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1. 发明公开

EP4382106A1 COMPOSITION FOR INHIBITING INFLAMMATION OR AGING OF STEM CELLS, AND METHOD FOR INHIBITING INFLAMMATION OR AGING BY USING SAME 审中-实审
公开(公告)号：EP4382106A1
公开(公告)日：2024-06-12
申请号：EP22788373.3
申请日：2022-04-11
申请人： MitoImmune Therapeutics Inc.
发明人： KIM, Soon Ha , LEE, Jae Ho , YU, Won Dong
IPC分类号： A61K31/541 , A61K35/28 , A61P29/00 , C12N5/0775 , C12P17/14
CPC分类号： A61K31/541 , A61P29/00 , C12N5/06 , C12P17/14 , A61K35/28
摘要： The present invention relates to a composition for inhibiting the inflammation or aging of stem cells, comprising, as an active ingredient, a compound of Chemical Formula 1 or a pharmaceutically acceptable salt thereof; a method for inhibiting the inflammation or aging of stem cells by using the same; and a method for preparing stem cells having inhibited inflammation or aging; and a pharmaceutical composition for preventing or treating inflammatory diseases, comprising the stem cells, wherein when stem cells are treated with the compound of Chemical Formula 1, the inflammation or aging of stem cells can be inhibited so that the function and morphology of stem cells and intracellular mitochondria damaged in an inflammatory environment can be restored, and the stem cells treated with the compound of Chemical Formula 1 can be effectively used in the prevention or treatment of inflammatory diseases.

2. 发明公开

EP3301109A1 NOVEL DEPSIPEPTIDE AND USES THEREOF 有权
标题翻译：新型的非利普普肽及其用途
公开(公告)号：EP3301109A1
公开(公告)日：2018-04-04
申请号：EP17202877.1
申请日：2013-12-03
申请人： Novobiotic Pharmaceuticals, LLC
发明人： PEOPLES, Aaron, J. , HUGHES, Dallas , LING, Losee, Lucy , MILLETT, William , NITTI, Anthony , SPOERING, Amy , STEADMAN, Victoria, Alexandra , CHIVA, Jean-Yves, Christophe , LAZARIDES, Linos , JONES, Michael, Kenyon , POULLENNEC, Karine, Gaelle , LEWIS, Kim , EPSTEIN, Slava
IPC分类号： C07K11/02
CPC分类号： C07K7/56 , A61K38/00 , A61K38/15 , C07K11/02 , C12P17/14 , C12P21/02 , C12R1/01 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/421 , Y02A50/423 , Y02A50/473 , Y02A50/478 , Y02A50/479 , Y02A50/481 , Y02A50/491
摘要： The present invention relates generally to novel depsipeptides, to methods for the preparation of these novel depsipeptides, to pharmaceutical compositions comprising the novel depsipeptides; and to methods of using the novel depsipeptides to treat or inhibit various disorders.
摘要翻译：本发明一般涉及新型缩酚酸肽，制备这些新型缩酚酸肽的方法，包含该新型缩酚酸肽的药物组合物; 并涉及使用该新型缩肽的治疗或抑制各种病症的方法。

3. 发明公开

EP3080284A1 PROCESS FOR THE PREPARATION OF CHIRAL 2-ARYL MORPHOLINES 有权
标题翻译： VERFAHREN ZUR HERSTELLUNG VON CHIRALEM 2-（4-氨基苯基）吗啉
公开(公告)号：EP3080284A1
公开(公告)日：2016-10-19
申请号：EP14808637.4
申请日：2014-12-08
申请人： F.Hoffmann-La Roche AG
发明人： TRUSSARDI, Rene , IDING, Hans
IPC分类号： C12P7/22 , C12P13/00
CPC分类号： C12P17/14 , C07D265/30 , C12P7/02 , C12P7/22 , C12P13/008 , Y02P20/55
摘要： The invention relates to a novel process for the preparation of chiral 2-(4-aminophenyl) morpholines of the formula (I) wherein R1 is hydrogen an amino protecting group. The chiral 2-(4-aminophenyl) morpholines of the formula I are key intermediates for the preparation of compounds that have a good affinity to the trace amine associated receptors (TAARs).
摘要翻译：式I的手性2-（4-氨基苯基）吗啉是制备与微量胺相关受体（TAAR）具有良好亲和力的化合物的关键中间体。

4. 发明公开

EP2925772A1 NOVEL DEPSIPEPTIDE AND USES THEREOF 有权
标题翻译：神经损伤患者在VERWENDUNGEN DAVON
公开(公告)号：EP2925772A1
公开(公告)日：2015-10-07
申请号：EP13812290.8
申请日：2013-12-03
申请人： Novobiotic Pharmaceuticals, LLC
发明人： PEOPLES, Aaron, J. , HUGHES, Dallas , LING, Losee, Lucy , MILLETT, William , NITTI, Anthony , SPOERING, Amy , STEADMAN, Victoria, Alexandra , CHIVA, Jean-Yves, Christophe , LAZARIDES, Linos , JONES, Michael, Kenyon , POULLENNEC, Karine, Gaelle , LEWIS, Kim , EPSTEIN, Slava
IPC分类号： C07K11/02
CPC分类号： C07K7/56 , A61K38/00 , A61K38/15 , C07K11/02 , C12P17/14 , C12P21/02 , C12R1/01 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/421 , Y02A50/423 , Y02A50/473 , Y02A50/478 , Y02A50/479 , Y02A50/481 , Y02A50/491
摘要： The present invention relates generally to novel depsipeptides, to methods for the preparation of these novel depsipeptides, to pharmaceutical compositions comprising the novel depsipeptides; and to methods of using the novel depsipeptides to treat or inhibit various disorders.
摘要翻译：本发明一般涉及用于制备这些新型去肽肽的新型脱肽，涉及包含新型脱肽的药物组合物; 以及使用新型depsipeptides来治疗或抑制各种疾病的方法。

5. 发明公开

EP2748304A4 ISOLATED BACTERIAL STRAIN OF THE GENUS BURKHOLDERIA AND PESTICIDAL METABOLITES THEREFROM-FORMULATIONS AND USES 审中-公开
标题翻译：类鼻疽菌的分离菌STRAND，农药代谢物和制剂及其用途
公开(公告)号：EP2748304A4
公开(公告)日：2015-02-11
申请号：EP12827368
申请日：2012-08-14
申请人： MARRONE BIO INNOVATIONS INC
发明人： ASOLKAR RATNAKAR , KOIVUNEN MARJA , MARRONE PAMELA
IPC分类号： C12N1/20 , A01N43/06 , A01N43/26 , A01N63/02 , A01P21/00 , C12N1/38 , C12P1/04
CPC分类号： A01N63/02 , A01N31/02 , A01N37/40 , A01N43/16 , A01N43/76 , A01N43/90 , A01N47/16 , A01N63/00 , C12P7/62 , C12P7/6436 , C12P17/02 , C12P17/14 , C12P17/16 , C12P17/162 , C12P17/187 , C12P17/188 , C12P21/00 , C12R1/00 , C12R1/01
摘要： A species of Burkholderia sp with no known pathogenicity to vertebrates but with pesticidal activity (e.g., plants, algae, arachnids, insects, fungi, weeds and nematodes) as well as methods for controlling algae using said species of Burkholderia. Also provided are natural products derived from a culture of said species and methods of controlling algae and/or arachnids using said natural products.

6. 发明授权

EP1809749B1 METHODS FOR HETEROLOGOUS EXPRESSION OF SECONDARY METABOLITES 有权
标题翻译：次生代谢物与方法异源表达
公开(公告)号：EP1809749B1
公开(公告)日：2009-02-11
申请号：EP05810933.1
申请日：2005-10-26
申请人： Gene Bridges Gmbh
发明人： ZHANG, Youming , MÜLLER, Rolf , STEWART, Francis , GROSS, Frank , WENZEL, Silke, C. , FU, Jun
IPC分类号： C12N15/63 , C12N1/21
CPC分类号： C12P17/14
摘要： The invention provides a method for the heterologous expression of a secondary metabolite encoded by a biosynthetic pathway. Also provided is a method for introducing a large sized DNA molecule into the chromosome of a heterologous host using a transposable element. Novel myxochromide S derivatives are also provided.

7. 发明公开

EP1561820A4 NOVEL SUBSTANCE FKI-1033 AND PROCESS FOR PRODUCING THE SAME 有权
标题翻译：新物质FKI-1033和工艺及其生产
公开(公告)号：EP1561820A4
公开(公告)日：2007-08-22
申请号：EP02780072
申请日：2002-11-12
申请人： KITASATO INST
发明人： OMURA SATOSHI , SHIOMI KAZURO , MASUMA ROKURO
IPC分类号： A01N43/72 , A01N63/04 , A61P33/00 , A61P43/00 , C07K11/02 , C12P17/00 , C12P17/14 , C12P21/02 , C12R1/645 , A61K31/395 , C07D273/00
CPC分类号： C07K11/02 , A01N43/72 , C12P17/14 , C12R1/645
摘要： The present invention is comprised of culturing microorganism having ability to produce FKI-1033 substance represented by the formula: in a medium, accumulating FKI-1033 substance in the cultured medium, and isolating FKI-1033 substance from the cultured mass. The thus obtained FKI-1033 substance has ryanodine binding inhibition activity, insecticidal activity and anthelmintic activity, and is expected as useful drugs as agrochemicals, veterinary drugs and medicaments in effectiveness and toxicity.

8. 发明公开

EP1808492A1 Synthesis of intermediates for the preparation of pramipexol 审中-公开
标题翻译： Herstellung von Pramipexol的Synthese von Zwischenproduktenfürdie
公开(公告)号：EP1808492A1
公开(公告)日：2007-07-18
申请号：EP07000277.9
申请日：2007-01-08
申请人： Dipharma Francis S.r.l.
发明人： Riva, Sergio , Fassi, Paola , Scarpellini, Michele , Allegrini, Pietro , Razzetti, Gabriele
IPC分类号： C12P17/14 , C12P41/00 , C07D277/82
CPC分类号： C12P17/14 , C07D277/82 , C12P41/005
摘要： A process for the preparation of an acid of formula (I), as the individual (R) enantiomer or (S), or a salt thereof

wherein R is a protected amino group; and the asterisk * denotes the stereogenic carbon atom, comprising contacting an ester of formula (II), as mixture of (R,S) enantiomers, or a salt thereof,

wherein R 1 is straight or branched C 1 -C 6 alkyl, optionally substituted with phenyl; and the asterisk * and R have the meanings defined above, with a lipase from Candida antarctica, under conditions effective to obtain a mixture comprising an acid of formula (I), as the individual (R) enantiomer, and an ester of formula (II), as the individual (S) enantiomer; the subsequent hydrolysis of the latter to obtain an acid of formula (I), as the individual (S) enantiomer; and, if desired, the conversion of an acid of formula (I), either as the (R) or (S) enantiomer, to a salt thereof.
摘要翻译：制备式（I）的酸作为单独的（R）对映异构体或（S）的酸的方法或其盐，其中R是被保护的氨基; 并且星号*表示立体碳原子，包括使式（II）的酯作为（R，S）对映异构体或其盐的混合物，其中R 1是直链或支链C 1 -C 6烷基，任选地被苯基取代; 和星号*和R具有上述定义，与来自南极念珠菌的脂肪酶在有效获得包含式（I）的酸的混合物作为单独的（R）对映体的条件下，和式（II）的酯），作为个体（S）对映异构体; 随后水解后者以获得式（I）的酸作为个体（S）对映异构体; 如果需要，将式（I）的酸作为（R）或（S）对映异构体转化为其盐。

9. 发明授权

EP1056356B1 PROCESS FOR THE PREPARATION OF FLAVOURING COMPOSITIONS AND USE OF THESE COMPOSITIONS IN BAKERY PRODUCTS 有权
标题翻译：用于生产香精及其在烘焙产品应用
公开(公告)号：EP1056356B1
公开(公告)日：2006-03-29
申请号：EP98957063.5
申请日：1998-12-14
申请人： Givaudan S.A.
发明人： BEL RHLID, Rachid , BLANK, Imre , STEEN, Christel, Gunilla
IPC分类号： A23L1/23 , A23L1/227
CPC分类号： C12P17/14 , A21D2/28 , A21D13/28 , A23L27/2056 , A23L27/24
摘要： The invention relates to a process for the preparation of a flavouring composition containing 2-acetyl-2-thiazoline (2-AT) and precursors thereof, as well as other flavour ingredients, which comprises the bioconversion of a sulfur containing compound and an organic acid or derivative thereof in presence of a yeast, separating and recovering the supernatant of the reaction mixture. The flavouring composition obtained can be used especially for enhancing the roasty notes of bakery products.

10. 发明公开

EP1633352A1 POLYENE OXAZOLES WITH ANTITUMOUR ACTIVITY AND PROCESSES FOR THEIR PREPARATION USING A STREPTOMYCES STRAIN 有权
标题翻译： POLYENOXAZOLE具有抗肿瘤效应AND METHOD FOR THE PRODUCTION BY链霉菌的菌株来
公开(公告)号：EP1633352A1
公开(公告)日：2006-03-15
申请号：EP04737813.8
申请日：2004-06-14
申请人： Ecopia Biosciences Inc.
发明人： MCALPINE, James, B. , FARNET, Chris, M , ZAZOPOULOS, Emmanuel , ISMAIL, Nargis , BACHMANN, Brian, O.
IPC分类号： A61K31/422 , C07D413/12 , A61K31/421 , C07D263/32 , C12P17/16 , C12R1/60 , A61P35/00
CPC分类号： C12R1/60 , C07D263/32 , C07D413/12 , C12P17/14
摘要： This invention relates to novel biologically active polyene oxazoles of Formula (I), their pharmaceutically acceptable salts and derivatives, and to methods of obtaining them. One method for obtaining the compounds is by cultivation of Streptomyces sparsogenes NRRL 2940 or a mutant or variant thereof. The pharmaceutical composition comprising a compound of the invention is useful as a cytotoxic agent and for inhibiting the growth of cancer cells.

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