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41. 发明专利

JP2002048752A FLOW CELL AND POLYMER FILM FORMING METHOD 失效
公开(公告)号：JP2002048752A
公开(公告)日：2002-02-15
申请号：JP2000238292
申请日：2000-08-07
申请人： NIPPON TELEGRAPH & TELEPHONE
发明人： MORIMOTO TAKASHI , HORIUCHI TSUTOMU , NIWA OSAMU
IPC分类号： G01N27/28 , G01N35/08 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To allow use without any leakage for analyzing gas or liquid with a high temperature or pressure and to facilitate separation between base boards tightly adhering to each other, replacement of an unnecessary part, and recovery of a degraded part so as to realize a multilayer structure flow cell for providing the flow cell and its manufacturing method allowing addition or change of a function of an analyzer economically and quickly. SOLUTION: In this flow cell, a base board having a fine flow passage pattern formed on the surface and a flat base board are tightly bonded face to face for forming a fine flow passage, while on at least one face side of the opposedly abutted faces between the base boards, an easily stickable/releasable plastic elastic film (PDMS film) is attached, and the tight abutting faces of the both PDMS film-attached base boards are overlapped by each other. Then, the flow cell is formed when the base boards are tightly bonded onto each other by means of a pressing means pressing the base boards from their both sides. In maintenance, the bonded faces of the both PDMS film-attached base boards are released so as to be separated from each other.

42. 发明专利

JP2001061497A HISTAMINE SENSOR 失效
公开(公告)号：JP2001061497A
公开(公告)日：2001-03-13
申请号：JP24082599
申请日：1999-08-27
申请人： NIPPON TELEGRAPH & TELEPHONE
发明人： HAYASHI KATSUYOSHI , NIWA OSAMU , HORIUCHI TSUTOMU , TORIMITSU KEIICHI , KURITA RIYOUJI , MAEYAMA KAZUTAKA , TANIZAWA KATSUYUKI
IPC分类号： C12Q1/26 , C12Q1/00 , C12Q1/28 , G01N27/28 , G01N27/416
摘要： PROBLEM TO BE SOLVED: To provide an electrochemical sensor for measuring histamine concentration in a specimen by a simple and convenient method with high sensitivity down to a low concentration in a good selectivity and reproducibility. SOLUTION: This histamine sensor features having the following constitution: histamine oxidase is immobilized within a reactor 6 in a channel where a specimen solution flows to oxidize histamine in the specimen with the histamine oxidase almost completely to form hydrogen peroxide; reducing the resultant hydrogen peroxide through electrode reaction with a working electrode 8 placed within a flow cell 7 and modified with a membrane having a hydrogen peroxide- reducing property; and measuring histamine concentration in the specimen by measuring current flowing in the working electrode 8 during the reductive reaction.

43. 发明专利

JP2000121590A ELECTROCHEMICAL DETECTOR 失效
公开(公告)号：JP2000121590A
公开(公告)日：2000-04-28
申请号：JP29331998
申请日：1998-10-15
申请人： NIPPON TELEGRAPH & TELEPHONE
发明人： MORIMOTO TAKASHI , MORITA MASAO , NIWA OSAMU , HORIUCHI TSUTOMU , TORIMITSU KEIICHI , KURITA RIYOUJI
IPC分类号： G01N27/28 , G01N27/416 , G01N30/64
摘要： PROBLEM TO BE SOLVED: To prevent a nonuniformity of the amount and mutual mixture of sample solution on an electrode by providing a plurality of channels and a reference electrode, counter electrode, and operation electrodes on the junction surface of a substrate and allowing a sample solution in a branch channel to be in contact with only one of the operation electrodes. SOLUTION: The electrochemical detector with a thin layer-type flow cell is provided with two operation electrodes 3 and 4 that are arranged symmetrically to each other and two closed channels being arranged symmetrically to each other where a sample solution flows while being branched uniformly into each of the operation electrodes 3 and 4 from a single approach capillary 14. Since the amount of the sample solution flowing on the operation electrodes 3 and 4 can be made uniform, the scattering in a measurement value can be reduced. Also, the sample solution that flows through each channel being branched is in contact with only one operation electrode, so that a sample flowing on one operation electrode does not mix onto another operation electrode, thus preventing the constituent ratio of each substance in the sample from being disturbed and enabling a measurement value corresponding to the amount of substance that is originally contained in the sample to be obtained.

44. 发明专利

JP2000097899A MINUTE-QUANTITY ON-LIFE BIOSENSOR AND ITS MANUFACTURE 失效
公开(公告)号：JP2000097899A
公开(公告)日：2000-04-07
申请号：JP26936398
申请日：1998-09-24
申请人： NTT ADVANCED TECH KK , NIPPON TELEGRAPH & TELEPHONE
发明人： KURITA RIYOUJI , TABEI HISAO , NIWA OSAMU , HORIUCHI TSUTOMU , TORIMITSU KEIICHI , MORITA MASAO
IPC分类号： C12Q1/00 , G01N27/28 , G01N27/327 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To remove electrochemically active material which becomes an obstacle at the time of electrochemical detection, by forming many minute projections on an upstream part of a working electrode in a passage. SOLUTION: In this sensor, a substrate 1 on which two minute passage 2 are formed by a micro-machine technology, and a working electrode 4 modified by enzymes or the like, a reference electrode 5, an opposed electrode 6, and a minute-projection structure electrode 3 comprising many minute projections 16 having surfaces modified by conductive material, placed on the upstream of the electrodes 4-6, are formed. Besides, the sensor has a substrate 13 having the electrodes 3-6 on which a passage 7 is formed. The surfaces of many minute projections 16 are modified by the conductive material. In the case where an obstacle material in a biosample, injected into a thin-layer electrochemical cell or a sensor simultaneously with target material in the biosample, is electrochemically active material, the obstacle material can be reacted on the minute- projection structure electrode 3 and removed by applying electric potential, because the surfaces of the minute projections 16 are conductive.

45. 发明专利

JPH1183784A MICROQUANTITY ONLINE BIOSENSOR AND MANUFACTURE THEREOF 失效
公开(公告)号：JPH1183784A
公开(公告)日：1999-03-26
申请号：JP25264297
申请日：1997-09-03
申请人： NIPPON TELEGRAPH & TELEPHONE , NTT ADVANCED TECH KK
发明人： NIWA OSAMU , HORIUCHI TSUTOMU , TORIMITSU KEIICHI , MORITA MASAO , TABEI HISAO , SAKUMA AYAKO , KURITA RIYOUJI
IPC分类号： G01N27/28 , C12Q1/00 , G01N27/327 , G01N37/00 , H01L49/00
摘要： PROBLEM TO BE SOLVED: To enable forming of a microsensor with a higher sensitivity which is built by laminating an insulating substrate on which a fine passage comprising a rectangular groove on a thin layer and an electrochemical cell formed on another substrate. SOLUTION: This microquantity online biosensor is so arranged to laminate an insulating substrate on which a fine passage comprising a rectangular groove is formed and a thin layer electrochemical cell formed on another substrate. A flowcell and a capillary for sampling or a microdialysis probe are connected to the fine passage. For example, the sensor is so arranged to laminate a substrate having a rectangular groove which is formed by micromachine technique, a thin film electrode 2 modified by enzyme or the like and a thin layer type resist film 3 formed surrounding it. This facilitates the connection of a capillary 4 for sampling and the microdialysis probe at an outlet/inlet.

46. 发明专利

JPH10253571A ELECTRODE OF NICKEL-TITANIUM OXIDE ALLOY, AND MANUFACTURE THEREOF 失效
公开(公告)号：JPH10253571A
公开(公告)日：1998-09-25
申请号：JP7890297
申请日：1997-03-13
申请人： NIPPON TELEGRAPH & TELEPHONE
发明人： MORITA MASAO , NIWA OSAMU , AJITO KATSUHIRO , WATANABE NORIYUKI
IPC分类号： G01N27/30
摘要： PROBLEM TO BE SOLVED: To improve the signal/noise ratio and also the throughout of the whole electrode by making a nickel electrode capable of proceeding electrochemical catalyst c reaction of sugar or alcohol very small and surrounding its periphery with an insulator. SOLUTION: A stencil having the shape of an electrode cut out is laid on a base, of which the surface or the whole has insulating properties. The base is set in a base holder of a thin-film forming apparatus such as a vacuum evaporation apparatus or a sputtering apparatus and a thin film of a nickel - titanium alloy is formed on the base by simultaneous evaporation or sputtering of nickel sand titanium. Next, an alloy electrode thus prepared is immersed in an alkali solution and a potential for oxidation is impressed on a silver/silver chloride reference electrode by a potentiostat. Thereby, the titanium on the surface is turned into a titanium oxide which can be treated normally as an insulator. In this state, nickel electrodes 2 dispersed in the titanium oxide 1 behave as a minute electrode array. Therefore a charging current can be made relatively small, while a current density of a signal becomes high, in contrast. Besides, an oxidation reaction can be made to proceed efficiently by using the nickel.

47. 发明专利

JP2556993B2 失效
公开(公告)号：JP2556993B2
公开(公告)日：1996-11-27
申请号：JP9009489
申请日：1989-04-10
申请人： NIPPON TELEGRAPH & TELEPHONE
发明人： MORITA MASAO , NIWA OSAMU , TABEI HISAO
IPC分类号： G01N27/30 , G01N27/416

48. 发明专利

JPH08261981A ELECTROCHEMICAL CONTROL ELECTRODE AND MANUFACTURE THEREOF 失效
公开(公告)号：JPH08261981A
公开(公告)日：1996-10-11
申请号：JP8590295
申请日：1995-03-20
申请人： NIPPON TELEGRAPH & TELEPHONE
发明人： IWASAKI GEN , MORITA MASAO , NIWA OSAMU
IPC分类号： G01N27/30 , G01N27/327
摘要： PURPOSE: To provide a method of manufacturing of an electrochemical control electrode capable of directly oxidizing or reducing protein on the electrode. CONSTITUTION: This electrochemical control electrode is formed with a portion identifying protein having electrochemical activity on the surface of the electrode. For the method of manufacturing it, protein having electrochemical activity is adsorbed on the electrode, then (1) the portion where no protein is adsorbed is covered with an insulator, or (2) a film of a conductor is formed around protein, or (3) the electrode is covered with protein and a monomer to polymerize the monomer, then the protein is desorbed, or (4) protein is deposited on a substrate, a film of a conductor is formed on it, then the deposit and conductor are separated, and the conductor is used. These methods have peculiarity for the purpose and substance, and they are useful for controlling and detecting the substance in a living body.

49. 发明专利

JPH08193968A ELECTROCHEMICAL DETECTOR AND ITS MANUFACTURE 失效
公开(公告)号：JPH08193968A
公开(公告)日：1996-07-30
申请号：JP622595
申请日：1995-01-19
申请人： NIPPON TELEGRAPH & TELEPHONE , NTT ADVANCED TECH KK
发明人： NIWA OSAMU , MORITA MASAO , TABEI HISAO
IPC分类号： G01N27/30 , G01N27/28 , G01N30/64
摘要： PURPOSE: To improve the sensitivity of a radial-flow-type electrochemical detector. CONSTITUTION: An operation electrode 21 in a shape where a circular shape with a diameter of 4mm is separated into four equal portions at 50μm with 90 degrees each and a reference electrode 22 where silver is plated to prevent polarization are formed on a substrate 20 and an opposing electrode block 23 is engaged through a shield ring 24. At this time, a liquid-introduction part 25 provided at the opposing electrode block 23 are arranged to overlap with the center of four operation electrodes 21.

50. 发明专利

JPH0735722A PRODUCTION OF CARBON MICROELECTRODE 失效
公开(公告)号：JPH0735722A
公开(公告)日：1995-02-07
申请号：JP19763293
申请日：1993-07-16
申请人： NIPPON TELEGRAPH & TELEPHONE
发明人： IWASAKI GEN , NIWA OSAMU , TABEI HISAO
IPC分类号： G01N27/30
摘要： PURPOSE:To obtain a thin carbon film electrode which can apply a potential accurately even if a fine pattern is formed by forming a thin film through electrolytic polymerization of an organic compound in a partially exposed region of a conductive thin film formed on a substrate. CONSTITUTION:A microelectrode of thin carbon film is formed in a partially exposed region of a conductive thin film formed on a substrate. In this regard, the thin film is formed through electrolytic polymerization of an organic compound and then it is heated. Since the carbon film is formed after formation of a thin polymer film through electrolytic polymerization, microelectrode of carbon can be produced easily. Furthermore, the entire surface of electrode is covered with a film in a short time because the electrolytic polymerization takes place on the microelectrode and thereby an electrolytic polymerization film is formed uniformly. The organic compound includes p-xylene tetrabromide, p-xylene hexachloride, pyrrole derivatives, etc.

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