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1. 发明公开

EP0648782A1 COMPOSITION CONTAINING HEMATOPOIESIS INHIBITOR 失效
标题翻译：抑制剂DU BLUTBILDUNG ENTHALTENDE ZUSAMMENSETZUNG。
公开(公告)号：EP0648782A1
公开(公告)日：1995-04-19
申请号：EP94901037.5
申请日：1993-12-03
申请人： TORAY INDUSTRIES, INC.
发明人： YAMADA, Tomoko 8-105, Wakatake-cho 8-chome , KATAOKA, Hiroshi 15-1, Sonoyama 2-chome
IPC分类号： C07K15/06 , C07K1/00 , C07K3/18 , A61M1/16 , A61M1/34 , A61K38/00 , A61K35/16
CPC分类号： C07K14/47 , A61K38/00 , C07K14/52
摘要： A composition containing a hematopoiesis inhibitor that inhibits CFU-E colony formation and comprising a substance present in the filtrate obtained by concentrating a dialyzate, obtained by dialyzing blood through a dialysis membrane having an albumin sieving coefficient of 0.01 or above, with a membrane having a fractionating molecular weight of 5,000 or less and then filtering the concentrate with a gel having a maximum fractionating molecular weight ranging from 0.2 to 1.5 million. The invention also relates to a method of treating blood characterized by removing an A I component so as to satisfy the following relationship: A I /A A ≧ 1/50 wherein A I represents the height of the absorbance value of a composition containing a hematopoiesis inhibitor, as set forth in any of claims 1 through 5, at a wavelength of 280 nm in the gel filtration pattern of the solute in the dialyzate, and A A represents the height of the maximum absorbance value in the gel filtration pattern. The invention further relates to a dialysis membrane characterised in that the following relationship holds: A I /A A ≧ 1/50 wherein A I , represents the height of the absorbance value of a composition containing a hematopoiesis inhibitor, as set forth in any of claims 1 through 5, at a wavelength of 280 nm in the gel filtration pattern of the solute in the dialyzate, and A A represents the height of the maximum absorbance value in the gel filtration pattern. In addition, the invention relates to a pharmaceutical composition and an erythrocytosis remedy each containing the hematopoiesis inhibitor.
摘要翻译：一种含有抑制CFU-E集落形成的造血抑制剂的组合物，其含有通过浓缩透析液获得的滤液中存在的物质，所述透析液是通过使透过透析膜的蛋白质筛分系数为0.01以上的血液透析得到的，分级分子量为5,000或更小，然后用最大分馏分子量范围为0.2-1.5百万的凝胶过滤浓缩物。本发明还涉及一种治疗血液的方法，其特征在于除去AI成分以满足以下关系：AI / AA> / = 1/50其中，AI表示含有造血抑制剂的组合物的吸光度值的高度，权利要求1〜5中任一项所述的透析液中的溶质的凝胶过滤图案中的波长为280nm，AA表示凝胶过滤图案中的最大吸光度值的高度。本发明还涉及一种透析膜，其特征在于以下关系成立：AI / AA> / = 1/50其中，AI代表含有造血抑制剂的组合物的吸光度值的高度，如权利要求 1〜5，透析液中溶质的凝胶过滤图案中波长280nm，AA表示凝胶过滤图案中最大吸光度值的高度。此外，本发明涉及每种含有造血抑制剂的药物组合物和红细胞增多症药物。

2. 发明公开

EP0588036A3 Composition for isolating apamin receptors, apamin binding protein and uses thereof 失效
标题翻译：一种分离Apaminrezeptoren，Apaminbindungsprotein和它们的用途的组合物。
公开(公告)号：EP0588036A3
公开(公告)日：1995-04-19
申请号：EP93112165.1
申请日：1993-07-29
申请人： AMERICAN CYANAMID COMPANY
发明人： Sokol, Patricia Tyson , Ziai, Mohammed Reza , Chandra, Manik
IPC分类号： C07K17/10 , C07K3/18 , C07K15/00 , A61K37/02 , C12P21/08 , C12N15/12 , C12N5/16 , C12N15/85 , G01N33/548 , C07K17/12
CPC分类号： C07K14/705 , A61K38/00 , C07K16/28 , C07K17/10
摘要： The present invention relates to a compositon of matter useful as an affinity matrix for isolating an apamin receptor from cellular material, comprising a derivatized agerose matrix having a free amino group covalently coupled to a free carboxyl group of apamin. It additionally relates to a protein, isolated from a vertebrate tissue sample, of approximately 80 KDa which specifically binds apamin, and to an approximately 55 KDa presumed degradation product of said protein, as well as antibodies which bind to said protein or to the presumed degradation product. The invention further relates to an isolated nucleic acid fragment, comprising a nucleic acid sequence encoding an apamin receptor protein, or a biologically active fragment thereof; and to host cells comprising said nucleic acid fragment.

3. 发明授权

EP0168214B1 Tumor necrosis factor, methods for its preparation, compositions containing it, DNA encoding it and assay method using such DNA 失效
标题翻译：肿瘤坏死因子，处理用于它的生产，含有组合物是相同的，对于编码DNA和该DNA用途测试。
公开(公告)号：EP0168214B1
公开(公告)日：1994-10-26
申请号：EP85304758.7
申请日：1985-07-03
申请人： GENENTECH, INC.
发明人： Aggarwal, Bharat Bhushan , Lee, Sang He , Goeddel, David Vannorman , Nedwin, Glenn Evan
IPC分类号： C07K3/18 , C07K13/00 , A61K37/02 , C12P21/02 , C12N15/00 , C12Q1/68 , A61K37/66
CPC分类号： C07K14/5255 , A61K38/00 , C07K14/525 , C07K2319/02 , G01N33/6863

4. 发明公开

EP0614912A1 Lipoprotein (a)-Peptide und deren Verwendung 失效
标题翻译：脂蛋白（a） - 肽和deren Verwendung。
公开(公告)号：EP0614912A1
公开(公告)日：1994-09-14
申请号：EP94101703.0
申请日：1994-02-04
申请人： BOEHRINGER MANNHEIM GMBH
发明人： Burns, Geoffrey, Dr. , Engel, Wolf-Dieter, Dr. , Seidel, Christoph, Dr.
IPC分类号： C07K7/06 , C07K7/08 , C07K15/06 , C07K3/18 , G01N33/92
CPC分类号： G01N33/92 , C07K14/775
摘要： Gegenstand der Erfindung sind Peptide, die eine Teilsequenz von Lipoprotein (a) aufweisen, sowie deren Verwendung zur affinitätschromatographischen Aufreinigung von Antikörpern, als Immunogen zur Herstellung von Antikörpern sowie als Standard in einem immunologischen Test oder als kompetitierendes Hapten in einem Agglutinationstest.
摘要翻译：本发明涉及具有脂蛋白（a）的部分序列的肽，以及其用于通过抗体亲和层析纯化的用途，作为免疫原以制备抗体，并且作为免疫学测定中的标准或作为竞争性半抗原凝集试验。

5. 发明授权

EP0336736B1 Purification of pertussis toxins and production of vaccine 失效
标题翻译：百日咳毒素和疫苗生产的净化。
公开(公告)号：EP0336736B1
公开(公告)日：1994-05-04
申请号：EP89303369.6
申请日：1989-04-05
申请人： CONNAUGHT LABORATORIES LIMITED
发明人： Tan, Larry U. L. , Jackson, Gail , Alkema, Dirk , Wah, Po S. , Fahim, Rafaat Emil Fahmy
IPC分类号： A61K39/10 , C07K3/18
CPC分类号： C07K14/235 , A61K39/00

6. 发明授权

EP0409883B1 MONOCLONAL ANTIBODY TO ENTEROVIRUSES 失效
标题翻译：单克隆抗体肠病毒。
公开(公告)号：EP0409883B1
公开(公告)日：1994-01-26
申请号：EP89904818.5
申请日：1989-04-12
申请人： 3i RESEARCH EXPLOITATION LIMITED
发明人： MOWBRAY, James Frederick , YOUSEF, Mohamed Galal Eldin
IPC分类号： C07K15/00 , C12P21/00 , C12N5/00 , C12N15/00 , C07K3/18 , G01N33/569
CPC分类号： C07K16/1009
摘要： A monoclonal antibody (designated 5-D8/1) is described which is produced by a hybridoma cell line and is capable of binding to an epitope of a VP1 protein of an enterovirus, which epitope is conserved throughout the group of viruses known as enteroviruses and excluding hepatitis A virus.

7. 发明授权

EP0454739B1 METHOD OF RECOVERING PURIFIED EPI PROTEIN FROM A SOLUTION ESPECIALLY A FERMENTATION SOLUTION 失效
标题翻译：工艺纯化的蛋白质EPI由溶液，特别是发酵溶液中回收。
公开(公告)号：EP0454739B1
公开(公告)日：1993-12-29
申请号：EP90902177.6
申请日：1990-01-18
申请人： NOVO NORDISK A/S
发明人： NORDFANG, Ole , CARLSEN, Soren
IPC分类号： C07K3/18
CPC分类号： C12Q1/56 , C07K5/0821 , C07K14/745 , C12Q2337/12 , G01N2333/96461
摘要： The EPI protein is isolated and purified from a fermentation solution, using chromatographic technique, wherein the solution containing the EPI protein is applied to a matrix coupled with heparin, preferably heparin-Sepharose.

8. 发明公开

EP0559234A1 Monoclonal antibodies specific for an epitope in the B chain of platelet-derived growth factor and their use in affinity chromatography 失效
标题翻译：具体为在血小板衍生的生长因子B链以及它们在亲和层析使用的表位的单克隆抗体。
公开(公告)号：EP0559234A1
公开(公告)日：1993-09-08
申请号：EP93104885.4
申请日：1988-03-10
申请人： AMGEN INC.
发明人： Thomason, Arlen R. , Nicolson, Margery A.
IPC分类号： C12P21/08 , C12N5/20 , C07K3/18 , C07K13/00
CPC分类号： C07K16/22 , A61K38/00 , C07K14/49 , C07K2319/00 , C07K2319/75
摘要： Monoclonal antibodies specific for epitopes found on the B chain of PDGF may be bound to columns and used for isolation and purification of a polypeptide having substantially the same biological activity as naturally occuring PDGF B. The immobilized monoclonal antibody is contacted with a solution containing said polypeptide and the polypeptide is eluted from the immobilized monoclonal antibody.

9. 发明授权

EP0286171B1 Dipeptidase, its isolation from lactic acid bacteria, antibodies against the dipeptidase, the use of the dipeptidase and of the antibodies against it 失效
标题翻译：脯氨酸酶，其从酸乳杆菌中分离出来的抗体，抗胰蛋白酶的抗体，抗病毒剂和抗体的使用
公开(公告)号：EP0286171B1
公开(公告)日：1993-03-31
申请号：EP88200607.5
申请日：1988-03-31
申请人： CAMPINA MELKUNIE B.V.
发明人： Konings, Willem Nicolaas , Van Boven, Aart
IPC分类号： C12N9/52 , C12P21/00 , C07K3/18 , C07K15/00 , G01N33/573 , G01N33/577 , A23C19/032 , A23L1/03
CPC分类号： C12Y304/13011 , A23Y2240/21 , C07K16/40 , C12N9/48 , Y10S435/814 , Y10S435/853

10. 发明公开

EP0498854A4 ANTIVENOMS AND METHODS FOR MAKING ANTIVENOMS 失效
标题翻译：用于制备抗生素的抗生素和方法
公开(公告)号：EP0498854A4
公开(公告)日：1993-03-03
申请号：EP91900530
申请日：1990-10-31
申请人： CARROLL SEAN B
发明人： CARROLL SEAN B
IPC分类号： A61K38/00 , A61K39/00 , A61P31/00 , C07K16/02 , C07K16/06 , C07K16/12 , C07K16/18 , C07K17/08 , A61K35/16 , A61K39/395 , C07K3/18 , C07K15/06 , C08G63/48 , G01N33/538
CPC分类号： C07K16/1282 , A61K38/00 , A61K39/00 , C07K16/02 , C07K16/065 , C07K16/18 , C07K17/08 , Y10S424/804 , Y10S436/824 , Y10S530/81 , Y10S530/813 , Y10S530/856 , Y10S530/858 , Y10S530/861

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