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21. 发明专利

JP2000212028A PREPARATION FOR EXTERNAL USE FOR SKIN FOR TREATMENT OF STRESS DISORDER 失效
公开(公告)号：JP2000212028A
公开(公告)日：2000-08-02
申请号：JP1805899
申请日：1999-01-27
申请人： POLA CHEM IND INC
发明人： TSUJI KUNIO , ISHIDA KINJI , MATSUMOTO KATSUO , NISHIMORI YASUTOMO , FUKUSHIMA MAKOTO
IPC分类号： A61K8/96 , A61K8/97 , A61K8/98 , A61K31/00 , A61K36/00 , A61P17/00 , A61K7/00 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To provide a means for treating the stress-induced disorder of skin. SOLUTION: This preparation for external use for skin contains one or more Chinese herb drug components selected from among the origin animals, origin vegetables and derived materials of herb drugs classified as Kaihyo-yaku, Risui-yaku, shageyaku, Seinetsu-yaku, Riki-yaku, Onrikyokan-yaku and koju- yaku. The effect of stress on the skin can be prevented, improved and suppressed by the application of the preparation of the present invention to enable the treatment of the skin disorder caused by stress.

22. 发明专利

JPH11228436A ENDOBIOTIC SUBSTANCE DISTRIBUTION UNUNIFORMITY IMPROVER 失效
公开(公告)号：JPH11228436A
公开(公告)日：1999-08-24
申请号：JP4437098
申请日：1998-02-10
申请人： POLA CHEM IND INC
发明人： KOSUGE TAKUO , FUKUSHIMA MAKOTO , KAWAI MITSUO , MATSUMOTO KATSUO , NISHIMORI YASUTOMO
IPC分类号： A23G3/34 , A23G3/00 , A23L1/30 , A61K8/00 , A61K8/96 , A61K8/97 , A61K8/98 , A61K9/20 , A61K36/00 , A61K36/18 , A61P3/00 , A61P43/00 , A61Q19/00 , A61K35/78 , A61K7/00 , A61K7/48
摘要： PROBLEM TO BE SOLVED: To obtain a medicament for treating/improving, with slight side effects, diseases or physical malconditions caused by the shortage of endobiotic physiologically active substances such as hormones. SOLUTION: This medicament as the subject improver comprises the respective essences of crude drugs having 'shineki' (a sort of body fluid)-improving action such as Rhei Rhizoma, Cassia glauca, aloe. ikurining, pharbitidis Semen, Daphnis genkwae flos, Euphorbiaceae, pokeweed root, zokuzuisi, Lepidii semen, pachyma hoelen, Chuling, Artemisiae capillaris flos, mokuboi, Sinomenium, coix seed, Dianthus superbus L., Kochiae fructus, Polygonus aviculare L., sekii, Plantago seed, Abutili semen, Desmodium styracifolium, Phaseolus angularis, Lobeliae chinensis herba, Crategus cuneata, Sitotroga cerealella, Galli stomachichum corium, Raphanus sativus L., Ephedra sinica, beefsteak plant leaf, Nepeta japonica and, etc. This improver is incorporated in compositions such as foods.

23. 发明专利

JPH09227395A MICTURITION PROMOTER 失效
公开(公告)号：JPH09227395A
公开(公告)日：1997-09-02
申请号：JP5557196
申请日：1996-02-19
申请人： POLA CHEM IND INC
发明人： MIYAZAKI HIROTAKA , FUKUSHIMA MAKOTO
IPC分类号： A23G3/34 , A23G3/00 , A23L1/30 , A23L2/52 , A23L21/10 , A61K36/18 , A61P7/10 , A61K35/78 , A23L1/06
摘要： PROBLEM TO BE SOLVED: To obtain a micturition promoter, comprising an essence of a plant body of a plant belonging to the genus Kochia of the family Chenopodiaceae, having ultrahigh safety and mild actions and suitable for preventing the onset of diseases due to protracted micturition such as cardiac infarction. SOLUTION: This micturition promoter comprises an essence (preferably an aqueous extract) of a plant body (preferably a fruit) of a plant belonging to the genus Kochia of the family Chenopodiaceae. The objective promoter is preferably perorally administered in a daily dose for an adult of 100-10000mg divided in several portions. The essence is preferably obtained by a method for adding a solvent in an amount of 0.5-10 times based on the plant body thereto and immersing the plant body therein at ambient temperature for several days or at a temperature near the boiling point of the solvent for several hr. Although the objective promoter can be blended with a food composition, e.g., a candy, a food and drink, e.g., a juice or a medicinal composition, e.g. a tablet, the promoter is preferably blended in the food and drink composition. The amount thereof blended is preferably 5-30wt.% based on the composition.

24. 发明专利

JPH09188626A MEDICINE FOR INHIBITING ANTIBODY-PRODUCING CELL AND COMPOSITION CONTAINING THE SAME 失效
公开(公告)号：JPH09188626A
公开(公告)日：1997-07-22
申请号：JP1719696
申请日：1996-01-06
申请人： POLA CHEM IND INC
发明人： NISHIMURA KEIICHI , FUKUSHIMA MAKOTO , YAMAMOTO MAKOTO , FUKUDA TOSHIYUKI , ABE SHINOBU
IPC分类号： A23G3/34 , A23G3/00 , A23L1/28 , A61K36/06 , A61P17/00 , A61P37/00 , A61P37/06 , A61P43/00 , A61K35/72
摘要： PROBLEM TO BE SOLVED: To obtain an antibody-producing cell-inhibiting medicine useful for treating and preventing atopic dermatitis, systemic lupus erythematosus, bronchial asthma, etc., by using a specific natural polymer. SOLUTION: This medicine for inhibiting antibody-producing cells contains a yeast- related polymer as an active ingredient. The yeast-related polymer is especially preferably either of yeast, a yeast extract or the enzymatic degradation product of the yeast. The yeast-related polymer is excellent in the action for inhibiting antibody- producing cells in a spleen, etc., to reduce the production of the antibodies. The yeast- related polymer is high in the effect for preventing autominue diseases, especially atopic dermatitis appearing in dependence on seasons, because the antibody-producing cell-inhibiting medicine can be administered in good timing, before the immune reaction is flared up. The content of the antibody-producing cell-inhibiting medicine in a medicine composition is approximately 0.1-60wt.%, especially 5-30wt.%. The content of the antibody-producing cell-inhibiting medicine in a food composition is approximately 0.1-80wt.%, especially 1-70wt.%. The content of the antibody-producing cell-inhibiting medicine in a skin preparation for external use or a cosmetic is also approximately 0.05-30wt.%, especially 0.1-20wt.%.

25. 发明专利

JPH09178730A SELECTION METHOD FOR HERB MEDICINE 失效
公开(公告)号：JPH09178730A
公开(公告)日：1997-07-11
申请号：JP33961495
申请日：1995-12-26
申请人： ITO MASAJIRO , POLA CHEM IND INC
发明人： ITO MASAJIRO , INAOKA YASUNORI , FUKUSHIMA MAKOTO
IPC分类号： G01N33/483 , G01N33/15
摘要： PROBLEM TO BE SOLVED: To select a herb medicine accurately such that it takes effect sufficiently for a patient by employing the mixed heat of a harb medicine essence with red blood cell, and blood or plasma of patient as an index. SOLUTION: Any one of absolute or relative quantity of mixed heat can be employed as a criterion for determining the effectiveness of dosage of herb medicine essence. Since the absolute value of mixed heat of herb medicine essence, red blood cell, and blood or plasma of patient is different between individuals, some relative criterion is preferably set including sheep red blood cell SRBC. If the quantity of heat produced upon addition of the red blood cell of patient is lower than the quantity of heat produced upon addition of SRBC, a decision is made that an effective treatment can be performed with no adverse effects.

26. 发明专利

JPH01246211A HAIR-RESTORING OR GROWING ACCELERATOR 失效
公开(公告)号：JPH01246211A
公开(公告)日：1989-10-02
申请号：JP31299287
申请日：1987-12-10
申请人： POLA CHEM IND INC
发明人： INAOKA YASUNORI , FUKUSHIMA MAKOTO
IPC分类号： A61K8/00 , A61K8/97 , A61Q5/00 , A61Q7/00
摘要： PURPOSE:To obtain a hair-restoring or growing accelerator with remarkable effect without skin disorder caused by long-term application, by using extracts from some kinds of herbs such as dittany, valerian and hawthorn with a water- soluble organic solvent only or its aqueous solution. CONSTITUTION:Herbs such as Dictmnus albus (root bark of dittany), Valeriana officinalis (roots of valerian) or Crataegus cuneata (fruits of hawthorn) are extracted with a water-soluble organic solvent only, such as methanol, ethanol, propanol, butanol, acetone, tetrahydrofuran or dioxane or their aqueous solution. The subject accelerator contains 0.1-10.0wt.%, preferably 0.5-5.0wt.% of at least one of these extracts. These active ingredients stimulate the hair roots, enhance blood circulation around the roots to activate the metabolism of the roots.

27. 发明专利

JPS6438010A PROMOTER FOR HAIR RESTORATION AND HAIR GROWTH 失效
公开(公告)号：JPS6438010A
公开(公告)日：1989-02-08
申请号：JP19207387
申请日：1987-07-31
申请人： POLA CHEM IND INC
发明人： INAOKA YASUNORI , FUKUSHIMA MAKOTO , KURODA HIDEO
IPC分类号： A61K8/00 , A61K8/97 , A61Q5/00 , A61Q7/00
摘要： PURPOSE:To obtain a cosmetic for hair restoration and hair growth continuously usable without strong irritation, having excellent effects, containing an active ingredient extracted from a crude drug of Grifola umbellata (Pers.) Pilat, Poria cocos (Schw.) Wolf or Akebia quinata (Thunb.) Decne with a water-insoluble organic solvent or a hydrous solvent thereof. CONSTITUTION:100g crude drug of Grifola umbellata (Pers.) Pilat, Poria cocos (Schw.) Wolf or Akebia quinata (Thunb.) Decne is extracted with 1l organic solvent such as primary alcohol (e.g. methanol or butanol), acetone, THF or dioxane alone or hydrous organic solvent containing >=50wt.% the organic solvent for 2hr each time 3 times, the extracted essence is put together, filtered by suction and concentrated under reduced pressure to give viscous essence of crude drug. 0.5-5.0wt.% of the essence as an active ingredient is directly added to a base or dissolved or dispersed in a proper solvent and diluted and added as the active ingredient to the base.

28. 发明专利

JPS63215612A SEBUM SECRETION INHIBITOR 失效
公开(公告)号：JPS63215612A
公开(公告)日：1988-09-08
申请号：JP4837587
申请日：1987-03-03
申请人： POLA CHEM IND INC
发明人： KURODA HIDEO , FUKUSHIMA MAKOTO , INAOKA YASUNORI
IPC分类号： A61K8/96 , A61K8/00 , A61K8/97 , A61Q5/00 , A61Q7/00 , A61Q19/00
摘要： PURPOSE:To obtain a safe sebum secretion inhibitor free from side effects such as hormone action, containing extracted essence prepared by extracting one or more crude drugs selected from Ginseng radix, Aurantii Nobilis Pericarpium and Houttuyniae herba with water, a hydrophilic organic solvent, a hydrous hydrophilic organic solvent or another organic solvent. CONSTITUTION:A sebum secretion inhibitor which contains 0.01-50wt.%, preferably 0.1-2.0wt.% extracted essence obtained by extracting one or more selected from Ginseng radix (Araliaceae), Aurantii Nobilis Pericarpium (Rutaceae) and Houttuyniae herba (Saururaceae) with water, a hydrophilic organic solvent, a hydrous hydrophilic organic solvent or another organic solvent, e.g. alcohols such as methanol, ethanol, propanol or butanol, organic solvents such as acetone, tetrahydrofuran or dioxane and hydrous organic solvents containing >=50wt.% of the alcohols or the organic solvents ad an active ingredient and has no side effects.

29. 发明专利

JPS63162611A COSMETIC 失效
公开(公告)号：JPS63162611A
公开(公告)日：1988-07-06
申请号：JP31571986
申请日：1986-12-24
申请人： POLA CHEM IND INC
发明人： FUKUSHIMA MAKOTO , YAGISAWA TOSHIKO , KINOSHITA KUNIO , SANO HARUKO
IPC分类号： A61K8/30 , A61K8/00 , A61K8/33 , A61K8/37 , A61K8/96 , A61K8/97 , A61Q5/00 , A61Q19/00
摘要： PURPOSE:To obtain a cosmetic, having skin beautifying and adjusting action based on wound curing promoting effects as well as excellent feeling of used and stability, by blending rosmarinic acid and/or salt thereof. CONSTITUTION:A cosmetic, obtained by blending rosmarinic acid, expressed by the formula and obtained by extracting a plant of the family Labiatae, preferably Rosmarinus officinalis L. (rosemary), Perilla frutescens Britton var. acuta Kudo, Perilla frutescens Britton var. crispa Decaisne f. viridi-crispa Makino, Agastache rugosa O. Kuntze, Isodon japonicus Hara, etc., particularly Rosmarinus officinalis L. or Perilla frutescens Britton var. crispa Decaisne f. viridi-crispa Makino and/or a salt thereof as an active ingredient in an amount of 0.005-5wt%, particularly 0.1-3wt% based on the total weight of the cosmetic and preferably further adding a water-soluble high polymer substance, e.g. polypeptide, soluble collagen, mucopolysaccharides, etc. and having the above-mentioned effects. Furthermore, the afore-mentioned active ingredient has also hair tonic effects in addition to the above-mentioned effects when using as a hair cosmetic.

30. 发明专利

JPS61263905A COSMETIC 失效
公开(公告)号：JPS61263905A
公开(公告)日：1986-11-21
申请号：JP10532385
申请日：1985-05-17
申请人： POLA CHEM IND INC
发明人： FUKUSHIMA MAKOTO , HOSHIZAKI SADAO
IPC分类号： A61K8/00 , A61K8/96 , A61K8/97 , A61K36/48 , A61Q5/00 , A61Q7/00 , A61Q19/00 , A61Q19/02
摘要： PURPOSE:A cosmetic, containing an extract component obtained by extracting a component from the root of Astragalus hoantchy Franch. as a natural product active constituent and further a water-soluble high polymer, and having improved skin beautifying, whitening and beautifying an humectant effect. CONSTITUTION:A cosmetic obtained by incorporating an extract prepared by extraction from mainly the dried root of Astragalus hoantchy Franch., e.g. Astragalus membranaceus Bunge, Atragalus mongholicus Bunge or Hedysarum polybotrys, known as a crude drug, e.g. tonic, diuretic, antinephritis, hypotensive, vasodilator or cardiotonic action, with an organic solvent and/or water in an amount of 0.01-10wt%, preferably 0.1-5wt% based on the total weight of the cosmetic, and further a water-soluble high polymer, e.g. polypeptide, water- soluble collagen or gelatin, in an amount of 0.001-1wt% based on the total weight with other components. EFFECT:Favorable effect, e.g. tension, gloss, smoothness of freshness, is produced.

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