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1. 发明专利

JP2010059200A Use for utilizing of physiological activity action of d-allose 有权
标题翻译：使用D-ALLOSE的生理活动行为
公开(公告)号：JP2010059200A
公开(公告)日：2010-03-18
申请号：JP2009277930
申请日：2009-12-07
申请人： Fushimi Pharm Co Ltd , Hayashibara Biochem Lab Inc , Kagawa Univ , Shikoku Res Inst Inc , Teikoku Seiyaku Co Ltd , 国立大学法人香川大学 , 帝國製薬株式会社 , 株式会社伏見製薬所 , 株式会社四国総合研究所 , 株式会社林原生物化学研究所
发明人： IKUMORI TAKESHI , TOKUDA MASAAKI , ITANO TOSHIFUMI , MIYAMOTO OSAMU , ISHIDA TOSHIHIKO , MURAO KOUJI , TASAKA TAIZO , MUNEUCHI IWAO , YAMAGUCHI AYANORI , TANAKA TERUKAZU , HOSSAIN MOHAMMAD AKRAM , UEKI MASAAKI , HIROOKA KAZUYUKI , TAMINATO ASAHIKO , TSUZAKI KEIJI , TAKAHASHI TAKEO , NAGATA MITSUHIRO , ISHIDA YUTAKA
IPC分类号： A61K31/7004 , A23L1/09 , A23L1/30 , A61K8/60 , A61P9/10 , A61P13/12 , A61P17/16 , A61P25/08 , A61P27/02 , A61P27/12 , A61P35/00 , A61P39/06 , A61Q19/00 , C07H3/02 , C12N5/08
CPC分类号： A61Q19/00 , A23L29/30 , A23L33/10 , A61K8/60 , A61K31/7004
摘要： PROBLEM TO BE SOLVED: To utilize the physiological activity action of especially D-allose relating to a rare saccharide and to produce a functional food, pharmaceuticals, etc., utilizing the physiological activity of the rare saccharide. SOLUTION: An intravital antioxidant having D-allose as an active component is used for a tissue preservation liquid or an infusion solution (a transfusion). The intravital antioxidant is contained in an ingesta of a mammal (including a human), a pharmaceutical composition or an external preparation for skin. The pharmaceutical composition is effective for treating or preventing of cranial nerve disease selected from cancer, skin flap necrosis, transient ischemic attack, cerebral apoplexy and traumatic epilepsy, kidney disease selected from acute renal failure and uremia, and ophthalmology disorder selected from retina degeneration disease, retinopathy of prematurity, cataract and eye inflammation. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：利用与稀有糖类相关的特别是D-丙氨酸的生理活性作用，并利用稀有糖类的生理活性产生功能性食品，药物等。解决方案：用于组织保存液体或输液（输液）的具有D-丙酮酸作为活性成分的活体抗氧化剂。活体抗氧化剂包含在哺乳动物（包括人）的摄食，药物组合物或皮肤外用制剂中。药物组合物对于治疗或预防选自癌症，皮肤瓣坏死，短暂性脑缺血发作，脑中风和创伤性癫痫，选自急性肾功能衰竭和尿毒症的肾脏疾病以及选自视网膜变性疾病的眼科疾病，早产儿视网膜病变，白内障和眼睛炎症。版权所有（C）2010，JPO＆INPIT

2. 发明专利

JP2007051136A Use of d-psicose for inhibiting d-fructose concentration rise in blood 有权
标题翻译：使用D-PSICOSE抑制血液中D型糖浓度升高
公开(公告)号：JP2007051136A
公开(公告)日：2007-03-01
申请号：JP2006196752
申请日：2006-07-19
申请人： Kagawa Univ , Teikoku Seiyaku Co Ltd , 国立大学法人香川大学 , 帝國製薬株式会社
发明人： NAGATA MITSUHIRO
IPC分类号： A61K31/7004 , A23K1/16 , A23L1/30 , A61P3/04 , A61P3/06 , A61P3/10
CPC分类号： A61K31/7004 , A23K20/163 , A23L33/10
摘要： PROBLEM TO BE SOLVED: To enable the prevention in the symptom aggravation of obesity, diabetes and metabolic syndrome, the prevention in crisis, and the improvement in symptoms. SOLUTION: This composition for inhibiting D-fructose concentration rise, preferably simultaneously D-glucose concentration rise, in blood, when a carbohydrate and/or a saccharide having or containing the D-fructose as a part of the structure is taken, is characterized by containing D-psicose and/or its derivative as an active ingredient. The composition, wherein the D-psicose is a mixture of D-psicose with D-fructose. The composition is a form selected from a sweetener, a seasoning, a food additive, a food material, a food or a drink, a health drink or a health food, a medicine, or a feed. A method for using D-psicose to inhibit D-fructose concentration rise, preferably simultaneously to inhibit D-glucose concentration rise, in blood, is characterized by giving D-psicose, when a carbohydrate and/or a saccharide having or containing D-fructose as a part of the structure is taken. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：为了预防肥胖症，糖尿病和代谢综合征的症状加重，预防危机和症状改善。解决方案：当采用具有或含有D-果糖作为结构的一部分的碳水化合物和/或糖类时，用于抑制D-果糖浓度的组合物，优选同时D-血糖浓度升高，其特征在于含有D-灵敏蛋白和/或其衍生物作为活性成分。所述组合物，其中所述D-灵糖蛋白是D-木糖与D-果糖的混合物。组合物是选自甜味剂，调味料，食品添加剂，食品材料，食品或饮料，健康饮料或保健食品，药物或饲料中的形式。当具有或含有D-果糖的碳水化合物和/或糖类时，使用D-灵敏蛋白来抑制D-果糖浓度升高，优选同时抑制血液中D-葡萄糖浓度升高的方法的特征在于给予D-灵糖蛋白作为结构的一部分。版权所有（C）2007，JPO＆INPIT

3. 发明专利

JP2007051135A Utilization of d-allose for anti-hyperglycemic effect 有权
标题翻译：用于抗高血压效应的D-ALLOSE的使用
公开(公告)号：JP2007051135A
公开(公告)日：2007-03-01
申请号：JP2006196751
申请日：2006-07-19
申请人： Kagawa Univ , Teikoku Seiyaku Co Ltd , 国立大学法人香川大学 , 帝國製薬株式会社
发明人： NAGATA MITSUHIRO
IPC分类号： A61K31/7004 , A23L1/30 , A61P3/02 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/10 , A61P9/10 , A61P43/00 , C07H3/02
CPC分类号： A61K31/7004 , A23L33/10 , A23V2002/00 , A23V2200/328
摘要： PROBLEM TO BE SOLVED: To provide a composition having an effect for inhibiting a sudden elevation of glycemia, when carbohydrates and/or saccharides are taken.
SOLUTION: This composition for inhibiting a sudden elevation of glycemia, when carbohydrates and/or saccharides are taken, is characterized by containing D-allose. The composition, wherein the D-allose is D-allose and/or its derivatives. The D-allose is preferably a mixture of D-allose with D-psicose and/or its derivative in a smaller weight rate than that of the D-allose. A method for moderating dietary restriction caused by the disorders of carbohydrate metabolism and/or lipid metabolism in human and/or animal to improve the quality of life (QOL).
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供当摄取碳水化合物和/或糖时具有抑制血糖突然升高的效果的组合物。解决方案：当采用碳水化合物和/或糖类时，用于抑制血糖突然升高的组合物的特征在于含有D-丙氨酸。所述组合物，其中所述D-丙氨酸是D-丙氨酸和/或其衍生物。 D-丙氨酸优选是D-丙糖与D-灵敏蛋白和/或其衍生物的混合物，其重量比D-allose更小。一种用于调节由人和/或动物中的碳水化合物代谢和/或脂质代谢紊乱引起的饮食限制以改善生活质量（QOL）的方法。版权所有（C）2007，JPO＆INPIT

4. 发明专利

JP2007051134A Utilization of d-allose and d-psicose for anti-neurogenic pain effect 有权
标题翻译： D-ALLOSE和D-PSICOSE对抗神经源性疼痛作用的应用
公开(公告)号：JP2007051134A
公开(公告)日：2007-03-01
申请号：JP2006196750
申请日：2006-07-19
申请人： Kagawa Univ , Teikoku Seiyaku Co Ltd , 国立大学法人香川大学 , 帝國製薬株式会社
发明人： NAGATA MITSUHIRO
IPC分类号： A61K31/7004 , A23K1/16 , A61P1/02 , A61P25/04 , A61P31/22 , A61P35/00 , C07H3/02
CPC分类号： A61K31/7004 , A23L33/10 , A23V2002/00 , A23V2200/308
摘要： PROBLEM TO BE SOLVED: To control neurogenic pains caused by various mechanisms. SOLUTION: This neurogenic pain-eliminating, mitigating or reducing composition comprises one or more substances selected from the group consisting of D-allose, D-allose derivatives, D-psicose and D-psicose derivatives preferably in an amount of 0.01 to 90 wt.% as an effective component. The composition comprises a mixture of D-allose and/or D-allose derivatives, and D-psicose and/or D-psicose derivatives in a ratio of 1:1 to 10:1. The neurogenic pain is caused by a disease selected from the group consisting of trigeminal neuralgia, postoperative pain, periodontitis, gingivitis, stomatitis, oral ulcer, herpes zoster, postherpetic neuralgia, diabetic neuritis, causalgia, phantom limb pain and malignant tumors. A method for using the neurogenic pain-eliminating, mitigating or reducing composition is characterized by giving one or more of the substances to a patient suffered from a neurogenic pain at a dose of 0.01 to 100 g a day. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：控制各种机制引起的神经源性疼痛。解决方案：这种神经源性疼痛消除，减轻或减少组合物包含选自D-丙氨酸，D-阿拉伯糖衍生物，D-灵芝蛋白和D-灵芝蛋白衍生物的一种或多种物质，优选的量为0.01〜 90重量％作为有效成分。所述组合物包含D-allose和/或D- allose衍生物的混合物，和D-psicose和/或D-灵芝糖衍生物的比例为1:1至10:1。神经源性疼痛是由选自三叉神经痛，术后疼痛，牙周炎，牙龈炎，口腔炎，口腔溃疡，带状疱疹，带状疱疹后神经痛，糖尿病性神经炎，灼痛，幻肢疼痛和恶性肿瘤的疾病引起的。使用神经源性疼痛消除，减轻或减少组合物的方法的特征在于，以每天0.01至100g的剂量给患有神经源性疼痛的患者给予一种或多种物质。版权所有（C）2007，JPO＆INPIT

5. 发明专利

JP2007051137A Body weight increase-inhibiting composition containing d-psicose and method for using the same 有权
标题翻译：含有D-PSICOSE的身体重量增加抑制组合物及其使用方法
公开(公告)号：JP2007051137A
公开(公告)日：2007-03-01
申请号：JP2006196753
申请日：2006-07-19
申请人： Kagawa Univ , Teikoku Seiyaku Co Ltd , 国立大学法人香川大学 , 帝國製薬株式会社
发明人： NAGATA MITSUHIRO
IPC分类号： A61K31/7004 , A61P3/04 , C07H3/02
CPC分类号： A61K31/7004
摘要： PROBLEM TO BE SOLVED: To provide a body weight increase-inhibiting composition which inhibits the excessive increase of body weight caused by various reasons to reduce body overweight.
SOLUTION: This composition for inhibiting the excessive increase of body weight and/or reducing body overweight is characterized by containing D-psicose. The composition for preventing obesity and/or improving an obese state is characterized by containing D-psicose. The D-psicose is preferably contained in an amount of 1 to 90 wt.%. The D-psicose is D-psicose and/or its derivative. A method for inhibiting the excessive increase of body weight and/or reducing body overweight is characterized by using the composition for a human being and/or an animal needing to inhibit the excessive increase of body weight and/or reducing body overweight. A method for preventing obesity and/or improving an obese state is characterized by using the composition for a human being and/or an animal needing to prevent obesity and/or improving an obese state.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供抑制由于各种原因引起的体重过度增加以减轻体重超重的体重增加抑制组合物。解决方案：用于抑制体重过度增加和/或减少体重超重的组合物的特征在于含有D-灵芝蛋白。用于预防肥胖症和/或改善肥胖状态的组合物的特征在于含有D-灵芝蛋白。 D-石棉糖的含量优选为1〜90重量％。 D-灵芝蛋白是D-灵敏蛋白和/或其衍生物。用于抑制体重过度增加和/或减少体重超重的方法的特征在于使用组合物用于需要抑制体重过度增加和/或减少体重超标的人和/或动物。用于预防肥胖症和/或改善肥胖状态的方法的特征在于使用组合物用于需要预防肥胖和/或改善肥胖状态的人和/或动物。版权所有（C）2007，JPO＆INPIT

6. 发明专利

JP2005213227A Use of blood sugar increase suppressing effect of d-psicose 有权
标题翻译：使用血糖增加抑制D-PSICOSE的作用
公开(公告)号：JP2005213227A
公开(公告)日：2005-08-11
申请号：JP2004024854
申请日：2004-01-30
申请人： Teikoku Seiyaku Co Ltd , 帝國製薬株式会社
发明人： NAGATA MITSUHIRO
IPC分类号： A23L2/52 , A23L33/20 , A61K31/7004 , A61P3/04 , A61P3/10 , C07H7/02 , A23L1/307
摘要： PROBLEM TO BE SOLVED: To suppress the increase of blood sugar level due to the oral administration of polysaccharide by using D-psicose. SOLUTION: The steep increase of the blood sugar level after taking a carbohydrate and/or a sugar composition containing D-psicose and/or its derivative is suppressed compared with the single taking of the carbohydrate and/or sugar. The composition contains 0.1-50 wt.% D-psicose and/or its derivative. This invention further provides a food additive containing the composition as an active component and effective for suppressing the increase of blood sugar level caused by the administration of a carbohydrate and/or sugar, and further a food additive for diabetic patient, a health food, a food for diabetic patient, a body slimming food, an agent for suppressing the increase of blood sugar level, a drink or a feed, and a method for suppressing the steep increase of blood sugar level after the intake of carbohydrate and/or sugar by using the blood sugar level increase suppressing function of D-psicose are provided. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：抑制通过使用D-灵芝糖口服多糖的口服血糖水平的升高。解决方案：与单次服用碳水化合物和/或糖相比，在服用含有D-灵糖和/或其衍生物的碳水化合物和/或糖组合物后，血糖水平的急剧增加被抑制。组合物含有0.1-50重量％的D-灵敏蛋白和/或其衍生物。本发明还提供了一种食品添加剂，其含有作为活性成分的组合物，并且有效地抑制由给予糖和/或糖引起的血糖水平升高，并且还提供了用于糖尿病患者的食品添加剂，保健食品，用于糖尿病患者的食物，减肥食品，抑制血糖水平升高的药剂，饮料或饲料，以及通过使用碳水化合物和/或糖摄入后抑制血糖水平急剧上升的方法提供了D-psicose的血糖水平增加抑制功能。版权所有（C）2005，JPO＆NCIPI

7. 发明专利

JP2005154367A Analgesic agent for neuropathic pain containing propafenone 有权
标题翻译：含有丙酮的神经性疼痛药物
公开(公告)号：JP2005154367A
公开(公告)日：2005-06-16
申请号：JP2003397665
申请日：2003-11-27
申请人： Teikoku Seiyaku Co Ltd , 帝國製薬株式会社
发明人： WATANABE TETSUYA , SHIBATA DAIKI , NAGATA MITSUHIRO
IPC分类号： A61P25/04 , A61K31/138
摘要： PROBLEM TO BE SOLVED: To obtain an analgesic agent extremely effective for suppressing neuropathic pain and having little side action.
SOLUTION: This analgesic agent for the neuropathic pain contains propafenone or its pharmaceutically permissible salt as an active component. This invention further discloses an analgesic agent for neuropathic pain containing propafenone hydrochloride as an active component.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：获得极度有效抑制神经性疼痛并且具有很小副作用的止痛剂。解决方案：用于神经性疼痛的镇痛剂包含普罗帕酮或其药学上允许的盐作为活性成分。本发明还公开了含有盐酸普罗帕酮作为活性成分的神经性疼痛镇痛剂。版权所有（C）2005，JPO＆NCIPI

8. 发明专利

JP2005154368A Analgesic agent for neuropathic pain containing disopyramide 审中-公开
标题翻译：含有二恶英的神经性疼痛的化学药剂
公开(公告)号：JP2005154368A
公开(公告)日：2005-06-16
申请号：JP2003397668
申请日：2003-11-27
申请人： Teikoku Seiyaku Co Ltd , 帝國製薬株式会社
发明人： WATANABE TETSUYA , SHIBATA DAIKI , NAGATA MITSUHIRO
IPC分类号： C07D213/56 , A61K31/4402 , A61P25/00
摘要： PROBLEM TO BE SOLVED: To obtain an analgesic agent extremely effective for suppressing neuropathic pain and having little side action.
SOLUTION: This analgesic agent for the neuropathic pain contains disopyramide or its salt as an active component. This invention further discloses an analgesic agent for neuropathic pain containing disopyramide phosphate as an active component.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：获得极度有效抑制神经性疼痛并且具有很小副作用的止痛剂。解决方案：用于神经性疼痛的止痛剂含有丙吡胺或其盐作为活性成分。本发明还公开了一种含有磷酸丙吡胺作为活性成分的神经性疼痛止痛剂。版权所有（C）2005，JPO＆NCIPI

9. 发明专利

JP2004202086A Medicator for electroporation, and system and method of medication for electroporation 审中-公开
标题翻译：用于电气的药物，以及用于电气的药物的系统和方法
公开(公告)号：JP2004202086A
公开(公告)日：2004-07-22
申请号：JP2002377275
申请日：2002-12-26
申请人： Teikoku Seiyaku Co Ltd , 帝國製薬株式会社
发明人： NAGATA MITSUHIRO , OKAMOTO KENSEI , INATSUKI SAYOKO , WATANABE TETSUYA
IPC分类号： A61N1/30
摘要： PROBLEM TO BE SOLVED: To provide a medicator for electroporation capable of further reducing the adverse reaction to an organism than a conventional one, with excellent efficiency in feeding and sending a medicament, to be easily handled, and a system and a method of medication for electroporation.
SOLUTION: Electrodes 112 are mounted on a plurality of recesses 114 formed in an electrode support body 113, and a medicine 131 comprising the medicament and electrolyte is stored in the recesses. As the electrode is not directly in contact with a subject of dosing 135, the adverse reaction to the organism can be further reduced than a conventional one. In addition, as the electricity can be fed from the electrode via the medicine, the dosing part functions as a microelectrode and the intensity of the electric field can be enhanced, so that the electroporation can be efficiently performed.
COPYRIGHT: (C)2004,JPO&NCIPI
摘要翻译：要解决的问题：提供一种能够进一步减少对常规的生物体的不良反应的电穿孔药剂，其具有优异的给药和送药效率，容易处理的效果，以及系统和方法用于电穿孔。解决方案：电极112安装在形成在电极支撑体113中的多个凹部114上，并且包含药物和电解质的药物131储存在凹部中。由于电极不直接与给药物135接触，对生物体的不良反应可以比常规方法进一步降低。此外，由于能够通过药物从电极供给电力，所以配量部件作为微电极起作用，能够提高电场强度，能够有效地进行电穿孔。版权所有（C）2004，JPO＆NCIPI

10. 发明专利

JP2005002009A Fentanyl-containing patch for mucous membrane in oral cavity 有权
标题翻译：含有口腔粘膜的口腔粘膜
公开(公告)号：JP2005002009A
公开(公告)日：2005-01-06
申请号：JP2003164943
申请日：2003-06-10
申请人： Teikoku Seiyaku Co Ltd , 帝國製薬株式会社
发明人： IHARA KATSUMI , NAGATA MITSUHIRO , INATSUKI SAYOKO
IPC分类号： A61K9/70 , A61K9/00 , A61K31/4468 , A61K47/32 , A61K47/38 , A61P25/04
CPC分类号： A61K31/4468 , A61K9/006
摘要： PROBLEM TO BE SOLVED: To provide an easily handleable and highly safe fentanyl-containing patch for the mucous membrane in the oral cavity rapidly raising blood level of a fentanyl drug and reducing migration to an alimentary canal.
SOLUTION: This fentanyl-containing patch for the mucous membrane in the oral cavity is obtained by successively laminating a water-insoluble or sparingly water-soluble support layer and a support to one surface of a drug layer containing fentanyl or its salt as a medicinal effective ingredient, a methyl vinyl ether-maleic anhydride copolymer as a pressure-sensitive adhesive and one or more kinds of substances selected from hydroxypropyl cellulose, hydroxypropyl methyl cellulose and hydroxyethyl cellulose as a thickener.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：为了提供容易处理和高度安全的含有芬太尼的口腔粘膜的贴剂，快速提高芬太尼药物的血液水平并减少向消化道的迁移。解决方案：通过将含有芬太尼或其盐的药物层的一个表面依次层压水不溶性或微水溶性支持层和支持体，来获得口腔内用于粘膜的含芬太尼的贴剂，作为药用有效成分，作为压敏粘合剂的甲基乙烯基醚 - 马来酸酐共聚物和选自羟丙基纤维素，羟丙基甲基纤维素和羟乙基纤维素作为增稠剂的一种或多种物质。版权所有（C）2005，JPO＆NCIPI

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