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1. 发明授权

EP3026110B1 METHOD FOR PROVIDING VASCULAR SYSTEM IN BIOLOGICAL TISSUE 有权
公开(公告)号：EP3026110B1
公开(公告)日：2020-09-16
申请号：EP14829625.4
申请日：2014-07-15
申请人： Public University Corporation Yokohama City University
发明人： TAKEBE, Takanori , TANIGUCHI, Hideki , TAKAHASHI, Yoshinobu
IPC分类号： A61L27/38 , A61L27/00 , C12N5/071 , A01K67/027 , C07D499/21 , G01N33/50

2. 发明公开

EP2986617A4 ANTI-BACTERIAL SIDEROPHORE-AMINOPENICILLIN CONJUGATES 无效
标题翻译：抗坏血酸盐 - 氨基宁霉素 - 酮聚糖
公开(公告)号：EP2986617A4
公开(公告)日：2017-03-22
申请号：EP13882608
申请日：2013-10-23
申请人： UNIV NOTRE DAME DU LAC
发明人： MILLER MARVIN J , JI CHENG , MILLER PATRICIA A
IPC分类号： C07D499/21 , A61K31/133 , A61K31/165 , A61K31/40 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/42 , A61K31/427 , A61K31/43 , A61K31/439 , A61K31/4409 , A61K31/4439 , A61K31/496 , A61K31/545 , A61K31/63 , A61K31/635 , A61K31/65 , A61K38/12 , A61P31/04 , C07D499/68
CPC分类号： A61K47/48023 , A61K31/133 , A61K31/165 , A61K31/167 , A61K31/235 , A61K31/40 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/42 , A61K31/427 , A61K31/43 , A61K31/439 , A61K31/4409 , A61K31/4439 , A61K31/496 , A61K31/545 , A61K31/63 , A61K31/635 , A61K31/65 , A61K31/702 , A61K31/7024 , A61K31/7036 , A61K31/704 , A61K31/7048 , A61K31/7056 , A61K47/547
摘要： An artificial tris-catecolate siderophore with a tripodal backbone and its conjugates with ampicillin and amoxicillin were synthesized. Both conjugates exhibited significantly enhanced in vitro antibacterial activities against Gram-negative species compared to the parent drugs, especially against P. aeruginosa. The conjugates appear to be assimilated by an induced bacterial iron transport process as their activities were inversely related to iron concentration. The easily synthesized tris-catecolate siderophores can be used with a variety of drugs as conjugates to target antibiotic-resistant Gram-negative bacteria.
摘要翻译：合成了具有三节体骨架的人造三碳酸酯铁载体及其与氨苄青霉素和阿莫西林的缀合物。两种缀合物与母体药物相比，特别是对于铜绿假单胞菌，显示出显着增强抗革兰氏阴性物质的体外抗菌活性。由于它们的活性与铁浓度呈负相关，所以共轭体似乎被诱导的细菌铁运输过程所吸收。容易合成的三邻苯二甲酸铁载体可以与各种药物一起用作共轭物，以靶向抗生素抗性革兰氏阴性细菌。

3. 发明公开

EP1303631A2 BIOTRANSFORMATION VON BIOLOGISCH AKTIVEN VERBINDUNGEN AUS VERSCHIEDENEN CHEMISCHEN STOFFKLASSEN MITTELS DER ENZYME LACCASE UND MANGANPEROXIDASE 有权
标题翻译：生物活性化合物从不同的化学物质种类的酶法和手段漆酶锰过氧化物酶的生物转化
公开(公告)号：EP1303631A2
公开(公告)日：2003-04-23
申请号：EP01951629.3
申请日：2001-06-23
申请人： Schauer, Frieder , Lindequist, Ulrike , Schäfer, Annett , Jülich, Wolf-Dieter, Dr.sc.Dipl.-Chem. , Hammer, Elke , Jonas, Ulrike
发明人： Schauer, Frieder , Lindequist, Ulrike , Schäfer, Annett , Jülich, Wolf-Dieter, Dr.sc.Dipl.-Chem. , Hammer, Elke , Jonas, Ulrike
IPC分类号： C12P11/00 , C12P13/00 , C12P17/12 , C12P17/14 , C12P35/00 , C12P37/00 , C07C235/60 , C07D501/18 , C07D499/21 , C07D499/68
CPC分类号： C12P13/001 , C12P11/00 , C12P17/12 , C12P17/14 , C12P35/00 , C12P37/00
摘要： The invention relates to a method for producing biologically active ingredients. Active ingredients comprising additional functional groups, a modified spectrum of activity and modified application properties can be obtained from medicaments or plant protection agents in the form of substrates which, as functional groups, carry at least one amino or hydroxyl group. Said active ingredients can be obtained by means of a one-electron reaction which is catalysed using enzymes or mixtures exhibiting enzymatic activity with a broad substrate spectrum. The method is characterised in that radical-forming enzymes are used as enzymes, and/or supernatants of ligninolytic mushrooms in an aqueous solution are used as mixtures exhibiting enzymatic activity. The following can be introduced in the form of additional functional groups: A) polyfunctional synthones which give the active ingredient a different solution behaviour in aqueous and lipophile systems, and high interfacial activity, B) aromatic molecules and heteroaromatic compounds, C) heterocyclic compounds, D) active ingredients with independent biological efficacy, and E) active ingredients which bring together independent activity and surfactant properties in one molecule. Together, said additional functional groups and the starting products produce covalently linked coupling products exhibiting modified distribution behaviour, by means of which polyfunctional interaction with the target organism is made possible.

4. 发明授权

EP1303631B9 BIOTRANSFORMATION VON BIOLOGISCH AKTIVEN VERBINDUNGEN AUS VERSCHIEDENEN CHEMISCHEN STOFFKLASSEN MITTELS DER ENZYME LACCASE UND MANGANPEROXIDASE 有权
标题翻译：生物活性化合物生物活性化合物的各种化学类型使用酶和漆酶和过氧化物酶
公开(公告)号：EP1303631B9
公开(公告)日：2010-09-08
申请号：EP01951629.3
申请日：2001-06-23
申请人： Dritte Patentportfolio Beteiligungsgesellschaft mbH & Co. KG
发明人： Jülich, Wolf Dieter , Schauer, Frieder , Lindequist, Ulrike , Hammer, Elke , Schäfer, Annett , Jonas, Ulrike
IPC分类号： C12P11/00 , C12P13/00 , C12P17/12 , C12P17/14 , C12P35/00 , C12P37/00 , C07C235/60 , C07D501/18 , C07D499/21 , C07D499/68 , C12N9/02
CPC分类号： C12P13/001 , C12P11/00 , C12P17/12 , C12P17/14 , C12P35/00 , C12P37/00

5. 发明公开

EP2046802A4 NOVEL 2-SUBSTITUTED METHYL PENAM DERIVATIVES 有权转让
标题翻译：新的2取代的甲基青霉烷衍生物
公开(公告)号：EP2046802A4
公开(公告)日：2010-06-02
申请号：EP07804590
申请日：2007-07-11
申请人： ORCHID CHEMICALS & PHARM LTD
发明人： UDAYAMPALAYAM PALANISAMY SENTH , GNANAPRAKASAM ANDREW , GANAPATHY PANCHAPAKESAN , MUKUT GOHAIN , VENKATASUBRAMANIAN HARIHARAN , SRIRAM RAJAGOPAL , PAUL-SATYASEELA MANEESH , SOLANKI SHAKTI SINGH , DEVARAJAN SATHISHKUMAR
IPC分类号： C07D499/87 , A61K31/431 , A61P31/00 , C07D499/21 , C07D499/28 , C07D499/32
CPC分类号： C07D499/86 , Y02P20/55

6. 发明公开

EP2046802A2 NOVEL 2-SUBSTITUTED METHYL PENAM DERIVATIVES 有权转让
标题翻译： 2-取代的甲基青霉烷衍生物
公开(公告)号：EP2046802A2
公开(公告)日：2009-04-15
申请号：EP07804590.3
申请日：2007-07-11
申请人： Orchid Chemicals and Pharmaceuticals Ltd
发明人： UDAYAMPALAYAM, Palanisamy, Senthilkumar , GNANAPRAKASAM, Andrew , GANAPATHY, Panchapakesan , MUKUT, Gohain , VENKATASUBRAMANIAN, Hariharan , SRIRAM, Rajagopal , PAUL-SATYASEELA, Maneesh , SOLANKI, Shakti, Singh , DEVARAJAN, Sathishkumar
IPC分类号： C07D499/87 , C07D499/21 , C07D499/28 , C07D499/32
CPC分类号： C07D499/86 , Y02P20/55
摘要： Novel 2-substituted methyl penam derivatives include the formula (I), their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their solvates, their pharmaceutically acceptable salts, and pharmaceutical compositions containing them; wherein A = C or N; Het is a three- to seven-membered heterocyclic ring; R1 represents carboxylate anion, or -COOR4 where R4 represents hydrogen, carboxylic acid protecting group or a pharmaceutically acceptable salt; R2 and R3 may be same or different and independently represent hydrogen, halogen, amino, alkyl, protected amino, optionally substituted alkyl, alkenyl, alkynyl and the like; R represents substituted or unsubstituted alkyl, alkenyl, aryl, aralkyl, cycloalkyl, heterocyclyl or heterocyclylalkyl.

7. 发明公开

EP2986617A1 ANTI-BACTERIAL SIDEROPHORE-AMINOPENICILLIN CONJUGATES 无效
标题翻译：抗菌铁载体氨基青霉素结合物
公开(公告)号：EP2986617A1
公开(公告)日：2016-02-24
申请号：EP13882608.6
申请日：2013-10-23
申请人： University of Notre Dame du Lac
发明人： MILLER, Marvin, J. , JI, Cheng , MILLER, Patricia, A.
IPC分类号： C07D499/21 , C07D499/68 , A61K31/43 , A61P31/04
CPC分类号： A61K47/48023 , A61K31/133 , A61K31/165 , A61K31/167 , A61K31/235 , A61K31/40 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/42 , A61K31/427 , A61K31/43 , A61K31/439 , A61K31/4409 , A61K31/4439 , A61K31/496 , A61K31/545 , A61K31/63 , A61K31/635 , A61K31/65 , A61K31/702 , A61K31/7024 , A61K31/7036 , A61K31/704 , A61K31/7048 , A61K31/7056 , A61K47/547 , Y02A50/473 , Y02A50/481 , Y02A50/483
摘要： An artificial tris-catecolate siderophore with a tripodal backbone and its conjugates with ampicillin and amoxicillin were synthesized. Both conjugates exhibited significantly enhanced in vitro antibacterial activities against Gram-negative species compared to the parent drugs, especially against P. aeruginosa. The conjugates appear to be assimilated by an induced bacterial iron transport process as their activities were inversely related to iron concentration. The easily synthesized tris-catecolate siderophores can be used with a variety of drugs as conjugates to target antibiotic-resistant Gram-negative bacteria.

8. 发明授权

EP2046802B1 2-SUBSTITUTED METHYL PENAM DERIVATIVES 有权转让
标题翻译： 2-取代的甲基青霉烷衍生物
公开(公告)号：EP2046802B1
公开(公告)日：2013-08-21
申请号：EP07804590.3
申请日：2007-07-11
申请人： Allecra Therapeutics GmbH
发明人： UDAYAMPALAYAM, Palanisamy, Senthilkumar , GNANAPRAKASAM, Andrew , GANAPATHY, Panchapakesan , MUKUT, Gohain , VENKATASUBRAMANIAN, Hariharan , SRIRAM, Rajagopal , PAUL-SATYASEELA, Maneesh , SOLANKI, Shakti, Singh , DEVARAJAN, Sathishkumar
IPC分类号： C07D499/87 , C07D499/21 , C07D499/28 , C07D499/32 , A61K31/431 , A61P31/00
CPC分类号： C07D499/86 , Y02P20/55

9. 发明授权

EP1303631B1 BIOTRANSFORMATION VON BIOLOGISCH AKTIVEN VERBINDUNGEN AUS VERSCHIEDENEN CHEMISCHEN STOFFKLASSEN MITTELS DER ENZYME LACCASE UND MANGANPEROXIDASE 有权
标题翻译：生物活性化合物从不同的化学物质种类的酶法和手段漆酶锰过氧化物酶的生物转化
公开(公告)号：EP1303631B1
公开(公告)日：2010-05-26
申请号：EP01951629.3
申请日：2001-06-23
申请人： Dritte Patentportfolio Beteiligungsgesellschaft mbH & Co. KG
发明人： Jülich, Wolf Dieter , Schauer, Frieder , Lindequist, Ulrike , Hammer, Elke , Schäfer, Annett , Jonas, Ulrike
IPC分类号： C12P11/00 , C12P13/00 , C12P17/12 , C12P17/14 , C12P35/00 , C12P37/00 , C07C235/60 , C07D501/18 , C07D499/21 , C07D499/68 , C12N9/02
CPC分类号： C12P13/001 , C12P11/00 , C12P17/12 , C12P17/14 , C12P35/00 , C12P37/00

10. 发明公开

EP3026110A4 METHOD FOR PROVIDING VASCULAR SYSTEM IN BIOLOGICAL TISSUE 有权
标题翻译： VERFAHREN ZUR BEREITSTELLUNG EINESGEFÄSSSYSMSMS生物科学GEWEBE
公开(公告)号：EP3026110A4
公开(公告)日：2017-04-05
申请号：EP14829625
申请日：2014-07-15
申请人： PUBLIC UNIV CORP YOKOHAMA CITY UNIV
发明人： TAKEBE TAKANORI , TANIGUCHI HIDEKI , TAKAHASHI YOSHINOBU
IPC分类号： C12N5/071 , A01K67/027 , A61L27/00 , C07D499/21 , G01N33/50
CPC分类号： C12N5/0691 , A01K67/0271 , A01K2207/12 , A01K2267/0325 , A01K2267/0331 , A01K2267/035 , A01K2267/0362 , A61K35/28 , A61K35/44 , A61K49/0008 , A61L27/3808 , A61L27/3834 , A61L27/3886 , C07D499/21 , C12N2502/13 , G01N33/5082
摘要： The present invention provides a method of constituting a tissue construct in vitro using a tissue without depending on scaffold materials. A method of integrating a biological tissue with a vascular system in vitro, comprising coculturing a biological tissue with vascular cells and mesenchymal cells. A biological tissue which has been integrated with a vascular system by the above-described method. A method of preparing a tissue or an organ, comprising transplanting the biological tissue described above into a non-human animal and differentiating the biological tissue into a tissue or an organ in which vascular networks have been constructed. A method of regeneration or function recovery of a tissue or an organ, comprising transplanting the biological tissue described above into a human or a non-human animal and differentiating the biological tissue into a tissue or an organ in which vascular networks have been constructed. A method of preparing a non-human chimeric animal, comprising transplanting the biological tissue described above into a non-human animal and differentiating the biological tissue into a tissue or organ in which vascular networks have been constructed. A method of evaluating a drug, comprising using at least one member selected from the group consisting of the biological tissue described above, the tissue or organ prepared by the method described above, and the non-human chimeric animal prepared by the method described above. A composition for regenerative medicine, comprising a biological tissue which has been integrated with a vascular system by the method described above.
摘要翻译：本发明提供了一种使用组织在体外构建组织构建体而不依赖于支架材料的方法。一种在体外将生物组织与血管系统整合的方法，包括将生物组织与血管细胞和间充质细胞共培养。通过上述方法与血管系统整合的生物组织。一种制备组织或器官的方法，包括将上述生物组织移植到非人动物中并将生物组织分化成其中构建血管网络的组织或器官。一种组织或器官的再生或功能恢复的方法，包括将上述生物组织移植到人或非人动物中并将生物组织分化成其中构建血管网络的组织或器官。一种制备非人嵌合动物的方法，包括将上述生物组织移植到非人动物中，并将生物组织分化成其中构建血管网络的组织或器官。一种药物评价方法，其特征在于，使用选自上述生物体组织，上述方法的组织或器官中的至少一种，以及通过上述方法制备的非人嵌合动物。一种用于再生医学的组合物，包括通过上述方法与血管系统整合的生物组织。

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