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    • 3. 发明公开
    • EP0869938A4 -
    • EP0869938A4 - Google专利
    • EP0869938A4
    • 1998-10-14
    • EP96923225
    • 1996-06-19
    • C07D521/00C07B61/00C07C323/11C07C323/15C07C323/16C07F7/18C09K11/07C07C69/00
    • C07C323/16C07C2603/74
    • Vinyl sulfides bearing protected arlyoxy substituents and a process for their preparation are provided. In the process a vinyl sulfide is formed by coupling a ketone compound and a thioester compound with a low valent titanium reagent to form both carbon-carbon bonds in the same step. The vinyl sulfide compounds are useful as intermediates which are convertible into triggerable sulfur-substituted dioxetanes by addition of oxygen to the double bond. The sulfur-substituted dioxetanes additionally are useful for producing chemiluminescence or for further conversion into triggerable alkoxy, alkenyloxy, alkynyloxy, aryloxy, aralkyloxy or acyloxy-substituted dioxetanes. Triggerable dioxetanes are useful for producing chemiluminescence and in detecting activating agents in assays such as immunoassays and nucleic acid hybridization assays.
    • 提供带有保护的芳氧基取代基的乙烯基硫醚及其制备方法。 在该方法中,通过将酮化合物和硫酯化合物与低价钛试剂偶联以在同一步骤中形成两个碳 - 碳键来形成乙烯基硫。 乙烯基硫化物化合物可用作中间体,通过将氧加成到双键上,中间体可转化成可触发的硫取代的二氧杂环丁烷。 硫取代的二恶丁环另外用于产生化学发光或用于进一步转化为可触发的烷氧基,烯氧基,炔氧基,芳氧基,芳烷氧基或酰氧基取代的二氧杂环丁烷。 可触发的二氧杂环丁烷可用于在诸如免疫测定和核酸杂交测定的测定中产生化学发光和检测活化剂。
    • 6. 发明公开
    • STABILIZERS AND ANTIOZONANTS FOR ELASTOMERS
    • 稳定剂UND OZONSCHUTZMITTEL FUER ELASTOMERE
    • EP1228135A1
    • 2002-08-07
    • EP00966147.1
    • 2000-10-10
    • Ciba Specialty Chemicals Holding Inc.
    • MEIER, Hans-RudolfKNOBLOCH, GerritEVANS, Samuel
    • C08K5/372C08K5/41C08L21/00C07C317/18C07C323/11C07C323/25
    • C07C323/25C07C317/28C07C317/44C07C323/52C07C2601/14C08K5/3725C08K5/41C08L21/00
    • Elastomers which have excellent stability to prevent oxidative, thermal, dynamic, light-induced and/or ozone-induced degradation comprise, as stabilizers, at least one compound of the formula (I): [R-S(=O)m-CH2-CH(OH)-CH2]n-N(R1)2-n-R2, in which R is C¿4?-C20alkyl, hydroxyl-substituted C4-C20alkyl; phenyl, benzyl, α-methylbenzyl, α,α-dimethylbenzyl, cyclohexyl or -(CH2)qCOOR?3¿, and, if m is 0, R may additionally be (a); and, if n is 1 and R4 is hydrogen, R may additionally be R?2-R1N-CH¿2-CH(OH)-CH2-S(=O)m-(CH2)x- or R?2-R1N-CH¿2-CH(OH)-CH2-S(=O)m-CH2-CH2-(O-CH2-CH2)y-, R1 is hydrogen, cyclohexyl or C¿3?-C12 alkyl, R?2¿ is (b), R3 is C1-C18alkyl, R4 is hydrogen or -CH¿2?-CH(OH)-CH2-S(=O)m-R, X is C1-C8alkyl, Y is C1-C8alkyl, m is 0 or 1, n is 1 or 2, q is 1 or 2, x is from 2 to 6, and y is 1 or 2. The compounds of the formula (I) are also suitable as stabilizers for elastomers to prevent contact discoloration of substrates coming into contact with elastomers.
    • 具有优异稳定性以防止氧化,热,动态,光诱导和/或臭氧诱导的降解的弹性体包含作为稳定剂的至少一种式(I)化合物:[RS(= O)m -CH 2 -CH (OH)-CH 2] n N(R 1)2-n R 2,其中R是C 4 -C 20烷基,羟基取代的C 4 -C 20烷基; 苯基,苄基,α-甲基苄基,α,α-二甲基苄基,环己基或 - (CH 2)q COOR 3,如果m为0,则R可另外为(a)。 并且如果n为1且R 4为氢,则R可另外为R 2 -R 1 N-CH 2 -CH(OH)-CH 2 -S(= O)m - (CH 2)x - 或R 2 -R 1 N-CH 2 -CH(OH)-CH 2 -S(= O)m -CH 2 -CH 2 - (OCH 2 -CH 2)y - ,R 1是氢,环己基或C 3 C 12烷基,R 2是(b),R 3是C 1 -C 18烷基,R 4是氢或-CH 2 -CH(OH)-CH 2 -S(= O)m R,X是C 1 -C 8烷基 Y为C1-C8烷基,m为0或1,n为1或2,q为1或2,x为2-6,y为1或2.式(I)化合物也适用 稳定弹性体以防止与弹性体接触的基底的接触变色。