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31. 发明专利

JP2006273725A Method for purifying mandelic acids 有权
标题翻译：纯化食用酸的方法
公开(公告)号：JP2006273725A
公开(公告)日：2006-10-12
申请号：JP2005091681
申请日：2005-03-28
申请人： Mitsubishi Rayon Co Ltd , 三菱レイヨン株式会社
发明人： OGURA KUNIYOSHI , SATO EIJI , MORI HIROYUKI , NOGAMI HIROYUKI , SAITO TAKAYUKI , KOKUBU NOBUTAKA , NINOMIYA YASUHIRO
IPC分类号： C07C51/43 , C07C59/11
摘要： PROBLEM TO BE SOLVED: To provide a method for purifying mandelic acids, capable of giving a high-purity crystal of the mandelic acids having a low content of a dimer of the mandelic acids, without using an organic solvent.
SOLUTION: This method for purifying the mandelic acids comprises mixing contact of a crystal containing the dimer of the mandelic acids and the mandelic acids with an aqueous solvent not containing the organic solvent (a mixed liquid after mixed may be such a solution that the mandelic acids are completely dissolved in water or may be such a mixed suspension that the mandelic acids are not completely dissolved therein), and then subjecting the mixed liquid to solid-liquid separation at 0-60°C under an acidic condition of a pH of 7.0 or less.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种纯化扁桃酸的方法，其能够提供扁桃酸的二聚体含量低的扁桃酸的高纯度晶体，而不使用有机溶剂。解决方案：用于纯化扁桃酸的方法包括将含有扁桃酸的二聚体和扁桃酸的晶体与不含有机溶剂的水性溶剂的混合物混合（混合后的混合液体可以是这样的溶液，扁桃酸完全溶解在水中，或者可以是这样的混合悬浮液，其中扁桃酸不完全溶解在其中），然后在0-60℃下在pH的酸性条件下使混合液体进行固液分离 7.0以下。版权所有（C）2007，JPO＆INPIT

32. 发明专利

JP2006213635A Method for producing mandelic acid and crystal of mandelic acid 审中-公开
标题翻译：生产苹果酸和水杨酸晶体的方法
公开(公告)号：JP2006213635A
公开(公告)日：2006-08-17
申请号：JP2005027775
申请日：2005-02-03
申请人： Mitsubishi Rayon Co Ltd , 三菱レイヨン株式会社
发明人： MORI HIROYUKI , SATO EIJI , NOGAMI HIROYUKI , SAITO TAKAYUKI , KOKUBU NOBUTAKA , NINOMIYA YASUHIRO , OGURA KUNIYOSHI
IPC分类号： C07C51/43 , C07B61/00 , C07C51/08 , C07C59/50
摘要： PROBLEM TO BE SOLVED: To provide a method for producing high purity mandelic acid useful as a medicinal and agrochemical row material, a liquid crystal material and a reagent for optical resolution, and to provide crystal of mandelic acid. SOLUTION: The method for producing the high purity mandelic acid comprises acid hydrolysis of mandelonitrile, aging of the produced mandelic acid in a state of precipitating a part thereof, and recovery of the crystal of the mandelic acid. The crystal of mandelic acid contains the dimer of not more than 0.1% (surface percentage) based on 100 surface% total of the mandelic acid and the dimer thereof in high performance liquid chromatographic measurement. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：提供一种生产用作药物和农业化学排料的高纯度扁桃酸的方法，液晶材料和用于光学拆分的试剂，并提供扁桃酸的晶体。解决方案：用于生产高纯度扁桃酸的方法包括扁桃酸的酸水解，在其部分沉淀的状态下老化生产的扁桃酸，以及回收扁桃酸的晶体。在高效液相色谱测量中，扁桃酸的晶体含有不超过0.1％（表面百分比）的二聚体，基于100％扁桃酸的总量及其二聚体。版权所有（C）2006，JPO＆NCIPI

33. 发明专利

JP2013009621A Method for producing optically-active 4-halo-3-hydroxybutyronitrile 审中-公开
标题翻译：用于生产光学活性的4-羟基-3-羟基丁酸的方法
公开(公告)号：JP2013009621A
公开(公告)日：2013-01-17
申请号：JP2011143895
申请日：2011-06-29
申请人： Mitsubishi Rayon Co Ltd , 三菱レイヨン株式会社
发明人： KUWAHARA FUMI , WATANABE TAKESHI , WATANABE FUMIAKI , SATO EIJI , NINOMIYA YASUHIRO
IPC分类号： C12P13/00 , C12N9/14 , C12N15/09
CPC分类号： Y02P20/52
摘要： PROBLEM TO BE SOLVED: To provide a method for producing 4-halo-3-hydroxybutyronitrile of high concentration and high optical purity.SOLUTION: There is provided the method for producing 4-halo-3-hydroxybutyronitrile from a 1, 3-dihalo-2-propanol and a cyanide donor by enzyme reaction. After the initiation of the enzyme reaction, the 1, 3-dihalo-2-propanol is supplied to a reaction liquid and the concentration of the 1, 3-dihalo-2-propanol is held in the range of not more than 0.43 mol/kg.
摘要翻译：待解决的问题：提供一种高浓度和高光学纯度的4-卤代-3-羟基丁腈的制备方法。解决方案：提供了通过酶反应从1,3-二卤代-2-丙醇和氰化物供体产生4-卤-3-羟基丁腈的方法。酶反应开始后，将1,3-二卤代-2-丙醇供给到反应液中，1,3-二卤代-2-丙醇的浓度保持在不大于0.43mol / 公斤。版权所有（C）2013，JPO＆INPIT

34. 发明专利

JP2012105671A METHOD FOR PRODUCING OPTICALLY ACTIVE CYANOHYDRIN AND METHOD FOR PRODUCING OPTICALLY ACTIVE α-HYDROXY CARBOXYLIC ACID 审中-公开
标题翻译：生产光学活性氰基橙的方法及生产光学活性α-羟基羧酸的方法
公开(公告)号：JP2012105671A
公开(公告)日：2012-06-07
申请号：JP2012042003
申请日：2012-02-28
申请人： Mitsubishi Rayon Co Ltd , 三菱レイヨン株式会社
发明人： OGURA KUNIYOSHI , SATO EIJI , MORI HIROYUKI , NOGAMI HIROYUKI , KATO OSAMU , SAITO TAKAYUKI , KOKUBU NOBUTAKA , NINOMIYA YASUHIRO
IPC分类号： C12P13/00 , C12N9/88 , C12N15/09 , C12P7/42
CPC分类号： Y02P20/52
摘要： PROBLEM TO BE SOLVED: To provide an efficient method for producing an optically active cyanohydrin, which can be accumulated in high concentration, and to provide a safe method for producing an optically active α-hydroxy carboxylic acid in high yield.SOLUTION: The method for producing the optically active cyanohydrin comprises an enzymatic reaction carried out in the presence of an organic solvent substantially immiscible with water by using an aromatic aldehyde and HCN as substrates. The method for producing the optically active cyanohydrin is characterized in that a hydroxynitrile lyase prepared by using a genetically recombined organism as an enzyme, and a state in which the molar concentration of the aromatic aldehyde in a reaction solution is ≤0.4 mol/kg and not higher than the molar concentration of the HCN is maintained for ≥2 hr at a reaction temperature of -10 to 40°C at pH 4.0-7.0, thereby accumulating the optically active cyanohydrin having optical purity of ≥90% e.e. in an amount of ≥35 wt.% in a reaction system.
摘要翻译：要解决的问题：提供可以高浓度积聚的光学活性羟腈的有效方法，并提供以高产率制备光学活性α-羟基羧酸的安全方法。解决方案：制备光学活性羟腈的方法包括通过使用芳族醛和HCN作为底物在与水基本上不混溶的有机溶剂的存在下进行的酶反应。光学活性羟腈的制造方法的特征在于，使用遗传重组生物体作为酶制备的羟基腈裂解酶和反应溶液中芳族醛的摩尔浓度为0.4mol / kg以下的状态，高于HCN的摩尔浓度在-10至40℃的反应温度下在pH 4.0-7.0下维持≥2小时，从而积聚光学纯度≥90％ee的光学活性羟腈在反应体系中的含量≥35重量％。版权所有（C）2012，JPO＆INPIT

35. 发明专利

JP2012092037A Method for purifying compound 审中-公开
标题翻译：净化化合物的方法
公开(公告)号：JP2012092037A
公开(公告)日：2012-05-17
申请号：JP2010240041
申请日：2010-10-26
申请人： Mitsubishi Rayon Co Ltd , 三菱レイヨン株式会社
发明人： INABA HIDEYUKI , HOSHINO MANABU , IIZUKA AYA , NINOMIYA YASUHIRO , SATO EIJI
IPC分类号： C07C231/24 , B01D61/44 , C07C237/06
CPC分类号： Y02A20/134
摘要： PROBLEM TO BE SOLVED: To provide a method for effectively removing impurities contained in a compound having a positive charge, and recovering a betaine contained in an aqueous solution so as not to form cloudiness or aggregates in the aqueous solution during electrodialysis.SOLUTION: There is provided the method including (a) a step of adjusting the pH of the aqueous solution containing the compound represented by formula (1) (wherein, R, R, and Rmay be same or different, and represent each 1-3C hydrocarbon etc.; and A represent ≥1 to ≤6C linear alkyl chain etc.), and having the positive charge to ≤4; and (b) a step of feeding the aqueous solution obtained in (a) to desalters 5 and 7, applying a voltage thereto, thereby permeating the compound having the positive charge through a cation exchange membrane C, and transferring the compound to a thickener 6.
摘要翻译：要解决的问题：提供一种有效去除具有正电荷的化合物中所含的杂质的方法，并回收水溶液中所含的甜菜碱，以便在电渗析期间不在水溶液中形成浑浊或聚集体。提供了这样的方法：（a）调节含有式（1）表示的化合物的水溶液的pH值的步骤（其中，R 1 ，R 2 ，并且R 3 可以相同或不同，并且表示每个1-3C烃等;而A表示 ≥1〜≤CC直链烷基链等），正电荷≤4; 和（b）将（a）中得到的水溶液供给到脱盐剂5和7中的步骤，向其中施加电压，从而通过阳离子交换膜C渗透具有正电荷的化合物，并将化合物转移到增稠剂6 （C）2012年，JPO＆INPIT

36. 发明专利

JP2011045361A Method for producing 4-halo-3-hydroxybutylamide 审中-公开
标题翻译：生产4-羟基-3-羟基丁酰胺的方法
公开(公告)号：JP2011045361A
公开(公告)日：2011-03-10
申请号：JP2010153559
申请日：2010-07-06
申请人： Mitsubishi Rayon Co Ltd , 三菱レイヨン株式会社
发明人： WATANABE TAKESHI , IIZUKA AYA , NINOMIYA YASUHIRO , OISHI KOSUKE , SATO EIJI
IPC分类号： C12P13/02
摘要： PROBLEM TO BE SOLVED: To provide a method for efficiently producing 4-halo-3-hydroxybutylamide. SOLUTION: (1) The method for producing 4-halo-3-hydroxybutylamide includes (a) a process in which the solution containing 4-halo-3-hydroxybutyronitrile and hypochlorous acid and/or its salt come into contact with, and, subsequently, (b) a process in which the nitrile is amidated by nitrile hydratase. (2) The method for producing 4-halo-3-hydroxybutylamide includes (a) a process in which the solution containing 4-halo-3-hydroxybutyronitrile and hypochlorous acid and/or its salt come into contact with, (b) a process in which the solution containing 4-halo-3-hydroxybutyronitrile and the salt and/or a complex of at least one sort of metal selected from the group consisting of cobalt, nickel and zinc come into contact with, and (c) a process in which, after the processes (a) and (b), the nitrile is amidated by nitrile hydratase. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供一种有效生产4-卤代-3-羟基丁酰胺的方法。（1）4-卤代-3-羟基丁酰胺的制造方法包括（a）使含有4-卤-3-羟基丁腈和次氯酸和/或其盐的溶液接触的方法，随后，（b）腈通过腈水合酶进行酰胺化的方法。（2）4-卤-3-羟基丁酰胺的制造方法，包括（a）使含有4-卤-3-羟基丁腈和次氯酸和/或其盐的溶液接触的方法，（b）其中含有4-卤代-3-羟基丁腈的溶液和选自钴，镍和锌的至少一种金属的盐和/或配合物与（c）和在方法（a）和（b）之后，腈被腈水合酶酰胺化。版权所有（C）2011，JPO＆INPIT

37. 发明专利

JP2010143857A Method for purifying carnitine 审中-公开
标题翻译：净化CARNITINE的方法
公开(公告)号：JP2010143857A
公开(公告)日：2010-07-01
申请号：JP2008322683
申请日：2008-12-18
申请人： Mitsubishi Rayon Co Ltd , 三菱レイヨン株式会社
发明人： TAKIGAWA YUYA , SATO EIJI , MORI HIROYUKI
IPC分类号： C07C221/00 , C07C229/22
摘要： PROBLEM TO BE SOLVED: To provide a method for purifying carnitine by reducing impurities produced by side reactions, and to provide highly pure carnitine having reduced impurities.
SOLUTION: The highly pure carnitine can be produced by adding an alcohol solvent to a carnitine mixture comprising at least one compound chosen from a compound represented by formula (1): R
2 -CH
2 -CHR
1 -CH
2 -COOH (wherein R
1 is a hydroxy group or a carbon-carbon double bond formed between the carbon at β position; and R
2 is a cyano group, a hydroxy group, an amide group; a primary, secondary or tertiary amino group or a carboxy group, provided that R
2 may be bound to the oxygen in one of the carboxy groups to form a ring), a trimethylammonium compound, an acidic substance, salts and betaines.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：解决问题的方法：提供通过减少副反应产生的杂质来提纯肉碱的方法，提供具有降低的杂质的高纯度肉碱。解决方案：可以通过向包含至少一种选自由式（1）表示的化合物的化合物的肉碱混合物中加入醇溶剂来制备高纯度肉毒碱：R SB <2 SB < > 2 -CHR 1 2 -COOH（其中R SB 1是/或碳 - 碳双键形成在β位的碳之间; R SB 2是氰基，羟基，酰胺基，伯，仲或叔氨基或羧基，条件是R 2 可以与一个羧基中的氧结合形成环），三甲基铵化合物，酸性物质，盐和甜菜碱。版权所有（C）2010，JPO＆INPIT

38. 发明专利

JP2010126487A Method for refining carnitine 审中-公开
标题翻译：精制CARNITINE的方法
公开(公告)号：JP2010126487A
公开(公告)日：2010-06-10
申请号：JP2008302833
申请日：2008-11-27
申请人： Mitsubishi Rayon Co Ltd , 三菱レイヨン株式会社
发明人： TAKIGAWA YUYA , SATO EIJI , MORI HIROYUKI
IPC分类号： C07C227/42 , A61K31/205 , A61P3/06 , A61P9/00 , A61P9/10 , C07C229/22
摘要： PROBLEM TO BE SOLVED: To provide a method for refining carnitine reduced in impurities formed by side reactions, namely, to provide a high-purity carnitine with reduced impurities, in view of the fact that L-carnitine is also referred to as vitamin BT, being an important compound associated with fatty acid metabolism in vivo, and being under attention as e.g. a cardiopathy treatment agent, hyperlipemia treatment agent, vein-related disease treatment agent.
SOLUTION: The carnitine with reduced impurities can be obtained by adding an alcoholic solvent to a carnitine mixture containing acidic substance(s) and/or salts thereof.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供一种通过副反应形成的减少杂质的肉碱的精制方法，即为了提供具有降低的杂质的高纯度肉碱，鉴于L-肉碱也被称为维生素BT是与体内脂肪酸代谢相关的重要化合物，并且受到关注心脏病治疗剂，高脂血症治疗剂，静脉相关疾病治疗剂。解决方案：通过向含有酸性物质和/或其盐的肉碱混合物中加入醇溶剂可以获得具有降低的杂质的肉碱。版权所有（C）2010，JPO＆INPIT

39. 发明专利

JP2010119357A Method for producing optically active 4-halo-3-hydroxybutyramide and optically active carnitine amide 审中-公开
标题翻译：生产光学活性的4-羟基-3-羟基丁酰胺和光学活性亚胺酰胺的方法
公开(公告)号：JP2010119357A
公开(公告)日：2010-06-03
申请号：JP2008297507
申请日：2008-11-21
申请人： Mitsubishi Rayon Co Ltd , 三菱レイヨン株式会社
发明人： NINOMIYA YASUHIRO , WATANABE TAKESHI , OISHI KOSUKE , SATO EIJI
IPC分类号： C12P13/02
摘要： PROBLEM TO BE SOLVED: To provide respective methods for producing an optically active 4-halo-3-hydroxybutyramide in high productivity with both excellent in terms of cost and environment, a precursor thereof and a derivative thereof. SOLUTION: The method for producing the optically active 4-halo-3-hydroxybutyramide includes: the step (1) of obtaining an optically active 4-halo-3-hydroxybutyronitrile by enzymatic reaction with a halohydrin epoxidase; the step (2) of distilling and concentrating the reaction liquid obtained by the step (1) to separate an unreacted raw material; the step (3) of subjecting a heating treatment and/or metal salt-addition treatment to the residues in the step (2); and the step (4) of adding a nitrile hydratase under specific conditions to the treatment liquid obtained by the step (3). The method for producing the precursor includes the steps (1) and (2). There is also provided the method for producing the derivative using the optically active 4-halo-3-hydroxybutyramide. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供生产成本和环境优异的光学活性4-卤-3-羟基丁酰胺的各种方法，其前体和其衍生物。解决方案：制备光学活性4-卤代-3-羟基丁酰胺的方法包括：通过与卤代醇环氧酶的酶反应获得光学活性4-卤代-3-羟基丁腈的步骤（1）蒸馏并浓缩由步骤（1）获得的反应液体以分离未反应的原料的步骤（2）; 对步骤（2）中的残留物进行加热处理和/或金属盐添加处理的步骤（3）; 以及在特定条件下向由步骤（3）获得的处理液中添加腈水合酶的步骤（4）。制造前体的方法包括步骤（1）和（2）。还提供了使用光学活性的4-卤代-3-羟基丁酰胺制备衍生物的方法。版权所有（C）2010，JPO＆INPIT

40. 发明专利

JP2010070551A Purification method of charged organic compound and production method of carnitine amide chloride or carnitine using the same 审中-公开
标题翻译：充电有机化合物的纯化方法和使用其的氯化亚铜或碳酰胺的生产方法
公开(公告)号：JP2010070551A
公开(公告)日：2010-04-02
申请号：JP2009191103
申请日：2009-08-20
申请人： Mitsubishi Rayon Co Ltd , 三菱レイヨン株式会社
发明人： HOSHINO MANABU , INABA HIDEYUKI , HIROHATA JITSUO , SATO EIJI
IPC分类号： C07C231/24 , B01D61/44 , C07C227/40 , C07C229/22 , C07C237/06
CPC分类号： Y02A20/134
摘要： PROBLEM TO BE SOLVED: To provide a method for obtaining a charged organic compound with high purity.
SOLUTION: There is provided a method for purifying an objective liquid containing a charged organic compound by using an electrodialyser, wherein the purification method comprises (a) supplying the objective liquid to a desalting vessel of the electrodialyser, (b) energizing on a condition that the pressure in a thickener is higher than the pressure in the desalting vessel and (c) transferring the charged compound supplied to the desalting vessel to the thickener through a cation exchange membrane or an anion exchange membrane.
COPYRIGHT: (C)2010,JPO&INPIT

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