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1. 发明授权

EP0307373B1 Purification process 失效
标题翻译：净化过程
公开(公告)号：EP0307373B1
公开(公告)日：1993-11-18
申请号：EP88830362.5
申请日：1988-09-09
申请人： ARES TRADING S.A.
发明人： Eshkol, Alisa , Maillard, François , Stiles, Gerald E.
IPC分类号： C07K3/26 , A61K35/30 , A61K37/36 , B01D61/14
CPC分类号： C07K1/34

2. 发明公开

EP0467992A4 PROCESS FOR PURIFYING A PROTEIN 失效
标题翻译：净化蛋白质的方法
公开(公告)号：EP0467992A4
公开(公告)日：1993-04-28
申请号：EP90908049
申请日：1990-04-12
申请人： BIOGEN, INC.
发明人： STAPLES, MARK, A. , PARGELLIS, CHRISTOPHER, A.
IPC分类号： C07K14/00 , B01D15/38 , C07K1/00 , C07K1/20 , C07K1/22 , C07K14/42 , C07K14/52 , C07K14/555 , C07K14/575 , C07K14/58 , C07K14/61 , C07K14/65 , C07K14/705 , C07K14/73 , C07K14/76 , C07K16/00 , C07K3/14 , C07K3/18 , C07K3/20 , C07K3/22 , C07K3/24 , C07K3/26 , C07K3/28 , C07K13/00 , C07K15/00 , C07K15/14
CPC分类号： B01D15/3828 , C07K1/22 , C07K14/70514
摘要： A process for the purification of proteins from solutions containing contaminants of similar net charge and molecular weight is provided, comprising contacting a solution containing the desired protein with an immobilized metal affinity chromatography resin in a buffer containing a low concentration of a weak ligand for the chelant of the resin. The adsorbed protein is then eluted using a buffer having a high concentration of the same weak ligand, e.g., Tris. Particularly preferred features employ agarose-iminodiacetic acid resins having copper cations and are especially useful in obtaining preparations of homogeneous, stable rsT4 proteins.

3. 发明授权

EP0253845B1 TANGENTIAL FLOW AFFINITY ULTRAFILTRATION 失效
标题翻译： TANGTITIAL FLOW AFFINITY ULTRAFILTRATION
公开(公告)号：EP0253845B1
公开(公告)日：1991-10-16
申请号：EP87900671.6
申请日：1987-01-09
申请人： HEMOSOL INC.
发明人： HSIA, Jen-Chang
IPC分类号： C07K3/26 , C07K3/28
CPC分类号： C07K1/34 , C07K14/805
摘要： Biological macromolecules are separated from liquid mixtures in which they are contained, in substantially pure form, by a process involving tangential flow ultrafiltration of the liquid mixture in the presence of an affinity gel which binds selectively to the biological macromolecule to be recovered in pure form, in either the positive affinity absorption mode or the negative affinity absorption mode. Thus a mixture containing the biological macromolecule of interest, such as hemoglobin or (oxy)hemoglobin is first mixed with an affinity gel, such as agarose-ATP, which selectively binds to the hemoglobin or (oxy)hemoglobin and then the liquid is subjected to tangential flow ultrafiltration, so that all components of the mixture except the gel-bond hemoglobin pass through the filter. In a second stage, the gel-bond hemoglobin is treated with a salt solution to displace the hemoglobin from the gel, and then the mixture is passed again over a tangential flow ultrafiltration membrane, so that the pure hemoglobin is separated from the gel, and collected in filtrate. The affinity gel which remains in retentate can then be regenerated and re-used.

4. 发明授权

EP0113447B1 Verfahren zur fraktionierten Auftrennung von Proteingemischen mittels Membranen 失效
标题翻译：用膜分离蛋白质混合物的方法
公开(公告)号：EP0113447B1
公开(公告)日：1988-02-10
申请号：EP83112350.0
申请日：1983-12-08
申请人： Schott Glaswerke , Carl-Zeiss-Stiftung trading as SCHOTT GLASWERKE
发明人： Schnabel, Roland, Dr. Dipl.-Chem. , von Baeyer, Hans, Dr.Med.
IPC分类号： B01D13/00 , C07K3/26
CPC分类号： A23C9/1422 , A23C2210/208 , A61M1/3472 , A61M1/3482 , A61M2205/7563 , B01D61/145 , B01D63/02 , B01D2313/30 , C12M29/04 , C12M47/10 , C12M47/12

5. 发明公开

EP0445414A3 Ultrafiltration method for purification of a pediococcal bacteriocin 失效
标题翻译：用于纯化磷酸胆碱酯酶的超滤方法
公开(公告)号：EP0445414A3
公开(公告)日：1992-05-20
申请号：EP90124948.2
申请日：1990-12-20
申请人： MICROLIFE TECHNICS, INC.
发明人： Vandenbergh, Peter A. , Kunka, Blair S. , Henderson, James T.
IPC分类号： C07K3/26 , C12N1/20 , C07K3/28
CPC分类号： C07K14/195
摘要： Purification of a bacteriocin from a Pediococcus by ultrafiltration of supernatant of a culture of the Pediococcus and having a molecular weight of between about 4,000 and 5,000 daltons is described. The bacteriocin is useful in foods to inhibit bacterial growth.

6. 发明公开

EP0484148A1 A method for producing a new medicine for both treating and preventing peptic ulcer diseases and gastritis and thus formulated medicines 失效
标题翻译：一种用于治疗都和预防胃溃疡和胃炎，以及适当配制的药物的药物的制造工艺。
公开(公告)号：EP0484148A1
公开(公告)日：1992-05-06
申请号：EP91310049.1
申请日：1991-10-31
申请人： IMMUNO JAPAN INC.
发明人： Ando, Kunio , Nakamura, Tetsuo
IPC分类号： A61K39/40 , C07K3/26
CPC分类号： A61K39/40 , A61K38/00 , A61K39/00 , C07K16/121
摘要： A method for producing a new medicine which is useful for both treating and/or preventing peptic ulcer diseases and gastritis (through the eradication of Helicobacter pylori colonizing the upper gastrointestinal tract) by anti- Helicobacter pylori antibodies which are extracted either from blood or milk of domestic animals, and the methods for preparing the medicines containing anti- Helicobacter pylori antibodies of either milk or blood origins as an active ingredient.
摘要翻译：一种用于生产新药物的所有这是有用的方法这两种治疗和/或预防消化性溃疡和胃炎（通过幽门螺杆菌定居于上胃肠道的消灭）由抗幽门螺杆菌抗体，所述抗体是从血液或牛奶中提取任家畜，并制备含有乳要么或血液来源的抗幽门螺杆菌抗体作为活性成分的药物的方法。

7. 发明公开

EP0393850A3 Process for producing kappa-casein glycomacropeptides 失效
标题翻译：生产κ-酪蛋白糖巨肽的方法
公开(公告)号：EP0393850A3
公开(公告)日：1990-11-28
申请号：EP90303044.3
申请日：1990-03-21
申请人： SNOW BRAND MILK PRODUCTS CO., LTD.
发明人： Tanimoto, Morimasa , Kawasaki, Yoshiro, Yukijirushi Nyugyo K.K. , Shinmoto, Hiroshi , Dosako, Shunichi , Tomizawa, Akira
IPC分类号： A23J1/20 , C07K3/26
CPC分类号： A23J1/202 , C07K14/4732
摘要： The invention provides a process for producing a kappa-casein glycomacropeptide which comprises adjusting the pH of a solution of milk starting materials containing the kappa-casein glycomacropeptide to below 4, treating the solution by ultrafiltration with a membrane passing a molecular weight fraction of 10,000-50,000, and concentrating the filtrate obtained with a membrane passing a molecular weight fraction of 50,000 or less.
摘要翻译：本发明提供了一种生产κ-酪蛋白糖巨肽的方法，该方法包括将含有κ-酪蛋白糖巨肽的乳原料溶液的pH调节到4以下，通过超滤用分子量为10,000- 50,000，浓缩滤液得到的分子量为50,000或更低的膜。

8. 发明公开

EP0113447A2 Verfahren zur fraktionierten Auftrennung von Proteingemischen mittels Membranen 失效
标题翻译：一种用于通过膜的手段蛋白质混合物的分级分离过程。
公开(公告)号：EP0113447A2
公开(公告)日：1984-07-18
申请号：EP83112350.0
申请日：1983-12-08
申请人： Schott Glaswerke , Carl-Zeiss-Stiftung trading as SCHOTT GLASWERKE
发明人： Schnabel, Roland, Dr. Dipl.-Chem. , von Baeyer, Hans, Dr.Med.
IPC分类号： B01D13/00 , C07K3/26
CPC分类号： A23C9/1422 , A23C2210/208 , A61M1/3472 , A61M1/3482 , A61M2205/7563 , B01D61/145 , B01D63/02 , B01D2313/30 , C12M29/04 , C12M47/10 , C12M47/12
摘要： Bei einem Verfahren zur fraktionierten Auftrennung von Stoffgemischen, beispielsweise in der Biotechnologie und' der Medizintechnik zum Zwecke der Reinigung, Konzentrierung und Gewinnung spezifischer Substanzen, werden Membranen (Plasmapherese) in mehrstufiger Modulanordnung eingesetzt, wobei zur Erhöhung der Selektivität bei der fraktionierten Auftrennung mit mindestens zehnfacher, vorzugsweise zwanzigfacher Verdünnung gearbeitet wird und Filtrationsraten von über 70 % erreicht werden können.
摘要翻译：在用于的物质的混合物的分级分离的方法，例如，在生物技术和医疗技术用于纯化，浓缩和特定物质回收的目的，膜（血浆）在多级模块组件中使用，以增加至少10倍的分级分离选择性，优选20倍稀释的工作和滤过率可以达到70％以上来实现。

9. 发明授权

EP0219295B1 Process for producing human growth hormone 失效
标题翻译：一种用于生产人生长激素的过程。
公开(公告)号：EP0219295B1
公开(公告)日：1994-01-19
申请号：EP86307707.9
申请日：1986-10-06
申请人： NIHON CHEMICAL RESEARCH KABUSHIKI KAISHA also known as JCR PHARMACEUTICALS CO., LTD
发明人： Hiratani, Hajime , Tateishi, Jun , Kitamoto, Tetsuyuki
IPC分类号： C07K3/26
CPC分类号： C07K14/615 , A61K38/00 , A61K38/27 , A61L2/0017 , A61L2/022
摘要： A membrane filter of 0.025 to 0.05 mu m pore size is previously treated by passing a solution of a water-soluble high molecular substance such as albumin, dextran,polyvinylpyrrolidone, polyethyleneglycol, gelatin or the like through the filter. Employing the filter thus treated, a solution of human growth hormone (HGH) is filtered at high recovery rate of HGH activity to remove Creutzfeldt-Jacob disease pathogen which may exist in HGH preparations.

10. 发明公开

EP0363896A2 Enrichment and concentration of proteins by ultrafiltration 失效
标题翻译： Bereicherung und Konzentrierung von Proteinen durch Ultrafiltration。
公开(公告)号：EP0363896A2
公开(公告)日：1990-04-18
申请号：EP89118796.5
申请日：1989-10-10
申请人： ABBOTT LABORATORIES
发明人： Cordle, Christopher Thurman , Thomas, Ronald Lewis , Criswell, Larry Grant
IPC分类号： C07K3/26
CPC分类号： C07K1/34 , A23C9/1425
摘要： Disclosed are ultrafiltration processes for the enrichment and concentration of selected proteins from protein containing fluids. Illustratively, IgG is concentrated from whey by means of multiple ultrafiltration "passes", using a metallic oxide ultrafiltration membrane, which are characterized by differing pH's.
摘要翻译：公开了用于从含蛋白质的流体富集和浓缩所选蛋白质的超滤方法。示例性地，使用以不同pH为特征的金属氧化物超滤膜，通过多次超滤“通过”从乳清中浓缩IgG。

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