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1. 发明公开

EP3362439A1 BIOMASS-DERIVED POLYMERS AND COPOLYMERS INCORPORATING MONOLIGNOLS AND THEIR DERIVATIVES 审中-实审
公开(公告)号：EP3362439A1
公开(公告)日：2018-08-22
申请号：EP16856362.5
申请日：2016-10-14
申请人： The Regents of the University of California
发明人： UPTON, Brianna Marie , KASKO, Andrea
IPC分类号： C07D265/14 , C08G63/44 , C08G69/04 , C08G69/40 , C08G73/02
CPC分类号： C07D265/16 , C07C51/09 , C07C67/14 , C07C67/28 , C07C67/31 , C07C67/343 , C08G69/40 , C08G69/44 , C08G73/0233 , C07C69/732 , C07C69/734 , C07C69/73 , C07C69/44 , C07C59/64
摘要： The invention includes methods and materials for forming and manipulating aromatic-based polymers and copolymers using biomass compounds as starting materials. Embodiments of the invention can be used in processes designed to replace those used in the petrochemical industry. Typical embodiments of the invention include methods and materials for forming and/or modifying compounds including dicarboxylic acid ester dimers, benzoxazines and dicarboxylic acid ether dimers. Embodiments of the invention further provide methods and materials for utilizing these compounds to form commercially desirable polymers having structures and physical properties akin to those found in polymers formed from petroleum products.

2. 发明公开

EP2831052A1 BENZOXAZINES AND COMPOSITIONS CONTAINING THE SAME 有权
标题翻译：苯并恶嗪和SO组合物
公开(公告)号：EP2831052A1
公开(公告)日：2015-02-04
申请号：EP13713697.4
申请日：2013-03-19
申请人： Cytec Technology Corp.
发明人： WARD, Steven, Richard , HARRIMAN, Mark, Edward
IPC分类号： C07D265/14 , C08K5/357 , C08J5/24 , C07D265/16
CPC分类号： C08G73/0233 , C07D265/16 , C08G14/06 , C08G59/00 , C08J5/24 , C08K5/357 , C08L61/34 , C08L79/02
摘要： Disclosed herein are monofunctional benzoxazine compounds having at least one electron-withdrawing group. The monofunctional benzoxazine compounds may be combined with one or more multifunctional benzoxazine compounds to form a unique benzoxazine blend. This benzoxazine blend may be combined with additional components such as catalysts and toughening agents to form a curable resin composition suitable for forming resinous films or composite materials. The presence of monofunctional benzoxazine improves the processability of the benzoxazine-based resin composition by reducing the viscosity of the resin composition, and results in improved tack and drape in the films and composite materials formed from the composition without the loss of modulus in the cured resin.

3. 发明授权

EP1874743B1 PURIFIED FORM OF TANAPROGET 有权
标题翻译： TANAPROGET的净化形式
公开(公告)号：EP1874743B1
公开(公告)日：2013-07-17
申请号：EP06769890.2
申请日：2006-04-26
申请人： Wyeth LLC
发明人： CHATLAPALLI, Ramarao , NAGI, Arwinder , POTOSKI, John , HELOM, Jean, Louise , WILK, Bogdan, Kazimierz , RUBEZHOV, Arkadiy, Zinoviy , DRAGAN, Vladimir
IPC分类号： C07D265/14 , C07D413/04 , A61K31/536 , A61P15/00
CPC分类号： C07D265/14 , C07D413/04

4. 发明公开

EP1948623A2 HETEROCYCLIC AMIDE DERIVATIVES AS RXR AGONISTS FOR THE TREATMENT OF DYSLIPIDEMIA, HYPERCHOLESTEROLEMIA AND DIABETES 审中-公开
标题翻译： AS RXR激动剂杂环酰胺衍生物FOR血脂异常，高胆固醇血症和糖尿病治疗
公开(公告)号：EP1948623A2
公开(公告)日：2008-07-30
申请号：EP06804129.2
申请日：2006-09-25
申请人： Janssen Pharmaceutica, N.V.
发明人： BHARAT, Lagu , LEBEDEV, Rimma , PIO, Barbara
IPC分类号： C07D241/44 , C07D265/14 , C07D265/36 , A61K31/538 , A61K31/536 , A61K31/498 , A61P3/06 , A61P3/10 , A61P9/10 , A61P9/12 , A61P29/00 , A61P35/00
CPC分类号： C07D265/14 , C07D241/44 , C07D265/12 , C07D265/36
摘要： The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating RXR mediated disorders. More particularly, the compounds of the present invention are RXR agonists useful for treating RXR mediated disorders.

5. 发明公开

EP1366053A1 FLAME-PROOFING AGENTS 有权
标题翻译：手段的闪存保护
公开(公告)号：EP1366053A1
公开(公告)日：2003-12-03
申请号：EP01273295.4
申请日：2001-11-20
申请人： Vantico AG
发明人： WEIDMANN, Ulrich , MAGENDIE, Franck
IPC分类号： C07F9/6571 , C07D265/14 , C07D265/20 , C08K5/00
CPC分类号： C08K5/5313 , C07F9/657172
摘要： Compounds of formula (I) or (II), wherein R1 is C1-C18alkyl; C5-C12cycloalkyl that is unsubstituted or substituted by one or more C1-C6alkyl groups or C1-C6alkoxy groups; C5-C22aryl that is unsubstituted or substituted by one or more C1-C6alkyl groups or C1-C6alkoxy groups; or C7-C30aralkyl that is unsubstituted or substituted by one or more C1-C6alkyl groups or C1-C6alkoxy groups, and the radicals R2 to R13 are each independently of the others hydrogen; -NO2; dialkylamino; alkylthio; alkylsulfonyl; halogen; C1-C18alkyl; C1-C18alkoxy; C1-C18alkoxyalkyl; C5-C12cycloalkyl that is unsubstituted or substituted by one or more C1-C6alkyl groups or C1-C6alkoxy groups; C5-C22aryl that is unsubstituted or substituted by one or more C1-C6alkyl groups or C1-C6alkoxy groups; or C7-C30aralkyl that is unsubstituted or substituted by one or more C1-C6alkyl groups or C1-C6alkoxy groups, are suitable as flame-proofing agents for thermoplastic or thermosetting polymers.

6. 发明公开

EP1175404A1 QUINAZOLINONE AND BENZOXAZINE DERIVATIVES AS PROGESTERONE RECEPTOR MODULATORS 审中-公开
标题翻译：喹唑啉酮和苯并恶嗪衍生物孕激素受体调节剂
公开(公告)号：EP1175404A1
公开(公告)日：2002-01-30
申请号：EP00930288.6
申请日：2000-05-01
申请人： American Home Products Corporation , LIGAND PHARMACEUTICALS INCORPORATED
发明人： ZHANG, Puwen , FENSOME, Andrew , TEREFENKO, Eugene, A. , ZHI, Lin , JONES, Todd, K. , EDWARDS, James, P. , TEGLEY, Christopher, M. , WROBEL, Jay, E.
IPC分类号： C07D215/22 , C07D413/04 , C07D239/80 , C07D265/14 , C07D239/78 , A61K31/517 , A61P5/00
摘要： This invention provides compounds which are agonists and antagonists of the progesterone receptor having general structure (I): wherein R?1 and R2¿ are independently selected from H, COR?A, or NRBCORA¿, or optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, or heterocyclic moieties; or R?1 and R2¿ are fused to form: 3 to 8 membered spirocyclic alkyl, alkenyl or heterocyclic rings; RA is H or optionally substituted alkyl, aryl, alkoxy, or aminoalkyl groups; RB is H, C¿1? to C3 alkyl or substituted C1 to C3 alkyl; R?3¿ is H, OH, NH¿2, COR?C or optionally substituted alkyl, alkenyl, or alkynyl; RC is H or optionally substituted alkyl, aryl, alkoxy, or aminoalkyl; R4 is H, halogen, CN, NO¿2?, or optionally substituted alkyl, alkynyl, alkoxy, amino or aminoalkyl; R?5¿ is an optionally substituted benzene or five or six membered ring with 1, 2, or 3 heteroatoms selected from O, S, SO, SO¿2? or NR?6; R6¿ is H or C¿1? to C3 alkyl; G1 is O, NR7, or CR7R8; G2 is CO, CS, or CR7R8; provided that when G1 is O, G2 is CR7R8, and G1 and G2 cannot both be CR7R8; R7 and R8 are H or an optionally substituted alkyl, aryl, or heterocyclic moiety; or pharmaceutically acceptable salt thereof, and methods using these compounds in mammals as agonists or antagonists of the progesterone receptor.

7. 发明公开

EP1132372A2 Bicyclic 1,3-aminoalcohols, d8-metal complexes and hydrogenation processes 审中-公开
标题翻译： Bicyclische 1,3-Aminoalcoholen，Komplexe mit d8-Metallen und Verfahren zur Hydrierung
公开(公告)号：EP1132372A2
公开(公告)日：2001-09-12
申请号：EP01105510.0
申请日：2001-03-05
申请人： Solvias AG
发明人： Herold, Peter
IPC分类号： C07C215/44 , B01J31/02 , C07C29/143 , C07D265/14 , C07C311/20 , C07C33/22
CPC分类号： B01J31/2243 , B01J31/1805 , B01J31/2295 , B01J2231/643 , B01J2231/645 , B01J2531/821 , B01J2531/822 , B01J2531/827 , C07B2200/07 , C07C29/143 , C07C215/44 , C07C311/20 , C07C2602/42 , C07D265/12 , C07C33/22
摘要： Bicyclic amino alcohols, whose amino group and hydroxy group are bonded in positions 1,3 adjacent to the bridge, for example
are valuable ligands for metal complexes of the d-8 metals of the periodic table of elements. The metal complexes in question are catalysts or catalyst precursors for the asymmetric hydrogenation or asymmetric transfer hydrogenation with hydrogen donors of prochiral organic compounds with carbon double bonds or carbon/hetero atom double bonds, for example ketones and imines.
摘要翻译：其氨基和羟基与位于桥附近的位置1,3键合的双环氨基醇例如是元素周期表的d-8金属的金属络合物的有价值的配体。所讨论的金属络合物是用具有碳双键或碳/杂原子双键的前手性有机化合物（例如酮和亚胺）的氢供体的不对称氢化或不对称转移氢化的催化剂或催化剂前体。

8. 发明授权

EP0463945B1 Nouvelles chalcones, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent 失效
标题翻译：查耳酮衍生物，它们的制备方法和含有它们的药物组合物
公开(公告)号：EP0463945B1
公开(公告)日：1995-12-27
申请号：EP91401679.5
申请日：1991-06-21
申请人： ADIR ET COMPAGNIE
发明人： Lesieur, Daniel , Caignard, Daniel-Henri , Lesieur, Isabelle , Devissaguet, Michelle , Guardiola, Béatrice
IPC分类号： C07D263/58 , A61K31/42 , C07D277/68 , A61K31/425 , C07D265/36 , C07D265/14 , C07D279/16 , C07D263/52 , C07D413/04
CPC分类号： C07D263/52 , C07D263/58 , C07D263/60 , C07D265/36 , C07D279/16

9. 发明公开

EP4446312A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND HAVING NRF2 ACTIVATION EFFECT 审中-实审
公开(公告)号：EP4446312A1
公开(公告)日：2024-10-16
申请号：EP23737317.0
申请日：2023-01-06
申请人： CHUGAI SEIYAKU KABUSHIKI KAISHA
发明人： KIMBARA Atsushi , HARADA Takeo , KOMIYAMA Susumu , OKUYAMA Mizuki , OHTAKE Yoshihito , MURATA Yoshihisa , SAITO Rie
IPC分类号： C07D217/06 , A61K31/472 , A61K31/4725 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K31/5415 , A61K31/551 , A61P11/00 , A61P13/12 , A61P25/00 , A61P43/00 , C07D237/32 , C07D265/14 , C07D279/08 , C07D401/10 , C07D401/14 , C07D403/10 , C07D413/10 , C07D413/12 , C07D417/10
CPC分类号： A61K31/472 , A61K31/4725 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K31/5415 , A61K31/551 , A61P11/00 , A61P13/12 , A61P25/00 , A61P43/00 , C07D217/06 , C07D237/32 , C07D265/14 , C07D279/08 , C07D401/10 , C07D401/14 , C07D403/10 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D471/04 , C07D487/04 , C07D487/10 , C07D491/048 , C07D491/107 , C07D498/04 , C07D498/08 , C07D519/00
摘要： Provided is a low-molecular compound or a salt thereof, or a solvate thereof which has the ability to activate Nrf2.
The present invention provides a compound represented by the formula (1) or a salt thereof, or a solvate thereof, wherein Xa1 is CRa1 or N, Xa3 is CRa3 or N, Ra1, Ra2 and Ra3 are each independently selected from the group consisting of hydrogen, halogen and C1-C6 alkoxy, Xb1, Xb2 and Xb3 are each independently selected from the group consisting of CH2, O, NH, S and C=O, Y is C6-ClO aryl optionally having a substituent or 5- to 10-membered heteroaryl optionally having a substituent, and Z is C6-ClO aryl optionally having a substituent, 5- to 10-membered heteroaryl optionally having a substituent or C1-C6 alkyl optionally having a substituent.

10. 发明授权

EP3265447B1 BENZOXAZINE LOW TEMPERATURE CURABLE COMPOSITION 有权
公开(公告)号：EP3265447B1
公开(公告)日：2023-03-01
申请号：EP16759547.9
申请日：2016-03-04
发明人： WANG, Dong , RECHICHAR, Bradley , KINCAID, Derek S. , SMITH, Ronald C.
IPC分类号： C07D265/14 , C07D265/16 , C08G73/06 , C08G73/22

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