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41. 发明专利

JPH0358996A INDOPHENYL-BETA-MALTOOLIGOSIDE DERIVATIVE, REAGENT FOR DETERMINING ALPHA-AMYLASE ACTIVITY AND DETERMINATION PROCESS FOR ALPHA-AMYLASE ACTIVITY USING THE SAME 失效
公开(公告)号：JPH0358996A
公开(公告)日：1991-03-14
申请号：JP19265189
申请日：1989-07-27
申请人： KIKKOMAN CORP
发明人： TOKUTAKE SHOICHI , INABA SHIGEYUKI , YAMATSUGU NOBUYUKI
IPC分类号： C12Q1/40 , C07H15/203
摘要： NEW MATERIAL:A compound of formula I (R is H, acyl; R1, R2 are H, hydrocarbon, or they incorporate to form a ring; X1 to X6 are H, halogen, nitro, cyano, azide, acyl, sulfonic acid, X3 and X4, X5 and X6 bind to each other to form a condensed aromatic ring; n is 1 to 6). EXAMPLE:Isopropylidene-phenolindophenyl-beta-D-maltopentaoside. USE:A reagent for determining alpha-amylase activity. PREPARATION:p-Nitrophenyl-beta-maltooligoside derivative of formula II is allowed to react with a carbonyl compound of formula III or its acetal to form alkylidene-p-nitrophenyl-beta-maltooligoside derivative, which is acylated and reduced to give the compound of formula IV. Then, the product is allowed to react with a quinone derivative of formula V followed by complete or partial deacylation.

42. 发明专利

JPH0242096A PHENOLINDO-3'-AZAPHENYL-BETA-D-GLUCOSIDE DERIVATIVE, PRODUCTION THEREOF AND APPLICATION THEREOF TO REAGENT FOR MEASUREMENT OF BETA-GLUCOSIDASE ACTIVITY 失效
公开(公告)号：JPH0242096A
公开(公告)日：1990-02-13
申请号：JP19069588
申请日：1988-08-01
申请人： KIKKOMAN CORP
发明人： TOKUTAKE SHOICHI
IPC分类号： C12Q1/34 , C07H17/02
摘要： NEW MATERIAL:Compounds of formula I (R is H or acyl; X1-X7 are H, halogen, nitro, cyano, azide, acyl, sulfonic acid, nitroso, sulfonyl, thiocyano, azo, alkyl, allyl, aryl, etc., where X4 and X5 and/or X6 and X7 may be mutually linked to form condensed aromatic ring, X2 and X3 may be respectively linked with X4 and X5 by ether bond). EXAMPLE:Tetraacetyl(phenolindo-3'-azaphenyl)-beta-D-glucoside. USE:A reagent for measurement of beta-glucosidase activity. PREPARATION:With 5-amino-2-pyridinyloxy-beta-D-glucoside derivative expressed by formula II, a quinone derivative represented by formula III is reacted.

43. 发明专利

JPS6419088A INDOPHENYL-BETA-D-GLUCOSIDE DERIVATIVE, PRODUCTION THEREOF AND UTILIZATION THEREOF TO REAGENT FOR MEASURING BETA-GLUCOSIDASE ACTIVITY 失效
公开(公告)号：JPS6419088A
公开(公告)日：1989-01-23
申请号：JP17484287
申请日：1987-07-15
申请人： KIKKOMAN CORP
发明人： TOKUTAKE SHOICHI , YAMATSUGU NOBUYUKI , TOMIKURA TADASHI , INABA SHIGEYUKI
IPC分类号： A61B10/00 , C07H15/203 , C12Q1/34
摘要： NEW MATERIAL:A compound expressed by formula I (R is H or acyl; X1-X6 are H, halogen, nitro, cyano, azido, acyl, sulfonic acid, nitroso, sulfonyl, sulfoxyl, thiocyano, isothiocyano, isonitrile, imino, azo, diazo, alkyl, allyl or aryl or X3 and X4 and X5 and X6 may be each together linked to form condensed aromatic ring). EXAMPLE:Phenolindo-3'-chlorophenyl-beta-D-glucoside. USE:A reagent for measuring beta-glucosidase activity. PREPARATION:A 4-aminophenyl-beta-D-glucoside derivative (e.g. 2-chloro-4- aminophenyl-beta-D-glucoside) expressed by formula II is reacted with a quinone derivative expressed by formula III to provide the aimed compound expressed by formula I.

44. 发明专利

JP2003128560A IMPROVING AGENT FOR BLOOD FLUIDITY 审中-公开
公开(公告)号：JP2003128560A
公开(公告)日：2003-05-08
申请号：JP2001324361
申请日：2001-10-23
申请人： KIKKOMAN CORP
发明人： YOSHIMURA MINEKA , SAITO MINORU , TOKUTAKE SHOICHI
IPC分类号： A23L2/38 , A23L1/30 , A23L2/52 , A61K31/765 , A61K36/00 , A61P7/00 , A61P9/00 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To provide an improving agent for blood fluidity comprising proanthocyanidine in which the existence thereof is known in plants as an active ingredient. SOLUTION: Bloodstreams are improved by converting the proanthocyanidine, especially extracted from grape seeds into a dosage form such as a tablet, a capsule or a solution according to a known method and ingesting the resultant improving agent.

45. 发明专利

JP2002360205A KONJAK FOOD 失效
公开(公告)号：JP2002360205A
公开(公告)日：2002-12-17
申请号：JP2001175191
申请日：2001-06-11
申请人： KIKKOMAN CORP
发明人： TOKUTAKE SHOICHI , KITAO SATORU
IPC分类号： A23L1/30 , A23L19/00 , A23L1/212
摘要： PROBLEM TO BE SOLVED: To provide konjak (paste made from the root of devil's tongue) food containing an antioxidant substance. SOLUTION: This konjak food is obtained by adding proanthocyanidin comprising an antioxidant substance stable against heat and alkali, in particular, extract from grape seeds to devil's tongue so that the konjak food contain it. Such a process results in producing the konjak food having both functionalities in devil's tongue and in the proanthocyanidin.

46. 发明专利

JPH11100401A CYCLIC OLIGOSACCHARIDE AND PREVENTIVE OR TREATING AGENT FOR RETROVIRUS DISEASE CONTAINING THE SAME 失效
公开(公告)号：JPH11100401A
公开(公告)日：1999-04-13
申请号：JP18728698
申请日：1998-07-02
申请人： KIKKOMAN CORP , NODA INST FOR SCIENTIFIC RES
发明人： TOBE KOUICHIROU , SAITO MINORU , TOKUTAKE SHOICHI , KITAO SATORU , OGUMA TETSUYA , FUJITA KAHEE
IPC分类号： A61K31/715 , A61P31/12 , A61P31/18 , A61P37/04 , C08B37/00 , C08B37/16 , A61K31/725
摘要： PROBLEM TO BE SOLVED: To obtain a cyclic oligosaccharide (or its salt) useful as a preventive or a treating agent for retrovirus disease by cyclically bonding a glucose in an α-1, 6 and bonding with an S-oxo-acid group. SOLUTION: This cyclic oligosaccharide (or its salt) is obtained by cyclically bonding preferably 7-9 pieces of glucose respectively in an α-1,6 bonding and bonding with at least one S-oxo-acid group. A cyclic isomaltoctaose sulfate of formula I (or its salt) X is SO3 M [M is H, an alkaline (earth) metal, ammonium, an organic amine] or H, and a total number of X as SO3 M is 7-11}, a cyclic isomaltheptaose sulfate of formula II (or its salt) (a total number of X as SO3 M is 6-10) or a cyclic isomaltnonaose sulfate of formula III (or its salt) (a total number of X as SO3 M is 8-12), etc., is exemplified as the compound. The oligosaccharide (or its salt) inhibits a bonding between gp120 of an AIDS virus and a CD4 receptor of a T-cell.

47. 发明专利

JPH1060006A PRODUCTION OF NONREDUCED-TERMINAL AZIDIZED ACETYLMALTOOLIGOSYL BROMIDE 失效
公开(公告)号：JPH1060006A
公开(公告)日：1998-03-03
申请号：JP24256496
申请日：1996-08-27
申请人： KIKKOMAN CORP
发明人： TOKUTAKE SHOICHI
IPC分类号： C07H1/00 , C07H13/06 , C08B37/00
摘要： PROBLEM TO BE SOLVED: To easily produce the subject compound suitable as a substrate for the determination of α-amylase activity in high reaction yield without accompanying side reactions by reacting a specific oligosaccharide with titanium tetrabromide in the presence of a nonpolar organic solvent. SOLUTION: The objective compound of the formula II such as 6 -azido-6 - deoxynonaacetylmaltotriosyl bromide can be produced by reacting (A) a nonreduced-terminal azidized acetylmaltooligosaccharide of the formula I (Ac is acetyl; (n) is 0-5) with (B) titanium tetrabromide in the presence of (C) a non-polar organic solvent. Preferably, the component C is a mixture of dichloromethane and ethyl acetate, the amount of the component B is usually 0.5-3.0 times mol-equivalent based on the component A and the reaction is carried out at 20-35 deg.C for 1-3 days.

48. 发明专利

JPH09322798A MEASUREMENT OF ALPHA-AMYLASE ACTIVITY AND REAGENT FOR MEASURING THE SAME 失效
公开(公告)号：JPH09322798A
公开(公告)日：1997-12-16
申请号：JP16509196
申请日：1996-06-06
申请人： KIKKOMAN CORP
发明人： TOKUTAKE SHOICHI , YAMATSUGU NOBUYUKI
IPC分类号： C12Q1/40
摘要： PROBLEM TO BE SOLVED: To precisely, safely, rapidly and efficiently measure the subject enzymatic activity useful for diagnosing pancreatic diseases, etc., by subjecting an α-amylase-containing specimen to an enzymatic reaction in the presence of a specific enzymatic substrate and a specified enzyme-activating agent and subsequently determining the liberated aromatic coloring compound. SOLUTION: This method for measuring the activity of α-amylase comprises subjecting a specimen containing the α-amylase to an enzymatic reaction in the presence of a non-reducing terminal-modified α-maltotrioside derivative of formula I [R is an aromatic coloring group expressed by formula II (W is H, a halogen, nitro), etc.; X is azide, a halogen, an N-monoalkylcarbamoyl, an aryl, an alkylsulfonyloxy; Y is an N-monoalkylcarbamoyloxy, an aryl, an alkylsulfonyloxy, α-glucosyl, α-maltosyl, hydroxyl group] as a substrate and an alkali metal cyanate salt as an enzyme-activating agent and subsequently determining the liberated aromatic coloring compound. Thus, the objective α-amylase activity useful for discriminating, diagnosing, etc., acute and chronic pancreatitis, pancreatic cancer, epidemic parotitis, pneumonia, renal insufficiency, etc., can be measured.

49. 发明专利

JPH09220098A MEASUREMENT OF ALPHA-AMYLASE 失效
公开(公告)号：JPH09220098A
公开(公告)日：1997-08-26
申请号：JP5255496
申请日：1996-02-16
申请人： KIKKOMAN CORP
发明人： SHIROKANE TAKAO , TOKUTAKE SHOICHI , TOBE KOUICHIROU , SUZUKI MASARU
IPC分类号： C12Q1/34
摘要： PROBLEM TO BE SOLVED: To rapidly and conveniently measure the subject enzyme in an excellent accuracy by adding a maltooligoside derivative inert to an exo type glycolytic enzyme and a conjugated enzyme system to a sample containing a specific amylase originating from a brewed product and then determining the compound liberated after completion of the reaction. SOLUTION: This method for measuring α-amylase comprises adding a maltooligoside derivative of the formula [(n) is 2-5; R is an aromatic coloring moiety; X is an azide, a halogen, an alkyl or aryloxy, an alkyl or arylsulfonyloxy and a carbamoyloxy; Y is H, an alkyl, an alkyl- or arylsulfonyl, a carbamoyl, etc.] not cleaved by an exo type sugar hydrolase and a conjugated enzyme system such as glucoamylase or the like to a specimen containing α-amylase arising from a brewed product and having an optimum pH of 3 0-5.0 to cause an enzyme reaction and finally determing a liberated compound such as an aromatic coloring compound or the like. The objective α-amylase is quite conveniently measured in a short time and in an excellent accuracy (sensitivity).

50. 发明专利

JP2542699B2 失效
公开(公告)号：JP2542699B2
公开(公告)日：1996-10-09
申请号：JP22484489
申请日：1989-08-31
申请人： KIKKOMAN CORP
发明人： TOKUTAKE SHOICHI , OGUMA TETSUYA , TOBE KOICHIRO , KIKUCHI MAMORU , MIZUSAWA KYOSHI , YAMATSUGU NOBUYUKI
IPC分类号： C12P19/20 , C07H3/08 , C08B30/20 , C08B37/16 , C12P19/14 , C12Q1/40

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