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1. 发明专利

JPH09274045A AUTOMATIC CHEMICAL ANALYZER 失效
公开(公告)号：JPH09274045A
公开(公告)日：1997-10-21
申请号：JP8120696
申请日：1996-04-03
申请人： HITACHI LTD , HITACHI INSTRUMENTS ENG
发明人： KAMIMURA YASUKO , YOKOSE TAIZO , SHICHIJI MASARU , SUGAWARA KENJI , HATTORI MITSUO
IPC分类号： G01N21/75 , G01N21/27 , G01N35/00 , G01N35/02
摘要： PROBLEM TO BE SOLVED: To obtain an automatic chemical analyzer in which a photometric accuracy during an analysis is diagnosed accurately, by which measures are taken quickly and precisely against the trouble of a photometric system and which prevents a delay in a measured result by a method wherein the absorbance of purified water is measured photometrically in a multiple manner at a specific wavelength which remarkably reflects the photometric accuracy. SOLUTION: The absorbance (water blank value) of purified water which is dispensed automatically into a reaction container 12 is measured photometarically in a multiple manner at two proper wavelength which reflect a photometaric accuracy remarkably. A central processing unit 11 accumulates the water clank value at every analysis which is measured in the same reaction container 12 so as to perform a statistical processing operation (to obtain an SD value). The SD value is compared with a tolerance which is set in advance as a parameter so as to be judged, and whether a photometric accuracy is good or not is judged. When the SD value is outside the tolerance, an alarm is issued immediately so as to be reported to an operator. When the SD value is within the tolerance, a sampling operation is started, and an ordinary analysis is performed. Thereby, since a photometric accuracy during an analysis can be controlled accurately, the defect of the photometric accuracy due to the reaction container 12 can be diagnosed quickly, and the efficiency of an inspection can be enhanced.

2. 发明专利

JPH09229939A METHOD FOR CONFIRMING ACCURACY OF PHOTOMETRIC SYSTEM IN AUTOMATIC CHEMICAL ANALYZER 失效
公开(公告)号：JPH09229939A
公开(公告)日：1997-09-05
申请号：JP3459796
申请日：1996-02-22
申请人： HITACHI LTD , HITACHI INSTRUMENTS ENG
发明人： SHICHIJI MASARU , YOKOSE TAIZO , SUGAWARA KENJI
IPC分类号： G01N35/00
摘要： PROBLEM TO BE SOLVED: To make it possible to efficiently confirm the accuracy of a photometric system during analyzing by disposing and rotating a plurality of reaction vessels on a disk, measuring the absorbance of reaction liquid as the vessel passes an optical path, and obtaining the absorbance difference before and after. SOLUTION: A reaction disk 7 repeats the operations of rotating and stopping a vessel at half rotation plus one rotation. When the initial vessel 12 is advanced to a sample discharge position 15, a sample disk 2 is rotated, a sample cup 1 is moved to a sampling position, and reagent disks 6a, 6b are moved to a pipetting position. A sample probe 3 sucks the sample from a sampling mechanism 4. A pipetting mechanism 5a sucks the reagent for a reagent disk 6a by a reagent probe 24a, and together discharge it to the vessel 12. As the disk 7 is rotated, the photometry is conducted each time the vessel 12 crosses the luminous flux. For example, absorbance difference before and after is obtained between the photometric points selected by the analysis parameter of the 50 times photometries, and when it is tolerance or more, an alarm is displayed, and for example, it is instructed to replace a lamp.

3. 发明专利

JPH09101311A AUTOMATIC CHEMICAL ANALYZER 失效
公开(公告)号：JPH09101311A
公开(公告)日：1997-04-15
申请号：JP25849395
申请日：1995-10-05
申请人： HITACHI LTD , HITACHI INSTRUMENTS ENG
发明人： IKEDA TOMOKO , YOKOSE TAIZO , SHICHIJI MASARU , SUGAWARA KENJI
IPC分类号： G01N35/00
摘要： PROBLEM TO BE SOLVED: To achieve higher reliability of photometric accuracy along with prevention of a delay in the results of inspection by eliminating much labor and time required from the study of the cause about a wrong measured value involved in a photometry system to the recovery of the apparatus. SOLUTION: This analyzer is made up of a sample disc 2 allowing the mounting of a plurality of sample couples 1 thereon, a sampling mechanism 4 to preparatorily isolate a sample, reagent pipetting mechanisms 5a and 5b to dispense a plurality of reagents, reagent discs 6a and 6b, a reaction disc 7 on which a plurality of reaction containers are held, agitation mechanisms 8a and 8b, a reaction container washing mechanism 9, a photometer 10 and a central processor 11 to perform a control of the mechanism system as a whole and a data processing.

4. 发明专利

JPH10282000A ENZYME ACTIVITY MEASUREMENT 失效
公开(公告)号：JPH10282000A
公开(公告)日：1998-10-23
申请号：JP9341097
申请日：1997-04-11
申请人： HITACHI LTD , HITACHI INSTRUMENTS ENG
发明人： SHICHIJI MASARU , YOKOSE TAIZO
IPC分类号： G01N21/75 , G01N35/00
摘要： PROBLEM TO BE SOLVED: To detect and reject an abnormal value for attaining accurate measured results by sequentially-calculating an gradient between respective photometry points in reacting process to obtain respective relative values, and comparing them with preset permissible values for confirmation of the linearity of a change in an absorption value. SOLUTION: In this enzyme activity measurement, such as GOT, which permits enzyme to react in a container disposed on a rotating disc and obtains the enzyme activity by the change of absorbancy, absorbancy measuring is conducted at a prescribed number of photometry points of a reaction time course. Gradient (absorbancy variance per unit-hour) is computed sequentially from the photometry point lm where calculation preset as analysis parameter is started, through points lm+1 , lm+2 ,..., the point ln where the calculation is completed. A relative value is calculated by a prescribed method for respective calculated gradients, and comparative discrimination with permissible value preset arbitrarily is conducted. By rejecting the absorbancy at the point which is discriminated to be abnormal compared with the permissible value, and obtaining absorbancy changing speed by the method of least squares from remaining data, it is possible to calculate the enzyme activity.

5. 发明专利

JPH07289286A METHOD FOR MEASURING ACTIVITY OF ENZYME IN AUTOMATIC CHEMICAL ANALYSIS DEVICE 失效
公开(公告)号：JPH07289286A
公开(公告)日：1995-11-07
申请号：JP9104294
申请日：1994-04-28
申请人： HITACHI LTD , HITACHI INSTRUMENTS ENG
发明人： OTAKI TOMOMASA , YOKOSE TAIZO , TSUJIKAWA ATSUKO
IPC分类号： G01N35/02 , C12Q1/00
摘要： PURPOSE:To eliminate the re-examination of a highly active specimen from a serious injury patient, the re-examination having been a problem on an enzyme with a conventional automatic chemical analysis device and by a conventional measuring method, and to shorten a time required for a clinical chemical examination. CONSTITUTION:This biochemical automatic analysis device comprises sample disks 2 having plural sample cups set therein, a sample probe 5 for sampling specimens, reaction containers used also as cuvettes, a spectroscope 9 for measuring the reduction (or increase) in absorbance, a reagent-injecting mechanism 32 for re-injecting a reagent into a reaction solution of reaction saturation state, and a central processing device 21 for performing the control of the whole device and the whole data-processing such as the calculation of the liquid volume correction coefficient of the reagent and the computation of the concentration (enzymatic activity).

6. 发明专利

JPH07159416A AUTOMATIC CHEMICAL ANALYZER 失效
公开(公告)号：JPH07159416A
公开(公告)日：1995-06-23
申请号：JP30250993
申请日：1993-12-02
申请人： HITACHI LTD , HITACHI INSTRUMENTS ENG
发明人： YOKOSE TAIZO , TSUJIKAWA ATSUKO , OTAKI TOMOMASA , SHIRAISHI SO
IPC分类号： G01N35/04 , G01N35/10
摘要： PURPOSE:To provide a highly reliable automatic chemical analyzer which can avoid cross contamination of a reagent probe intrinsic to a reagent pipetting system without lowing function of the analyzer while eliminating the occurrence of undesired results of analysis. CONSTITUTION:This apparatus is made up of a sample disc 2 which allows the mounting of a plurality of sample cups 1 thereon, a sampling mechanism 4 to dispense a sample, reagent pipetting mechanisms 6a and 6b adapted to dispense a plurality of regents, a reaction disc 9 which holds reagent discs 7a and 7b and a plurality of reaction containers 8, an agitation mechanism 10, a reaction container washing mechanism 11, a multi-wavelength photometer 12 and a central processing unit to perform a control of a mechanism system as a whole and a data processing.

7. 发明专利

JPH06303992A METHOD FOR MEASURING ENZYMIC ACTIVITY IN AUTOMATIC CHEMICAL ANALYZER 失效
公开(公告)号：JPH06303992A
公开(公告)日：1994-11-01
申请号：JP9574593
申请日：1993-04-22
申请人： HITACHI LTD , HITACHI INSTRUMENTS ENG
发明人： SHICHIJI MASARU , YOKOSE TAIZO
IPC分类号： C12M1/34 , C12Q1/00 , C12Q1/42 , C12Q1/52 , G01N35/02
摘要： PURPOSE:To eliminate the retest of a highly active specimen in serious diseases and shorten the time required for clinical chemical tests. CONSTITUTION:The automatic biochemical analyzer is composed of a sample disk 2 for installing plural sample cups therein, a sample probe 5 for collecting a specimen, reactional containers (4b) used in the former half of bisected reactional times, reactional containers (4b) used in the latter half of the bisected reactional times for continuously measuring the specimen in a highly active area, a spectroscope 9 for measuring the reduction (or increase) in absorbance based on the reactional product according to the enzymic activity, a pipetting mechanism 6 for the reactional solution capable of pipetting the reactional solution in a reactional saturated state in a process of analysis, a suction probe 7 for the reactional solution, a central processor 21 for carrying out the control of the whole apparatus including the mechanical system and general data processing such as calculation of the correction coefficient for the amount of the liquid of the reagent and computing of the concentration (enzymic activity), etc.

8. 发明专利

JPH0694731A MONITORING DEVICE FOR EVAPORATION OF SPECIMEN FOR AUTOMATIC CHEMICAL ANALYZER 失效
公开(公告)号：JPH0694731A
公开(公告)日：1994-04-08
申请号：JP24301992
申请日：1992-09-11
申请人： HITACHI LTD , HITACHI INSTRUMENTS ENG
发明人： YOKOSE TAIZO , OTAKI TOMOMASA , USUI SHINOBU
IPC分类号： G01N35/02 , G01N35/10 , G01N35/06
摘要： PURPOSE:To improve reliability of analysis result by measuring sample amount before starting analysis and at the time of starting, monitoring sample evapora tion and correcting an evaporation amount. CONSTITUTION:A sampling arm 6 of a sample probe 5 integral with a liquid surface sensor mounted at the arm 6 falls according to a pulse signal to a pulse counting motor 8 for vertically driving the am, and the probe 5 senses a liquid surface. After sensing, the arm 6 rises under the control of a microcomputer. In this case, the microcomputer calculates a height from a bottom of a sample cup 1 to the liquid surface, converts it into a liquid amount and obtains a sample amount V1 in a cup 1 before starting the analysis. Similarly, a sample amount V1 at the time of starting the analysis is obtained. After a predetermined amount of the sample is gathered and reagent is added after the liquid surface is sensed, absorbance is measured. In this case, the amount V1 is compared with the amount V2 by an evaporation amount calculator 13 before starting the analysis and at the time of starting, the evaporation amount is calculated as to the sample decided as V1>V2, corrected as prescribed, and an analysis result is obtained.

9. 发明专利

JPH0560769A METHOD FOR SAMPLING MINUTE AMOUNT OF SPECIMEN FOR AUTOMATIC ANALYZER 失效
公开(公告)号：JPH0560769A
公开(公告)日：1993-03-12
申请号：JP22394691
申请日：1991-09-04
申请人： HITACHI LTD , HITACHI INSTRUMENTS ENG
发明人： YOKOSE TAIZO , USUI SHINOBU , OTAKI TOMOMASA
IPC分类号： G01N1/00 , G01N21/31 , G01N31/20 , G01N31/22 , G01N35/10
摘要： PURPOSE:To sample a minute amount of specimen efficiently and highly accurately by detecting the level of a sample-shortage detecting region with a sample probe, which also serves the role of a liquid-level sensor, and controlling the depth of the tip of the probe and the driving of a syringe. CONSTITUTION:A sampling arm 5 is driven 6. A sampling probe 4, which also serves the roles of a liquid level sensor and a sampling nozzle, is brought into contact with the liquid surface of a specimen in a sample cup 10b, and the specimen is sampled. When the amount of the specimen is as minute as about, e.g. 20-30mul, the tip of the probe 4 is inserted down to the bottom of the cup 10b. Therefore, there is no dummy amount of the specimen, which is caused by the difference between the heights of both tips of the sensor and the nozzles, at all. The tip of the probe 4 is inserted beneath the liquid surface by the amount of the level after the tip of the probe 4 comes into contact with the liquid surface based on the level information in a sample-shortage detecting region from the bottom of the cup 10b. Therefore, the specimen is not attached. When the total amount of the specimen becomes lower than the maximum amount of the apparatus, the driving of a specimen sampling syringe 1 is controlled, and the sucking of air is prevented. Therefore, the sampling accuracy can be maintained.

10. 发明专利

JP2000105239A BIOCHEMICAL AUTOMATIC ANALYZER 失效
公开(公告)号：JP2000105239A
公开(公告)日：2000-04-11
申请号：JP27459598
申请日：1998-09-29
申请人： HITACHI LTD , HITACHI INSTRUMENTS ENG
发明人： OTAKI TOMOMASA , SAITO KIYOTAKA , YOKOSE TAIZO , IMAI KYOKO
IPC分类号： G01N33/52 , G01N21/27 , G01N35/00
摘要： PROBLEM TO BE SOLVED: To simply and surely detect abnormality, and to predict a life of a replacing component, by measuring an absorbance using a colored substance after absorbance measurement using pure water to determine that a data trouble exists in any side out of a photometric system and a dispensing system. SOLUTION: Washing for reaction vessels is started, a fixed amount of water are dispensed into one specified vessel and a plurality of reaction vessels, respectively, to measure absorbances, and measured results are determined as a check (1) and a check (2) respectively. The check (1) is compared with the check (2) to judge whether a cause exists in the reaction vessel or a light source based on an allowance value. Pure water is thereafter dispensed after a fixed amount of colored substance are dispenced from a sample probe into the plural reaction vessels (group A) after washing. The fixed amounts of the colored substance and pure water are delivered at the same time into another reaction vessels (group B) with no sample dispensed, using a reagent probe. Absorbance- measured values of the groups A, B are determined as checks (4), (5), and the checks (4), (5) are compared each other to judge whether a cause exists in deterioration of sampling precision or in a reagent pipetting mechanism.

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