专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明专利

JP2001226263A PROPHYLACTIC OF OBESITY 失效
公开(公告)号：JP2001226263A
公开(公告)日：2001-08-21
申请号：JP2000039297
申请日：2000-02-17
申请人： KANEBO LTD
发明人： HARA MARIKO , IKEMOTO TAKESHI , INOUE SHINTARO
IPC分类号： A61K31/70 , A61K31/047 , A61K31/05 , A61K31/702 , A61P3/04
摘要： PROBLEM TO BE SOLVED: To prepare a prophylactic of obesity, effective for the improvement of the constitution of the obesity by promoting the decrease of the whole-body or topical adipose tissue, or the suppression or prevention of the obesity by inhibiting the increase of the same tissue. SOLUTION: This prophylactic of the obesity comprises a compound of general formula (1) (wherein, R is a hydrogen atom, a residue of monosaccharides or oligosaccharides).

32. 发明专利

JP2000178118A HUMECTANT, SKIN COSMETIC AND BATHING AGENT 失效
公开(公告)号：JP2000178118A
公开(公告)日：2000-06-27
申请号：JP36063098
申请日：1998-12-18
申请人： KANEBO LTD
发明人： ENDO YOKO , SAKAI SHINGO , INOUE SHINTARO , HAYASE MOTOI
IPC分类号： A61K8/30 , A61K8/00 , A61K8/44 , A61K31/00 , A61K31/198 , A61P17/00 , A61P17/16 , A61Q19/00 , A61Q19/10 , A61K7/00 , A61K7/50
摘要： PROBLEM TO BE SOLVED: To obtain a humectant, a skin cosmetic and a bathing agent having excellent moisture absorption ability and moisture retaining ability free from a feeling of stickiness. SOLUTION: This humectant characteristically contains N-monomethylglycine. This skin cosmetic and a bathing agent contain the humectant. N-Methylglycine used in this invention is a well-known substance, named sarcosine as another name and is readily obtainable. The amount of the humectant related to this invention is preferably 0.001-30.0 wt.%, more preferably 0.01-10.0 wt.% based on the total of the skin cosmetic. When the amount of the humectant is =30.0 wt.%, occasionally an effect corresponding to the mixed amount is not obtained.

33. 发明专利

JPH11292765A CHOLESTEROL AND FATTY ACID SYNTHESIS PROMOTER 失效
公开(公告)号：JPH11292765A
公开(公告)日：1999-10-26
申请号：JP9742898
申请日：1998-04-09
申请人： KANEBO LTD
发明人： TANNO OSAMU , OTA YUKIKO , INOUE SHINTARO
IPC分类号： A61K8/67 , A61K8/00 , A61K8/49 , A61K31/44 , A61K31/455 , A61K31/675 , A61P3/02 , A61P3/08 , A61P17/00 , A61Q19/08 , A61K7/00
摘要： PROBLEM TO BE SOLVED: To obtain the subject promoter with nicotinic acid or the like as active ingredient, having such action as to vitalize synthesis of cholesterol or the like by epidermal cells themselves inside the cutaneous surface layer, and therefore having sustainable effect on rough skin improvement owing to skin barrier function recovery, dermatoses therapies and the recovery from barrier function decline associated with senescence. SOLUTION: This promoter contains, as active ingredient, pref. 0.00001-5 wt.% of at least one kind of compound selected from the group consisting of nicotinic acid, derivatives thereof, nicotinic alcohol and salts thereof; wherein the nicotinic acid derivatives are pref. compounds of formula I (R1 is H, OH, NH2 or the like; R2 is absent, an aliphatic monoamine or the like) or formula II (R5 and R6 are each OH or NH2 ) (pref. methylnicotinic acid or the like), while the nicotinic alcohol salts are pref. compounds of formula III (R9 is absent or a monovalent organic acid) (pref. tartaric acid nicotinic alcohol salt or the like).

34. 发明专利

JPH1180004A INHIBITOR FOR DECOMPOSITION OF HYALURONIC ACID, AGENT FOR IMPROVING AND TREATING DISEASE CAUSING ABNORMAL DECOMPOSITION OF HYALURONIC ACID AND AGENT FOR PREVENTING GINGIVITIS AND AGENT FOR PREVENTING DRY SKIN OR ROUGH SKIN 失效
公开(公告)号：JPH1180004A
公开(公告)日：1999-03-23
申请号：JP25289497
申请日：1997-09-01
申请人： KANEBO LTD
发明人： SAKAI SHINGO , SAYO TETSUYA , INOUE SHINTARO
IPC分类号： A61K9/08 , A61K8/00 , A61K8/72 , A61K8/73 , A61K9/20 , A61K9/48 , A61K31/715 , A61P1/02 , A61P1/16 , A61P9/10 , A61P17/00 , A61P29/00 , A61P35/00 , A61P43/00 , A61Q19/10 , C08B37/10 , A61K31/725
摘要： PROBLEM TO BE SOLVED: To obtain an inhibitor for decomposition of hyaluronic acid, acting on a cell which exists in human binding tissue and inhibiting decomposition of hyaluronic acid and useful as an agent for improving and treating diseases causing abnormal decomposition of hyaluronic acid such as rheumatism, osteoarthritis and malignant tumor by including heparin. SOLUTION: This inhibitor contains heparin and/or its salt extracted according to ordinary method from intestine or the like of pig or the like, preferably in an amount of 0.001-5 g based on 100 g total amount of medicine. Daily doses of the compound is preferably 1-10 g as total amount of heparin and its salt in the case of oral administration and preferably 0.1-5 g in the case of parenteral administration. The medicine is useful as an agent for improving and treating diseases causing abnormal decomposition of hyaluronic acid, e.g. hepatitis, gingivitis and fibrosis.

35. 发明专利

JPH09235293A NEW TRITERPENE 失效
公开(公告)号：JPH09235293A
公开(公告)日：1997-09-09
申请号：JP7119896
申请日：1996-02-29
申请人： KANEBO LTD
发明人： TANNO OSAMU , INOUE SHINTARO , KAWAGISHI HIROKAZU
IPC分类号： C12N9/99 , A61K8/00 , A61K31/575 , A61K36/07 , A61P17/00 , A61P27/02 , A61P29/00 , A61P43/00 , A61Q11/00 , C07J9/00 , A61K35/84
摘要： PROBLEM TO BE SOLVED: To obtain a new triterpene through extraction from mushroom basidiocarp, which has collagenase inhibitory action, thus is useful for treating diseases attributable to collagenase activity sthenia such as arthrosis, bone resorption disorder, periodontosis, corneal ulcer and bullous epidermolysis. SOLUTION: This new triterpene is expressed by the formula, having a molecular formula: C30 H40 O5 and a molecular weight of 484, having inhibitory activity against collagenase as an enzyme involving connective tissue matrix metabolism, therefore being useful for e.g. treating various diseases attributable to collagenase activity sthenia such as arthrosis, bone resorption disorder, periodontosis, corneal ulcer and bullous epidermolysis. This compound is obtained by the following process: the basidiocarp of a kind of mushroom such as Trametes mushroom is lyophilized and then subjected to extraction with 85% ethanol, and the resultant extract liquid is concentrated and then further subjected to extraction with ethyl acetate, and the resultant extract is put to a silica get column and eluted with chloroform-acetone (8:2), and the resultant elute is subjected to high-performance liquid chromatography and purified.

36. 发明专利

JPH08163983A HYARULONIC ACID PRODUCTION PROMOTER 失效
公开(公告)号：JPH08163983A
公开(公告)日：1996-06-25
申请号：JP33399394
申请日：1994-12-15
申请人： KANEBO LTD
发明人： SAYO TETSUYA , SAKAI SHINGO , INOUE SHINTARO
IPC分类号： C12N9/50 , A61K36/06 , C12P19/26
摘要： PURPOSE: To obtain a hyarulonic acid production promoter containing, as active ingredient, yeast extract, capable of promoting the hyarulonic acid productivity in human skin fibroblast, thus useful for preventing skin aging and treating such diseases as to involve the abnormal decomposition of hyarulonic acid, and safe to the human body. CONSTITUTION: A mixture comprising cetanol, lipophilic monostearic acid glycerin-polyoxyethylene cetyl ether, liquid paraffin, methylpolysiloxane, etc., is first prepared by homogeneously mixing these components at 80 deg.C, and butyl p-oxybenzoate is added to and dissolved in the mixture. Separately, a second mixture comprising sodium N-stearoyl-L-glutamate, dipropylene glycol and water is prepared by homogeneously mixing these components at 80 deg.C, and a yeast extract is added to and dissolved in this mixture. Subsequently, the resultant two solutions are mutually mixed and then cooled to 30 deg.C under through agitation, thus obtaining the objective promoter having the above- mentioned advantages.

37. 发明专利

JPH08157321A COSMETIC 失效
公开(公告)号：JPH08157321A
公开(公告)日：1996-06-18
申请号：JP33011494
申请日：1994-12-05
申请人： KANEBO LTD
发明人： SAYO TETSUYA , SAKAI SHINGO , KAMIO MICHIKO , INOUE SHINTARO
IPC分类号： A61K8/30 , A61K8/00 , A61K8/41 , A61K8/49 , A61K31/13 , A61K31/44 , A61K31/495 , A61K31/54 , A61K45/00 , A61P17/00 , A61P43/00 , A61Q19/00 , A61K7/00 , A61K7/48
摘要： PURPOSE: To obtain a cosmetic comprising histamine H1 -antagonist(s) or salt(s) thereof, having inhibitory action on the decomposition of hyarulonic acid, thus effective for remedying the chapped skin and dried skin. CONSTITUTION: This cosmetic contains at least one kind of histamine H1 - antagonist or salt thereof, having inhibitory action on the decomposition of hyarulonic acid important for skin dampishness and firmness, therefore, can remedy chapped or dried skin. The histamine H1 -antagonist is esp. pref. chlorpheniramine, pyrilamine, diphenhydramine, tripelennamine, brompheniramine, cyclizine, or promethazine. The salt thereof is e.g. a hydrochloride, hydrobromide, sulfate, acetate, fumarate, maleate, tartrate. This cosmetic can take such a form as gel, cream, spray, cataplasm, lotion, pack, milky lotion, or powder.

38. 发明专利

JPH07194375A PROMOTER FOR SYNTHESIZING COLLAGEN AND COLLAGEN METABOLISM ACTIVATOR 失效
公开(公告)号：JPH07194375A
公开(公告)日：1995-08-01
申请号：JP35265493
申请日：1993-12-28
申请人： KANEBO LTD
发明人： YOSHIDA MASAKI , INOUE SHINTARO
IPC分类号： C12N9/48 , A61K8/30 , A61K8/44 , A61K8/49
摘要： PURPOSE:To obtain a collagen-synthesizing promoter and a collagen metabolism activator capable of increasing collagen protein-synthesizing ability of a promoting substance for synthesizing collagen, e.g. an ascorbic acid derivative by acting on a fibroblast and capable of promoting both of synthesis and decomposition of the collagen and useful for medicines, cosmetics, etc. CONSTITUTION:This promotor for synthesizing a collagen contains three kinds of amino acids of glycine, proline and alanine or contains three kinds of amino acids of glycine, proline and alanine and a promoting substance for synthesizing collagen, which is preferably ascorbic acid or its derivative. In the promoter for synthesizing the collagen, the molar ratio of glycine, proline and alanine is 3:2:1. This collagen metabolism activator contains the promotor for synthesizing the collagen and a promoter for producing collagenase.

39. 发明专利

JPH07188036A COLLAGEN METABOLISM IMPROVING AGENT, COSMETICS AND BATHING MEDICINE 失效
公开(公告)号：JPH07188036A
公开(公告)日：1995-07-25
申请号：JP35193893
申请日：1993-12-27
申请人： KANEBO LTD
发明人： NAKADA MASANORI , KAMIO MICHIKO , INOUE SHINTARO , MATSUDA SEIJI , ISHIDA TAKAO
IPC分类号： A61K8/19 , A61K8/00 , A61K8/11 , A61K8/25 , A61K8/67 , A61K33/00 , A61K33/06 , A61K33/12 , A61P3/00 , A61P3/14 , A61P17/00 , A61Q5/00 , A61Q7/00 , A61Q19/00 , A61Q19/08 , A61Q19/10 , A61K7/00 , A61K7/06 , A61K7/48 , A61K7/50
摘要： PURPOSE:To obtain a collagen metabolism improving agent which contains a silicic acid-relating substance or its salt and has effects such as skin smoothing, hair tonic, depilation prevention and improves the diseases caused by anomalous accumulation of collagen or reduction in collagen metabolism accompanied by senility. CONSTITUTION:This improving agent contains silicic acid-relating compounds such as silicic acid, metasilicic acid, orthosilicic acid and water glass, preferably calcium silicate, sodium metasilicate, sodium orthosilicate or their salt. The agent is added to skin cosmetics, hair tonic cosmetic, and bathing agents. It is preferred that the bathing agents further contain ascorbic acid or its derivative.

40. 发明专利

JPH06157232A COLLAGEN METABOLISM ACTIVATOR 失效
公开(公告)号：JPH06157232A
公开(公告)日：1994-06-03
申请号：JP33251992
申请日：1992-11-17
申请人： KANEBO LTD
发明人： YOSHIDA MASAKI , INOUE SHINTARO , MATSUI TADASHI
IPC分类号： A61K8/30 , A61K8/00 , A61K8/19 , A61K8/23 , A61K8/41 , A61K8/44 , A61K8/49 , A61K8/67 , A61K31/133 , A61K31/198 , A61K31/375 , A61K31/522 , A61K33/00 , A61K45/06 , A61P17/00 , A61Q19/00 , C12N9/50 , A61K7/00
摘要： PURPOSE:To provide a collagen metabolism activator potentiating collagenase activity along with being capable of increasing collagen production. CONSTITUTION:The collagen metabolism activator is characterized by containing (A) a collagenase production-promoting substance selected from ethanolamine derivatives, pentoxifylline, sulfates and serine derivatives and (B) a collagen synthesis-promoting substance.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式