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31. 发明专利

JP2000319535A PRODUCTION OF CAROTENOID-BASED COLORING MATTER- CONTAINING COMPOSITION 失效
公开(公告)号：JP2000319535A
公开(公告)日：2000-11-21
申请号：JP13063599
申请日：1999-05-11
申请人： LION CORP , MORI SEIYU KK
发明人： SOMEYA KEITA , FURUE MASAHIKO , KAWAZOE YOSHIHISA , MORIKAWA KATSUMI
IPC分类号： A23L1/275 , C09B61/00 , C09B67/54
摘要： PROBLEM TO BE SOLVED: To obtain the subject high-quality composition without bringing about quality deterioration of the carotenoid-based coloring matter through reducing contaminative microorganisms and other fine contaminants. SOLUTION: This carotenoid-based coloring matter-contg. composition is obtained by the following process: an extract containing a carotenoid-based coloring matter is subjected, after the coloring matter is solubilized, to a surface filtration device with a pore size of 0.5-5 μm; wherein, in solubilizing the coloring matter, it is preferable that, for avoiding its quality deterioration, the extract is heated at

32. 发明专利

JP2000236843A PRODUCTION OF CURCUMINS 失效
公开(公告)号：JP2000236843A
公开(公告)日：2000-09-05
申请号：JP4391699
申请日：1999-02-22
申请人： LION CORP
发明人： SOMEYA KEITA , ISOBE KENJI , FURUE MASAHIKO
IPC分类号： A23L27/10 , A61K36/18 , A23L1/221 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To suppress the deterioration of curcumin, reduce the amount of an extracting solvent and produce high-purity curcumins useful for medicines, foods, colorants, or the like, by dispersing a curcumin-containing extract solution in a solvent having a polarity different from that of the extracting solvent and then fractionating the curcumin. SOLUTION: For example, Curcuma longa L. is pulverized to 250-500 μm size to thereby provide a curcumin-containing extract solution according to a solid-liquid extracting method or a Soxhlet method, or the like, using an extracting solvent such as acetone. The resultant extract solution is then dispersed in a solvent having a polarity different from that of the extracting solvent and having high safety such as hydrous ethanol, hydrous denatured ethanol or water and the curcumin is subsequently fractionated to afford curcumins. For example, a deposition fractionating method by regulation of hydrogen ions of a solution, temperature regulation or polarity regulation is used as the method for fractionating the curcumins.

33. 发明专利

JP2003176225A COMPOSITION FOR ORAL CAVITY AND EXTERNAL USE FOR SKIN 审中-公开
公开(公告)号：JP2003176225A
公开(公告)日：2003-06-24
申请号：JP2002319014
申请日：2002-09-27
申请人： LION CORP
发明人： OISHI HIDEYUKI , KIYOSHIGE TATSUO , SOMEYA KEITA , SHIMIZU HIROYUKI , KURUSU KEIJI
IPC分类号： A61K8/30 , A61K8/00 , A61K8/33 , A61K8/64 , A61K8/65 , A61K8/96 , A61K8/97 , A61K31/192 , A61K36/18 , A61K36/47 , A61K36/48 , A61K36/81 , A61K36/899 , A61K38/00 , A61P1/02 , A61P17/00 , A61Q11/00 , A61Q15/00 , A61Q19/00 , A61K7/00 , A61K7/16 , A61K7/26 , A61K7/32 , A61K7/48 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To provide a safe composition having excellent anti-oxidation stress effects on the oxidation stress by an activated oxygen, and good sense of use. SOLUTION: This composition for the oral cavity and external use for the skin is obtained by formulating an extract of a plant belonging to the genus Oryza of the grass family, an extract of a plant belonging to the genus Myrica of Myricaceae, an extract of a plant belonging to the genus Jatropha of the spurge family, an extract of a plant belonging to the genus Solanum of Solanaceae, an extract of H. stilgocarga of the genus Hymenaea of Febaceae, a peptide and a phenylpropanoid. COPYRIGHT: (C)2003,JPO

34. 发明专利

JPS6438007A SKIN EXTERNAL PREPARATION 失效
公开(公告)号：JPS6438007A
公开(公告)日：1989-02-08
申请号：JP4292588
申请日：1988-02-25
申请人： LION CORP
发明人： SUNAZAKI KAZUHIKO , SOMEYA KEITA , TANAKA YOSHIMASA , TOTANI EISEI
IPC分类号： A61K8/30 , A61K8/00 , A61K8/36 , A61K8/92 , A61K8/96 , A61K8/99 , A61K31/20 , A61K31/202 , A61P17/00 , A61Q1/00 , A61Q1/04 , A61Q1/12 , A61Q19/00 , C11D9/48 , C12P7/64 , C12R1/645
摘要： PURPOSE:To obtain a skin external preparation for remedying the heel with chapped keratin or corns, having excellent moisture retaining effect, making soft and smooth skin, showing antimicrobial action and inhibitory action on sebum secretion free from side effects, containing an arachidonic acid-containing lipid as an active ingredient. CONSTITUTION:A skin external preparation containing an arachidonic acid- containing lipid as an active ingredient. In use, the active ingredient is blended with components such as an oil, water, a surface active agent and a humectant and in the case of especially a skin keratin improver, the blend is mixed with 0.001-10%, especially 0.01-5% antioxidant. An arachidonic acid-containing lipid produced by a mold belonging to the genus Mortierella is preferable as the active ingredient and further one extracted from a fish oil is also usable. The amount of the active ingredient is 0.001-30wt.%, preferably 0.5-20wt.% in the case of skin cosmetic, 0.001-10wt.%, preferably 0.05-5wt.% in the case of a remedy for skin acne and preferably 0.1-5wt.% in the case of the skin keratin improver.

35. 发明专利

JP2000300904A PRODUCTION OF NATURAL EXTRACT 失效
公开(公告)号：JP2000300904A
公开(公告)日：2000-10-31
申请号：JP11628499
申请日：1999-04-23
申请人： LION CORP , TOYOTAMA PERFUMERY
发明人： SOMEYA KEITA , IMADA HIROSHI , FURUE MASAHIKO , SAKAI ANRI , MIZOGUCHI TOMOKI , NAGAURA RIKIHIRO
IPC分类号： B01D11/04 , C11B1/10 , C11B1/12 , C11B3/16 , C11B9/02
摘要： PROBLEM TO BE SOLVED: To simply remove the residual solvent in a natural extract without deteriorating a target substance. SOLUTION: The natural extract extracted with an extraction solvent is redissolved in a solvent compatible with the extraction solvent and different from the extraction solvent while pressurized under a condition of 0.0001-20 kg/cm2 or redissolved in a water-containing solvent with a hydrogen ion concn. of 10-7.5 M or more before a target substance is fractionated.

36. 发明专利

JPH11246399A LIPID METABOLISM IMPROVING COMPOSITION 失效
公开(公告)号：JPH11246399A
公开(公告)日：1999-09-14
申请号：JP5102198
申请日：1998-03-03
申请人： LION CORP
发明人： SOMEYA KEITA , MIYAZAWA HARUO , ASAI AKIRA
IPC分类号： A23L1/30 , A61K31/12 , A61K36/18 , A61P3/06
摘要： PROBLEM TO BE SOLVED: To obtain the subject composition harmless to human body and having triglyceride lowering action by including a curcumin as an active ingredient. SOLUTION: This composition is obtained by including one or more selected from a curcumin [e.g. 1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione] and its derivative e.g. demethoxycurcumin [4-hydroxy-cinnamoyl-(4-hydroxy-3- methoxy-cinnamoyl)methane]} as an active ingredient. The composition, when to be used as a pharmaceutical, can be administered by oral administration, intravenous injection, hypodermic injection or the like using a curcumin or its derivative, as necessary, combinedly with another lipid metabolism improving composition and the daily adult dose is preferably 1-30 mg/kg-body weight. The composition can be prepared as soft capsules, tablets, granuled or the like.

37. 发明专利

JPH0441424A CARCINOGENIC PROMOTION INHIBITOR 失效
公开(公告)号：JPH0441424A
公开(公告)日：1992-02-12
申请号：JP14600690
申请日：1990-06-04
申请人： LION CORP
发明人： NISHINO HOUYOKU , MURAKOSHI TOMOAKI , SOMEYA KEITA , IWASAKI RYOZO
IPC分类号： A61K31/035 , A61P35/00
摘要： PURPOSE:To obtain a carcinogenic promotion inhibitor, containing squalene as an active ingredient and having anti-carcinogenic promotion activity with low toxicity. CONSTITUTION:A carcinogenic promotion inhibitor containing squalene extracted, separated and purified from liver oil of a shark or other fish oils, yeast, wheat embryonic oil, rice bran oil, olive oil, palm oil, other various food raw materials, etc., as an active ingredient. The squalene is alone or, as necessary, together with other medicinal ingredients, can be used and orally or parenterally administered. The dose thereof is normally within the range of 100-200 mg for an adult a day for oral administration. If the squalene is used with alpha-carotene in combination as the active ingredient, the carcinogenic promotion inhibitory effects of the squalene can be further enhanced.

38. 发明专利

JPH02142486A PRODUCTION OF UNSATURATED FATTY ACID-CONTAINING LIPID 失效
公开(公告)号：JPH02142486A
公开(公告)日：1990-05-31
申请号：JP29728388
申请日：1988-11-25
申请人： LION CORP
发明人： SOMEYA KEITA , WATANABE YOSHIHIRO , TOTANI EISEI
IPC分类号： C12P7/64 , C12R1/645
摘要： PURPOSE:To form microbial cells into a particular or granular shape, reduce tackiness, facilitate oxygen feed and obtain the subject lipid in high yield by keeping a carbon source in a culture medium in a low concentration and applying a physical stress thereto in culturing a mold. CONSTITUTION:A microorganism (e.g., Mortierella alpina.ATCC32221), belonging to the genus Mortierella and capable of producing unsaturated fatty acids is cultured using a carbon source as a restriction substrate and/or cultured in a liquid culture medium under conditions of, e.g., pH4-7 and 20-30 deg.C for 2-30 days, while applying >=5kg/m .sec physical stress to afford the objective lipid.

39. 发明专利

JP2000178295A ANTITUMOR COMPOSITION 失效
公开(公告)号：JP2000178295A
公开(公告)日：2000-06-27
申请号：JP35953598
申请日：1998-12-17
申请人： LION CORP
发明人： SOMEYA KEITA , MATSUMOTO HIROHIKO , YAMANE TETSUO , NISHINO HOYOKU , TSURUTA ATSUSHI , KOMURA MARI
IPC分类号： A61K36/18 , A61K31/00 , A61P35/00 , C07J19/00 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To obtain an antitumor composition having a suppressing effect against the promotion, progression, etc., of carcinogenic mechanism and also safe to human body by containing a cyanidin glucoside as an active ingredient. SOLUTION: This antitumor composition contains a cyaniding glucoside such as cyanidin-3-glucoside, cyanidin-3, 5-diglucoside, etc., as an active ingredient. Further, the cyanidin glucoside can be administered singly or simultaneously with other antitumor agent as necessary in various methods such as an oral administration, an intravenous injection, a subcutaneous injection, an intramuscular injection, an intrarectal administration by a suppository, etc., and since the amount of administration can be controlled by administration routes and number of administrations, it can be varied widely in accordance with symptoms, e.g. it can be set as 15 μg-30 mg/kg body weight or 1-300 mg/kg body weight for an adult daily.

40. 发明专利

JPH07118137A BEAUTIFYING AGENT 失效
公开(公告)号：JPH07118137A
公开(公告)日：1995-05-09
申请号：JP28434093
申请日：1993-10-19
申请人： LION CORP
发明人： SOMEYA KEITA , TANAKA YOSHIRO , KOIKE YASUSHI
IPC分类号： A61K8/30 , A61K8/00 , A61K8/97 , A61K31/015 , A61P17/00 , A61Q19/00 , A61Q19/02 , A61K7/48 , A61K7/00
摘要： PURPOSE:To obtain a beautifying agent having excellent effect on beauty culture of skin, high safety and improved absorption in body free from fear of side effects, comprising a carotene mixture extracted from a palm oil as an active ingredient. CONSTITUTION:For example, a palm oil is subjected to alcoholysis with a lower alcohol, the prepared ester is diluted with a hydrophilic solvent and water is added to the solution to give precipitate. Then the precipitate is purified by vacuum distillation to give a carotene mixture. A beautifying agent comprises the carotene mixture extracted from the palm oil as an active ingredient. The extract of the palm oil is a mixture usually comprising 30-40% of alpha-carotene, 55-66% of beta-carotene and 5-15% of other components such as carotenoids. Since various administration methods of this beautifying agent can be applied, the administration method and a does can be controlled depending upon the condition of a disease. Further a large amount of the beautifying agent can be used, the agent is effective for preventing and treating disorder in terms of health and beauty culture.

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