雅尔巴圣诞老人。抗过敏剂，组胺释放抑制剂和化妆品组合物具有组胺释放抑制作用，可用于预防和改善患有过敏或特应性皮肤炎症性疾病（例如，耀斑，湿疹，水肿等）的皮肤和头皮，肿胀等），皮肤粗糙，瘙痒等。抗过敏剂，组胺释放抑制剂和化妆品组合物也可用于一般食品和饮料。版权所有（C）2004，JPO

54. 发明专利

JP2003081868A Stress inhibitor 审中-公开
标题翻译：应力抑制剂
公开(公告)号：JP2003081868A
公开(公告)日：2003-03-19
申请号：JP2001276264
申请日：2001-09-12
申请人： Ichimaru Pharcos Co Ltd , 一丸ファルコス株式会社
发明人： NISHIBE YUKINAGA , WAKAMATSU KANAE , NABA YOSHIHIKO
IPC分类号： A23L1/30 , A23L1/305 , A61K8/00 , A61K8/02 , A61K8/06 , A61K8/64 , A61K8/65 , A61K8/72 , A61K8/96 , A61K8/97 , A61K36/18 , A61K36/42 , A61K36/53 , A61K38/17 , A61P25/20 , A61Q1/00 , A61Q1/02 , A61Q5/00 , A61Q5/02 , A61Q5/12 , A61Q17/04 , A61Q19/00 , A61Q19/08 , A61Q19/10 , A61K7/00 , A61K7/02 , A61K7/06 , A61K7/075 , A61K7/08 , A61K7/42 , A61K7/48 , A61K7/50 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To provide a new and safe stress inhibitor and a cosmetic composition and food and beverage including the same. SOLUTION: The stress inhibitor includes at least one of protein hydrolyzate selected from silk protein, keratin protein and collagen protein and food and beverage including the hydrolyzate are provided. Further, the food and the beverage additionally including at least one kind of the extracts from the following plants: Robdosia japnicus Hara, Isodon trichocarpus, Hypericum peroratum, Salvia officinalis, Tilia platyphyllo Scop and Momordica grosvernorii Swingle. The cosmetic, food and beverage including the plant extracts has the stress- inhibitory action, particularly inhibiting the reduction of the skin elasticity and the moisture retention and are effective for prevention and treatment of stressrelating diseases, for example, the muscle stiffness of shoulder, neck and eyes, skin ageing, skin gloss and resilience and dry skin and can be applied to all kinds of preparations (medicines, quasi drugs, cosmetics and foods).
摘要翻译：要解决的问题：提供新的和安全的应激抑制剂和化妆品组合物以及包括其的食品和饮料。解决方案：应用抑制剂包括选自丝蛋白，角蛋白和胶原蛋白的蛋白质水解产物和包括水解产物的食品和饮料中的至少一种。此外，食品和饮料还包括至少一种来自以下植物的提取物：罗氏：ara（Isodon trichocarpus），金丝桃属（Hypericum peroratum），Salvia officinalis，Tilia platyphyllo Scop和Momordica grosvernorii Swingle。包括植物提取物在内的化妆品，食品和饮料具有应激抑制作用，特别是抑制皮肤弹性和保湿性的降低，并且有效预防和治疗与压力相关的疾病，例如肩部，颈部的肌肉僵硬眼睛，皮肤老化，皮肤光泽，恢复力和皮肤干燥，适用于各种制剂（药品，准药品，化妆品和食品）。

55. 发明专利

JP2003073287A Hyaluronidase activity inhibitor or cosmetic composition 审中-公开
标题翻译：羟丙酸酶活性抑制剂或化妆品组合物
公开(公告)号：JP2003073287A
公开(公告)日：2003-03-12
申请号：JP2001260943
申请日：2001-08-30
申请人： Ichimaru Pharcos Co Ltd , 一丸ファルコス株式会社
发明人： NISHIBE YUKINAGA , WAKAMATSU KANAE
IPC分类号： A61K8/96 , A61K8/00 , A61K8/02 , A61K8/03 , A61K8/06 , A61K8/97 , A61K36/18 , A61P17/00 , A61P17/04 , A61P17/14 , A61P29/00 , A61P43/00 , A61Q1/00 , A61Q1/02 , A61Q1/12 , A61Q5/00 , A61Q5/02 , A61Q5/06 , A61Q5/12 , A61Q7/00 , A61Q11/00 , A61Q17/04 , A61Q19/00 , A61Q19/08 , A61Q19/10 , A61K35/78 , A61K7/00 , A61K7/02 , A61K7/06 , A61K7/075 , A61K7/08 , A61K7/11 , A61K7/26 , A61K7/42 , A61K7/48 , A61K7/50
摘要： PROBLEM TO BE SOLVED: To provide a new safe hyaluronidase activity inhibitor or cosmetic composition. SOLUTION: The hyaluronidase activity inhibitor or cosmetic composition contains an extract of one or more vegetables selected from Kokemomo (Vaccinium vitis-idaea L.) and Tarayou (Ilexlatifolia Thunb.). The composition has hyaluronidase activity inhibiting action and is effective for improving the springiness, luster, crease and sag of the skin and ameliorating inflammatory skin diseases such as eczema, itchiness and roughened skin. Accordingly, the composition is effective for preventing the aging or inflammation of the skin.
摘要翻译：要解决的问题：提供新的安全透明质酸酶活性抑制剂或化妆品组合物。解决方案：透明质酸酶活性抑制剂或化妆品组合物含有选自Kokemomo（Vaccinium vitis-idaea L.）和Tarayou（Ilexlatifolia Thunb。）的一种或多种蔬菜的提取物。该组合物具有透明质酸酶活性抑制作用，对于改善皮肤的弹性，光泽，褶皱和下垂以及改善炎症皮肤疾病如湿疹，瘙痒和粗糙皮肤是有效的。因此，该组合物对于防止皮肤老化或发炎是有效的。

56. 发明专利

JP2014208596A 角質層を透明にする化粧料审中-公开
标题翻译：化妆品制作HORNY层透明度
公开(公告)号：JP2014208596A
公开(公告)日：2014-11-06
申请号：JP2013086053
申请日：2013-04-16
申请人：一丸ファルコス株式会社 , Ichimaru Pharcos Co Ltd , 国立大学法人岐阜大学 , Gifu Univ
发明人： MASUTANI TERUAKI , KOJIMA HIROYUKI , ITO KENICHI
IPC分类号： A61K8/97 , A61Q19/00
CPC分类号： A61K8/97 , A61Q19/00
摘要：【課題】新規で有用であり、角質層を透明にする化粧料、角質層の透明性予防改善剤、又は、光散乱低減剤、偏光低減剤を提供する。【解決手段】マンダリンオレンジ果皮抽出物を有効成分とする、角質層を透明にする化粧料、角質層の透明性予防改善剤、又は、光散乱低減剤、偏光低減剤。【選択図】なし
摘要翻译：要解决的问题：提供用于制造角质层透明的新型有用的化妆品，角质层透明度防止改善剂，光散射降低剂和偏振还原剂。解决方案：本发明提供了用于制造角质层透明的化妆品其包含作为活性成分的橘子果皮提取物，角质层透明度防止改善剂，光散射降低剂和偏振还原剂。

57. 发明专利

JP2014073976A Deodorizing agent, antibacterial agent, and skin external agent composition containing the same 有权
标题翻译：除虫剂，抗菌剂和含有其的皮肤外用剂组合物
公开(公告)号：JP2014073976A
公开(公告)日：2014-04-24
申请号：JP2012220852
申请日：2012-10-03
申请人： Ichimaru Pharcos Co Ltd , 一丸ファルコス株式会社
发明人： ARUNASIRI IDDAMALGODA , FUJITA SACHIKO
IPC分类号： A61K8/97 , A61K36/18 , A61P17/00 , A61P31/04 , A61Q15/00
CPC分类号： Y02A50/478
摘要： PROBLEM TO BE SOLVED: To provide a deodorizing agent and an antibacterial agent specifically and remarkably deodorizing odor causing body odor, particularly sweat odor, body odor of old people, having excellent antibacterial characteristics to Legionella and being safe and extremely useful for skin sanitation; and a skin external agent composition for body odor deodorization/anti-Legionella, containing them.SOLUTION: The present invention comprises: a deodorizing agent of odor due to ammonia, acetic acid, iso-valeric acid, 2-nonenal or the like, having an extract from a fruit of Ritha (Sapindus trifoliatus) as an active ingredient; an antibacterial agent against Legionella (Legionella pneumophila); and a skin external agent composition for body odor deodorization/anti-Legionella, containing them.
摘要翻译：要解决的问题：提供除臭剂和抗菌剂，特别是具有极高的除臭气味，导致身体异味，特别是汗渍，老年人的身体异味，对军团菌具有优异的抗菌特性，对皮肤卫生具有安全性和极其有用; 和含有它们的体外除臭/抗军团菌的皮肤外用剂组合物。本发明包括：由氨，乙酸，异戊酸，2-壬烯醛等引起的臭味的除臭剂，具有来自Ritha（Sapindus trifoliatus）的果实的提取物作为活性成分; 针对军团菌（Legionella pneumophila）的抗菌剂; 和用于身体除臭/抗军团菌的皮肤外用剂组合物，含有它们。

58. 发明专利

JP2014019683A Mitogenic agent for melanin-containing keratinocyte 审中-公开
标题翻译：含有梅毒素的杀伤细胞的生物剂
公开(公告)号：JP2014019683A
公开(公告)日：2014-02-03
申请号：JP2012162203
申请日：2012-07-23
申请人： Ichimaru Pharcos Co Ltd , 一丸ファルコス株式会社
发明人： TANAKA KIYOTAKA
IPC分类号： A61K8/97 , A61K35/64 , A61K36/00 , A61K36/07 , A61K36/28 , A61K36/73 , A61P17/00 , A61P17/16 , A61P43/00 , A61Q19/02
摘要： PROBLEM TO BE SOLVED: To provide a mitogenic agent for melanin-containing keratinocytes, and a composition useful for alleviating, preventing or improving various pigmentation symptoms including blemishes and freckles on the skin.SOLUTION: The invention provides a mitogenic agent for melanin-containing keratinocytes, comprising a specific plant extract (Gynostemma pentaphyllum, kiwi fruit, burdock, shiitake mushroom, wax gourd, Eucommia ulmoides, jujube, safflower, prune, royal jelly) as an active ingredient, a pigmentation inhibitor based on mitogenic action on keratinocytes, and various compositions comprising the mitogenic agent for keratinocytes (pharmaceutical compositions, cosmetic compositions, and dietary compositions).
摘要翻译：要解决的问题：提供含黑色素的角质形成细胞的促有丝分裂剂，以及可用于缓解，预防或改善皮肤上各种色素沉着症状（包括瑕疵和雀斑）的组合物。解决方案：本发明提供含黑色素角质形成细胞的促有丝分裂剂包括作为活性成分的特定植物提取物（绞股蓝绞痛，猕猴桃，牛蒡，香菇，葫芦，杜仲，枣，红花，胡桃，蜂王浆）的特定植物提取物，基于角质形成细胞的促有丝分裂作用的色素沉着抑制剂包含角质形成细胞促有丝分裂剂（药物组合物，化妆品组合物和饮食组合物）的组合物。

59. 发明专利

JP2013241383A Keratinocyte migration promoter 审中-公开
标题翻译： KERATINOCYTE MIGRATION PROMOTER
公开(公告)号：JP2013241383A
公开(公告)日：2013-12-05
申请号：JP2012117084
申请日：2012-05-23
申请人： Ichimaru Pharcos Co Ltd , 一丸ファルコス株式会社 , Univ Of Miyazaki , 国立大学法人宮崎大学
发明人： TSUBOI MAKOTO , TAKAYAMA SATORU , YAMAGUCHI MASATOSHI , MADHYASTHA HARISHKUMAR , SAMEJIMA HIROSHI
IPC分类号： A61K36/75 , A61K8/97 , A61K36/00 , A61P17/00 , A61P17/02 , A61P43/00 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide a keratinocyte migration promoter which is useful for quick healing of a wound, or an external preparation composition or a pharmaceutical composition for healing a wound.SOLUTION: This invention relates to: a keratinocyte migration promoter containing a Citrus Tamurana form Orange Hyuganatu extract, a water-soluble component of the Citrus Tamurana form Orange Hyuganatu extract, or a fraction having a molecular weight of 2,000-200,000 obtained by gel filtration chromatography from the Citrus Tamurana form Orange Hyuganatu extract as an active ingredient; or an external preparation composition or a pharmaceutical composition containing the keratinocyte migration promoter.
摘要翻译：要解决的问题：提供可用于快速愈合伤口的角质形成细胞迁移促进剂，或外用制剂组合物或用于治愈伤口的药物组合物。解决方案：本发明涉及：含有柑橘属形成橙色Hyuganatu提取物，Citrus Tamurana形式的橙色Hyuganatu提取物的水溶性成分，或通过凝胶过滤色谱法从Citrus Tamurana形式的橙色Hyuganatu提取物获得的分子量为2,000-200,000的级分作为活性成分; 或外用制剂组合物或含有角化细胞迁移促进剂的药物组合物。

60. 发明专利

JP2013166712A Kinesin inhibitor 审中-公开
标题翻译：金氏抑制剂
公开(公告)号：JP2013166712A
公开(公告)日：2013-08-29
申请号：JP2012029433
申请日：2012-02-14
申请人： Ichimaru Pharcos Co Ltd , 一丸ファルコス株式会社
发明人： TANAKA KIYOTAKA
IPC分类号： A61K8/97 , A23L1/30 , A61K36/18 , A61K36/28 , A61K36/53 , A61K36/71 , A61K36/73 , A61K36/75 , A61Q17/04 , A61Q19/02
摘要： PROBLEM TO BE SOLVED: To provide a new and useful kinesin inhibitor; and to provide a composition which is useful for easing, preventing or improving various pigmentation symptoms such as a skin blemish and a freckle.SOLUTION: A kinesin inhibitor containing a specific plant extract (a geranium extract, a Zanthoxylum piperitum extract, a Paeonia lactiflora extract, a mugwort extract, a lemon balm extract, and a rose hip extract) as an active ingredient, a pigmentation inhibitor based on kinesin inhibition action, and various compositions (pharmaceutical compositions, food compositions and cosmetic compositions) containing the kinesin inhibitor are provided.
摘要翻译：要解决的问题：提供一种新的有用的驱动蛋白抑制剂; 并提供可用于缓解，预防或改善各种色素沉着症状如皮肤瑕疵和雀斑的组合物。解决方案：含有特定植物提取物（天竺葵提取物，花椒酱提取物，芍药提取物，艾草提取物，柠檬香膏提取物和玫瑰果提取物）作为活性成分，基于驱动蛋白抑制作用的色素沉着抑制剂和含有驱动蛋白抑制剂的各种组合物（药物组合物，食品组合物和化妆品组合物）。

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