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1. 发明公开

EP3131875A4 ALLENAMIDE AS AN ORTHOGONAL HANDLE FOR SELECTIVE MODIFICATION OF CYSTEINE IN PEPTIDES AND PROTEINS 审中-公开
公开(公告)号：EP3131875A4
公开(公告)日：2018-04-04
申请号：EP15780447
申请日：2015-03-27
申请人： UNIV NANYANG TECH
发明人： ABBAS ATA , LOH TECK PENG , XING BENGANG
IPC分类号： C07C233/09 , A61K47/54 , C07C233/07 , C07C233/38 , C07C233/49 , C07C235/28 , C07D209/14 , C07D209/18 , C07D311/16 , C07D403/06 , C07D493/10 , C07K1/13
CPC分类号： C07D209/14 , A61K47/48023 , A61K47/54 , C07B59/002 , C07B59/004 , C07B2200/05 , C07C233/07 , C07C233/09 , C07C233/38 , C07C233/49 , C07C2101/14 , C07C2601/14 , C07D209/18 , C07D311/16 , C07D403/06 , C07D493/10 , C07K1/1077 , C07K1/13
摘要： There is provided a compound of formula I, having the structure: wherein R1 to R5 have the meanings given in the description.

2. 发明公开

EP3134421A1 NEW LIPOPHENOL COMPOUNDS AND USES THEREOF 有权转让
标题翻译：新的脂肪醇化合物及其用途
公开(公告)号：EP3134421A1
公开(公告)日：2017-03-01
申请号：EP15720662.4
申请日：2015-04-24
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , Centre Hospitalier Universitaire de Montpellier , Université d'Auvergne , Université de Montpellier
发明人： BRABET, Philippe , CIA, David , GUILLOU, Laurent , HAMEL, Christian , VIGOR, Claire , DURAND, Thierry , CRAUSTE, Céline , VERCAUTEREN, Joseph
IPC分类号： C07F9/10 , C07C69/24 , C07C69/58 , C07C69/587 , A61K31/661 , A61K31/23 , A61K31/232 , A61P29/00 , A61P35/00 , A61P3/00
CPC分类号： C07F9/10 , C07B59/001 , C07B59/004 , C07B2200/05 , C07C69/017 , C07C69/587 , C07F9/106
摘要： The present invention relates to a compound of formula (I) wherein: - i is 0 or 1; j is 0 or 1; k is 0 or 1; - R1 and R2 are in particular H, (C1-C12)alkyl, or a group of formula C(O)R; - R is a, linear or branched, alkyl radical, comprising at least 19 carbon atoms; - R3 is H and k=0 when j=1; or, when j=0, R3 is -C(O)R or -L-C(O)R; - L, U and L" are linkers; wherein, when j=0, at least one of the groups R1; R2 and R3 comprises a radical R.
摘要翻译：本发明涉及式（I）的化合物，其中：-i是0或1; j是0或1; k是0或1; -R 1和R 2特别是H，（C 1 -C 12）烷基或式C（O）R的基团; -R是直链或支链烷基，包含至少19个碳原子; - 当j = 1时，R3是H并且k = 0; 或者当j = 0时，R 3是-C（O）R或-L-C（O）R; -L，U和L“是连接体;其中当j = 0时，基团R 1，R 2和R 3中的至少一个包含基团R.

3. 发明公开

EP3131875A1 ALLENAMIDE AS AN ORTHOGONAL HANDLE FOR SELECTIVE MODIFICATION OF CYSTEINE IN PEPTIDES AND PROTEINS 审中-公开
标题翻译： ALLENAMID正交办理肽和蛋白中的半胱氨酸选择性修饰
公开(公告)号：EP3131875A1
公开(公告)日：2017-02-22
申请号：EP15780447.7
申请日：2015-03-27
申请人： Nanyang Technological University
发明人： ABBAS, Ata , LOH, Teck Peng , XING, Bengang
IPC分类号： C07C233/09 , C07C235/28 , C07D311/16 , C07C233/38 , C07D493/10 , C07D403/06
CPC分类号： C07D209/14 , A61K47/48023 , A61K47/54 , C07B59/002 , C07B59/004 , C07B2200/05 , C07C233/07 , C07C233/09 , C07C233/38 , C07C233/49 , C07C2101/14 , C07C2601/14 , C07D209/18 , C07D311/16 , C07D403/06 , C07D493/10 , C07K1/1077 , C07K1/13
摘要： There is provided a compound of formula I, having the structure: wherein R1 to R5 have the meanings given in the description.
摘要翻译：本发明提供式I的化合物，具有以下结构：worin R1至R5具有说明书中给出的含义。

4. 发明授权

EP2803653B1 An automated synthesis device to produce Re-188-Liposome and method thereof 有权
标题翻译：以产生重新188脂质体，并且该方法的自动化合成GERAT
公开(公告)号：EP2803653B1
公开(公告)日：2016-10-12
申请号：EP13167400.4
申请日：2013-05-13
申请人： Institute of Nuclear Energy Research, Atomic
发明人： Chiu, Shu-Pei , Li, Ming-Hsin , Chang, Chih-Hsien , Li, Te-Wei
IPC分类号： C07B59/00 , C07F13/00
CPC分类号： C07B59/004 , C07F13/005

5. 发明公开

EP3052507A1 PROCESS FOR THE TRANS-SELECTIVE HYDROBORATION OF INTERNAL ALKYNES 有权
标题翻译： VERFAHREN ZUR TRANSSELEKTIVEN HYDROBORIERUNG VON INTERNEN ALKINEN
公开(公告)号：EP3052507A1
公开(公告)日：2016-08-10
申请号：EP14781135.0
申请日：2014-09-30
申请人： Studiengesellschaft Kohle mbH
发明人： FÜRSTNER, Alois , SUNDARARAJU, Basker
IPC分类号： C07F5/02 , B01J31/00
CPC分类号： C07F5/025 , B01J31/2295 , B01J2231/323 , B01J2531/821 , C07B59/004 , C07B2200/09 , C07B2200/13 , C07F5/02
摘要： The present invention refers to a process for the trans-selective hydroboration of internal alkynes and the so-obtained products. The inventive process makes use of a borane of the formula X 1 X 2 BH selected from the group of dialkyl boranes or di(alkoxy)boranes which are reacted with the internal alkynes in the presence of a cyclyopentadienyl-coordinated ruthenium catalyst.
摘要翻译：本发明涉及内部炔烃的反式选择性氢化和所得产物的方法。本发明的方法利用在环戊二烯基配位的钌催化剂存在下与内炔反应的二烷基硼烷或二（烷氧基）硼烷组的式X 1 X 2 BH的硼烷。

6. 发明授权

EP2880005B1 RADIOFLUORINATION METHOD 有权
标题翻译：放射性氟化法
公开(公告)号：EP2880005B1
公开(公告)日：2016-05-25
申请号：EP13744519.3
申请日：2013-07-30
申请人： Technical University of Denmark
发明人： ZHURAVLEV, Fedor , MATHIESSEN, Bente
IPC分类号： C07B59/00 , B01D15/36
CPC分类号： C07B59/004 , A61K51/065 , A61K51/1244 , B01D15/36 , B01J19/24 , B01J2219/24 , C07B59/00 , C07B2200/11
摘要： A method of conducting radiofluorination of a substrate, includes: (a) contacting an aqueous solution of [18F] fluoride with a polymer supported phosphazene base for sufficient time for trapping of [18F] fluoride on the polymer supported phosphazene base; and (b) contacting a solution of the substrate with the polymer supported phosphazene base having [18F] fluoride trapped thereon obtained in step (a) for sufficient time for a radiofluorination reaction to take place.

7. 发明公开

EP2803653A1 An automated synthesis device to produce Re-188-Liposome and method thereof 有权
标题翻译： Eine automatisierte Synthese Gerat an Re-188-Liposomen zu erzeugen und das Verfahren
公开(公告)号：EP2803653A1
公开(公告)日：2014-11-19
申请号：EP13167400.4
申请日：2013-05-13
申请人： Institute of Nuclear Energy Research, Atomic
发明人： Chiu, Shu-Pei , Li, Ming-Hsin , Chang, Chih-Hsien , Li, Te-Wei
IPC分类号： C07B59/00 , C07F13/00
CPC分类号： C07B59/004 , C07F13/005
摘要： An automated synthesis device to produce Re-188-BMEDA solution including: a plurality of reagent vials, three-way solenoid valves, gel filtration columns and micro pumps, and a reaction vial, a product vial, a temporary storage vial, a filter membrane, and a waste vial, wherein the plurality of reagent vials include first reagent vial and second reagent vials being connected to the reaction vial through first micro pump, the third reagent vial and fourth reagent vial being connected to the reaction vial through second micro pump, fifth reagent vial being connected to the reaction vial through third micro pump, and sixth reagent vial being connected to the temporary storage vial through fourth micro pump, wherein the reaction vial is connected to the plurality of gel filtration columns through the micro-pump, respectively. The automated synthesis device is operable with program to upgrade yield and avoid contamination.
摘要翻译：一种用于生产Re-188-BMEDA溶液的自动化合成装置，包括：多个试剂瓶，三通电磁阀，凝胶过滤柱和微型泵，以及反应瓶，产品小瓶，临时储存小瓶，过滤膜和废物小瓶，其中所述多个试剂小瓶包括通过第一微泵连接到所述反应小瓶的第一试剂小瓶和第二试剂小瓶，所述第三试剂小瓶和第四试剂小瓶通过第二微泵连接到所述反应小瓶，第五试剂小瓶通过第三微泵连接到反应小瓶，第六试剂小瓶通过第四微泵连接到临时存储小瓶，其中反应小瓶分别通过微型泵连接到多个凝胶过滤柱。自动合成装置可与程序一起操作以提高产量并避免污染。

8. 发明公开

EP1995236A1 Tellurium (Te) precursors for making phase change memory materials 有权
标题翻译：碲（Te）前体的相变存储器材料的制造
公开(公告)号：EP1995236A1
公开(公告)日：2008-11-26
申请号：EP08155034.5
申请日：2008-04-23
申请人： Air Products and Chemicals, Inc.
发明人： Xiao, Manchao , Gaffney, Thomas, Richard
IPC分类号： C07C395/00
CPC分类号： C23C16/06 , C01B19/002 , C07B59/004 , C07B2200/05 , C07C395/00 , C23C16/305 , C23C16/45525 , C23C16/56 , H01L21/02365 , H01L21/02562 , H01L45/06 , H01L45/144 , H01L45/1616
摘要： Tellurium (Te)-containing precursors, Te containing chalcogenide phase change materials are disclosed in the specification. A method of making Te containing chalcogenide phase change materials using ALD, CVD or cyclic CVD process is also disclosed in the specification in which at least one of the disclosed tellurium (Te)-containing precursors is introduced to the process.

9. 发明公开

EP1970064A1 Silicon-derivatives for pet-imaging 审中-公开
标题翻译： Siliciumderivate zur PET-Abbildung
公开(公告)号：EP1970064A1
公开(公告)日：2008-09-17
申请号：EP07090043.6
申请日：2007-03-12
申请人： Bayer Schering Pharma Aktiengesellschaft
发明人： Srinivasan, Ananth , Klar, Ulrich , Lehmann, Lutz , Voigtmann, Ulrike , Stellfeld, Timo , Höhne, Aileen , Mu, Linjing , Ametamey, Simon
IPC分类号： A61K31/695 , C07F7/02 , C07K7/06
CPC分类号： C07K7/02 , C07B59/004 , C07B59/008 , C07F7/0818 , C07F7/0836 , C07F7/0896 , C07F7/1844
摘要： This invention relates to silicon compounds suitable for labelling or already labelled with 18 F, methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging, preferably positron emission tomography (PET).
摘要翻译：本发明涉及适用于标记或已经用18F标记的硅化合物，制备这种化合物的方法，包含这些化合物的组合物，包含这些化合物或组合物的试剂盒和用于诊断成像的组合物或试剂盒，优选正电子发射断层扫描（PET）。

10. 发明公开

EP1282631A4 METHODS OF SYNTHESIS AND USE OF RADIOLABELLED PLATINUM CHEMOTHERAPEUTIC AGENTS 有权
标题翻译：工艺编制和使用无线电MARK铂化疗药物
公开(公告)号：EP1282631A4
公开(公告)日：2005-02-09
申请号：EP01913394
申请日：2001-03-23
申请人： AUSTRALIAN NUCLEAR SCIENCE TEC
发明人： SMITH SUZANNE VIRGINIA
IPC分类号： A61K51/00 , A61K31/282 , A61K33/24 , A61K51/02 , A61P35/00 , C07B59/00 , C07F15/00
CPC分类号： A61K51/02 , C07B59/004 , C07F15/0093

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