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11. 发明专利

JPH07228859A SKIN EXTERNAL PREPARATION 失效
公开(公告)号：JPH07228859A
公开(公告)日：1995-08-29
申请号：JP4769794
申请日：1994-02-22
申请人： SHISEIDO CO LTD
发明人： SUETSUGU MASARU , SHINOJIMA SATORU , ONUMA MASAMI , SHIBATA YUKI , KAKO RUMIKO , HARIGAI TAKESHI , KOBAYASHI HIROSHI , KITAMURA KANEMOTO
IPC分类号： A61K8/30 , A61K8/00 , A61K8/33 , A61K8/35 , A61K8/37 , A61K8/41 , A61K8/42 , A61K8/49 , A61Q17/04 , A61Q19/02 , C09K3/00 , A61K7/00 , A61K7/42 , A61K7/44
摘要： PURPOSE:To obtain the subject external preparation, containing an ultraviolet absorber and a specific amide derivative of tranexamic acid, capable of suppressing the skin irritancy by the ultraviolet absorber, remarkably improved in skin beautifying and whitening effects and having high safety. CONSTITUTION:This external preparation contains (A) an ultraviolet absorber and (B) at least one or more of an amide derivative of tranexamic acid expressed by formula I [R1 is H or a lower alkyl; R2 is an (cyclo)alkyl, an (cyclo)alkenyl, pyridyl, trifluoromethyl, a (substituted)1-3C alkylphenyl, a (substituted)phenyl or a (substituted)styryl] and its salt. Furthermore, the component (A) is preferably 2-hydroxy-4-methoxybenzophenone, octyl p- dimethylaminobenzoate, octyl p-methoxycinnamate, glyceryl di-p- methoxycinnamate mono-2-ethylhexanoate or 4-tert-butyl-4'- methoxybenzoylmethane.

12. 发明专利

JP2009174867A Evaluation method of skin quality using quantity ratio of soluble protein of horny layer protein as index 有权
标题翻译：使用蛋白质蛋白质可溶性蛋白质量的比例评估方法作为指标
公开(公告)号：JP2009174867A
公开(公告)日：2009-08-06
申请号：JP2008010701
申请日：2008-01-21
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： KATSUTA YUJI , HARIGAI TAKESHI , AOKI HIROFUMI
IPC分类号： G01N33/50 , G01N1/04 , G01N33/48 , G01N33/68
摘要： PROBLEM TO BE SOLVED: To provide a simple and quantitative skin quality evaluation method.
SOLUTION: In the evaluation method of skin quality using the quantity ratio of soluble protein of horny layer protein as an index, a sticking tape sample, to which a horny layer is adhered, obtained by tape stripping is immersed in an aqueous buffer solution to elute soluble protein in the aqueous buffer solution (Step a), the sticking tape sample is separated from the aqueous buffer solution and the soluble protein eluted in the aqueous buffer solution is quantified (Step b), the sticking tape sample separated in the Step (b) is next immersed in a reducing agent-containing buffer solution to elute insoluble protein (Step c), the sticking tape sample is separated from the reducing agent-containing buffer solution and insoluble protein eluted in the reducing agent-containing buffer solution is quantified (Step d) and the ratio of the quantified value of the soluble protein to the quantified value of the insoluble protein is calculated (Step e).
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供简单和定量的皮肤质量评估方法。解决方案：使用以角质层蛋白质的可溶性蛋白质的量比例作为指标的皮肤质量的评价方法中，将通过带剥离获得的粘附有角质层的贴带样品浸渍在水性缓冲液在缓冲液水溶液中洗脱可溶性蛋白质的溶液（步骤a），从缓冲溶液水溶液中分离出粘着带样品，并将缓冲溶液中洗脱的可溶性蛋白质定量（步骤b），将粘贴带样品分离接下来将步骤（b）浸入含还原剂的缓冲溶液中以洗脱不溶性蛋白质（步骤c），将粘带样品与含还原剂的缓冲溶液分离，并将不溶性蛋白质洗脱在含还原剂的缓冲溶液中（步骤d），计算可溶性蛋白质的定量值与不溶性蛋白质的定量值的比例（步骤e）。版权所有（C）2009，JPO＆INPIT

13. 发明专利

JP2007061307A Method for classifying fleck 审中-公开
标题翻译：分类方法
公开(公告)号：JP2007061307A
公开(公告)日：2007-03-15
申请号：JP2005250174
申请日：2005-08-30
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： YAMASHITA TOYONOBU , KUNISAWA NAOMI , HARIGAI TAKESHI , YANAI MOTOHIRO
IPC分类号： A61B5/107 , A61B5/00 , G06T1/00
摘要： PROBLEM TO BE SOLVED: To provide a method for classifying a fleck, that is a method for classifying the flecks by acquiring the image of melanin at a fleck section existing in the skin using a confocal microscope and analyzing and evaluating the state of melanin based on the acquired image in detail, and to provide a method for evaluating melanin at the fleck section to classify the fleck and classifying a patient based on the classified fleck for beam treatment such as IPL/laser therapy for improving and treating the fleck by the classification of the fleck. SOLUTION: The image of melanin in the skin of the fleck section is acquired using the confocal microscope and the state of melanin at the fleck section is analyzed and evaluated by analyzing the acquired image to classify the fleck. For example, based on the evaluation of melanin, an effect of the IPL/laser therapy to the fleck on the skin is judged previously, and the patient can be classified based on the fleck classified for the IPL/laser therapy. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于对斑点进行分类的方法，即通过使用共聚焦显微镜在皮肤上存在的斑点部分获取黑色素的图像来分类斑点的方法，并分析和评估基于所获得的图像的详细黑色素，并提供一种评估斑点部分的黑色素的方法，以分类斑点并根据用于光束治疗的分类斑点进行分类，例如IPL /激光治疗，用于改善和治疗斑点斑马的分类。解决方案：使用共焦显微镜获取斑点部分皮肤黑色素的图像，并通过分析获得的图像对斑点进行分析和评估，从而对斑点部分的黑色素状态进行分析和评估。例如，基于黑色素的评价，IPL /激光治疗对皮肤上的斑点的影响是先前判断的，并且可以根据IPL /激光治疗分类的斑点对患者进行分类。版权所有（C）2007，JPO＆INPIT

14. 发明专利

JP2004028698A Inspection method for skin disorder and sensitive skin, and kit used therefor 有权
公开(公告)号：JP2004028698A
公开(公告)日：2004-01-29
申请号：JP2002183318
申请日：2002-06-24
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： KOBAYASHI YUSUKE , SHIBATA MICHIO , ASHIKAGA TAKAO , ICHIKAWA HIDEYUKI , HARIGAI TAKESHI , IKEZAWA YOSHIRO
IPC分类号： G01N33/50
摘要： PROBLEM TO BE SOLVED: To provide a noninvasive and simple inspection method for skin disorder and sensitive skin and a kit used for the method.
SOLUTION: The inspection method for skin disorder and sensitive skin and the kit used for the method in which an amount of NGF and/or NT-4 included in a horny cell layer sample are measured are provided.
COPYRIGHT: (C)2004,JPO

15. 发明专利

JP2002193824A SYMPATHETIC NERVOUS SYSTEM-ACTIVATING PERFUME COMPOSITION AND ANTI-OBESITY PERFUME COMPOSITION CHARACTERIZED BY CONTAINING GRAPE FRUIT OIL 失效
公开(公告)号：JP2002193824A
公开(公告)日：2002-07-10
申请号：JP2000393470
申请日：2000-12-25
申请人： SHISEIDO CO LTD
发明人： KOIZUMI YUKIKO , AITSU YOKO , HAJI SHINICHIRO , HARIGAI TAKESHI , SHIBATA MICHIO
IPC分类号： A61K8/96 , A61K8/00 , A61K8/97 , A61K36/75 , A61P3/04 , A61P3/10 , A61P25/02 , A61Q13/00 , A61K35/78 , A61K7/00 , A61K7/46
摘要： PROBLEM TO BE SOLVED: To provide new sympathetic nervous system-activating perfume composition and anti-obesity perfume composition. SOLUTION: This sympathetic nervous system-activating perfume composition and anti-obesity perfume composition each is characterized by containing grape fruit oil.

16. 发明专利

JPH10304880A MEASUREMENT OF NUCLEIC ACID, AND REAGENT THEREFOR 失效
公开(公告)号：JPH10304880A
公开(公告)日：1998-11-17
申请号：JP27758097
申请日：1997-10-09
申请人： SHISEIDO CO LTD
发明人： HATAO MASATO , ICHIKAWA HIDEYUKI , HARIGAI TAKESHI , TSUDA TAKAYA , SHIBATA MICHIO
IPC分类号： G01N33/50 , C07H21/02 , C12N15/09 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To estimate allergic activities of a chemical material by measuring an mRNA or a cDNA by using each specific primer and probe, and carrying out a polymerase chain reaction under a specified condition. SOLUTION: A mRNA or cDNA encoding interleukin-2, interferon-γ, interleukin-10, interleukin-12 p35 subunit and interleukin-12 p40 subunit is measured by carrying out a polymerase chain reaction by a DNA polymerase having 5'→3' exonuclease activities by using a forward primer having a base sequence, etc., of formula I, a reverse primer having a base sequence, etc., of formula II, and a probe having a reporter and a quencher, hybridizing with a template nucleic acid within a region placed between the both primers, and having base sequence, etc., of formula III.

17. 发明专利

JP2010024208A Ucp2 expression promotor 审中-公开
标题翻译： UCP2表达式启动器
公开(公告)号：JP2010024208A
公开(公告)日：2010-02-04
申请号：JP2008190348
申请日：2008-07-23
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： SAWANE MIKA , HARIGAI TAKESHI
IPC分类号： A61K31/05 , A61P3/04 , A61P29/00 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To elucidate a substance promoting expression of a UCP (UnCoupling Protein) existing in mitochondrial inner membrane, particularly a UCP2, and to develop such as a skin external preparation, a drug, food and drink products, and feeds (such as pet foods) useful for treatment and prevention of various symptoms, pathological conditions and diseases (such as obesity and inflammation) relating to UCP2 using the UCP2 promoting substance.
SOLUTION: The UCP2 expression promotor composed of resveratrol. The UCP2 expression promotor is blended with such as a skin external preparation, a drug, food and drink products, and feeds (such as pet foods).
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：阐明促进存在于线粒体内膜，特别是UCP2中的UCP（UnCoupling Protein）的表达的物质，并开发诸如皮肤外用制剂，药物，食品和饮料产品，以及用于治疗和预防与使用UCP2促进物质的UCP2相关的各种症状，病理状况和疾病（如肥胖和炎症）的饲料（例如宠物食品）。解决方案：由白藜芦醇组成的UCP2表达启动子。 UCP2表达启动子与皮肤外用制剂，药物，食品和饮料产品以及饲料（如宠物食品）混合。版权所有（C）2010，JPO＆INPIT

18. 发明专利

JP2007260227A Beautiful skin game system, beautiful skin game program and recording medium recorded with program 审中-公开
标题翻译：美丽的皮肤游戏系统，美丽的皮肤游戏程序和记录与程序的记录媒体
公开(公告)号：JP2007260227A
公开(公告)日：2007-10-11
申请号：JP2006090960
申请日：2006-03-29
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： KITAMURA NAOMI , HARIGAI TAKESHI , KOBAYASHI YUSUKE , SATO TAKASHI
IPC分类号： A63F13/00
CPC分类号： A63F13/655 , A61B5/0059 , A61B5/442 , A63F13/10 , A63F13/213 , A63F13/46 , A63F2300/1012 , A63F2300/1087 , A63F2300/61 , A63F2300/66 , A63F2300/695
摘要： PROBLEM TO BE SOLVED: To provide a beautiful skin game system dispensing with a correction of skin data by external environment data, simply reflecting unique skin data of a player on a game and capable of sustaining the player's interest. SOLUTION: A game progress means has functions importing a texture analysis result of the player formed by analyzing the texture state from the skin data of the player, reflecting it on the game such as converting the texture analysis result into points, and progressing the beautiful skin game. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种美丽的皮肤游戏系统，其通过外部环境数据分配皮肤数据的校正，简单地反映玩家在游戏中的独特皮肤数据并且能够维持玩家的兴趣。游戏进度意味着具有通过从玩家的皮肤数据分析纹理状态而形成的玩家的纹理分析结果的功能，将其反映在游戏上，例如将纹理分析结果转换为点，并且进行美丽的皮肤游戏。版权所有（C）2008，JPO＆INPIT

19. 发明专利

JP2007033201A Method and kit for evaluating sensitive skin 有权
标题翻译：用于评估敏感性皮肤的方法和工具包
公开(公告)号：JP2007033201A
公开(公告)日：2007-02-08
申请号：JP2005216103
申请日：2005-07-26
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： EHAMA RITSUKO , HARIGAI TAKESHI , YANAI MOTOHIRO
IPC分类号： G01N33/50 , A61B5/00 , A61B10/00
摘要： PROBLEM TO BE SOLVED: To provide a novel method and a kit for evaluating a sensitive skin, which can simply and surely evaluate whether or not a skin is sensitive, by using a biochemical index.
SOLUTION: The existential amount of calprotectin in a horny cell derived from the sensitive skin has been found significantly higher than that derived from a healthy skin. The horny cell used therefor can be extracted by a simple method called tape stripping which extracts only a surface layer of a superficial skin. Moreover, the existential amount of calprotectin in the horny cell can be measured without applying any stimulus such as ultraviolet rays, chemicals or the like. Therefore, the sensitive skin can be evaluated simply by using the calprotectin in the horny cell as the index.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：通过使用生化指标，提供用于评价敏感性皮肤的新颖方法和试剂盒，其可以简单且可靠地评价皮肤是否敏感。解决方案：发现敏感性皮肤角质细胞中钙卫蛋白的存在量明显高于健康皮肤。用于此的角质细胞可以通过称为胶带剥离的简单方法提取，其仅提取表面皮肤的表面层。此外，可以测量角质细胞中钙卫蛋白的存在量，而不施加任何刺激如紫外线，化学品等。因此，通过使用角质细胞中的钙卫蛋白作为指标，可以简单地评价敏感性皮肤。版权所有（C）2007，JPO＆INPIT

20. 发明专利

JP2003063977A Slimming drug for the skin for external use 审中-公开
标题翻译：用于外用皮肤的减肥药
公开(公告)号：JP2003063977A
公开(公告)日：2003-03-05
申请号：JP2001258346
申请日：2001-08-28
申请人： Shiseido Co Ltd , 株式会社資生堂
发明人： HARIGAI TAKESHI , SHIBATA MICHIO , ICHIKAWA HIDEYUKI , SOMA TSUTOMU
IPC分类号： A61K8/30 , A61K8/00 , A61K8/02 , A61K8/06 , A61K8/34 , A61K8/49 , A61K8/67 , A61K8/73 , A61K8/96 , A61K8/97 , A61K31/045 , A61K31/047 , A61K31/07 , A61K31/202 , A61K31/522 , A61K31/56 , A61K31/737 , A61K36/00 , A61K36/02 , A61K36/18 , A61K36/23 , A61K36/28 , A61K36/42 , A61K36/48 , A61K36/53 , A61K36/71 , A61K36/81 , A61K36/899 , A61K45/00 , A61P3/00 , A61P3/04 , A61P17/00 , A61P43/00 , A61K35/78 , A61K7/00 , A61K35/80
摘要： PROBLEM TO BE SOLVED: To provide a new slimming drug for external use which is applied to the skin. SOLUTION: A deconjugate protein expression-promoting agent which contains as an active ingredient one or more substances selected from the extracts from Coix lacryma, Gynostemma pentaphyllum, Styrax benzoin, Atractylodes lancea De candolle and azuki beans, octacosanol, rodisterol and vitamin A, and a slimming drug for external use for the skin which contains the substance as an active ingredient.
摘要翻译：要解决的问题：提供一种适用于皮肤的新型外用减肥药。解决方案：一种脱结核蛋白表达促进剂，其含有选自枸杞，绞股蓝，苯达辛（Styrax benzoin），白术（Atractylodes lancea De candolle）和芸豆，二十八烷醇，维生素A和维生素A的提取物中的一种或多种物质作为活性成分，减肥用于皮肤外用的药物含有该物质作为活性成分。

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