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1. 发明专利

JP2011104369A Electron beam sterilization of medical device with bioactive coating 有权
标题翻译：具有生物涂层的医疗设备的电子束灭菌
公开(公告)号：JP2011104369A
公开(公告)日：2011-06-02
申请号：JP2010254523
申请日：2010-11-15
申请人： Cordis Corp , コーディス・コーポレイションCordis Corporation
发明人： FALOTICO ROBERT , LI CHENGXUE , NGUYEN THAI MINH , PARKER THEODORE L , ZHAO JONATHON Z
IPC分类号： A61L2/08 , A61M37/00
CPC分类号： B65B31/00 , A61L2/087 , A61L2202/21 , B65B55/00 , B65B55/16 , B65D81/266
摘要： PROBLEM TO BE SOLVED: To provide a method for single-step terminal sterilization process for bioactive heparin coatings on materials and biomaterials containing heparin used in medical devices, such as catheters, tissue engineering scaffolds, or drug delivery carrier materials. SOLUTION: The present invention may include a medical device or an implant that could benefit from improved antithrombotic and biocompatible heparin surfaces. Other relevant device examples may include heparin or a heparin derivative-coated stents for reducing clotting and restenosis, dental or ophthalmological implants. These materials may, in cases, include additional polymeric compositions, such as polyethyleneimine, dextran sulfate, or their modified forms. These polymers together with heparin coatings may be applied to other substrate of medical devices such as metal, ceramics, or biologically derived materials. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于医疗装置（例如导管，组织工程支架或药物递送载体材料）中含有肝素的材料和生物材料上的生物活性肝素涂层的一步终端灭菌方法。解决方案：本发明可以包括可以从改进的抗血栓形成和生物相容性肝素表面中受益的医疗装置或植入物。其它有关的装置实例可包括肝素或用于减少凝血和再狭窄的肝素衍生物涂层的支架，牙科或眼科植入物。在这些情况下，这些材料可以包括另外的聚合物组合物，例如聚乙烯亚胺，硫酸葡聚糖或其改性形式。这些聚合物与肝素涂层一起可以应用于诸如金属，陶瓷或生物衍生材料的医疗装置的其它基底。版权所有（C）2011，JPO＆INPIT

2. 发明专利

JP2011172927A Bare metal stent with drug eluting reservoir 有权
标题翻译：具有药液储存的裸金属瓶
公开(公告)号：JP2011172927A
公开(公告)日：2011-09-08
申请号：JP2011035553
申请日：2011-02-22
申请人： Cordis Corp , コーディス・コーポレイションCordis Corporation
发明人： NGUYEN THAI MINH , PARKER THEODORE L , SHANLEY JOHN F
IPC分类号： A61F2/82 , A61L31/00
CPC分类号： A61F2/91 , A61F2/88 , A61F2/915 , A61F2002/91558 , A61F2210/0076 , A61F2230/0054 , A61F2250/0068 , A61L31/022 , A61L31/10 , A61L31/16 , A61L2300/416 , C08L67/04
摘要： PROBLEM TO BE SOLVED: To provide a device for locally delivering a therapeutic drug and/or a combination of therapeutic drugs. SOLUTION: An implantable medical device may be used for locally delivering one or more kinds of drug or therapeutic drug to treat various states of treatment including the treatment of the biological organism reaction to the introduction of the implantable medical device. These therapeutic drugs may be released under controlled directional conditions from a stent 100 so that one or more kinds of therapeutic drug reach the correct target area, for example, a surrounding tissue. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供用于局部递送治疗药物和/或治疗药物的组合的装置。解决方案：可植入医疗装置可用于局部输送一种或多种药物或治疗药物以治疗各种治疗状态，包括治疗生物体生物反应以引入可植入医疗装置。这些治疗药物可以在受控制的方向条件下从支架100释放，使得一种或多种治疗药物到达正确的靶区域，例如周围组织。版权所有（C）2011，JPO＆INPIT

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