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21. 发明专利

JPS60168389A NOVEL A-898 SUBSTANCE, ITS PREPARATION AND ANTITUMOR AGENT CONTAINING SAID SUBSTANCE AS ACTIVE COMPONENT 失效
公开(公告)号：JPS60168389A
公开(公告)日：1985-08-31
申请号：JP2088384
申请日：1984-02-09
申请人： SAPPORO BREWERIES
发明人： MUNAKATA MASANOBU , AONO HIROSHI , WATANABE NOBUHIRO , MORI YOSHITADA
IPC分类号： C07K14/195 , A61K35/74 , A61K38/00 , A61P35/00 , C07G11/00 , C07K14/00 , C07K14/41 , C12P1/06 , C12R1/465
摘要： PURPOSE:To produce the novel A-898 substance useful as an antitumor agent, by culturing a microbial strain belonging to Streptomyces genus in an alkaline liquid medium. CONSTITUTION:A novel strain belonging to Streptomyces genus and capable of producing A-898 substance, i.e. Streptomyces A-898 strain (FERM-P No.7340) is cultured in an alkaline liquid medium, and the objective A-898 substance is separated from the cultured product. The substance exhibits strong cytotoxicity to the SV40 tumor transformed cell of the renal fibroblast cell of mouse in vitro, and has antitumor activity to actively inhibit the proliferation of said tumor.

22. 发明专利

JPS5948094A Preparation of maltopentaose 失效
标题翻译：麦芽糖苷的制备
公开(公告)号：JPS5948094A
公开(公告)日：1984-03-19
申请号：JP15809982
申请日：1982-09-13
申请人： Sapporo Breweries Ltd
发明人： YOSHIGI HISAHIRO , KONNO TAKAHIDE , MORI YOSHITADA
IPC分类号： C12P19/00 , C12P19/04 , C12P19/14 , C12R1/07
CPC分类号： C12P19/04 , C12P19/14 , Y10S435/834
摘要： PURPOSE: To prepare maltopentaose, industrially, by culturing a microbial strain belonging to Bacillus genus and capable of producing maltopentaose, under aerobic condition.
CONSTITUTION: Bacillus cereus NY-14 (FERM-P No.6648) is inoculated in a medium containing a polysaccharide containing α-1,4-glucoside.glucose, e.g. starch, amylopectin, amylose, dextrin, etc. and other essential nutrients. The concentration of polysaccharide in the medium is maintained to 2W20%. After inoculation, the bacterial cell is cultured aerobically at about 30°C for 24W48hr to produce and accumulate maltopentaose in the cuture liquid. The liquid is filtered, and the filtrate is subjected to the gel-filtration, a chromatography such as ion exchange chromatograhy, etc. to obtain purified maltopentaose.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：目的：在有氧条件下，通过培养属于芽孢杆菌属的微生物菌株并能够产生麦芽五糖来在工业上制备麦芽五糖。构成：将蜡状芽孢杆菌NY-14（FERM-P No.6648）接种在含有含有α-1,4-葡萄糖苷葡萄糖的多糖的培养基中，例如，淀粉，支链淀粉，直链淀粉，糊精等必需营养素。培养基中多糖的浓度保持在2-20％。接种后，细菌细胞在约30℃下有氧培养24-48小时，以在切割液中产生并积累麦芽五糖。过滤液体，滤液进行凝胶过滤，离子交换色谱等层析，得到纯化的麦芽五糖。

23. 发明专利

JPH0441154B2 失效
公开(公告)号：JPH0441154B2
公开(公告)日：1992-07-07
申请号：JP15395683
申请日：1983-08-23
申请人： RIKAGAKU KENKYUSHO , SATSUHORO BIIRU KK
发明人： OGAWA TOMOYA , YAMAMOTO HISAO , MORI YOSHITADA
IPC分类号： C07H3/06 , C07H13/06 , C07H15/18

24. 发明专利

JPH0425275B2 失效
公开(公告)号：JPH0425275B2
公开(公告)日：1992-04-30
申请号：JP15395783
申请日：1983-08-23
申请人： RIKAGAKU KENKYUSHO , SATSUHORO BIIRU KK
发明人： OGAWA TOMOYA , YAMAMOTO HISAO , MORI YOSHITADA
IPC分类号： C07H3/06 , C07H13/06 , C07H15/18 , C08B37/00

25. 发明专利

JPH0261960B2 失效
公开(公告)号：JPH0261960B2
公开(公告)日：1990-12-21
申请号：JP14666382
申请日：1982-08-24
申请人： RIKAGAKU KENKYUSHO
发明人： OGAWA TOMOYA , YAMAMOTO HISAO , MORI YOSHITADA
IPC分类号： C07H3/06 , C07H13/06 , C07H15/18 , C08B37/00

26. 发明专利

JPH0259836B2 失效
公开(公告)号：JPH0259836B2
公开(公告)日：1990-12-13
申请号：JP14666282
申请日：1982-08-24
申请人： RIKAGAKU KENKYUSHO , SATSUHORO BIIRU KK
发明人： OGAWA TOMOYA , YAMAMOTO HISAO , MORI YOSHITADA
IPC分类号： C07H3/06 , C07H13/06 , C07H15/18

27. 发明专利

JPH025762B2 失效
公开(公告)号：JPH025762B2
公开(公告)日：1990-02-05
申请号：JP14666482
申请日：1982-08-24
申请人： RIKAGAKU KENKYUSHO , SATSUHORO BIIRU KK
发明人： OGAWA TOMOYA , YAMAMOTO HISAO , MORI YOSHITADA
IPC分类号： C08B37/00 , A61K31/715 , A61P35/00

28. 发明专利

JPH0425276B2 失效
公开(公告)号：JPH0425276B2
公开(公告)日：1992-04-30
申请号：JP15395883
申请日：1983-08-23
申请人： RIKAGAKU KENKYUSHO , SATSUHORO BIIRU KK
发明人： OGAWA TOMOYA , YAMAMOTO HISAO , MORI YOSHITADA
IPC分类号： C07H3/06 , C07H13/06 , C07H13/08 , C07H15/18

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