专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP2966060A4 ISOTHIOCYANATE PRODUCTION METHOD, COMPOSITION FOR TRANSPORTING AND STORING N-SUBSTITUTED O-SUBSTITUTED THIOCARBAMATE, AND ISOTHIOCYANATE COMPOSITION 有权转让
标题翻译： ISOTHIOCYANATHERSTELLUNGSVERFAHREN，COMPOSITION运输和贮存N-取代邻位取代的硫代氨基甲酸酯和ISOTHIOCYANATZUSAMMENSETZUNG
公开(公告)号：EP2966060A4
公开(公告)日：2016-08-03
申请号：EP14760523
申请日：2014-02-28
申请人： ASAHI KASEI CHEMICALS CORP
发明人： SHINOHATA MASAAKI , KOSUGI YUJI , MIYAKE NOBUHISA
IPC分类号： C07C331/30 , C07C329/04 , C07C331/20 , C07C331/22 , C07C333/04 , C07C333/06 , C07C333/08 , C07C335/08 , C07C335/10 , C07C335/14 , C07C335/16
CPC分类号： C07C331/30 , C07C329/04 , C07C331/20 , C07C331/22 , C07C333/04 , C07C333/06 , C07C333/08 , C07C333/20 , C07C333/22 , C07C333/24 , C07C335/08 , C07C335/10 , C07C335/14 , C07C335/16 , C07C2601/14
摘要： The present invention relates to an isothiocyanate production method using an organic primary amine and thiourea as starting materials; to a composition for transporting and storing an N-substituted O-substituted thiocarbamate that includes an N-substituted O-substituted thiocarbamate and a hydroxy compound, the equivalent weight ratio of hydroxy groups of the hydroxy compound with respect to the carbamate groups of the N-substituted O-substituted thiocarbamate being in the range of 1 to 100; to a composition for transporting and storing a compound with a thioureido group that includes a compound with a thioureido group and a hydroxy compound, the equivalent weight ratio of hydroxy groups of the hydroxy compound with respect to the thioureido groups of the compound with a thioureido group being in the range of 1 to 100; and to an isothiocyanate composition containing an isothiocyanate and a compound with a specific functional group.

2. 发明公开

EP2647623A4 METHOD FOR PRODUCING ISOTHIOCYANATE COMPOUND 审中-公开
标题翻译： VERFAHREN ZUR HERSTELLUNG EINER ISOTHIOCYANATVERBINDUNG
公开(公告)号：EP2647623A4
公开(公告)日：2015-12-30
申请号：EP10860193
申请日：2010-11-29
申请人： NISSAN CHEMICAL IND LTD
发明人： TAKADA JUNKO , IWAMOTO SHUNSUKE , NAKANO SATOSHI
IPC分类号： C07C331/20 , C07C331/24 , C07C331/28 , C07C331/30
CPC分类号： C07C331/28

3. 发明公开

EP2854862A1 SULFORAPHANE ISOLATION AND PURIFICATION 有权转让
标题翻译：硫化物的分离和纯化
公开(公告)号：EP2854862A1
公开(公告)日：2015-04-08
申请号：EP13730628.8
申请日：2013-05-31
申请人： Pharmagra Labs, Inc.
发明人： DAMIREDDI, Sahadeva Reddy , AKUE, Kpakpo Ambroise , NELSON, Jared K. , FRISBEE, Albert Roger , NEWSOME, Peter Wyatt
IPC分类号： A61K47/48 , A61K31/26 , C07C331/20 , C08B37/16 , C08L5/16
CPC分类号： A61K31/275 , A61K47/61 , A61K47/6951 , B82Y5/00 , C07C331/20 , C08B37/0015 , C08L5/16
摘要： The present invention relates to methods of isolating and purifying sulforaphane. More specifically, the present invention relates to methods of isolating and purifying sulforaphane from natural sources. The present invention also relates to methods of forming high purity complexes of sulforaphane with cyclodextrin.
摘要翻译：本发明涉及分离和纯化萝卜硫烷的方法。更具体地说，本发明涉及从天然来源分离和纯化萝卜硫烷的方法。本发明还涉及形成高纯度萝卜硫素与环糊精的复合物的方法。

4. 发明公开

EP2662354A2 Sulfur containing fluoroalkyl amines and isocyanates 审中-公开
标题翻译：氟烷基胺和异氰酸酯
公开(公告)号：EP2662354A2
公开(公告)日：2013-11-13
申请号：EP13179255.8
申请日：2008-12-01
申请人： E. I. du Pont de Nemours and Company
发明人： Herzog, Axel, Hans-Joachim , Warren, Hollis, Thomas , Gonska, Brent, Ryan
IPC分类号： C07C317/28 , C07C331/20
CPC分类号： C07C315/02 , C07C317/28 , C07C319/16 , C07C319/18 , C07C319/20 , C07C323/25 , C07C331/20 , C07D207/27 , C07C323/41
摘要： The present invention provides sulfur containing fluoroalkyl amines represented by the formula Rf-Q-S(O) x -C(H) i (CH 3 ) j -(CH 2 ) z+(i-1) -NHR and isocyanate/isothiocyanate derivatives thereof represented by the formula Rf-Q-S(O) x -C(H) i (CH 3 ) j -(CH 2 ) z+(i-1) -N=C=X 1 wherein R f is chosen from a C 2 -C 12 perfluoroalkyl provided that: i) one fluorine atom of the perfluoroalkyl can be optionally replaced by hydrogen, and/or ii) the perfluoro-alkyl can be optionally interrupted by at least one oxygen, methylene, or ethylene; Q is chosen from the group consisting of a C 2 -C 12 hydrocarbylene optionally interrupted by at least one divalent organic group; x is 1 or 2; z is 0 or 1; i is 1 or 2; j is 0 or 1; provided that i+j=2; R is chosen from H or a C 1 to C 4 alkyl; and X 1 is O or S.
摘要翻译：本发明提供由式Rf-QS（O）x -C（H）i（CH 3）j - （CH 2）z +（i-1）-NHR表示的含硫氟烷基胺及其异氰酸酯/异硫氰酸酯衍生物通过式Rf-QS（O）x -C（H）i（CH 3）j - （CH 2）z +（i-1）-N = C = X 1其中R f选自C 2 -C 12全氟烷基，条件是：i）全氟烷基中的一个氟原子可任选被氢替代，和/或ii）全氟烷基可以任选被至少一个氧，亚甲基或亚乙基所取代; Q选自任选被至少一个二价有机基团间隔的C 2 -C 12亚烃基; x为1或2; z为0或1; 我是1或2; j为0或1; 条件是i + j = 2; R选自H或C 1至C 4烷基; X 1为O或S.

5. 发明公开

EP2595953A1 PROCEDE DE SYNTHESE D'ISOTHIOCYANATES ET LEURS DERIVES ET UTILISATIONS DE CEUX-CI 审中-公开
标题翻译：过程衍生品和异硫氰酸酯，以及它们的用途的合成
公开(公告)号：EP2595953A1
公开(公告)日：2013-05-29
申请号：EP11734106.5
申请日：2011-07-20
申请人： Auriga International
发明人： DUBOIS, Jacques , MARCHAL, Alfred , LACROIX, Damien , CABOU, Jérôme
IPC分类号： C07C315/02 , C07C317/28 , C07C319/14 , C07C319/20 , C07C323/25 , C07C323/60 , C07C331/20 , C07C333/04 , C07C333/20 , C07C335/08 , C07D211/06 , C07D241/04 , C07D265/30 , A61K31/17 , A61K31/26
CPC分类号： C07C331/24 , C07C315/02 , C07C319/14 , C07C319/20 , C07C331/20 , C07C333/04 , C07C333/20 , C07C335/08 , C07D211/58 , C07D295/215 , C07C317/28 , C07C323/25 , C07C323/60
摘要： Process for the synthesis of an isothiocyanate of general formula (I) SCN‑R
1 -R
4 -R
2 in which R
1 and R
2 represent, independently of one another, an alkyl, aryl or alkylaryl group, R
4 represents a carbonyl, sulphinyl or sulphonyl group or a sulphide and derivatives thereof comprising a step of reacting an alkylalkylamine having the general formula (II) NH
2
_ R
1
_ R
4
_ R
2 in which R
1 and R
2 represent, independently of one another, an alkyl, aryl or alkylaryl group, R
4 represents a carbonyl, sulphinyl, sulphonyl or sulphide group, in the presence of carbon sulphide and of di-
tert -butyl dicarbonate with formation of the aforesaid corresponding isothiocyanate, compounds obtained by this process and also uses thereof.

6. 发明公开

EP3611163A1 HIGH-PURITY ISOTHIOCYANATE COMPOUND PREPARATION METHOD FOR INDUSTRIAL PRODUCTION 有权
公开(公告)号：EP3611163A1
公开(公告)日：2020-02-19
申请号：EP18756601.3
申请日：2018-02-27
申请人： JC (Wuxi) COMPANY, Inc.
发明人： CHENG, Jingcai , GU, Guolin , HUANG, Biao
IPC分类号： C07C331/24 , C07C331/22 , C07C331/20
摘要： The present invention provides a high-purity isothiocyanate compound preparation method for industrial production. Specifically, in the method, organic amine and CS2 are used as raw materials to prepare the thiocarbamate, and then desulfurization is carried out, and the high-purity isothiocyanate compound is obtained by using purification, post-processing and other methods. The method in the present invention is suitable for industrial production, is simple in the post-processing, has a high yield rate, and allows the product to have a high purity, and is suitable for the production of the isothiocyanate compound in the pharmaceutical industry.

7. 发明公开

EP3363785A1 ISOTHIOCYANATE PRODUCTION METHODS 有权转让
公开(公告)号：EP3363785A1
公开(公告)日：2018-08-22
申请号：EP18162365.3
申请日：2014-02-28
申请人： Asahi Kasei Chemicals Corporation
发明人： SHINOHATA, Masaaki , KOSUGI, Yuji , MIYAKE, Nobuhisa
IPC分类号： C07C331/30 , C07C333/06 , C07C333/08 , C07C333/04 , C07C335/08 , C07C335/14 , C07C331/20 , C07C331/22 , C07C329/04 , C07C335/10 , C07C335/16
摘要： The present invention relates to an isothiocyanate production method using an organic primary amine and thiourea as starting materials; to a composition for transporting and storing an N-substituted O-substituted thiocarbamate that includes an N-substituted O-substituted thiocarbamate and a hydroxy compound, the equivalent weight ratio of hydroxy groups of the hydroxy compound with respect to the carbamate groups of the N-substituted O-substituted thiocarbamate being in the range of 1 to 100; to a composition for transporting and storing a compound with a thioureido group that includes a compound with a thioureido group and a hydroxy compound, the equivalent weight ratio of hydroxy groups of the hydroxy compound with respect to the thioureido groups of the compound with a thioureido group being in the range of 1 to 100; and to an isothiocyanate composition containing an isothiocyanate and a compound with a specific functional group.

8. 发明授权

EP2854861B1 METHOD OF SYNTHESISING SULFORAPHANE 有权转让
标题翻译：合成磺酰胺的方法
公开(公告)号：EP2854861B1
公开(公告)日：2017-10-04
申请号：EP13726846.2
申请日：2013-05-31
申请人： PharmAgra Labs, Inc.
发明人： DAMIREDDI, Sahadeva Reddy , AKUE, Kpakpo Ambroise , NELSON, Jared K. , FRISBEE, Albert Roger , NEWSOME, Peter Wyatt
IPC分类号： C07C331/20 , C08B37/16 , C08L5/16
CPC分类号： A61K31/26 , A61K31/724 , A61K47/6951 , B82Y5/00 , C07C315/02 , C07C331/20 , C08B37/0015 , C08L5/16 , A61K2300/00
摘要： The present invention relates to a method of synthesising sulforaphane by reacting a compound of formula (A) with an oxidizing agent in an aqueous solvent and in the presence of a catalyst. The invention further provides a method of synthesising a stabilised complex of sulforaphane and cyclodextrin by mixing the sulforaphane prepared by the methodology defined herein with cyclodextrin in an aqueous solvent.
摘要翻译：本发明涉及通过使式（A）的化合物与氧化剂在含水溶剂中并且在催化剂存在下反应来合成萝卜硫烷的方法。本发明进一步提供了通过将通过本文定义的方法制备的萝卜硫烷与环糊精在水性溶剂中混合来合成稳定的萝卜硫素和环糊精络合物的方法。

9. 发明公开

EP2215056A2 SULFUR CONTAINING FLUOROALKYL AMINES AND ISOCYANATES 有权
标题翻译：含S fluoroalkylamines和异氰酸酯
公开(公告)号：EP2215056A2
公开(公告)日：2010-08-11
申请号：EP08857668.1
申请日：2008-12-01
申请人： E. I. du Pont de Nemours and Company
发明人： HERZOG, Axel, Hans-Joachim , WARREN, Hollis, Thomas , GONSKA, Brent, Ryan
IPC分类号： C07C315/02 , C07C317/28 , C07C319/16 , C07C319/18 , C07C319/20 , C07C323/25 , C07C331/20 , C07D207/27
CPC分类号： C07C315/02 , C07C317/28 , C07C319/16 , C07C319/18 , C07C319/20 , C07C323/25 , C07C331/20 , C07D207/27 , C07C323/41
摘要： The present invention provides fluoroalkyl amines represented by the formula R1-Q-S(O)x-C(H),(CH3)r(CH2)z+(1-1)-NHR and fluoroalkyl isocyanates and isothiocyanates represented by the formula RrQ-S(O)x-C(H)l(CH3)r(CH2)Z+(1-1)-N=C=X1, where x is 1 or 2; z Is 0 or 1; I is 1 or 2 and j is 0 or 1, such that i+j=2; R is chosen from H or a C1 to C4 alkyl and X1 is O or S. Additionally, the invention provides a method for making a sulfur-containing fluoroalkyl amine comprising the steps of (a) reacting a thiol represented by R1-Q-SH with a /V-vinylamide represented by H2C=CH-(CH2)y-NR-C(O)-R to produce an amide intermediate represented by RrQ-S-C(H)1(CH3)J-(CH2)z+(1-1)-NR-C(O)-R; (b) optionally reacting the amide intermediate with an oxidizing agent to produce a sulfur oxide intermediate represented by RrQ-S(O)x-C(H)1(CH3)1-(CH2)z+(1-1)-NR-C(O)-R and (c) subjecting the amide intermediate or the sulfur oxide intermediate to deacylation to produce the sulfur-containing fluoroalkyl amine.

10. 发明公开

EP0446420A1 Verfahren zur Herstellung von Alkylisothiocyansäureestern 失效
标题翻译：制备烷基异硫氰酸酯的方法
公开(公告)号：EP0446420A1
公开(公告)日：1991-09-18
申请号：EP90120855.3
申请日：1990-10-31
申请人： Degussa Aktiengesellschaft
发明人： Giesselmann, Günther, Dr. , Günther, Kurt, Dr.
IPC分类号： C07C331/20
CPC分类号： C07C331/20
摘要： Alkylisothiocyansäureester der Formel R-N=C=S lassen sich durch Umsetzung von N-Alkyldithiocarbaminaten mit Wasserstoffperoxid in wäßiger Phase bei 95 bis 130 o C herstellen. Erfindungsgemäß bringt man die wäßrige N-Alkyldithiocarbaminatlösung mit einer 20 bis 40 gew.-%igen wäßrigen Wasserstoffperoxidlösung im Volumenverhältnis von 1 zu 0,8 bis 1 unter Einhaltung eines pH-Wertes von 1,5 bis 4,5 zur Reaktion. Vorzugsweise werden die Lösungen in einen Reaktor versprüht, wobei das gebildete Alkylisothiocyanat dampfförmig abdestilliert und sich die Nebenprodukte enthaltende wäßrige Phase im Reaktor sammelt.
Durch das erfindungsgemäße Verfahren konnte die Raum-Zeit-Ausbeute signifikant erhöht werden, weil gegenüber dem vorbekannten Verfahren, das bei pH 5 bis 9 erfolgt, viel weniger Schwefel gebildet und damit die Stillstandszeiten für die Reinigung des Reaktors minimiert werden konnten.
摘要翻译：式R-N = C = S的烷基异硫氰酸酯可以通过使N-烷基二硫代氨基甲酸酯与过氧化氢在95-130℃的水相中反应来制备根据本发明，使N-烷基二硫代氨基甲酸钠水溶液与体积比为1:0.8:1的20至40重量％的过氧化氢水溶液同时保持反应的pH为1.5至4.5。优选地，将溶液喷雾到反应器中，其中形成的蒸气形式的异硫氰酸烷基酯被蒸出，并且含副产物的水相收集在反应器中。本发明的方法，时空收率可以显着提高，因为与先前已知的方法相比，所述方法在pH5至9发生，形成少得多的硫，因此反应器纯化的停机时间可以最小化。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式